Statistics of regulated genes

Genome	Genes	Operons
Haemophilus influenzae Rd KW20	11	5
Aggregatibacter aphrophilus NJ8700	10	4
Pasteurella multocida subsp. multocida str. Pm70	8	5
Mannheimia succiniciproducens MBEL55E	6	5
Actinobacillus succinogenes 130Z	9	5
Haemophilus somnus 2336	9	4
Actinobacillus pleuropneumoniae serovar 7 str. AP76	6	3
Haemophilus ducreyi 35000HP
Haemophilus parasuis SH0165	9	3

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes										Function
CRON 1.
HAPS_0395	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	* Haemophilus parasuis SH0165 Site: position = -52 score = 6.58143 sequence = TGTACTATTTTAATAGTACA Gene: HAPS_0395: ABC transporter, substrate binding component	ABC transporter, substrate binding component
CRON 2.
aroG	* Haemophilus influenzae Rd KW20 Site: position = -81 score = 6.23662 sequence = CGAACTAGTTTACTAGTACA Gene: HI1547: 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (EC 2.5.1.54)	Aggregatibacter aphrophilus NJ8700	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -123 score = 5.89992 sequence = AAAACTAGTTTACTAGTGTA Gene: PM0563: 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (EC 2.5.1.54)	* Mannheimia succiniciproducens MBEL55E Site: position = -90 score = 5.89808 sequence = TGTACTAGTTTACCAATGCA Gene: MS1184: 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (EC 2.5.1.54)	* Actinobacillus succinogenes 130Z Site: position = -176 score = 6.65185 sequence = TGAACTAGTTTACTAGTGCA Gene: Asuc_1428: 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (EC 2.5.1.54)	* Haemophilus somnus 2336 Site: position = -104 score = 5.58052 sequence = GAAATTAGTTTACTAGTACA Gene: HSM_1416: 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (EC 2.5.1.54)	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -106 score = 6.32082 sequence = TGTACTAGTAAAATAGTTCA Gene: APP7_0666: 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (EC 2.5.1.54)	Haemophilus ducreyi 35000HP Gene: HD1475: 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (EC 2.5.1.54)	Haemophilus parasuis SH0165 Gene: HAPS_0321: 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (EC 2.5.1.54)	2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (EC 2.5.1.54)
CRON 3.
trpR	* Haemophilus influenzae Rd KW20 Site: position = -36 score = 6.65185 sequence = TGCACTAGTTTAATAGTGTA Gene: HI0830: trp operon repressor	* Aggregatibacter aphrophilus NJ8700 Site: position = -31 score = 6.23662 sequence = CGCACTAGTTTAATAGTATA Gene: NT05HA_1280: trp operon repressor	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM0325: trp operon repressor	* Mannheimia succiniciproducens MBEL55E Site: position = -42 score = 6.16087 sequence = TATACTAGTTTAATAGTATG Gene: MS1566: trp operon repressor	* Actinobacillus succinogenes 130Z Site: position = -33 score = 6.65185 sequence = TGCACTAGTTTAATAGTGTA Gene: Asuc_1556: trp operon repressor	* Haemophilus somnus 2336 Site: position = -29 score = 5.50754 sequence = TACACTAGTTTAATAGTCAG Gene: HSM_1017: trp operon repressor	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_0553: trp operon repressor	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_0251: trp operon repressor	trp operon repressor
CRON 4.
mtr	* Haemophilus influenzae Rd KW20 Site: position = -41 score = 6.46254 sequence = TGTACTACTATAATAGTGCA Gene: HI0287: Tryptophan-specific transport protein	* Aggregatibacter aphrophilus NJ8700 Site: position = -44 score = 6.19971 sequence = TGTACTATTATAATAGTCCA Gene: NT05HA_1570: Tryptophan-specific transport protein	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -61 score = 6.08274 sequence = TGCACTATTAAAATAGTGCA Gene: PM1192: Tryptophan-specific transport protein	* Mannheimia succiniciproducens MBEL55E Site: position = 1 score = 6.34514 sequence = TGTACTACTATAATAGTTCA Gene: MS1895: Tryptophan-specific transport protein	* Actinobacillus succinogenes 130Z Site: position = -44 score = 6.37151 sequence = TGCACTACTATAATAGTGCA Gene: Asuc_0628: Tryptophan-specific transport protein	* Haemophilus somnus 2336 Site: position = -49 score = 6.30536 sequence = TGAACTATTATAATAGTTCA Gene: HSM_0462: Tryptophan-specific transport protein	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Tryptophan-specific transport protein
CRON 5.
trpE	* Haemophilus influenzae Rd KW20 Site: position = -45 score = 6.75485 sequence = TGCACTAGTTTAATAGTACA Gene: HI1387: Anthranilate synthase, aminase component (EC 4.1.3.27)	* Aggregatibacter aphrophilus NJ8700 Site: position = -51 score = 6.9369 sequence = TGTACTAGTTTAATAGTGCA Gene: NT05HA_0807: Anthranilate synthase, aminase component (EC 4.1.3.27)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -51 score = 6.56981 sequence = TAAACTAGTTTAATAGTTCA Gene: PM0584: Anthranilate synthase, aminase component (EC 4.1.3.27)	* Mannheimia succiniciproducens MBEL55E Site: position = -50 score = 6.9369 sequence = TGTACTAGTTTAATAGTGCA Gene: MS1149: Anthranilate synthase, aminase component (EC 4.1.3.27)	* Actinobacillus succinogenes 130Z Site: position = -46 score = 6.9369 sequence = TGTACTAGTTTAATAGTGCA Gene: Asuc_1272: Anthranilate synthase, aminase component (EC 4.1.3.27)	* Haemophilus somnus 2336 Site: position = -52 score = 6.40428 sequence = CGCACTAGTTTAATAGTTCA Gene: HSM_1315: Anthranilate synthase, aminase component (EC 4.1.3.27)	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -48 score = 6.3549 sequence = TATACTAGTTTAATAGTACG Gene: APP7_1221: Anthranilate synthase, aminase component (EC 4.1.3.27)	Haemophilus ducreyi 35000HP	* Haemophilus parasuis SH0165 Site: position = -47 score = 6.6872 sequence = TATACTAGTTTAATAGTACA Gene: HAPS_1997: Anthranilate synthase, aminase component (EC 4.1.3.27)	Anthranilate synthase, aminase component (EC 4.1.3.27)
trpG	Haemophilus influenzae Rd KW20 Gene: HI1388: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0808: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM0583: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)	Mannheimia succiniciproducens MBEL55E Gene: MS1150: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)	Actinobacillus succinogenes 130Z Gene: Asuc_1271: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)	Haemophilus somnus 2336 Gene: HSM_1314: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1222: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_1996: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)	Anthranilate synthase, amidotransferase component (EC 4.1.3.27)
trpD	Haemophilus influenzae Rd KW20 Gene: HI1389: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0810: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -57 score = 6.21816 sequence = TGTACTAGTTTAATAGTTTT Gene: PM0581: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	Mannheimia succiniciproducens MBEL55E Gene: MS1151: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	Actinobacillus succinogenes 130Z Gene: Asuc_1270: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	Haemophilus somnus 2336 Gene: HSM_1313: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1223: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_1995: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	Anthranilate phosphoribosyltransferase (EC 2.4.2.18)
trpC	Haemophilus influenzae Rd KW20 Gene: HI1389.1: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0811: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM0580: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)	Mannheimia succiniciproducens MBEL55E Gene: MS1152: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)	Actinobacillus succinogenes 130Z Gene: Asuc_1269: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)	Haemophilus somnus 2336 Gene: HSM_1312: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_0918: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_1994: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)	Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)
trpB	Haemophilus influenzae Rd KW20 Gene: HI1431: Tryptophan synthase beta chain (EC 4.2.1.20)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0825: Tryptophan synthase beta chain (EC 4.2.1.20)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -93 score = 6.84587 sequence = TGAACTAGTTTAATAGTGCA Gene: PM0578: Tryptophan synthase beta chain (EC 4.2.1.20)	* Mannheimia succiniciproducens MBEL55E Site: position = -52 score = 6.65185 sequence = TGTACTAGTTTAATAGTATA Gene: MS1153: Tryptophan synthase beta chain (EC 4.2.1.20)	* Actinobacillus succinogenes 130Z Site: position = -52 score = 5.78551 sequence = TGTACTAGTTAACTAGTATG Gene: Asuc_1478: Tryptophan synthase beta chain (EC 4.2.1.20)	Haemophilus somnus 2336 Gene: HSM_1311: Tryptophan synthase beta chain (EC 4.2.1.20)	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -47 score = 6.67246 sequence = TGTACTATTTTAATAGTGCA Gene: APP7_0546: Tryptophan synthase beta chain (EC 4.2.1.20)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_1993: Tryptophan synthase beta chain (EC 4.2.1.20)	Tryptophan synthase beta chain (EC 4.2.1.20)
trpA	Haemophilus influenzae Rd KW20 Gene: HI1432: Tryptophan synthase alpha chain (EC 4.2.1.20)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0826: Tryptophan synthase alpha chain (EC 4.2.1.20)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM0577: Tryptophan synthase alpha chain (EC 4.2.1.20)	Mannheimia succiniciproducens MBEL55E Gene: MS1154: Tryptophan synthase alpha chain (EC 4.2.1.20)	Actinobacillus succinogenes 130Z Gene: Asuc_1479: Tryptophan synthase alpha chain (EC 4.2.1.20)	Haemophilus somnus 2336 Gene: HSM_1310: Tryptophan synthase alpha chain (EC 4.2.1.20)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_0547: Tryptophan synthase alpha chain (EC 4.2.1.20)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_1992: Tryptophan synthase alpha chain (EC 4.2.1.20)	Tryptophan synthase alpha chain (EC 4.2.1.20)
HI1388.1	Haemophilus influenzae Rd KW20 Gene: HI1388.1: hypothetical protein	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0809: hypothetical protein	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	hypothetical protein
COG4221	* Haemophilus influenzae Rd KW20 Site: position = -46 score = 6.53019 sequence = TGTACTACTTTAATAGTACA Gene: HI1430: Short-chain alcohol dehydrogenase of unknown specificity	* Aggregatibacter aphrophilus NJ8700 Site: position = -102 score = 5.26195 sequence = TGTACTAGTGTAGTAGTATG Gene: NT05HA_0824: Short-chain alcohol dehydrogenase of unknown specificity	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E Gene: MS1568: Short-chain alcohol dehydrogenase of unknown specificity	Actinobacillus succinogenes 130Z Gene: Asuc_0225: Short-chain alcohol dehydrogenase of unknown specificity	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Short-chain alcohol dehydrogenase of unknown specificity
CRON 6.
HAPS_1139	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	* Haemophilus parasuis SH0165 Site: position = -26 score = 5.74584 sequence = TGTACTAGTAAAATAGTATT Gene: HAPS_1139: ABC transporter, inner-membrane component	ABC transporter, inner-membrane component
HAPS_1138	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_1138: ABC transporter, ATP-binding protein	ABC transporter, ATP-binding protein

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