Regulog His_leader - Pasteurellales

Properties
Regulator type:	RNA regulatory element
Name:	His_leader
RFAM:	RF00514
Regulation mode:
Biological process:	Histidine biosynthesis
Effector:
Phylum:	Proteobacteria

Member of regulog collections

By taxonomy - Pasteurellales
By RNA motif - His_leader
By pathway - Histidine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Haemophilus influenzae Rd KW20	9	2
Aggregatibacter aphrophilus NJ8700	5	2
Pasteurella multocida subsp. multocida str. Pm70	12	1
Mannheimia succiniciproducens MBEL55E	4	1
Actinobacillus succinogenes 130Z	7	1
Haemophilus somnus 2336
Actinobacillus pleuropneumoniae serovar 7 str. AP76	10	1
Haemophilus ducreyi 35000HP
Haemophilus parasuis SH0165	1	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes										Function

CRON 1.
hisG	* Haemophilus influenzae Rd KW20 Site: position = -165 score = 65.21 sequence = CATCATCACCACACC... Gene: HI0468: ATP phosphoribosyltransferase (EC 2.4.2.17)	* Aggregatibacter aphrophilus NJ8700 Site: position = -173 score = 61.13 sequence = ACCATCATCACCGTT... Gene: NT05HA_1777: ATP phosphoribosyltransferase (EC 2.4.2.17)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -163 score = 65.64 sequence = CATCACCATCTACCC... Gene: PM1195: ATP phosphoribosyltransferase (EC 2.4.2.17)	* Mannheimia succiniciproducens MBEL55E Site: position = -181 score = 73.09 sequence = CTCATCACCATCATC... Gene: MS1893: ATP phosphoribosyltransferase (EC 2.4.2.17)	* Actinobacillus succinogenes 130Z Site: position = -166 score = 53.86 sequence = CATCACCGTCATTAT... Gene: Asuc_0630: ATP phosphoribosyltransferase (EC 2.4.2.17)	Haemophilus somnus 2336	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -178 score = 47.61 sequence = CATCACCATCATTCA... Gene: APP7_2106: ATP phosphoribosyltransferase (EC 2.4.2.17)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	ATP phosphoribosyltransferase (EC 2.4.2.17)
PM1196	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1196: unknown	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	unknown
vatB	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1197: VatB	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	VatB
hisD	Haemophilus influenzae Rd KW20 Gene: HI0469: Histidinol dehydrogenase (EC 1.1.1.23)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1776: Histidinol dehydrogenase (EC 1.1.1.23)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1198: Histidinol dehydrogenase (EC 1.1.1.23)	Mannheimia succiniciproducens MBEL55E Gene: MS1892: Histidinol dehydrogenase (EC 1.1.1.23)	Actinobacillus succinogenes 130Z Gene: Asuc_0631: Histidinol dehydrogenase (EC 1.1.1.23)	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_2107: Histidinol dehydrogenase (EC 1.1.1.23)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Histidinol dehydrogenase (EC 1.1.1.23)
hisC	Haemophilus influenzae Rd KW20 Gene: HI0470: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1775: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1199: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Mannheimia succiniciproducens MBEL55E Gene: MS1891: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Actinobacillus succinogenes 130Z Gene: Asuc_0633: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_2108: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Histidinol-phosphate aminotransferase (EC 2.6.1.9)
hisB	Haemophilus influenzae Rd KW20 Gene: HI0471: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1774: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1200: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Mannheimia succiniciproducens MBEL55E Gene: MS1890: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Actinobacillus succinogenes 130Z Gene: Asuc_0634: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_2110: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
PM1201	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1201: unknown	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	unknown
hisH	Haemophilus influenzae Rd KW20 Gene: HI0472: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1772: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1202: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Mannheimia succiniciproducens MBEL55E Gene: MS1885: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	2 Actinobacillus succinogenes 130Z Gene: Asuc_0636: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Gene: Asuc_1766: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_2112: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
hisA	Haemophilus influenzae Rd KW20 Gene: HI0473: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1770: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1203: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Mannheimia succiniciproducens MBEL55E Gene: MS1883: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Actinobacillus succinogenes 130Z Gene: Asuc_1768: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_2113: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
hisF	Haemophilus influenzae Rd KW20 Gene: HI0474: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1769: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1204: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Mannheimia succiniciproducens MBEL55E Gene: MS1882: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Actinobacillus succinogenes 130Z Gene: Asuc_1769: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_2114: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
PM1205	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1205: unknown	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	unknown
hisI	Haemophilus influenzae Rd KW20 Gene: HI0475: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1767: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1206: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Mannheimia succiniciproducens MBEL55E Gene: MS1881: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Actinobacillus succinogenes 130Z Gene: Asuc_1770: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_2115: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
NT05HA_1771	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1771: Transposase IS200-like protein	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_2109: Transposase IS200-like protein	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Transposase IS200-like protein
APP7_2111	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_2111: hypothetical protein	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	hypothetical protein
Asuc_0632	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z Gene: Asuc_0632: Threonine efflux protein	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Threonine efflux protein
Asuc_0635	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z Gene: Asuc_0635: hypothetical protein	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	hypothetical protein

CRON 2.
yuiF	* Haemophilus influenzae Rd KW20 Site: position = -218 score = 77.43 sequence = CATCATCACCATTCA... Gene: HI0325: Histidine permease YuiF	* Aggregatibacter aphrophilus NJ8700 Site: position = -230 score = 61.07 sequence = CATCACCACCATGTA... Gene: NT05HA_1368: Histidine permease YuiF	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM0989: Histidine permease YuiF	Mannheimia succiniciproducens MBEL55E Gene: MS0701: Histidine permease YuiF	Actinobacillus succinogenes 130Z Gene: Asuc_1810: Histidine permease YuiF	Haemophilus somnus 2336 Gene: HSM_1491: Histidine permease YuiF	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1032: Histidine permease YuiF	Haemophilus ducreyi 35000HP Gene: HD1717: Histidine permease YuiF	* Haemophilus parasuis SH0165 Site: position = -195 score = 51.43 sequence = ACCGTCATCACCATT... Gene: HAPS_0311: Histidine permease YuiF	Histidine permease YuiF

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog His_leader - Pasteurellales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --