Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
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Collection of regulogs for His_leader (RF00514) RNA regulatory element

The histidine operon leader is an RNA element that was found upstream of some histidine biosynthesis his operons in Escherichia coli and related bacteria and that is involved in the amino acid dependent attenuation of their transcription [6186194]. The leader sequence can assume two different secondary structures known as the terminator and the anti-terminator structure. The leader also codes for very short peptide sequence that is rich in Histidine. The terminator structure is recognized as a termination signal for RNA polymerase and the operon is not transcribed. This structure forms when the cell has an excess of histidine and ribosome movement over the leader transcript is not impeded. more

Phylum Regulog RNA regulons (studied genomes) RNA sites
Proteobacteria His_leader - Enterobacteriales 12 (12) 12
Proteobacteria His_leader - Pasteurellales 7 (9) 9
Proteobacteria His_leader - Shewanellaceae 16 (16) 16
Proteobacteria His_leader - Vibrionales 10 (10) 10
Thermotogae His_leader - Thermotogales 1 (11) 1