Collection of regulogs for Fis transcription factor family
| TF regulogs | 68 |
| TF regulons | 433 |
| TF binding sites | 2126 |
Fis family of transcription factors includes numerous characterized activators/repressors of diverse biological processes. Founding member of the family, Fis (?factor for inversion stimulation? [12588863, 19332822]), functions as a global nucleoid-associated regulator that controls a number of growth-related genes in E. coli [12588863]. Fis-family regulators share a conserved N-terminal HTH DNA binding domain (PF02954). Many regulators of nitrogen metabolism in the Fis family including NtrC, NorR, BkdR, RocR, and AcoR possess diverse multidomain structure including an N-terminal signal sensing/receiving domain (PF00989, PF01590, or 7103015), the central sigma-54 interacting domain (PF00158), and the C-terminal Fis-type HTH domain (PF02954).
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When induced by their respective effector or a protein partner, these regulators function as sigma-54-depending activators of genes from involved in various aspects of the nitrogen metabolism.
| Phylum | Regulog | TF regulons (studied genomes) | TFBSs | Logo |
|---|---|---|---|---|
| Firmicutes | AcoR - Bacillales | 6 (11) | 6 |  |
| Firmicutes | BkdR - Bacillales | 10 (11) | 26 |  |
| Proteobacteria/Delta | DVU0110 - Desulfovibrionales | 4 (10) | 5 |  |
| Proteobacteria/delta | DVU0118 - Desulfovibrionales | 2 (10) | 2 |  |
| Proteobacteria/Delta | DVU0151 - Desulfovibrionales | 5 (10) | 9 |  |
| Proteobacteria/delta | DVU0539/DVU0946 - Desulfovibrionales | 7 (10) | 30 |  |
| Proteobacteria/delta | DVU0569 - Desulfovibrionales | 7 (10) | 17 |  |
| Proteobacteria/Delta | DVU0619 - Desulfovibrionales | 3 (10) | 9 |  |
| Proteobacteria/delta | DVU0621 - Desulfovibrionales | 6 (10) | 17 |  |
| Proteobacteria/Delta | DVU0744 - Desulfovibrionales | 3 (10) | 12 |  |
| Proteobacteria/Delta | DVU0804 - Desulfovibrionales | 3 (10) | 3 |  |
| Proteobacteria/Delta | DVU1063 - Desulfovibrionales | 9 (10) | 86 |  |
| Proteobacteria/Delta | DVU1156 - Desulfovibrionales | 1 (10) | 3 |  |
| Proteobacteria/delta | DVU1419 - Desulfovibrionales | 6 (10) | 11 |  |
| Proteobacteria/delta | DVU2106 - Desulfovibrionales | 5 (10) | 9 |  |
| Proteobacteria/delta | DVU2114 - Desulfovibrionales | 5 (10) | 18 |  |
| Proteobacteria/delta | DVU2275 - Desulfovibrionales | 3 (10) | 6 |  |
| Proteobacteria/delta | DVU2359 - Desulfovibrionales | 3 (10) | 9 |  |
| Proteobacteria/delta | DVU2394 - Desulfovibrionales | 7 (10) | 15 |  |
| Proteobacteria/delta | DVU2827 - Desulfovibrionales | 5 (10) | 26 |  |
| Proteobacteria/Delta | DVU2894 - Desulfovibrionales | 10 (10) | 27 |  |
| Proteobacteria/delta | DVU2934 - Desulfovibrionales | 7 (10) | 20 |  |
| Proteobacteria/Delta | DVU2956 - Desulfovibrionales | 4 (10) | 9 |  |
| Proteobacteria/delta | DVU3023 - Desulfovibrionales | 6 (10) | 26 |  |
| Proteobacteria/delta | DVU3305 - Desulfovibrionales | 6 (10) | 20 |  |
| Proteobacteria/Delta | DVUA0057 - Desulfovibrionales | 5 (10) | 29 |  |
| Proteobacteria/delta | DVUA0100 - Desulfovibrionales | 4 (10) | 18 |  |
| Proteobacteria/delta | DVUA0143 - Desulfovibrionales | 5 (10) | 22 |  |
| Proteobacteria/delta | KdpR - Desulfovibrionales | 2 (10) | 4 |  |
| Proteobacteria/alpha | NifA - Rhizobiales | 11 (15) | 130 |  |
| Proteobacteria/alpha | NifA - Rhodobacterales | 1 (15) | 12 |  |
| Proteobacteria/alpha | NifA - Rhodospirillales | 6 (9) | 54 |  |
| Proteobacteria/alpha | NifA - Sphingomonadales | 1 (7) | 6 |  |
| Proteobacteria/delta | NifA-1 - Desulfovibrionales | 7 (10) | 101 |  |
| Proteobacteria/beta | NorR - Burkholderia | 2 (8) | 5 |  |
| Proteobacteria/beta | NorR - Comamonadaceae | 6 (11) | 25 |  |
| Proteobacteria/beta | NorR - Ralstonia | 6 (6) | 35 |  |
| Proteobacteria/gamma | NorR - Alteromonadales | 4 (9) | 18 |  |
| Proteobacteria/gamma | NorR - Enterobacteriales | 7 (12) | 33 |  |
| Proteobacteria/gamma | NorR - Oceanospirillales/Alteromonadales | 4 (12) | 13 |  |
| Proteobacteria/gamma | NorR - Pseudomonadaceae | 6 (8) | 40 |  |
| Proteobacteria/gamma | NorR - Psychromonadaceae/Aeromonadales | 3 (6) | 21 |  |
| Proteobacteria/gamma | NorR - Shewanellaceae | 13 (16) | 91 |  |
| Proteobacteria/gamma | NorR - Vibrionales | 6 (10) | 40 |  |
| Proteobacteria/gamma | NorR2 - Vibrionales | 6 (10) | 19 |  |
| Proteobacteria/alpha | NtrC - Caulobacterales | 4 (4) | 15 |  |
| Proteobacteria/alpha | NtrC - Desulfuromonadales | 9 (9) | 56 |  |
| Proteobacteria/alpha | NtrC - Rhizobiales | 14 (15) | 86 |  |
| Proteobacteria/alpha | NtrC - Rhodobacterales | 14 (15) | 92 |  |
| Proteobacteria/alpha | NtrC - Rhodospirillales | 8 (9) | 40 |  |
| Proteobacteria/alpha | NtrC - Sphingomonadales | 6 (7) | 25 |  |
| Proteobacteria/beta | NtrC - Burkholderia | 8 (8) | 27 |  |
| Proteobacteria/beta | NtrC - Comamonadaceae | 11 (11) | 52 |  |
| Proteobacteria/beta | NtrC - Ralstonia | 6 (6) | 28 |  |
| Proteobacteria/beta | NtrC - Various betaproteobacteria | 9 (12) | 47 |  |
| Proteobacteria/gamma | NtrC - Alteromonadales | 9 (9) | 26 |  |
| Proteobacteria/gamma | NtrC - Enterobacteriales | 12 (12) | 130 |  |
| Proteobacteria/gamma | NtrC - Moraxellaceae | 4 (4) | 27 |  |
| Proteobacteria/gamma | NtrC - Oceanospirillales/Alteromonadales | 12 (12) | 63 |  |
| Proteobacteria/gamma | NtrC - Pseudomonadaceae | 8 (8) | 49 |  |
| Proteobacteria/gamma | NtrC - Psychromonadaceae/Aeromonadales | 6 (6) | 25 |  |
| Proteobacteria/gamma | NtrC - Shewanellaceae | 16 (16) | 94 |  |
| Proteobacteria/gamma | NtrC - Vibrionales | 9 (10) | 29 |  |
| Proteobacteria/gamma | NtrC - Xanthomonadales | 4 (4) | 10 |  |
| Proteobacteria/delta | OhcR - Desulfovibrionales | 6 (10) | 10 |  |
| Proteobacteria/delta | PspF - Desulfovibrionales | 5 (10) | 8 |  |
| Firmicutes | RocR - Bacillales | 8 (11) | 26 |  |
| Proteobacteria/delta | ZraR - Desulfovibrionales | 7 (10) | 24 |  |