Collection of regulogs in Streptomycetaceae taxonomic group
Genomes | 4 |
TF regulogs | 36 |
TF regulons | 120 |
TF binding sites | 653 |
RNA regulogs | 3 |
RNA regulons | 8 |
RNA sites | 17 |
This collection involves all regulons that were tentatively predicted by applying integrative comparative genomic approach to a single taxonomic group of closely-related genomes. To infer the regulons operated by transcription factors (TFs), we combined the identification of TF binding sites and cross-genome comparison of regulons with the analysis of the genomic and functional context of candidate target genes. To infer the regulons operated by regulatory RNAs such as riboswitches, we identified candidate RNA regulatory elements using HMM profiles and further analyzed their genomic and functional context.
TF | RNA | Total | ||||
---|---|---|---|---|---|---|
Genomes | Regulons | Sites | Regulons | Sites | Regulons | Sites |
Streptomyces avermitilis MA-4680 | 33 | 168 | 2 | 5 | 35 | 173 |
Streptomyces coelicolor A3(2) | 29 | 186 | 2 | 4 | 31 | 190 |
Streptomyces griseus subsp. griseus NBRC 13350 | 27 | 144 | 2 | 4 | 29 | 148 |
Streptomyces scabiei 87.22 | 31 | 155 | 2 | 4 | 33 | 159 |
Family | Type | Regulator | Function | ||||
---|---|---|---|---|---|---|---|
ArgR | TF | ArgR |
6
ArgR
Streptomyces coelicolor A3(2) |
5
ArgR
Streptomyces avermitilis MA-4680 |
4
ArgR
Streptomyces scabiei 87.22 |
4
ArgR
Streptomyces griseus subsp. griseus NBRC 13350 |
Arginine biosynthesis |
FUR | TF | Nur |
3
Nur
Streptomyces coelicolor A3(2) |
2
Nur
Streptomyces avermitilis MA-4680 |
2
Nur
Streptomyces scabiei 87.22 |
2
Nur
Streptomyces griseus subsp. griseus NBRC 13350 |
Nickel homeostasis |
TF | Zur |
5
Zur
Streptomyces coelicolor A3(2) |
3
Zur
Streptomyces avermitilis MA-4680 |
4
Zur
Streptomyces scabiei 87.22 |
3
Zur
Streptomyces griseus subsp. griseus NBRC 13350 |
Zinc homeostasis | |
GntR/MocR | TF | PdxQ |
2
PdxQ
Streptomyces coelicolor A3(2) |
2
PdxQ
Streptomyces avermitilis MA-4680 |
2
PdxQ
Streptomyces scabiei 87.22 |
2
PdxQ
Streptomyces griseus subsp. griseus NBRC 13350 |
Pyridoxine/pyridoxal homeostasis; Metabolite transport |
TF | PdxQ3 |
1
PdxQ3
Streptomyces avermitilis MA-4680 |
1
PdxQ3
Streptomyces scabiei 87.22 |
1
PdxQ3
Streptomyces griseus subsp. griseus NBRC 13350 |
Pyridoxine/pyridoxal homeostasis | ||
TF | PdxR3 |
2
PdxR3
Streptomyces coelicolor A3(2) |
4
PdxR3
Streptomyces avermitilis MA-4680 |
2
PdxR3
Streptomyces scabiei 87.22 |
4
PdxR3
Streptomyces griseus subsp. griseus NBRC 13350 |
Pyridoxine/pyridoxal homeostasis | |
TF | PdxW |
2
PdxW
Streptomyces coelicolor A3(2) |
3
PdxW
Streptomyces avermitilis MA-4680 |
2
PdxW
Streptomyces scabiei 87.22 |
2
PdxW
Streptomyces griseus subsp. griseus NBRC 13350 |
Pyridoxine/pyridoxal homeostasis | |
TF | SCO4836 |
2
SCO4836
Streptomyces coelicolor A3(2) |
3
SCO4836
Streptomyces avermitilis MA-4680 |
1
SCO4836
Streptomyces scabiei 87.22 |
3
SCO4836
Streptomyces griseus subsp. griseus NBRC 13350 |
Metabolite transport | |
GntR/Others | TF | AnsR |
1
AnsR
Streptomyces avermitilis MA-4680 |
1
AnsR
Streptomyces scabiei 87.22 |
Aspartate utilization; Asparagine degradation | ||
TF | DasR |
33
DasR
Streptomyces coelicolor A3(2) |
25
DasR
Streptomyces avermitilis MA-4680 |
21
DasR
Streptomyces scabiei 87.22 |
31
DasR
Streptomyces griseus subsp. griseus NBRC 13350 |
N-acetylglucosamine utilization | |
TF | IolR |
10
IolR
Streptomyces coelicolor A3(2) |
7
IolR
Streptomyces avermitilis MA-4680 |
6
IolR
Streptomyces scabiei 87.22 |
5
IolR
Streptomyces griseus subsp. griseus NBRC 13350 |
Inositol utilization | |
TF | LldR |
3
LldR
Streptomyces griseus subsp. griseus NBRC 13350 |
Lactate utilization | ||||
TF | LndYR |
1
LndYR
Streptomyces coelicolor A3(2) |
1
LndYR
Streptomyces avermitilis MA-4680 |
2
LndYR
Streptomyces scabiei 87.22 |
3
LndYR
Streptomyces griseus subsp. griseus NBRC 13350 |
Antibiotic resistance | |
TF | PhnF |
1
PhnF
Streptomyces griseus subsp. griseus NBRC 13350 |
Phosphonate utilization; 2-aminoethylphosphonate utilization | ||||
TF | SCO1410 |
4
SCO1410
Streptomyces coelicolor A3(2) |
2
SCO1410
Streptomyces avermitilis MA-4680 |
2
SCO1410
Streptomyces scabiei 87.22 |
|||
TF | SCO3812 |
1
SCO3812
Streptomyces coelicolor A3(2) |
1
SCO3812
Streptomyces griseus subsp. griseus NBRC 13350 |
Multidrug efflux | |||
HrcA | TF | HrcA |
4
HrcA
Streptomyces coelicolor A3(2) |
4
HrcA
Streptomyces avermitilis MA-4680 |
4
HrcA
Streptomyces scabiei 87.22 |
4
HrcA
Streptomyces griseus subsp. griseus NBRC 13350 |
Heat shock response |
HxlR | TF | QorR |
2
QorR
Streptomyces coelicolor A3(2) |
2
QorR
Streptomyces avermitilis MA-4680 |
2
QorR
Streptomyces scabiei 87.22 |
2
QorR
Streptomyces griseus subsp. griseus NBRC 13350 |
Energy metabolism |
IclR | TF | LtbR |
2
LtbR
Streptomyces coelicolor A3(2) |
2
LtbR
Streptomyces avermitilis MA-4680 |
2
LtbR
Streptomyces scabiei 87.22 |
2
LtbR
Streptomyces griseus subsp. griseus NBRC 13350 |
Leucine biosynthesis |
LacI | TF | BgaR |
2
BgaR
Streptomyces coelicolor A3(2) |
2
BgaR
Streptomyces avermitilis MA-4680 |
2
BgaR
Streptomyces scabiei 87.22 |
Galactosides utilization | |
TF | CelR |
12
CelR
Streptomyces coelicolor A3(2) |
10
CelR
Streptomyces avermitilis MA-4680 |
11
CelR
Streptomyces scabiei 87.22 |
6
CelR
Streptomyces griseus subsp. griseus NBRC 13350 |
Cellobiose utilization | |
TF | IolR |
2
IolR
Streptomyces avermitilis MA-4680 |
2
IolR
Streptomyces scabiei 87.22 |
Inositol utilization | |||
TF | ManR |
5
ManR
Streptomyces coelicolor A3(2) |
4
ManR
Streptomyces avermitilis MA-4680 |
2
ManR
Streptomyces scabiei 87.22 |
3
ManR
Streptomyces griseus subsp. griseus NBRC 13350 |
Mannosides utilization; Mannose utilization | |
TF | RbsR |
1
RbsR
Streptomyces coelicolor A3(2) |
1
RbsR
Streptomyces avermitilis MA-4680 |
1
RbsR
Streptomyces griseus subsp. griseus NBRC 13350 |
Ribose utilization | ||
TF | RhaR |
6
RhaR
Streptomyces coelicolor A3(2) |
4
RhaR
Streptomyces avermitilis MA-4680 |
4
RhaR
Streptomyces scabiei 87.22 |
Rhamnose utilization | ||
TF | SAV1329 |
2
SAV1329
Streptomyces avermitilis MA-4680 |
2
SAV1329
Streptomyces scabiei 87.22 |
Galactosides utilization | |||
TF | SCO1956 |
1
SCO1956
Streptomyces coelicolor A3(2) |
1
SCO1956
Streptomyces avermitilis MA-4680 |
Sugar utilization | |||
TF | SCO2753 |
3
SCO2753
Streptomyces coelicolor A3(2) |
2
SCO2753
Streptomyces avermitilis MA-4680 |
2
SCO2753
Streptomyces scabiei 87.22 |
3
SCO2753
Streptomyces griseus subsp. griseus NBRC 13350 |
Sugar utilization | |
TF | SCO4158 |
3
SCO4158
Streptomyces coelicolor A3(2) |
3
SCO4158
Streptomyces avermitilis MA-4680 |
3
SCO4158
Streptomyces scabiei 87.22 |
3
SCO4158
Streptomyces griseus subsp. griseus NBRC 13350 |
Nucleoside utilization | |
TF | SCO5692 |
3
SCO5692
Streptomyces coelicolor A3(2) |
3
SCO5692
Streptomyces avermitilis MA-4680 |
3
SCO5692
Streptomyces scabiei 87.22 |
Sugar utilization | ||
LexA | TF | LexA |
8
LexA
Streptomyces coelicolor A3(2) |
6
LexA
Streptomyces avermitilis MA-4680 |
5
LexA
Streptomyces scabiei 87.22 |
5
LexA
Streptomyces griseus subsp. griseus NBRC 13350 |
SOS response |
NrdR | TF | NrdR |
2
NrdR
Streptomyces coelicolor A3(2) |
2
NrdR
Streptomyces avermitilis MA-4680 |
2
NrdR
Streptomyces scabiei 87.22 |
2
NrdR
Streptomyces griseus subsp. griseus NBRC 13350 |
Deoxyribonucleotide biosynthesis |
NrtR | TF | NrtR |
2
NrtR
Streptomyces coelicolor A3(2) |
4
NrtR
Streptomyces avermitilis MA-4680 |
4
NrtR
Streptomyces scabiei 87.22 |
4
NrtR
Streptomyces griseus subsp. griseus NBRC 13350 |
NAD biosynthesis |
Rex | TF | Rex |
10
Rex
Streptomyces coelicolor A3(2) |
9
Rex
Streptomyces avermitilis MA-4680 |
8
Rex
Streptomyces scabiei 87.22 |
9
Rex
Streptomyces griseus subsp. griseus NBRC 13350 |
Energy metabolism |
TetR | TF | AmtR |
3
AmtR
Streptomyces avermitilis MA-4680 |
3
AmtR
Streptomyces scabiei 87.22 |
Nitrogen metabolism | ||
TF | PaaR |
5
PaaR
Streptomyces coelicolor A3(2) |
5
PaaR
Streptomyces avermitilis MA-4680 |
5
PaaR
Streptomyces scabiei 87.22 |
5
PaaR
Streptomyces griseus subsp. griseus NBRC 13350 |
Phenylacetic acid degradation | |
RF00050 | RNA | FMN |
1
FMN
Streptomyces coelicolor A3(2) |
1
FMN
Streptomyces avermitilis MA-4680 |
1
FMN
Streptomyces scabiei 87.22 |
1
FMN
Streptomyces griseus subsp. griseus NBRC 13350 |
Riboflavin biosynthesis |
RF00059 | RNA | TPP |
3
TPP
Streptomyces coelicolor A3(2) |
4
TPP
Streptomyces avermitilis MA-4680 |
3
TPP
Streptomyces scabiei 87.22 |
3
TPP
Streptomyces griseus subsp. griseus NBRC 13350 |
Thiamine biosynthesis |
RF01055 | RNA | MOCO_RNA_motif |