Regulog IolR - Streptomycetaceae

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:
Biological process:	Inositol utilization
Effector:
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 35 sites [see more]

Member of regulog collections

By taxonomy - Streptomycetaceae
By TF family - GntR/Others
By pathway - Inositol utilization

Statistics of regulated genes
Genome	Genes	Operons
Streptomyces avermitilis MA-4680	24	7
Streptomyces coelicolor A3(2)	24	10
Streptomyces griseus subsp. griseus NBRC 13350	11	5
Streptomyces scabiei 87.22	13	6

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes					Function

CRON 1.
iolTA2	* Streptomyces avermitilis MA-4680 Site: position = -75 score = 3.01748 sequence = CCGATGTCCGGATGCACG Gene: SAV_1983: Inositol ABC transport system, sugar-binding protein	* Streptomyces coelicolor A3(2) Site: position = -153 score = 4.92093 sequence = GCAATGTCCGGACAATGT Gene: SCO6257: Inositol ABC transport system, sugar-binding protein	* Streptomyces griseus subsp. griseus NBRC 13350 Site: position = -192 score = 3.5129 sequence = GGTAGGTCCGGACACCTG Gene: SGR_1275: Inositol ABC transport system, sugar-binding protein	Streptomyces scabiei 87.22	Inositol ABC transport system, sugar-binding protein
iolTB2	Streptomyces avermitilis MA-4680 Gene: SAV_1982: Inositol ABC transport system, permease protein	Streptomyces coelicolor A3(2) Gene: SCO6258: Inositol ABC transport system, permease protein	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_1274: Inositol ABC transport system, permease protein	Streptomyces scabiei 87.22	Inositol ABC transport system, permease protein
iolTC2	Streptomyces avermitilis MA-4680 Gene: SAV_1981: Inositol ABC transport system, ATP-binding protein	Streptomyces coelicolor A3(2) Gene: SCO6259: Inositol ABC transport system, ATP-binding protein	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_1273: Inositol ABC transport system, ATP-binding protein	Streptomyces scabiei 87.22	Inositol ABC transport system, ATP-binding protein

CRON 2.
iolG3	Streptomyces avermitilis MA-4680 Gene: SAV_7155: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)	* Streptomyces coelicolor A3(2) Site: position = -103 score = 4.60126 sequence = TCTTTGTCCTGTCAAAAG Gene: SCO6988: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)	Streptomyces griseus subsp. griseus NBRC 13350	Streptomyces scabiei 87.22 Gene: SCAB_19091: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)	Myo-inositol 2-dehydrogenase (EC 1.1.1.18)

CRON 3.
iolC	2 Streptomyces avermitilis MA-4680* Site: position = -78 score = 4.84431 sequence = CGAATGTCTGGACAAAAC Gene: SAV_5338: 5-keto-2-deoxygluconokinase (EC 2.7.1.92) Site: position = -147 score = 4.52018 sequence = ACTTTGTTAAGACATCAT Site: position = -115 score = 5.0903 sequence = CGAATGTCCGTACAAACT Gene: SAV_7150: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	* Streptomyces coelicolor A3(2) Site: position = -123 score = 4.80425 sequence = ACTTTGTCAAGACATCAT Site: position = -91 score = 4.55373 sequence = CGAATGTAAGTACAAAGT Gene: SCO6978: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	* Streptomyces griseus subsp. griseus NBRC 13350 Site: position = -82 score = 5.3403 sequence = CGAATGTCCGGACAAAAT Gene: SGR_4834: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	* Streptomyces scabiei 87.22 Site: position = -79 score = 5.10975 sequence = CGAATGTCTGGACAAAGT Gene: SCAB_58891: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	5-keto-2-deoxygluconokinase (EC 2.7.1.92)
iolJ	2 Streptomyces avermitilis MA-4680 Gene: SAV_5339: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29) Gene: SAV_7149: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Streptomyces coelicolor A3(2) Gene: SCO6977: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_4835: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Streptomyces scabiei 87.22 Gene: SCAB_58901: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
iolB	2 Streptomyces avermitilis MA-4680 Gene: SAV_5340: 5-deoxy-glucuronate isomerase (EC 5.3.1.-) Gene: SAV_7148: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Streptomyces coelicolor A3(2) Gene: SCO6976: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_4836: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Streptomyces scabiei 87.22 Gene: SCAB_58911: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	5-deoxy-glucuronate isomerase (EC 5.3.1.-)
iolD	2 Streptomyces avermitilis MA-4680 Gene: SAV_5341: Epi-inositol hydrolase (EC 3.7.1.-) Gene: SAV_7147: Epi-inositol hydrolase (EC 3.7.1.-)	2 Streptomyces coelicolor A3(2)* Gene: SCO6975: Epi-inositol hydrolase (EC 3.7.1.-) Site: position = -86 score = 5.09772 sequence = CGAATGTCCGGACAAAAC Gene: SCO2727: Epi-inositol hydrolase (EC 3.7.1.-)	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_4837: Epi-inositol hydrolase (EC 3.7.1.-)	Streptomyces scabiei 87.22 Gene: SCAB_58921: Epi-inositol hydrolase (EC 3.7.1.-)	Epi-inositol hydrolase (EC 3.7.1.-)
iolA	Streptomyces avermitilis MA-4680 Gene: SAV_5342: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Streptomyces coelicolor A3(2) Gene: SCO2726: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_4838: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Streptomyces scabiei 87.22 Gene: SCAB_58931: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
iolR	Streptomyces avermitilis MA-4680 Gene: SAV_7146: Inositol utilization transcriptional regulator, GntR family	2 Streptomyces coelicolor A3(2)* Gene: SCO6974: Inositol utilization transcriptional regulator, GntR family Site: position = -91 score = 5.40241 sequence = CGTATGTCCGGACAATCG Gene: SCO6256: Inositol utilization transcriptional regulator, GntR family	* Streptomyces griseus subsp. griseus NBRC 13350 Site: position = -33 score = 5.06766 sequence = GCTTTGTCCGGACAAGCG Site: position = -93 score = 5.31526 sequence = CGTTTGTCCTGACAAATG Gene: SGR_1276: Inositol utilization transcriptional regulator, GntR family	* Streptomyces scabiei 87.22 Site: position = -65 score = 4.66944 sequence = CTCATGTCAGGACAATGC Gene: SCAB_19081: Inositol utilization transcriptional regulator, GntR family	Inositol utilization transcriptional regulator, GntR family

CRON 4.
iolE	* Streptomyces avermitilis MA-4680 Site: position = -72 score = 4.84431 sequence = GTTTTGTCCAGACATTCG Gene: SAV_5337: Inosose dehydratase (EC 4.2.1.44)	Streptomyces coelicolor A3(2)	* Streptomyces griseus subsp. griseus NBRC 13350 Site: position = -64 score = 5.3403 sequence = ATTTTGTCCGGACATTCG Gene: SGR_4833: Inosose dehydratase (EC 4.2.1.44)	* Streptomyces scabiei 87.22 Site: position = -63 score = 5.10975 sequence = ACTTTGTCCAGACATTCG Gene: SCAB_58881: Inosose dehydratase (EC 4.2.1.44)	Inosose dehydratase (EC 4.2.1.44)

CRON 5.
iolG	* Streptomyces avermitilis MA-4680 Site: position = -55 score = 5.09215 sequence = CGGTTGTCCGGACAAACC Gene: SAV_1985: Inositol 2-dehydrogenase (EC 1.1.1.18 )	* Streptomyces coelicolor A3(2) Site: position = -55 score = 5.40241 sequence = CGATTGTCCGGACATACG Gene: SCO6255: Inositol 2-dehydrogenase (EC 1.1.1.18 )	* Streptomyces griseus subsp. griseus NBRC 13350 Site: position = -116 score = 5.06766 sequence = CGCTTGTCCGGACAAAGC Site: position = -56 score = 5.31526 sequence = CATTTGTCAGGACAAACG Gene: SGR_1277: Inositol 2-dehydrogenase (EC 1.1.1.18 )	* Streptomyces scabiei 87.22 Site: position = -56 score = 4.98966 sequence = CGGTTGTCCGGACAAAGC Gene: SCAB_18231: Inositol 2-dehydrogenase (EC 1.1.1.18 )	Inositol 2-dehydrogenase (EC 1.1.1.18 )

CRON 6.
iolR1	* Streptomyces avermitilis MA-4680 Site: position = -79 score = 5.09215 sequence = GGTTTGTCCGGACAACCG Gene: SAV_1984: Inositol utilization transcriptional regulator, GntR family	Streptomyces coelicolor A3(2)	Streptomyces griseus subsp. griseus NBRC 13350	* Streptomyces scabiei 87.22 Site: position = -91 score = 4.98966 sequence = GCTTTGTCCGGACAACCG Gene: SCAB_18221: Inositol utilization transcriptional regulator, GntR family	Inositol utilization transcriptional regulator, GntR family
iolTA	Streptomyces avermitilis MA-4680 Gene: SAV_1983: Inositol ABC transport system sugar-binding protein	* Streptomyces coelicolor A3(2) Site: position = -153 score = 4.92093 sequence = GCAATGTCCGGACAATGT Gene: SCO6257: Inositol ABC transport system sugar-binding protein	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_1275: Inositol ABC transport system sugar-binding protein	Streptomyces scabiei 87.22	Inositol ABC transport system sugar-binding protein
iolTB	Streptomyces avermitilis MA-4680 Gene: SAV_1982: Inositol ABC transport system permease protein	Streptomyces coelicolor A3(2) Gene: SCO6258: Inositol ABC transport system permease protein	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_1274: Inositol ABC transport system permease protein	Streptomyces scabiei 87.22	Inositol ABC transport system permease protein
iolTC	Streptomyces avermitilis MA-4680 Gene: SAV_1981: Inositol ABC transport system ATP-binding protein	Streptomyces coelicolor A3(2) Gene: SCO6259: Inositol ABC transport system ATP-binding protein	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_1273: Inositol ABC transport system ATP-binding protein	Streptomyces scabiei 87.22	Inositol ABC transport system ATP-binding protein
SCO6259	Streptomyces avermitilis MA-4680 Gene: SAV_1980: Putative sugar kinase	Streptomyces coelicolor A3(2) Gene: SCO6260: Putative sugar kinase	Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_1272: Putative sugar kinase	Streptomyces scabiei 87.22 Gene: SCAB_18211: Putative sugar kinase	Putative sugar kinase

CRON 7.
SCO6985	Streptomyces avermitilis MA-4680 Gene: SAV_7190: Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin	* Streptomyces coelicolor A3(2) Site: position = -57 score = 4.94892 sequence = CGTTTGTCAGGACAAGAA Gene: SCO6985: Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin	Streptomyces griseus subsp. griseus NBRC 13350	Streptomyces scabiei 87.22 Gene: SCAB_79031: Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin
iolG2	Streptomyces avermitilis MA-4680 Gene: SAV_7188: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Streptomyces coelicolor A3(2) Gene: SCO6984: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Streptomyces griseus subsp. griseus NBRC 13350	Streptomyces scabiei 87.22 Gene: SCAB_16031: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)

CRON 8.
iolR2	Streptomyces avermitilis MA-4680 Gene: SAV_7191: Transcriptional regulator for inositol utilization, LacI family	* Streptomyces coelicolor A3(2) Site: position = -90 score = 4.94892 sequence = TTCTTGTCCTGACAAACG Gene: SCO6986: Transcriptional regulator for inositol utilization, LacI family	Streptomyces griseus subsp. griseus NBRC 13350	Streptomyces scabiei 87.22 Gene: SCAB_16011: Transcriptional regulator for inositol utilization, LacI family	Transcriptional regulator for inositol utilization, LacI family

CRON 9.
iolTA2	* Streptomyces avermitilis MA-4680 Site: position = -178 score = 4.52018 sequence = ATGATGTCTTAACAAAGT Site: position = -210 score = 5.0903 sequence = AGTTTGTACGGACATTCG Gene: SAV_7151: Inositol ABC transport system sugar-binding protein	* Streptomyces coelicolor A3(2) Site: position = -148 score = 4.80425 sequence = ATGATGTCTTGACAAAGT Site: position = -180 score = 4.55373 sequence = ACTTTGTACTTACATTCG Gene: SCO6979: Inositol ABC transport system sugar-binding protein	Streptomyces griseus subsp. griseus NBRC 13350	* Streptomyces scabiei 87.22 Site: position = -216 score = 4.70485 sequence = ATAATGTCTTAACAAAGT Site: position = -248 score = 4.56508 sequence = GCTTTGTACTGACATCCT Gene: SCAB_19051: Inositol ABC transport system sugar-binding protein	Inositol ABC transport system sugar-binding protein
iolTB2	Streptomyces avermitilis MA-4680 Gene: SAV_7152: Inositol ABC transport system permease protein	Streptomyces coelicolor A3(2) Gene: SCO6980: Inositol ABC transport system permease protein	Streptomyces griseus subsp. griseus NBRC 13350	Streptomyces scabiei 87.22 Gene: SCAB_19041: Inositol ABC transport system permease protein	Inositol ABC transport system permease protein
iolTC2	Streptomyces avermitilis MA-4680 Gene: SAV_7153: Inositol ABC transport system ATP-binding protein	Streptomyces coelicolor A3(2) Gene: SCO6981: Inositol ABC transport system ATP-binding protein	Streptomyces griseus subsp. griseus NBRC 13350	Streptomyces scabiei 87.22 Gene: SCAB_19031: Inositol ABC transport system ATP-binding protein	Inositol ABC transport system ATP-binding protein
iolE2	Streptomyces avermitilis MA-4680 Gene: SAV_7154: Inosose dehydratase (EC 4.2.1.44)	Streptomyces coelicolor A3(2) Gene: SCO6982: Inosose dehydratase (EC 4.2.1.44)	Streptomyces griseus subsp. griseus NBRC 13350	Streptomyces scabiei 87.22	Inosose dehydratase (EC 4.2.1.44)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog IolR - Streptomycetaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --