Collection of regulogs for Rrf2 transcription factor family

Rrf2 family of transcription factors comprises widespread in Bacteria family of regulators that control diverse metabolic processes including (i) FeS cluster biogenesis (IscR) [16677314], (ii) nitric oxide-detoxification systems (NsrR) [16261196], (iii) iron uptake (RirA) [17173478], (iv) cysteine metabolism (CymR) [21624051] and photosynthesis [19692537]. DNA binding activity of Rrf2-family regulators is controlled via diverse mechanisms. In CymR regulator, the activation is achieved through protein-protein interaction with the protein that directly senses the cysteine pool in the cell [21624051]. more

DNA binding affinity of other Rrf2-family proteins depends on coordination of FeS cluster in the regulator [21624051]. Rrf2-family regulators are composed of an N-terminal winged HTH DNA binding domain (PF02082) and an additional dimerization domain.