Statistics of regulated genes

Genome	Genes	Operons
Azoarcus sp. EbN1
Thauera sp. MZ1T	3	2
Dechloromonas aromatica RCB
Nitrosomonas europaea ATCC 19718	5	2
Nitrosospira multiformis ATCC 25196
Thiobacillus denitrificans	1	1
Chromobacterium violaceum ATCC 12472	7	4
Neisseria meningitidis MC58
Laribacter hongkongensis HLHK9
Methylobacillus flagellatus KT	1	1
Methylotenera mobilis JLW8	2	2
Methylophilales bacterium HTCC2181

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes													Function
CRON 1.
Tmz1t_0413	Azoarcus sp. EbN1	* Thauera sp. MZ1T Site: position = -46 score = 5.75833 sequence = GATGCATTTAATATGTATC Gene: Tmz1t_0413: Hemerythrin HHE cation binding domain protein	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58 Gene: NMB0438: Hemerythrin HHE cation binding domain protein	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Hemerythrin HHE cation binding domain protein
fdxA	Azoarcus sp. EbN1 Gene: ebB155: 4Fe-4S ferredoxin, iron-sulfur binding	Thauera sp. MZ1T Gene: Tmz1t_0414: 4Fe-4S ferredoxin, iron-sulfur binding	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00641: 4Fe-4S ferredoxin, iron-sulfur binding	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	4Fe-4S ferredoxin, iron-sulfur binding
CRON 2.
hmp	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	* Thiobacillus denitrificans Site: position = -48 score = 5.68654 sequence = CATGCATACGGTATGCATG Gene: Tbd_2329: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	* Chromobacterium violaceum ATCC 12472 Site: position = -32 score = 3.4874 sequence = GATGTATTTTTTAAATATC Site: position = -96 score = 2.68385 sequence = CATGTATTATTTGAACATC Gene: CV3488: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	* Methylobacillus flagellatus KT Site: position = -32 score = 4.23781 sequence = GTTTCCTATTAAATACAAC Gene: Mfla_0639: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	* Methylotenera mobilis JLW8 Site: position = -36 score = 5.54928 sequence = GTAGCATTTTAAATGCAAC Gene: Mmol_1063: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	Methylophilales bacterium HTCC2181	Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)
nsrR	Azoarcus sp. EbN1	* Thauera sp. MZ1T Site: position = -93 score = 5.75833 sequence = GATACATATTAAATGCATC Gene: Tmz1t_0412: Nitrite-sensitive transcriptional repressor NsrR	Dechloromonas aromatica RCB	* Nitrosomonas europaea ATCC 19718 Site: position = -218 score = 4.02575 sequence = GGTGTATATTAGATACATC Site: position = -125 score = 3.13051 sequence = GATATATTATTAATATATC Gene: NE0928: Nitrite-sensitive transcriptional repressor NsrR	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans Gene: Tbd_2014: Nitrite-sensitive transcriptional repressor NsrR	Chromobacterium violaceum ATCC 12472 Gene: CV3487: Nitrite-sensitive transcriptional repressor NsrR	Neisseria meningitidis MC58 Gene: NMB0437: Nitrite-sensitive transcriptional repressor NsrR	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT Gene: Mfla_0640: Nitrite-sensitive transcriptional repressor NsrR	* Methylotenera mobilis JLW8 Site: position = -41 score = 5.96981 sequence = GTTGCATATTAAATGCAAC Gene: Mmol_1062: Nitrite-sensitive transcriptional repressor NsrR	Methylophilales bacterium HTCC2181	Nitrite-sensitive transcriptional repressor NsrR
CRON 3.
nirK	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	*2 Nitrosomonas europaea ATCC 19718 Gene: NE0924: Copper-containing nitrite reductase (EC 1.7.2.1) Site: position = -94 score = 3.13051 sequence = GATATATTAATAATATATC Site: position = -1 score = 4.02575 sequence = GATGTATCTAATATACACC Gene: NE0927: Copper-containing nitrite reductase (EC 1.7.2.1)	Nitrosospira multiformis ATCC 25196 Gene: Nmul_A1998: Copper-containing nitrite reductase (EC 1.7.2.1)	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -74 score = 3.92294 sequence = CATGTATTAATTATGCATT Gene: CV2007: Copper-containing nitrite reductase (EC 1.7.2.1)	Neisseria meningitidis MC58 Gene: NMB1623: Copper-containing nitrite reductase (EC 1.7.2.1)	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8 Gene: Mmol_1061: Copper-containing nitrite reductase (EC 1.7.2.1)	Methylophilales bacterium HTCC2181	Copper-containing nitrite reductase (EC 1.7.2.1)
NE0926	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718 Gene: NE0926: Cytochrome c, class I	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Cytochrome c, class I
cccA	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718 Gene: NE0925: Cytochrome c, class I	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Cytochrome c, class I
PF03781	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2008: Probable signal peptide protein	Neisseria meningitidis MC58 Gene: NMB1624: Probable signal peptide protein	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8 Gene: Mmol_1060: Probable signal peptide protein	Methylophilales bacterium HTCC2181	Probable signal peptide protein
PF02630	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2009: Copper chaperone, SCO1/SenC family protein	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8 Gene: Mmol_1059: Copper chaperone, SCO1/SenC family protein	Methylophilales bacterium HTCC2181	Copper chaperone, SCO1/SenC family protein
CRON 4.
norB	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -85 score = 3.34322 sequence = GATGTGCAATATATACATC Site: position = -59 score = 4.60123 sequence = GATGCATGTATTCTGCATC Gene: CV3494: Nitric-oxide reductase (EC 1.7.99.7), quinol-dependent	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Nitric-oxide reductase (EC 1.7.99.7), quinol-dependent
CRON 5.
nasA	Azoarcus sp. EbN1 Gene: ebA1213: Nitrate/nitrite transporter	Thauera sp. MZ1T Gene: Tmz1t_1145: Nitrate/nitrite transporter	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -31 score = 5.48016 sequence = CATGCAAACCATATGCATG Gene: CV2228: Nitrate/nitrite transporter	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8 Gene: Mmol_1651: Nitrate/nitrite transporter	Methylophilales bacterium HTCC2181	Nitrate/nitrite transporter

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