Regulog CymR - Clostridia-1

Properties
Regulator type:	Transcription factor
Regulator family:	Rrf2
Regulation mode:	repressor
Biological process:	Cysteine metabolism
Effector:
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 16 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-1
By TF family - Rrf2
By pathway - Cysteine metabolism

Statistics of regulated genes
Genome	Genes	Operons
Clostridium acetobutylicum ATCC 824	20	6
Clostridium beijerincki NCIMB 8052	5	4
Clostridium botulinum A str. ATCC 3502	4	2
Clostridium butyricum 5521	9	2
Clostridium kluyveri DSM 555
Clostridium novyi NT
Clostridium perfringens ATCC 13124
Clostridium tetani E88	1	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
sbpA	Clostridium acetobutylicum ATCC 824	2 Clostridium beijerincki NCIMB 8052* Site: position = -98 score = 5.80464 sequence = AAAATCCTACTAAACATATATGAATAT Gene: Cbei_4193: Sulfate-binding protein Sbp Site: position = -170 score = 5.29586 sequence = TAATTCCCATTGAAATAATAGGAATTA Gene: Cbei_4194: Sulfate-binding protein Sbp	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Sulfate-binding protein Sbp

CRON 2.
metY	* Clostridium acetobutylicum ATCC 824 Site: position = -77 score = 5.04179 sequence = CATTACATAGTAAAGTAATATGTTTTA Site: position = -277 score = 5.70855 sequence = ATATTCATATTAATATAGTAGGAATTA Gene: CAC0102: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
cysC	Clostridium acetobutylicum ATCC 824 Gene: CAC0103: Adenylylsulfate kinase (EC 2.7.1.25)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_1799: Adenylylsulfate kinase (EC 2.7.1.25)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Adenylylsulfate kinase (EC 2.7.1.25)
aprA	Clostridium acetobutylicum ATCC 824 Gene: CAC0104: Adenylylsulfate reductase alpha-subunit (EC 1.8.99.2)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4189: Adenylylsulfate reductase alpha-subunit (EC 1.8.99.2)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3242: Adenylylsulfate reductase alpha-subunit (EC 1.8.99.2)	Clostridium kluyveri DSM 555 Gene: CKL_1798: Adenylylsulfate reductase alpha-subunit (EC 1.8.99.2)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Adenylylsulfate reductase alpha-subunit (EC 1.8.99.2)
aprB	Clostridium acetobutylicum ATCC 824 Gene: CAC0105: Adenylylsulfate reductase beta-subunit (EC 1.8.99.2)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3243: Adenylylsulfate reductase beta-subunit (EC 1.8.99.2)	Clostridium kluyveri DSM 555 Gene: CKL_1797: Adenylylsulfate reductase beta-subunit (EC 1.8.99.2)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Adenylylsulfate reductase beta-subunit (EC 1.8.99.2)
CAC0106	Clostridium acetobutylicum ATCC 824 Gene: CAC0106: ABC-type probable sulfate transporter, periplasmic binding protein	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	ABC-type probable sulfate transporter, periplasmic binding protein
CAC0107	Clostridium acetobutylicum ATCC 824 Gene: CAC0107: ABC-type probable sulfate transporter, ATPase component	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	ABC-type probable sulfate transporter, ATPase component
CAC0108	Clostridium acetobutylicum ATCC 824 Gene: CAC0108: ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
cysD	Clostridium acetobutylicum ATCC 824 Gene: CAC0109: Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_1796: Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4)
cysN	Clostridium acetobutylicum ATCC 824 Gene: CAC0110: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_1795: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)
cysT	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4192: Sulfate transport system permease protein CysT	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -81 score = 5.59672 sequence = TAATTCATAGTAATTCTATAAGAATAA Gene: CBY_3239: Sulfate transport system permease protein CysT	Clostridium kluyveri DSM 555 Gene: CKL_1802: Sulfate transport system permease protein CysT	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Sulfate transport system permease protein CysT
cysW	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4191: Sulfate transport system permease protein CysW	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3240: Sulfate transport system permease protein CysW	Clostridium kluyveri DSM 555 Gene: CKL_1801: Sulfate transport system permease protein CysW	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Sulfate transport system permease protein CysW
cysA	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4190: Sulfate and thiosulfate import ATP-binding protein CysA (EC 3.6.3.25)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3241: Sulfate and thiosulfate import ATP-binding protein CysA (EC 3.6.3.25)	Clostridium kluyveri DSM 555 Gene: CKL_1800: Sulfate and thiosulfate import ATP-binding protein CysA (EC 3.6.3.25)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Sulfate and thiosulfate import ATP-binding protein CysA (EC 3.6.3.25)
cysD	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4187: Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3244: sulfate adenylyltransferase, small subunit	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4)
cysN	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4186: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3245: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)

CRON 3.
tcyP	Clostridium acetobutylicum ATCC 824	* Clostridium beijerincki NCIMB 8052 Site: position = -48 score = 5.29715 sequence = ATAAATATACTAATTATATAGGAATTG Gene: Cbei_4344: L-cystine uptake protein TcyP	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_1191: L-cystine uptake protein TcyP	Clostridium tetani E88	L-cystine uptake protein TcyP

CRON 4.
CAC3325	* Clostridium acetobutylicum ATCC 824 Site: position = -354 score = 5.58509 sequence = GTATACCTACTTGTATACTAGGAATAT Gene: CAC3325: L-Cystine ABC transporter, periplasmic cystine-binding protein TcyA	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	L-Cystine ABC transporter, periplasmic cystine-binding protein TcyA
CAC3326	Clostridium acetobutylicum ATCC 824 Gene: CAC3326: L-Cystine ABC transporter, permease protein TcyB	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	L-Cystine ABC transporter, permease protein TcyB
CAC3327	Clostridium acetobutylicum ATCC 824 Gene: CAC3327: L-Cystine ABC transporter, ATP-binding protein TcyC	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	L-Cystine ABC transporter, ATP-binding protein TcyC

CRON 5.
cysK	* Clostridium acetobutylicum ATCC 824 Site: position = -49 score = 5.83312 sequence = ATATTCCTAGTAAACAAATGTGTTTAA Gene: CAC2235: Cysteine synthase (EC 2.5.1.47)	Clostridium beijerincki NCIMB 8052	* Clostridium botulinum A str. ATCC 3502 Site: position = -303 score = 5.93953 sequence = GAATACCTAGTAAACAAATAAGAATAA Gene: CBO1179: Cysteine synthase (EC 2.5.1.47)	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0572: Cysteine synthase (EC 2.5.1.47)	Clostridium perfringens ATCC 13124	Clostridium tetani E88 Gene: CTC01343: Cysteine synthase (EC 2.5.1.47)	Cysteine synthase (EC 2.5.1.47)
CAC0878	* Clostridium acetobutylicum ATCC 824 Site: position = -70 score = 5.77605 sequence = TTAAACATATTAGTTTAGTAGGTATTT Gene: CAC0878: Cysteine ABC transporter permease component	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO1180: Cysteine ABC transporter permease component	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Cysteine ABC transporter permease component
CAC0880	Clostridium acetobutylicum ATCC 824 Gene: CAC0880: Cysteine ABC transporter, substrate-binding protein	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO1181: Cysteine ABC transporter, substrate-binding protein	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Cysteine ABC transporter, substrate-binding protein
CAC0879	Clostridium acetobutylicum ATCC 824 Gene: CAC0879: Cysteine ABC transporter, ATPase component	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Cysteine ABC transporter, ATPase component

CRON 6.
ubiG	* Clostridium acetobutylicum ATCC 824 Site: position = -473 score = 5.36547 sequence = AAAAACCTACTTATCAGATATGAAAAA Gene: CAC0929: SAM-dependent methlytransferase UbiG	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO0727: SAM-dependent methlytransferase UbiG	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_1001: SAM-dependent methlytransferase UbiG	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_0168: SAM-dependent methlytransferase UbiG	Clostridium tetani E88	SAM-dependent methlytransferase UbiG
mccB	Clostridium acetobutylicum ATCC 824 Gene: CAC0930: Cystathionine gamma-lyase (EC 4.4.1.1)	* Clostridium beijerincki NCIMB 8052 Site: position = -140 score = 5.67029 sequence = TAAAACACAGTAAACAAATAAGAATAA Gene: Cbei_0629: Cystathionine gamma-lyase (EC 4.4.1.1)	Clostridium botulinum A str. ATCC 3502 Gene: CBO0726: Cystathionine gamma-lyase (EC 4.4.1.1)	* Clostridium butyricum 5521 Site: position = -100 score = 5.52502 sequence = TAATTCCAAGTAAACAAATAGTAATAG Gene: CBY_1162: Cystathionine gamma-lyase (EC 4.4.1.1)	Clostridium kluyveri DSM 555 Gene: CKL_1002: Cystathionine gamma-lyase (EC 4.4.1.1)	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_0169: Cystathionine gamma-lyase (EC 4.4.1.1)	Clostridium tetani E88	Cystathionine gamma-lyase (EC 4.4.1.1)
CAC0931	Clostridium acetobutylicum ATCC 824 Gene: CAC0931: Cystathionine beta-synthase (EC 4.2.1.22)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0630: Cystathionine beta-synthase (EC 4.2.1.22)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_0170: Cystathionine beta-synthase (EC 4.2.1.22)	Clostridium tetani E88	Cystathionine beta-synthase (EC 4.2.1.22)
mccA	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO0724: Cystathionine beta-synthase (EC 4.2.1.22)	Clostridium butyricum 5521 Gene: CBY_1163: Cystathionine beta-synthase (EC 4.2.1.22)	Clostridium kluyveri DSM 555 Gene: CKL_1003: Cystathionine beta-synthase (EC 4.2.1.22)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Cystathionine beta-synthase (EC 4.2.1.22)

CRON 7.
cymR	* Clostridium acetobutylicum ATCC 824 Site: position = -86 score = 5.30689 sequence = AAAATTCTACTTGACAAGTAAAATTTT Gene: CAC2236: Predicted transcriptional regulator of cysteine synthase, Rrf2 family	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1748: Predicted transcriptional regulator of cysteine synthase, Rrf2 family	* Clostridium botulinum A str. ATCC 3502 Site: position = -45 score = 5.74509 sequence = ATAATCATAGTAAATAGATAGGAATAC Gene: CBO1178: Predicted transcriptional regulator of cysteine synthase, Rrf2 family	Clostridium butyricum 5521 Gene: CBY_1066: Predicted transcriptional regulator of cysteine synthase, Rrf2 family	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	* Clostridium tetani E88 Site: position = -40 score = 5.77564 sequence = ATAATCATACTAAACATATAGGAATAG Gene: CTC01344: Predicted transcriptional regulator of cysteine synthase, Rrf2 family	Predicted transcriptional regulator of cysteine synthase, Rrf2 family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CymR - Clostridia-1

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --