Regulog IscR - Clostridia-3

Properties
Regulator type:	Transcription factor
Regulator family:	Rrf2
Regulation mode:	repressor
Biological process:	Iron-sulfur cluster biogenesis
Effector:	Iron-sulfur cluster redox state
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 9 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-3
By TF family - Rrf2
By effector - Iron-sulfur cluster redox state
By pathway - Iron-sulfur cluster biogenesis

Statistics of regulated genes
Genome	Genes	Operons
Bacteroides pectinophilus ATCC 43243
Blautia hansenii DSM 20583	4	1
Bryantella formatexigens DSM 14469	4	1
Clostridiales bacterium 1_7_47_FAA
Clostridium bolteae ATCC BAA-613
Clostridium nexile DSM 1787	4	1
Clostridium scindens ATCC 35704	4	1
Dorea formicigenerans ATCC 27755	4	1
Dorea longicatena DSM 13814	5	1
Eubacterium eligens ATCC 27750
Eubacterium rectale ATCC 33656	4	1
Roseburia intestinalis L1-82
Ruminococcus gnavus ATCC 29149	4	1
Ruminococcus lactaris ATCC 29176	4	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes															Function

CRON 1.
iscR	Bacteroides pectinophilus ATCC 43243	* Blautia hansenii DSM 20583 Site: position = -43 score = 5.57175 sequence = AGAAATCAGAGTAAAACAGTCGGAATTGA Gene: BLAHAN_03017: Iron-sulfur cluster assembly transcription factor IscR	* Bryantella formatexigens DSM 14469 Site: position = -53 score = 6.20065 sequence = AGAAATCCGAGTAATTTAGTAGGATTTAA Gene: BRYFOR_01246: Iron-sulfur cluster assembly transcription factor IscR	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	* Clostridium nexile DSM 1787 Site: position = -51 score = 5.91229 sequence = ATAAACCCTAGTAATTCACTAGGAATTAA Gene: CLONEX_03012: Iron-sulfur cluster assembly transcription factor IscR	* Clostridium scindens ATCC 35704 Site: position = 18 score = 5.74359 sequence = AGAAATCCTAGCAAATTGCTAGGAATTAA Gene: CLOSCI_01399: Iron-sulfur cluster assembly transcription factor IscR	* Dorea formicigenerans ATCC 27755 Site: position = -37 score = 4.69748 sequence = TAAATCCCCAGTATTTTGCTAGGGATTGG Gene: DORFOR_01426: Iron-sulfur cluster assembly transcription factor IscR	* Dorea longicatena DSM 13814 Site: position = -43 score = 5.39194 sequence = AAAAATCCTAGTAAAATACTGGGGATTAA Gene: DORLON_02444: Iron-sulfur cluster assembly transcription factor IscR	Eubacterium eligens ATCC 27750	* Eubacterium rectale ATCC 33656 Site: position = -45 score = 5.32536 sequence = TGAATGTATAGTAAAGCAGTAGGAAATGA Gene: EUBREC_0307: Iron-sulfur cluster assembly transcription factor IscR	Roseburia intestinalis L1-82	* Ruminococcus gnavus ATCC 29149 Site: position = -60 score = 4.49887 sequence = GGAAATCCTAGTAAAACAATAGGGATTGG Gene: RUMGNA_01751: Iron-sulfur cluster assembly transcription factor IscR	* Ruminococcus lactaris ATCC 29176 Site: position = -54 score = 4.58676 sequence = GAAAATCCTAGTACAATACTAGGGATAAT Gene: RUMLAC_01913: Iron-sulfur cluster assembly transcription factor IscR	Iron-sulfur cluster assembly transcription factor IscR
DORLON_02443	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814 Gene: DORLON_02443: hypothetical protein	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176	hypothetical protein
iscS	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583 Gene: BLAHAN_03016: Cysteine desulfurase (EC 2.8.1.7)	Bryantella formatexigens DSM 14469 Gene: BRYFOR_01247: Cysteine desulfurase (EC 2.8.1.7)	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787 Gene: CLONEX_03011: Cysteine desulfurase (EC 2.8.1.7)	Clostridium scindens ATCC 35704 Gene: CLOSCI_01400: Cysteine desulfurase (EC 2.8.1.7)	Dorea formicigenerans ATCC 27755 Gene: DORFOR_01427: Cysteine desulfurase (EC 2.8.1.7)	Dorea longicatena DSM 13814 Gene: DORLON_02442: Cysteine desulfurase (EC 2.8.1.7)	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656 Gene: EUBREC_0308: Cysteine desulfurase (EC 2.8.1.7)	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_01752: Cysteine desulfurase (EC 2.8.1.7)	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_01914: Cysteine desulfurase (EC 2.8.1.7)	Cysteine desulfurase (EC 2.8.1.7)
iscU	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583 Gene: BLAHAN_03015: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Bryantella formatexigens DSM 14469 Gene: BRYFOR_01248: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787 Gene: CLONEX_03010: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Clostridium scindens ATCC 35704 Gene: CLOSCI_01401: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Dorea formicigenerans ATCC 27755 Gene: DORFOR_01428: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Dorea longicatena DSM 13814 Gene: DORLON_02441: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656 Gene: EUBREC_0309: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_01753: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_01915: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Iron-sulfur cluster assembly scaffold protein IscU/NifU-like
trmU	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583 Gene: BLAHAN_03014: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Bryantella formatexigens DSM 14469 Gene: BRYFOR_01249: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787 Gene: CLONEX_03009: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Clostridium scindens ATCC 35704 Gene: CLOSCI_01402: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Dorea formicigenerans ATCC 27755 Gene: DORFOR_01429: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Dorea longicatena DSM 13814 Gene: DORLON_02440: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656 Gene: EUBREC_0310: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_01754: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_01916: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog IscR - Clostridia-3

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --