Regulog IscR - Clostridia-1

Properties
Regulator type:	Transcription factor
Regulator family:	Rrf2
Regulation mode:	repressor
Biological process:	Iron-sulfur cluster biogenesis
Effector:	Iron-sulfur cluster redox state
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 19 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-1
By TF family - Rrf2
By effector - Iron-sulfur cluster redox state
By pathway - Iron-sulfur cluster biogenesis

Statistics of regulated genes
Genome	Genes	Operons
Clostridium acetobutylicum ATCC 824	6	2
Clostridium beijerincki NCIMB 8052	5	2
Clostridium botulinum A str. ATCC 3502	3	1
Clostridium butyricum 5521	4	1
Clostridium kluyveri DSM 555	8	2
Clostridium novyi NT	4	1
Clostridium perfringens ATCC 13124	8	4
Clostridium tetani E88	4	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
hesB	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -76 score = 4.76628 sequence = TTTATTTTGTTTAAAATTATATAATTTAA Site: position = -101 score = 5.28721 sequence = TAAATTCCTACTAAAATAGTCTTGATTTA Gene: CPF_0654: HesB family protein	Clostridium tetani E88	HesB family protein

CRON 2.
yxeON	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -69 score = 5.34994 sequence = TCAAAGTTGACAATTTTGATGGGAATTAA Gene: CPF_2350: Cysteine ABC transporter, substrate-binding protein fused to permease component	Clostridium tetani E88	Cysteine ABC transporter, substrate-binding protein fused to permease component
yxeM	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_2349: Amino acid ABC transporter, ATP-binding protein	Clostridium tetani E88	Amino acid ABC transporter, ATP-binding protein

CRON 3.
ldh	Clostridium acetobutylicum ATCC 824 Gene: CAC0267: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1014: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium botulinum A str. ATCC 3502 Gene: CBO1519: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium butyricum 5521 Gene: CBY_2757: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium kluyveri DSM 555 Gene: CKL_1381: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium novyi NT Gene: NT01CX_0236: L-lactate dehydrogenase (EC 1.1.1.27)	* Clostridium perfringens ATCC 13124 Site: position = -46 score = 5.54367 sequence = ATAATTCAGAGTAATTAACTAGGAATTAG Gene: CPF_0098: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium tetani E88 Gene: CTC01998: L-lactate dehydrogenase (EC 1.1.1.27)	L-lactate dehydrogenase (EC 1.1.1.27)

CRON 4.
sufC	* Clostridium acetobutylicum ATCC 824 Site: position = -58 score = 5.41844 sequence = TGAATTCCGACTTAAATGGTCAAGATTAA Gene: CAC3288: Iron-sulfur cluster assembly ATPase protein SufC	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1848: Iron-sulfur cluster assembly ATPase protein SufC	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	* Clostridium kluyveri DSM 555 Site: position = -41 score = 5.71541 sequence = TTAAATATGAGTCAAATACTCGGATTTAA Gene: CKL_0828: Iron-sulfur cluster assembly ATPase protein SufC	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Iron-sulfur cluster assembly ATPase protein SufC
sufB	Clostridium acetobutylicum ATCC 824 Gene: CAC3289: Iron-sulfur cluster assembly protein SufB	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1849: Iron-sulfur cluster assembly protein SufB	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_0829: Iron-sulfur cluster assembly protein SufB	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Iron-sulfur cluster assembly protein SufB
sufD	Clostridium acetobutylicum ATCC 824 Gene: CAC3290: Iron-sulfur cluster assembly protein SufD	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1850: Iron-sulfur cluster assembly protein SufD	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_0830: Iron-sulfur cluster assembly protein SufD	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Iron-sulfur cluster assembly protein SufD
sufS	Clostridium acetobutylicum ATCC 824 Gene: CAC3291: Cysteine desulfurase (EC 2.8.1.7), SufS subfamily	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1851: Cysteine desulfurase (EC 2.8.1.7), SufS subfamily	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_0831: Cysteine desulfurase (EC 2.8.1.7), SufS subfamily	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Cysteine desulfurase (EC 2.8.1.7), SufS subfamily
sufE	Clostridium acetobutylicum ATCC 824 Gene: CAC3292: Putative iron-sulfur cluster assembly scaffold protein for SUF system	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1852: Putative iron-sulfur cluster assembly scaffold protein for SUF system	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_0832: Putative iron-sulfur cluster assembly scaffold protein for SUF system	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Putative iron-sulfur cluster assembly scaffold protein for SUF system

CRON 5.
cysK	Clostridium acetobutylicum ATCC 824	* Clostridium beijerincki NCIMB 8052 Site: position = -55 score = 5.18973 sequence = TTATAACATAGTAAACTGATAAGAATTAT Gene: Cbei_4356: Cysteine synthase (EC 2.5.1.47)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Cysteine synthase (EC 2.5.1.47)

CRON 6.
iscR	* Clostridium acetobutylicum ATCC 824 Site: position = -41 score = 5.77827 sequence = ACAAAGTAGAGTATTATTGTCGGAATTAA Gene: CAC1675: Iron-sulfur cluster assembly transcription factor IscR	* Clostridium beijerincki NCIMB 8052 Site: position = -105 score = 5.67628 sequence = CAAAAGCCGAGTATTTTGGTAAGATATAA Gene: Cbei_1097: Iron-sulfur cluster assembly transcription factor IscR	* Clostridium botulinum A str. ATCC 3502 Site: position = -43 score = 6.02153 sequence = ATAAATCATAGTAAAGTGGTCAACATTAA Site: position = -82 score = 4.78731 sequence = ATATTGTTGACAGGTTTAGTCTGATTTGC Gene: CBO2569: Iron-sulfur cluster assembly transcription factor IscR	* Clostridium butyricum 5521 Site: position = -61 score = 5.25534 sequence = CAATAGCCGAGTATTTTGATAAGATATAA Gene: CBY_2622: Iron-sulfur cluster assembly transcription factor IscR	* Clostridium kluyveri DSM 555 Site: position = -71 score = 5.76577 sequence = TTATTGTTGACAAGTTTACTCTGATTTGA Gene: CKL_1317: Iron-sulfur cluster assembly transcription factor IscR	* Clostridium novyi NT Site: position = -41 score = 5.60115 sequence = AGAATTCATAGTATAACACTCGGATTTAA Site: position = -82 score = 5.91078 sequence = TTAATGTTGACAAAAACACTCGGATTTGA Gene: NT01CX_2284: Iron-sulfur cluster assembly transcription factor IscR	* Clostridium perfringens ATCC 13124 Site: position = -80 score = 5.82798 sequence = TTATTGTTGACAAATTTACTCGGTTTTGA Site: position = -39 score = 5.03984 sequence = ATAAAGTACATCGAATTAGTCAGATTTAG Gene: CPF_2040: Iron-sulfur cluster assembly transcription factor IscR	* Clostridium tetani E88 Site: position = -52 score = 5.49248 sequence = TGAAAGTTTAGTAAAGCAGTAGACTTTCA Site: position = -92 score = 5.21816 sequence = TTATAGTTGACAGGAATACTCGGATTTGT Gene: CTC01049: Iron-sulfur cluster assembly transcription factor IscR	Iron-sulfur cluster assembly transcription factor IscR
iscS	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1098: Cysteine desulfurase (EC 2.8.1.7)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2568: Cysteine desulfurase (EC 2.8.1.7)	Clostridium butyricum 5521 Gene: CBY_2621: Cysteine desulfurase (EC 2.8.1.7)	Clostridium kluyveri DSM 555 Gene: CKL_1318: Cysteine desulfurase (EC 2.8.1.7)	Clostridium novyi NT Gene: NT01CX_2283: Cysteine desulfurase (EC 2.8.1.7)	Clostridium perfringens ATCC 13124 Gene: CPF_2039: Cysteine desulfurase (EC 2.8.1.7)	Clostridium tetani E88 Gene: CTC01050: Cysteine desulfurase (EC 2.8.1.7)	Cysteine desulfurase (EC 2.8.1.7)
iscU	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1099: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Clostridium botulinum A str. ATCC 3502 Gene: CBO2567: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Clostridium butyricum 5521 Gene: CBY_2620: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Clostridium kluyveri DSM 555 Gene: CKL_1319: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Clostridium novyi NT Gene: NT01CX_2282: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Clostridium perfringens ATCC 13124 Gene: CPF_2038: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Clostridium tetani E88 Gene: CTC01051: Iron-sulfur cluster assembly scaffold protein IscU/NifU-like	Iron-sulfur cluster assembly scaffold protein IscU/NifU-like
trmU	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1100: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2905: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Clostridium butyricum 5521 Gene: CBY_2619: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Clostridium kluyveri DSM 555 Gene: CKL_1088: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Clostridium novyi NT Gene: NT01CX_2281: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Clostridium perfringens ATCC 13124 Gene: CPF_2037: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	Clostridium tetani E88 Gene: CTC01052: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog IscR - Clostridia-1

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --