Collection of regulogs for ModE transcription factor family

ModE is a dual regulator that controls transcription of genes involved in the homeostasis of molybdenum. ModE-dependent regulation was experimentally characterized in Escherichia coli. ModE regulon includes molybdenum transporters, genes involved in the synthesis of molybdenum cofactors (e.g., molybdopterin guanine dinucleotide in E. coli), and some molybdenum-containing enzymes [19772354, 9325422]. ModE binds molybdate (form of soluble molybdenum) as an effector. Efficient DNA-binding requires protein dimerization and molybdate binding, leading to extensive conformational changes and largely enhanced affinity for specific operator sequences. more

Some ModE-family regulators control tungsten uptake and homeostasis genes in the presence tungsten [19919002]. ModE-family regulators contain a characteristic N-terminal DNA-binding HTH domain (COG2005) and one or two molybdate/tungsten-binding domains (PF03459). The latter effector-binding domain is absent in several ModE homologs in Alphaproteobacteria. ModE-family regulators were found both in Bacteria and Archaea.