Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulons of Bacillus subtilis subsp. subtilis str. 168

Allows to visualize regulome content in the context of metabolic pathways
Type Regulator Effector Pathway Operons Sites
TF AcoR Acetoin Acetoin utilization 1 1
TF AdaA DNA alkylation response 3 2
TF AlsR Acetate Acetoin production 2 2
TF AnsR Asparagine Asparagine degradation 2 2
TF AraR Arabinose Arabinose utilization 5 8
TF ArgR Arginine Arginine biosynthesis; Arginine degradation 5 10
TF ArsR Arsenite; Cadmium, ion (Cd2+); Silver ion, (Ag+) Arsenic resistance 2 3
TF AseR Arsenite Arsenic resistance 2 2
TF BceR BceS, sensor histidine kinase (bacitracin) Bacitracin resistance 1 1
TF BglR Beta-glucoside-6-phosphate Beta-glucosides utilization 2 2
TF BglZ Beta-glucoside Beta-glucosides utilization 2 2
TF BirA Biotin Biotin biosynthesis 3 3
TF BkdR Branched-chain amino acid degradation 2 3
TF BltR Multidrug resistance 3 1
TF BmrR Multidrug resistance 1 1
TF BsdA Salicylate Salicylic acid resistance 2 2
TF Btr Bacillibactin; Fe-Bacillibactin Iron homeostasis 2 1
TF CcpA HPr, phosphocarrier protein Carbon catabolism 96 89
TF CcpC Citrate Citrate metabolism 3 3
TF CcpN Gluconeogenesis 2 2
TF CggR Fructose-1,6-diphosphate Glycolysis 1 1
TF CitR Citrate metabolism 2 2
TF CitT Citrate Citrate utilization 1 1
TF CodY Guanosine triphosphate; Branched-chain amino acids Amino acid metabolism 106 81
TF ComA ComP, sensor histidine kinase (ComX) Competence 8 7
TF CsoR Copper ion, (Cu+) Copper resistance 5 3
TF CssR CssS, sensor histidine kinase Protein secretion stress response 3 6
TF CtsR Heat shock Heat shock response 5 3
TF CymR O-acetyl-L-serine; CysK, cysteine synthetase Cysteine metabolism 13 8
TF CysL Sulfate; Sulfite; Thiosulfate Sulfite reduction 5 3
TF CzrA Zinc ion, (Zn2+); Silver ion, (Ag+); Nickel ion, (Ni2+); Copper ion, (Cu2+); Cobalt ion, (Co2+); Cadmium, ion (Cd2+) Zinc resistance; Nickel resistance; Copper resistance; Cobalt resistance; Cadmium resistance 3 2
TF DctR C4-dicarboxylate transport 1 1
TF DeoR Deoxyribose-5-phosphate Deoxynucleoside utilization 1 2
TF DesR Cold shock response 1 1
TF ExuR Glucuronate; Galacturonate Glucuronate utilization; Galacturonate utilization 1 1
TF FadR Palmitoyl-CoA; Oleoyl-CoA Fatty acid degradation 6 5
TF FapR Malonyl-CoA Fatty acid biosynthesis 7 5
TF FatR Oleate; Gamma-linolenic acid; Linoleate; Phytanate Toxic fatty acid stress response 1 1
TF Fnr Oxygen Anaerobic metabolism 5 6
TF FrlR Fructoselysine 6-phosphate Fructoselysine utilization 4 6
TF FruR Fructose-6-phosphate Fructose utilization 1 2
TF Fur Iron ion, (Fe2+) Iron homeostasis 27 31
TF GabR Pyridoxal-5-phosphate; Gamma-aminobutyric acid Gamma-aminobutyrate utilization 1 1
TF GamR Glucosamine-6-phosphate Glucosamine utilization 2 4
TF GanR Beta-galactosides Galactan utilization 2 2
TF GbsR (YuaC) Choline Glycine betaine synthesis 1 1
TF GlcR 1 2
TF GlnL GlnK, sensor histidine kinase (glutamine) Aspartate utilization; Glutamine utilization 1 2
TF GlnR Feedback-inhibited GlnA, glutamine synthetase Nitrogen assimilation 4 4
TF GltC Glutamate; 2-oxoglutarate; RocG, glutamate dehydrogenase Glutamate metabolism 2 4
TF GltR unknown 2 2
TF GlvR Maltose-6-phosphate Maltose utilization 1 1
TF GmuR Glucomannan utilization 1 1
TF GntR D-gluconate; D-glucono-delta-lactone Gluconate utilization 1 1
TF GudR Glucarate utilization; Galactarate utilization 2 2
TF GutR Sorbitol Sorbitol utilization 2 2
TF HisR Histidine Histidine biosynthesis 2 2
TF HrcA Heat shock Heat shock response 3 2
TF HxlR Formaldehyde Ribulose monophosphate pathway 1 1
TF IolR 2-deoxy-5-keto-D-gluconate 6-phosphate Inositol utilization 3 2
TF IolR1 Inositol utilization 4 3
TF KdgR 2-keto-3-deoxygluconate Galacturonate utilization; Glucuronate utilization 2 4
TF KipR Sporulation 2 2
TF LevR Levan utilization 1 1
TF LexA DNA damage SOS response 31 35
TF LiaR LiaS, sensor histidine kinase (bacitracin, nisin, ramoplanin, vancomycin) Cell wall-active antibiotics stress response 1 1
TF LicR HPr, phosphocarrier protein; LicB, lichenan-specific enzyme IIB PTS component Beta-glucosides utilization 2 1
TF LmrA Quercetin; Fisetin; Catechin Multidrug resistance 3 4
TF LutR L-lactate Lactate utilization 3 3
TF LytT Penicillin resistance 1 2
TF MalR MalK, sensor histidine kinase (malate) Malate utilization 3 3
TF ManR ManP, mannose-specific enzyme IIBCA PTS component; HPr, phosphocarrier protein Mannose utilization 2 2
TF MdxR Maltose Maltodextrin utilization; Maltose utilization 2 2
TF MhqR 2-Methylhydroquinone and catechol resistance 6 5
TF MntR Manganese ion, (Mn2+) Manganese homeostasis 2 2
TF MsmR Alpha-galactosides Alpha-galactosides utilization 1 1
TF MtlR MtlA, mannitol-specific enzyme IICB PTS component; HPr, phosphocarrier protein Mannitol utilization 2 2
TF MurR N-acetylmuramate-6-phosphate N-acetylmuramate utilization 1 1
TF NagR N-acetylglucosamine-6-phosphate N-acetylglucosamine utilization 2 2
TF NiaR Niacin NAD biosynthesis 3 3
TF NrdR Deoxyribonucleotides Deoxyribonucleotide biosynthesis 1 2
TF NsrR Nitric oxide Nitrosative stress response 3 3
TF NtdR 3,3'-neotrehalosadiamine Neotrehalosadiamine biosynthesis 2 2
TF OhrR tert-Butyl hydroperoxide; Diamide; Cumene hydroperoxide; Hydrogen peroxide Peroxide stress response 2 2
TF PadR p-Coumaric acid; Ferulic acid Phenolic acid stress response 2 1
TF PerR Hydrogen peroxide; Manganese ion, (Mn2+); Iron ion, (Fe2+) Oxidative stress response; Peroxide stress response 14 14
TF PurR 5-phosphoribosyl 1-pyrophosphate Purine metabolism 11 11
TF PutR Proline Proline utilization 1 1
TF QdoR Quercetin; Fisetin; Tamarixetin; Galangin Multidrug resistance 3 4
TF RbsR Ribose Ribose utilization 1 1
TF Rex NADH Energy metabolism 9 8
TF RhaR Rhamnulose-1-phosphate Rhamnose utilization 1 1
TF RhgR Rhamnogalacturonides utilization 1 1
TF RmgR Rhamnogalacturonides utilization 2 2
TF RocR Ornithine; L-citrulline Arginine degradation; Ornithine degradation 4 4
TF SdpR SdpI, signal transduction protein Toxin-antitoxin system 1 1
TF SinR SinI, antirepressor protein Biofilm formation 3 3
TF TnrA NrgB, ammonium uptake protein; NrgA, ammonium uptake protein; Feedback-inhibited GlnA, glutamine synthetase Nitrogen assimilation 52 60
TF TreR Trehalose-6-phosphate Trehalose utilization 1 2
TF XylR Xylose Xylose utilization 3 3
TF YbfI Drug resistance 1 1
TF YbzH Metabolite transport 2 2
TF YcnK Copper ion, (Cu+) Copper homeostasis 1 1
TF YcxD Multidrug efflux 1 1
TF YczG Utilization of aromatic compounds 2 2
TF YdeF Metabolite transport 1 1
TF YdfD/YisV Metabolite transport 4 4
TF YdfF 2 2
TF YdfI Metabolite transport 1 1
TF YdfL Multidrug resistance 1 1
TF YetL Flavonoids Flavonoids response 2 2
TF YfmP Metal efflux 1 1
TF YhcF Multidrug resistance; Multidrug efflux 1 1
TF YhdI/YdeL Metabolite transport 2 2
TF YhgD 1 1
TF YisR Metabolite transport 1 1
TF YodB/CatR Diamide; Quinone Oxidative stress response 8 5
TF YrkD Multidrug resistance 2 3
TF YtcD 2 2
TF YtlI L-cystine transporter 2 4
TF YtrA Ramoplanin Ramoplanin resistance 2 2
TF YvbF/YvaV Osmotic stress response 4 4
TF YvcP YvcQ, sensor histidine kinase Bacitracin resistance 1 1
TF YvfU YvfT, sensor histidine kinase Metabolite transport 1 1
TF YwbI Cell wall metabolism 2 2
TF YwrC Metal homeostasis 1 1
TF YybA Polyamine homeostasis 4 4
TF YybR/YdeP Multidrug resistance 5 5
TF Zur Zinc ion, (Zn2+) Zinc homeostasis 7 7
RNA Cobalamin Adenosylcobalamin Cobalamin biosynthesis 2 1
RNA FMN Flavin mononucleotide Riboflavin biosynthesis 2 2
RNA Glycine Glycine Glycine metabolism 1 2
RNA L10_leader Ribosome biogenesis 1 1
RNA L13_leader Ribosome biogenesis 1 1
RNA L19_leader Ribosome biogenesis 1 1
RNA L20_leader Ribosome biogenesis 1 1
RNA L21_leader Ribosome biogenesis 1 1
RNA Lysine Lysine Lysine biosynthesis 3 2
RNA PreQ1 Pre-queuosine1 Queuosine biosynthesis 2 1
RNA Purine Adenine; Guanine Purine metabolism 11 5
RNA PyrR PyrR Pyrimidine metabolism 3 3
RNA SAM S-adenosylmethionine Methionine biosynthesis 16 11
RNA T-box(Ala) Ala-tRNA Amino acid metabolism 1 1
RNA T-box(Asn) Asn-tRNA Amino acid metabolism 1 1
RNA T-box(Cys) Cys-tRNA Amino acid metabolism 1 1
RNA T-box(Gly) Gly-tRNA Amino acid metabolism 1 1
RNA T-box(Ile) Ile-tRNA Amino acid metabolism 3 1
RNA T-box(Leu) Leu-tRNA Amino acid metabolism 4 3
RNA T-box(Phe) Phe-tRNA Amino acid metabolism 1 1
RNA T-box(Pro) Pro-tRNA Amino acid metabolism 4 2
RNA T-box(Ser) Ser-tRNA Amino acid metabolism 2 1
RNA T-box(Thr) Thr-tRNA Amino acid metabolism 4 2
RNA T-box(Trp) Trp-tRNA Amino acid metabolism 3 2
RNA T-box(Tyr) Tyr-tRNA Amino acid metabolism 4 2
RNA T-box(Val) Val-tRNA Amino acid metabolism 1 1
RNA TPP Thiamine pyrophosphate Thiamine biosynthesis 6 5
RNA glmS Glucosamine-6-phosphate Amino sugar metabolism 1 1
RNA ydaO-yuaA Cell wall metabolism; Osmotic stress response 2 2
RNA ykkC-yxkD Multidrug resistance 2 2
RNA ykoK Magnesium ion, (Mg2+) Magnesium homeostasis 1 1
RNA ylbH 1 1
RNA yybP-ykoY 3 2
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