Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of SAM in Bacillus subtilis subsp. subtilis str. 168

Properties
Regulator type: RNA regulatory element
Name: SAM
RFAM: RF00162
Regulation mode:
Biological process: Methionine biosynthesis
Effector: S-adenosylmethionine
Regulog: SAM - Bacillales
Under regulation:
- Genes 26
- Operons 11
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -266
Score: 83.4
Sequence: ACTTATCAAGAGCGG...
Locus tag: BSU15570
Name: cysH
Funciton: Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)
Locus tag: BSU15580
Name: cysP
Funciton: Sulfate permease, Pit-type
Locus tag: BSU15590
Name: sat
Funciton: Sulfate adenylyltransferase, dissimilatory-type (EC 2.7.7.4)
Locus tag: BSU15600
Name: cysC
Funciton: Adenylylsulfate kinase (EC 2.7.1.25)
Locus tag: BSU15610
Name: cysG
Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
Locus tag: BSU15620
Name: sirB
Funciton: Sirohydrochlorin ferrochelatase (EC 4.99.1.4)
Locus tag: BSU15630
Name: sirC
Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76)
cysH
Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)
cysP
Sulfate permease, Pit-type
sat
Sulfate adenylyltransferase, dissimilatory-type (EC 2.7.7.4)
cysC
Adenylylsulfate kinase (EC 2.7.1.25)
cysG
Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
sirB
Sirohydrochlorin ferrochelatase (EC 4.99.1.4)
sirC
Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76)

Position: -307
Score: 73.2
Sequence: ACTCTTATCCCGAGC...
Locus tag: BSU30550
Name: metK
Funciton: S-adenosylmethionine synthetase (EC 2.5.1.6)
metK
S-adenosylmethionine synthetase (EC 2.5.1.6)

Position: -183
Score: 85.1
Sequence: CCTTATCAAGAGAGG...
Locus tag: BSU38960
Name: metE3
Funciton: Putative methionine synthase II (cobalamin-independent)
metE3
Putative methionine synthase II (cobalamin-independent)

Position: -188
Score: 94.8
Sequence: CCTTATCAAGAGAGG...
Locus tag: BSU38950
Name: metE2
Funciton: Putative methionine synthase II (cobalamin-independent)
metE2
Putative methionine synthase II (cobalamin-independent)

Position: -213
Score: 94.4
Sequence: TCTCTTATCAAGAGA...
Locus tag: BSU32750
Name: metN
Funciton: Methionine ABC transporter ATP-binding protein
Locus tag: BSU32740
Name: metP
Funciton: Methionine ABC transporter permease protein
Locus tag: BSU32730
Name: metQ
Funciton: Methionine ABC transporter substrate-binding protein
metN
Methionine ABC transporter ATP-binding protein
metP
Methionine ABC transporter permease protein
metQ
Methionine ABC transporter substrate-binding protein

Position: -187
Score: 93.9
Sequence: TCTTATCGTGAGAGG...
Locus tag: BSU11870
Name: metI
Funciton: Cystathionine gamma-synthase (EC 2.5.1.48)
Locus tag: BSU11880
Name: metC
Funciton: Cystathionine beta-lyase (EC 4.4.1.8)
metI
Cystathionine gamma-synthase (EC 2.5.1.48)
metC
Cystathionine beta-lyase (EC 4.4.1.8)

Position: -208
Score: 97.4
Sequence: GTTCTTATCAAGAGA...
Locus tag: BSU11010
Name: metF
Funciton: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain
metF
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain

Position: -284
Score: 66.8
Sequence: TCTCTTATCGAGAGT...
Locus tag: BSU13180
Name: metE
Funciton: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
metE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)

Position: -157
Score: 83.2
Sequence: TCTTATCAAGAGCAG...
Locus tag: BSU13590
Name: mtnW
Funciton: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase
Locus tag: BSU13600
Name: mtnX
Funciton: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
Locus tag: BSU13610
Name: mtnB
Funciton: Methylthioribulose-1-phosphate dehydratase (EC 4.2.1.109)
Locus tag: BSU13620
Name: mtnD
Funciton: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54)
mtnW
2,3-diketo-5-methylthiopentyl-1-phosphate enolase
mtnX
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
mtnB
Methylthioribulose-1-phosphate dehydratase (EC 4.2.1.109)
mtnD
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54)

Position: -244
Score: 58.3
Sequence: TCTCTTATCGAGAGT...
Locus tag: BSU13560
Name: mtnK
Funciton: 5-methylthioribose kinase (EC 2.7.1.100)
Locus tag: BSU13550
Name: mtnA
Funciton: Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)
mtnK
5-methylthioribose kinase (EC 2.7.1.100)
mtnA
Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)

Position: -176
Score: 85.5
Sequence: TTTTCTATCCAGAGA...
Locus tag: BSU18560
Name: yoaD
Funciton: Hydroxypyruvate reductase (EC 1.1.1.81)
Locus tag: BSU18550
Name: yoaC
Funciton: Sugar kinase similar to xylulokinase, FGGY family
Locus tag: BSU18540
Name: yoaB
Funciton: Predicted sulfate transporter
yoaD
Hydroxypyruvate reductase (EC 1.1.1.81)
yoaC
Sugar kinase similar to xylulokinase, FGGY family
yoaB
Predicted sulfate transporter
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