Collection of regulogs for HutC transcription factor

Transcription factor HutC from the GntR protein family regulates the histidine utilization genes in Proteobacteria. It was originally characterized in Klebsiella aerogenes and Pseudomonas putida as a repressor of the hut catabolic genes. cis-Urocanic acid, the first intermediate of the hut pathway, is an inducer that interacts with HutC, causing a conformational change that dissociates the repressor from the promoter sequences. After dissociation, transcription of the hut genes is derepressed.