Regulog HutC - Ralstonia

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:
Biological process:	Histidine utilization
Effector:	cis-Urocanic acid
Phylum:	Proteobacteria/beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 22 sites [see more]

Member of regulog collections

By taxonomy - Ralstonia
By trascription factor - HutC
By TF family - GntR/Others
By effector - cis-Urocanic acid
By pathway - Histidine utilization

Statistics of regulated genes
Genome	Genes	Operons
Cupriavidus taiwanensis	13	3
Ralstonia eutropha H16	12	3
Ralstonia eutropha JMP134	15	4
Ralstonia metallidurans CH34	14	3
Ralstonia pickettii 12J	7	3
Ralstonia solanacearum GMI1000	5	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes							Function

CRON 1.
hutH	* Cupriavidus taiwanensis Site: position = -26 score = 5.62207 sequence = TAAGCTGTATAGACAGGAAC Gene: RALTA_A2492: Histidine ammonia-lyase (EC 4.3.1.3)	* Ralstonia eutropha H16 Site: position = -26 score = 5.62207 sequence = TAAGCTGTATAGACAGGAAC Gene: H16_A3018: Histidine ammonia-lyase (EC 4.3.1.3)	2 Ralstonia eutropha JMP134* Gene: Reut_B5637: Histidine ammonia-lyase (EC 4.3.1.3) Site: position = -40 score = 5.62207 sequence = TAAGCTGTATAGACAGGAAC Gene: Reut_A2716: Histidine ammonia-lyase (EC 4.3.1.3)	2 Ralstonia metallidurans CH34* Gene: Rmet_5047: Histidine ammonia-lyase (EC 4.3.1.3) Site: position = -59 score = 5.08975 sequence = TAACCTGTATAGACAGGCCC Gene: Rmet_2855: Histidine ammonia-lyase (EC 4.3.1.3)	Ralstonia pickettii 12J Gene: Rpic_2880: Histidine ammonia-lyase (EC 4.3.1.3)	Ralstonia solanacearum GMI1000 Gene: RSc2646: Histidine ammonia-lyase (EC 4.3.1.3)	Histidine ammonia-lyase (EC 4.3.1.3)
hutU	2 Cupriavidus taiwanensis* Gene: RALTA_A2491: Urocanate hydratase (EC 4.2.1.49) Site: position = -83 score = 5.55162 sequence = GCACTTGTATATACAGGAAT Gene: RALTA_A0654: Urocanate hydratase (EC 4.2.1.49)	2 Ralstonia eutropha H16* Site: position = -83 score = 5.40951 sequence = ATGCCTGTATATACAGGACT Gene: H16_A0695: Urocanate hydratase (EC 4.2.1.49) Gene: H16_A3017: Urocanate hydratase (EC 4.2.1.49)	3 Ralstonia eutropha JMP134* Gene: Reut_A2715: Urocanate hydratase (EC 4.2.1.49) Site: position = -94 score = 5.59118 sequence = ATGCTTGTATATACAACACT Gene: Reut_A0896: Urocanate hydratase (EC 4.2.1.49) Site: position = -94 score = 5.59118 sequence = ATGCTTGTATATACAACACT Gene: Reut_B5636: Urocanate hydratase (EC 4.2.1.49)	2 Ralstonia metallidurans CH34* Site: position = -88 score = 4.73014 sequence = CAACTTGTCTATACAATACT Gene: Rmet_5048: Urocanate hydratase (EC 4.2.1.49) Gene: Rmet_2854: Urocanate hydratase (EC 4.2.1.49)	* Ralstonia pickettii 12J Site: position = -60 score = 6.10331 sequence = TAAGTTGTATATACAACATA Gene: Rpic_2881: Urocanate hydratase (EC 4.2.1.49)	* Ralstonia solanacearum GMI1000 Site: position = -53 score = 5.78373 sequence = TTATTTGTATATACAACATA Gene: RSc2647: Urocanate hydratase (EC 4.2.1.49)	Urocanate hydratase (EC 4.2.1.49)
hutD	Cupriavidus taiwanensis Gene: RALTA_A2490: Conserved hypothetical protein related to histidine degradation	Ralstonia eutropha H16 Gene: H16_A3016: Conserved hypothetical protein related to histidine degradation	Ralstonia eutropha JMP134 Gene: Reut_A2714: Conserved hypothetical protein related to histidine degradation	Ralstonia metallidurans CH34 Gene: Rmet_2853: Conserved hypothetical protein related to histidine degradation	Ralstonia pickettii 12J	Ralstonia solanacearum GMI1000	Conserved hypothetical protein related to histidine degradation
hutI	Cupriavidus taiwanensis Gene: RALTA_A2489: Imidazolonepropionase (EC 3.5.2.7)	Ralstonia eutropha H16 Gene: H16_A3015: Imidazolonepropionase (EC 3.5.2.7)	Ralstonia eutropha JMP134 Gene: Reut_A2713: Imidazolonepropionase (EC 3.5.2.7)	Ralstonia metallidurans CH34 Gene: Rmet_2852: Imidazolonepropionase (EC 3.5.2.7)	Ralstonia pickettii 12J Gene: Rpic_2878: Imidazolonepropionase (EC 3.5.2.7)	Ralstonia solanacearum GMI1000 Gene: RSc2644: Imidazolonepropionase (EC 3.5.2.7)	Imidazolonepropionase (EC 3.5.2.7)
hutF	Cupriavidus taiwanensis Gene: RALTA_A2488: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Ralstonia eutropha H16 Gene: H16_A3014: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Ralstonia eutropha JMP134 Gene: Reut_A2712: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Ralstonia metallidurans CH34 Gene: Rmet_2851: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Ralstonia pickettii 12J	Ralstonia solanacearum GMI1000	Formiminoglutamic iminohydrolase (EC 3.5.3.13)
hutG	Cupriavidus taiwanensis Gene: RALTA_A2487: N-formylglutamate deformylase (EC 3.5.1.68)	Ralstonia eutropha H16 Gene: H16_A3013: N-formylglutamate deformylase (EC 3.5.1.68)	Ralstonia eutropha JMP134 Gene: Reut_A2711: N-formylglutamate deformylase (EC 3.5.1.68)	Ralstonia metallidurans CH34 Gene: Rmet_2850: N-formylglutamate deformylase (EC 3.5.1.68)	Ralstonia pickettii 12J	Ralstonia solanacearum GMI1000	N-formylglutamate deformylase (EC 3.5.1.68)
hutG2	2 Cupriavidus taiwanensis Gene: RALTA_A0652: Formiminoglutamase (EC 3.5.3.8) Gene: RALTA_A0010: Formiminoglutamase (EC 3.5.3.8)	Ralstonia eutropha H16 Gene: H16_A0044: Formiminoglutamase (EC 3.5.3.8)	Ralstonia eutropha JMP134 Gene: Reut_A1591: Formiminoglutamase (EC 3.5.3.8)	Ralstonia metallidurans CH34 Gene: Rmet_5045: Formiminoglutamase (EC 3.5.3.8)	2 Ralstonia pickettii 12J Gene: Rpic_2879: Formiminoglutamase (EC 3.5.3.8) Gene: Rpic_2795: Formiminoglutamase (EC 3.5.3.8)	Ralstonia solanacearum GMI1000 Gene: RS04571: Formiminoglutamase (EC 3.5.3.8)	Formiminoglutamase (EC 3.5.3.8)
hisT	Cupriavidus taiwanensis	Ralstonia eutropha H16	Ralstonia eutropha JMP134 Gene: Reut_B5638: Histidine transport protein (permease)	Ralstonia metallidurans CH34 Gene: Rmet_5046: Histidine transport protein (permease)	* Ralstonia pickettii 12J Site: position = -126 score = 5.53292 sequence = CATGATGTATATACAACAAC Gene: Rpic_0834: Histidine transport protein (permease)	Ralstonia solanacearum GMI1000	Histidine transport protein (permease)
COG2814 (AraJ)	Cupriavidus taiwanensis Gene: RALTA_A0653: Putative histidine permease, major facilitator superfamily	Ralstonia eutropha H16 Gene: H16_A0694: Putative histidine permease, major facilitator superfamily	3 Ralstonia eutropha JMP134 Gene: Reut_B5304: Putative histidine permease, major facilitator superfamily Gene: Reut_C6354: Putative histidine permease, major facilitator superfamily Gene: Reut_A0897: Putative histidine permease, major facilitator superfamily	Ralstonia metallidurans CH34	Ralstonia pickettii 12J Gene: Rpic_0835: Putative histidine permease, major facilitator superfamily	Ralstonia solanacearum GMI1000	Putative histidine permease, major facilitator superfamily

CRON 2.
hisX	* Cupriavidus taiwanensis Site: position = -247 score = 5.65278 sequence = GATCCTGTCTATACAGCAAC Site: position = -93 score = 5.43936 sequence = TGACTTGTATATACAGGCAT Gene: RALTA_A2496: Putative histidine ABC transporter, substrate binding protein	* Ralstonia eutropha H16 Site: position = -93 score = 5.60807 sequence = TGACTTGTATATACAGGTAC Site: position = -249 score = 5.20991 sequence = TGTCCTGTCTATACAGCAGC Gene: H16_A3022: Putative histidine ABC transporter, substrate binding protein	* Ralstonia eutropha JMP134 Site: position = -94 score = 5.67179 sequence = TGACTTGTATATACAGGATT Site: position = -249 score = 5.37126 sequence = ACTCCTGTCTATACAGCAAC Gene: Reut_A2720: Putative histidine ABC transporter, substrate binding protein	* Ralstonia metallidurans CH34 Site: position = -114 score = 5.21767 sequence = TGACTTGTATATACAGCGTT Site: position = -271 score = 5.83693 sequence = CTTGTTGTATATACAGCAAT Gene: Rmet_2859: Putative histidine ABC transporter, substrate binding protein	Ralstonia pickettii 12J	Ralstonia solanacearum GMI1000	Putative histidine ABC transporter, substrate binding protein
hisY	Cupriavidus taiwanensis Gene: RALTA_A2495: Putative histidine ABC transporter, permease protein	Ralstonia eutropha H16 Gene: H16_A3021: Putative histidine ABC transporter, permease protein	Ralstonia eutropha JMP134 Gene: Reut_A2719: Putative histidine ABC transporter, permease protein	Ralstonia metallidurans CH34 Gene: Rmet_2858: Putative histidine ABC transporter, permease protein	Ralstonia pickettii 12J	Ralstonia solanacearum GMI1000	Putative histidine ABC transporter, permease protein
hisZ	Cupriavidus taiwanensis Gene: RALTA_A2494: Putative histidine ABC transporter, ATPase protein	Ralstonia eutropha H16 Gene: H16_A3020: Putative histidine ABC transporter, ATPase protein	Ralstonia eutropha JMP134 Gene: Reut_A2718: Putative histidine ABC transporter, ATPase protein	Ralstonia metallidurans CH34 Gene: Rmet_2857: Putative histidine ABC transporter, ATPase protein	Ralstonia pickettii 12J	Ralstonia solanacearum GMI1000	Putative histidine ABC transporter, ATPase protein
hutC	Cupriavidus taiwanensis Gene: RALTA_A2493: Histidine utilization repressor, GntR family	Ralstonia eutropha H16 Gene: H16_A3019: Histidine utilization repressor, GntR family	Ralstonia eutropha JMP134 Gene: Reut_A2717: Histidine utilization repressor, GntR family	Ralstonia metallidurans CH34 Gene: Rmet_2856: Histidine utilization repressor, GntR family	Ralstonia pickettii 12J	Ralstonia solanacearum GMI1000	Histidine utilization repressor, GntR family

CRON 3.
hutC	Cupriavidus taiwanensis	Ralstonia eutropha H16	Ralstonia eutropha JMP134	Ralstonia metallidurans CH34	* Ralstonia pickettii 12J Site: position = -114 score = 6.10331 sequence = TATGTTGTATATACAACTTA Gene: Rpic_2882: Histidine utilization repressor, GntR family	* Ralstonia solanacearum GMI1000 Site: position = -99 score = 5.78373 sequence = TATGTTGTATATACAAATAA Gene: RSc2648: Histidine utilization repressor, GntR family	Histidine utilization repressor, GntR family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HutC - Ralstonia

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --