Regulog HutC - Enterobacteriales

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:	repressor
Biological process:	Histidine utilization
Effector:	cis-Urocanic acid
Phylum:	Proteobacteria/gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 27 sites [see more]

Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - HutC
By TF family - GntR/Others
By effector - cis-Urocanic acid
By pathway - Histidine utilization

Statistics of regulated genes
Genome	Genes	Operons
Escherichia coli str. K-12 substr. MG1655
Salmonella typhimurium LT2	3	1
Citrobacter koseri ATCC BAA-895	12	3
Klebsiella pneumoniae subsp. pneumoniae MGH 78578	8	4
Enterobacter sp. 638	5	2
Erwinia amylovora ATCC 49946	7	4
Yersinia pestis KIM	7	4
Serratia proteamaculans 568	12	4
Erwinia carotovora subsp. atroseptica SCRI1043
Edwardsiella tarda EIB202
Proteus mirabilis HI4320
Photorhabdus luminescens subsp. laumondii TTO1	6	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
COG1457 (CodB)	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -111 score = 5.87176 sequence = ATGCTTGTATATACAAGAAC Gene: KPN_01286: Permease, cytosine/purines, uracil, thiamine, allantoin family protein	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_2047: Permease, cytosine/purines, uracil, thiamine, allantoin family protein	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Permease, cytosine/purines, uracil, thiamine, allantoin family protein

CRON 2.
hutU	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	* Citrobacter koseri ATCC BAA-895 Site: position = -61 score = 5.33952 sequence = CAAGTTGTATAGACAAGTAT Gene: CKO_02357: Urocanate hydratase (EC 4.2.1.49)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -62 score = 6.11964 sequence = ATGCTTGTATAGACAAGTAT Gene: KPN_00795: Urocanate hydratase (EC 4.2.1.49)	* Enterobacter sp. 638 Site: position = -58 score = 4.93645 sequence = GGGGTTGTCTATACAAGTAT Gene: Ent638_1263: Urocanate hydratase (EC 4.2.1.49)	Erwinia amylovora ATCC 49946 Gene: EAM_1253: Urocanate hydratase (EC 4.2.1.49)	* Yersinia pestis KIM Site: position = -72 score = 5.86861 sequence = GTACTTGTCTATACAAGTAT Gene: y4038: Urocanate hydratase (EC 4.2.1.49)	* Serratia proteamaculans 568 Site: position = -20 score = 6.28949 sequence = ATGCTTGTACATACAAGTAT Gene: Spro_0805: Urocanate hydratase (EC 4.2.1.49)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -69 score = 4.58751 sequence = TCTATTGAATATACATGTAT Site: position = -59 score = 5.98791 sequence = ATACATGTATATACAACTAT Gene: plu3193: Urocanate hydratase (EC 4.2.1.49)	Urocanate hydratase (EC 4.2.1.49)
hutH	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2 Gene: STM0791: Histidine ammonia-lyase (EC 4.3.1.3)	Citrobacter koseri ATCC BAA-895 Gene: CKO_02356: Histidine ammonia-lyase (EC 4.3.1.3)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_00796: Histidine ammonia-lyase (EC 4.3.1.3)	Enterobacter sp. 638 Gene: Ent638_1264: Histidine ammonia-lyase (EC 4.3.1.3)	* Erwinia amylovora ATCC 49946 Site: position = -83 score = 4.18381 sequence = AGACAAGAATATACAAATGT Site: position = -93 score = 5.04691 sequence = GTAGTTGTATAGACAAGAAT Gene: EAM_1254: Histidine ammonia-lyase (EC 4.3.1.3)	Yersinia pestis KIM Gene: y4037: Histidine ammonia-lyase (EC 4.3.1.3)	Serratia proteamaculans 568 Gene: Spro_0804: Histidine ammonia-lyase (EC 4.3.1.3)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu3192: Histidine ammonia-lyase (EC 4.3.1.3)	Histidine ammonia-lyase (EC 4.3.1.3)
hisT	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_00797: Histidine transport protein (permease)	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM Gene: y4036: Histidine transport protein (permease)	Serratia proteamaculans 568 Gene: Spro_0803: Histidine transport protein (permease)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu3191: Histidine transport protein (permease)	Histidine transport protein (permease)
hutX	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_0802: Histidine ABC transporter, histidine-binding protein (TC 3.A.1)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Histidine ABC transporter, histidine-binding protein (TC 3.A.1)
hutW	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_0801: Histidine ABC transporter, permease protein (TC 3.A.1)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Histidine ABC transporter, permease protein (TC 3.A.1)
hutV	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_0800: Histidine ABC transporter, ATP-binding protein (TC 3.A.1)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Histidine ABC transporter, ATP-binding protein (TC 3.A.1)
hutH2	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_0799: Histidine ammonia-lyase (EC 4.3.1.3)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Histidine ammonia-lyase (EC 4.3.1.3)

CRON 3.
hutI	Escherichia coli str. K-12 substr. MG1655	* Salmonella typhimurium LT2 Site: position = -43 score = 4.73636 sequence = ATAAATGTCTATACAACCCA Gene: STM0787: Imidazolonepropionase (EC 3.5.2.7)	* Citrobacter koseri ATCC BAA-895 Site: position = -29 score = 4.73636 sequence = ATAAATGTATAGACAACCCA Gene: CKO_02360: Imidazolonepropionase (EC 3.5.2.7)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -36 score = 4.73636 sequence = ATAAATGTCTATACAACCCA Gene: KPN_00792: Imidazolonepropionase (EC 3.5.2.7)	* Enterobacter sp. 638 Site: position = -4 score = 4.86622 sequence = ATAAATGTCTATACAACTCA Gene: Ent638_1260: Imidazolonepropionase (EC 3.5.2.7)	* Erwinia amylovora ATCC 49946 Site: position = -63 score = 4.59801 sequence = GAGGTTGTATATACATATAC Gene: EAM_1258: Imidazolonepropionase (EC 3.5.2.7)	* Yersinia pestis KIM Site: position = -113 score = 5.89372 sequence = ATGATTGTATATACAAGTTG Gene: y2340: Imidazolonepropionase (EC 3.5.2.7)	* Serratia proteamaculans 568 Site: position = -51 score = 5.87955 sequence = TTAATTGTATATACAACCAT Gene: Spro_2077: Imidazolonepropionase (EC 3.5.2.7)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA1022: Imidazolonepropionase (EC 3.5.2.7)	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -104 score = 5.89505 sequence = ATAAATGTATATACAATTAA Gene: plu3197: Imidazolonepropionase (EC 3.5.2.7)	Imidazolonepropionase (EC 3.5.2.7)
hutG2	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2 Gene: STM0788: Formiminoglutamase (EC 3.5.3.8)	Citrobacter koseri ATCC BAA-895 Gene: CKO_02359: Formiminoglutamase (EC 3.5.3.8)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_00793: Formiminoglutamase (EC 3.5.3.8)	Enterobacter sp. 638 Gene: Ent638_1261: Formiminoglutamase (EC 3.5.3.8)	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu3196: Formiminoglutamase (EC 3.5.3.8)	Formiminoglutamase (EC 3.5.3.8)
hutC	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2 Gene: STM0789: Histidine utilization repressor, GntR family	Citrobacter koseri ATCC BAA-895 Gene: CKO_02358: Histidine utilization repressor, GntR family	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_00794: Histidine utilization repressor, GntR family	Enterobacter sp. 638 Gene: Ent638_1262: Histidine utilization repressor, GntR family	* Erwinia amylovora ATCC 49946 Site: position = -202 score = 5.04691 sequence = ATTCTTGTCTATACAACTAC Site: position = -212 score = 4.18381 sequence = ACATTTGTATATTCTTGTCT Gene: EAM_1255: Histidine utilization repressor, GntR family	* Yersinia pestis KIM Site: position = -80 score = 5.78482 sequence = TTACTTGTATATACATATAC Gene: y2339: Histidine utilization repressor, GntR family	* Serratia proteamaculans 568 Site: position = -80 score = 5.32729 sequence = TTAGTTGTATATACATATAC Gene: Spro_2078: Histidine utilization repressor, GntR family	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu3195: Histidine utilization repressor, GntR family	Histidine utilization repressor, GntR family
hutG	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_1259: N-formylglutamate deformylase (EC 3.5.1.68)	Yersinia pestis KIM Gene: y2341: N-formylglutamate deformylase (EC 3.5.1.68)	Serratia proteamaculans 568 Gene: Spro_2076: N-formylglutamate deformylase (EC 3.5.1.68)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	N-formylglutamate deformylase (EC 3.5.1.68)

CRON 4.
COG1732 (OpuBC)	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	* Citrobacter koseri ATCC BAA-895 Site: position = -50 score = 5.98323 sequence = TGGTTTGTATATACAAGTAA Gene: CKO_02925: ABC proline/glycine/betaine transporter, periplasmic binding domain	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	ABC proline/glycine/betaine transporter, periplasmic binding domain
hutH2	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895 Gene: CKO_02926: Histidine ammonia-lyase (EC 4.3.1.3)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Histidine ammonia-lyase (EC 4.3.1.3)
COG1174 (OpuBB)	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	2 Citrobacter koseri ATCC BAA-895 Gene: CKO_02927: ABC proline/glycine/betaine transporter, permease component Gene: CKO_02928: ABC proline/glycine/betaine transporter, permease component	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	ABC proline/glycine/betaine transporter, permease component
COG1125 (OpuBA)	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895 Gene: CKO_02929: ABC proline/glycine/betaine transporter, ATPase component	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	ABC proline/glycine/betaine transporter, ATPase component
COG2423	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895 Gene: CKO_02930: Predicted ornithine cyclodeaminase, mu-crystallin homolog (EC 4.3.1.12)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Predicted ornithine cyclodeaminase, mu-crystallin homolog (EC 4.3.1.12)
COG3221 (PhnD)	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895 Gene: CKO_02931: ABC phosphate/phosphonate transporter, periplasmic binding component	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638 Gene: Ent638_2351: ABC phosphate/phosphonate transporter, periplasmic binding component	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1449: ABC phosphate/phosphonate transporter, periplasmic binding component	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	ABC phosphate/phosphonate transporter, periplasmic binding component

CRON 5.
hutF	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	* Erwinia amylovora ATCC 49946 Site: position = -38 score = 4.59801 sequence = GTATATGTATATACAACCTC Gene: EAM_1257: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Yersinia pestis KIM Site: position = -33 score = 5.78482 sequence = GTATATGTATATACAAGTAA Gene: y2338: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Serratia proteamaculans 568 Site: position = -117 score = 5.32729 sequence = GTATATGTATATACAACTAA Gene: Spro_2079: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Formiminoglutamic iminohydrolase (EC 3.5.3.13)
hutD	Escherichia coli str. K-12 substr. MG1655 Gene: b1742: Conserved hypothetical protein related to histidine degradation	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895 Gene: CKO_01767: Conserved hypothetical protein related to histidine degradation	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -147 score = 5.87176 sequence = GTTCTTGTATATACAAGCAT Gene: KPN_01285: Conserved hypothetical protein related to histidine degradation	Enterobacter sp. 638 Gene: Ent638_1702: Conserved hypothetical protein related to histidine degradation	Erwinia amylovora ATCC 49946 Gene: EAM_1256: Conserved hypothetical protein related to histidine degradation	Yersinia pestis KIM Gene: y2337: Conserved hypothetical protein related to histidine degradation	Serratia proteamaculans 568 Gene: Spro_2080: Conserved hypothetical protein related to histidine degradation	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Conserved hypothetical protein related to histidine degradation

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HutC - Enterobacteriales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --