Regulog HutC - Rhodobacterales

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:	repressor
Biological process:	Histidine utilization
Effector:	cis-Urocanic acid
Phylum:	Proteobacteria/alpha
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 29 sites [see more]

Member of regulog collections

By taxonomy - Rhodobacterales
By trascription factor - HutC
By TF family - GntR/Others
By effector - cis-Urocanic acid
By pathway - Histidine utilization

Statistics of regulated genes
Genome	Genes	Operons
Rhodobacter sphaeroides 2.4.1	5	2
Paracoccus denitrificans PD1222	12	2
Jannaschia sp. CCS1
Rhodobacterales bacterium HTCC2654
Oceanicola granulosus HTCC2516	5	2
Loktanella vestfoldensis SKA53
Oceanicola batsensis HTCC2597
Roseovarius nubinhibens ISM	5	3
Roseovarius sp. 217	7	4
Sulfitobacter sp. EE-36
Silicibacter TM1040	6	3
Silicibacter pomeroyi DSS-3	6	2
Roseobacter sp. MED193	5	2
Hyphomonas neptunium ATCC 15444	6	2
Oceanicaulis alexandrii HTCC2633	5	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
hutC	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516 Gene: OG2516_07757: Histidine utilization repressor, GntR family	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	* Roseovarius nubinhibens ISM Site: position = -67 score = 4.02333 sequence = TCTATGTGCGTACAAATT Gene: ISM_02745: Histidine utilization repressor, GntR family	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	* Silicibacter pomeroyi DSS-3 Site: position = -133 score = 4.59037 sequence = TTTATGTCCAGTCATAAA Site: position = -51 score = 4.02897 sequence = TCGATTTGTATACATAAA Site: position = -49 score = 4.33437 sequence = GATTTGTATACATAAATT Gene: SPO2190: Histidine utilization repressor, GntR family	Roseobacter sp. MED193 Gene: MED193_01690: Histidine utilization repressor, GntR family	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Histidine utilization repressor, GntR family

CRON 2.
hutI	* Rhodobacter sphaeroides 2.4.1 Site: position = -48 score = 4.84514 sequence = ATTATGTGCACACAAATT Gene: RSP_2934: Imidazolonepropionase (EC 3.5.2.7)	* Paracoccus denitrificans PD1222 Site: position = -73 score = 4.39773 sequence = AATAAGTTTAGACATAGA Site: position = -50 score = 4.39773 sequence = AATAAGTTTAGACATAGA Gene: Pden_0710: Imidazolonepropionase (EC 3.5.2.7)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	* Oceanicola granulosus HTCC2516 Site: position = -56 score = 4.48907 sequence = GTTATGTGCAGACATAAC Gene: OG2516_07747: Imidazolonepropionase (EC 3.5.2.7)	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	* Roseovarius nubinhibens ISM Site: position = -86 score = 5.69878 sequence = ATTATGTATGGACATAAT Gene: ISM_05640: Imidazolonepropionase (EC 3.5.2.7)	* Roseovarius sp. 217 Site: position = -86 score = 6.19847 sequence = AATATGTATAGACATAAT Gene: ROS217_11786: Imidazolonepropionase (EC 3.5.2.7)	Sulfitobacter sp. EE-36	* Silicibacter TM1040 Site: position = -67 score = 5.17492 sequence = CTTATGTATAGACATAAC Gene: TM1040_3004: Imidazolonepropionase (EC 3.5.2.7)	* Silicibacter pomeroyi DSS-3 Site: position = -48 score = 4.33437 sequence = AATTTATGTATACAAATC Site: position = -46 score = 4.02897 sequence = TTTATGTATACAAATCGA Gene: SPO2191: Imidazolonepropionase (EC 3.5.2.7)	* Roseobacter sp. MED193 Site: position = -71 score = 5.33833 sequence = TTTATGTCTAGACATATG Gene: MED193_01670: Imidazolonepropionase (EC 3.5.2.7)	2 Hyphomonas neptunium ATCC 15444* Gene: HNE_0404: Imidazolonepropionase (EC 3.5.2.7) Site: position = -55 score = 6.19847 sequence = ATTATGTCTATACATATT Gene: HNE_2395: Imidazolonepropionase (EC 3.5.2.7)	* Oceanicaulis alexandrii HTCC2633 Site: position = 15 score = 6.22479 sequence = AATATGTATAGACATATT Gene: OA2633_11044: Imidazolonepropionase (EC 3.5.2.7)	Imidazolonepropionase (EC 3.5.2.7)
hutH	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2935: Histidine ammonia-lyase (EC 4.3.1.3)	Paracoccus denitrificans PD1222 Gene: Pden_0711: Histidine ammonia-lyase (EC 4.3.1.3)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516 Gene: OG2516_07742: Histidine ammonia-lyase (EC 4.3.1.3)	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM Gene: ISM_05635: Histidine ammonia-lyase (EC 4.3.1.3)	Roseovarius sp. 217 Gene: ROS217_11781: Histidine ammonia-lyase (EC 4.3.1.3)	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_3005: Histidine ammonia-lyase (EC 4.3.1.3)	Silicibacter pomeroyi DSS-3 Gene: SPO2192: Histidine ammonia-lyase (EC 4.3.1.3)	Roseobacter sp. MED193 Gene: MED193_01675: Histidine ammonia-lyase (EC 4.3.1.3)	Hyphomonas neptunium ATCC 15444 Gene: HNE_2396: Histidine ammonia-lyase (EC 4.3.1.3)	Oceanicaulis alexandrii HTCC2633 Gene: OA2633_11049: Histidine ammonia-lyase (EC 4.3.1.3)	Histidine ammonia-lyase (EC 4.3.1.3)
hutG	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_0712: N-formylglutamate deformylase (EC 3.5.1.68)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516 Gene: OG2516_07737: N-formylglutamate deformylase (EC 3.5.1.68)	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	* Roseovarius sp. 217 Site: position = -52 score = 4.07831 sequence = AATATGCTTAATCATATT Gene: ROS217_15945: N-formylglutamate deformylase (EC 3.5.1.68)	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_3006: N-formylglutamate deformylase (EC 3.5.1.68)	Silicibacter pomeroyi DSS-3 Gene: SPOA0448: N-formylglutamate deformylase (EC 3.5.1.68)	Roseobacter sp. MED193 Gene: MED193_01680: N-formylglutamate deformylase (EC 3.5.1.68)	Hyphomonas neptunium ATCC 15444 Gene: HNE_2397: N-formylglutamate deformylase (EC 3.5.1.68)	Oceanicaulis alexandrii HTCC2633	N-formylglutamate deformylase (EC 3.5.1.68)
COG1804 (CaiB)	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_0713: CAIB/BAIF family protein	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	CAIB/BAIF family protein
COG1960 (CaiA)	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_0714: Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2)
hutU	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2936: Urocanate hydratase (EC 4.2.1.49)	Paracoccus denitrificans PD1222 Gene: Pden_0715: Urocanate hydratase (EC 4.2.1.49)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516 Gene: OG2516_07727: Urocanate hydratase (EC 4.2.1.49)	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM Gene: ISM_05630: Urocanate hydratase (EC 4.2.1.49)	Roseovarius sp. 217 Gene: ROS217_11776: Urocanate hydratase (EC 4.2.1.49)	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_3007: Urocanate hydratase (EC 4.2.1.49)	Silicibacter pomeroyi DSS-3 Gene: SPO2193: Urocanate hydratase (EC 4.2.1.49)	Roseobacter sp. MED193 Gene: MED193_01685: Urocanate hydratase (EC 4.2.1.49)	Hyphomonas neptunium ATCC 15444 Gene: HNE_2398: Urocanate hydratase (EC 4.2.1.49)	Oceanicaulis alexandrii HTCC2633 Gene: OA2633_11054: Urocanate hydratase (EC 4.2.1.49)	Urocanate hydratase (EC 4.2.1.49)
COG834 (HisJ)	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_0716: ABC amino acid transporter, periplasmic binding protein	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC amino acid transporter, periplasmic binding protein
COG765 (HisM)	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_0717: ABC amino acid transporter, permease component	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC amino acid transporter, permease component
COG4160 (ArtM)	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_0718: ABC amino acid transporter, permease component	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC amino acid transporter, permease component
COG1126 (GlnQ)	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_0719: ABC amino acid transporter, ATPase component	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC amino acid transporter, ATPase component
hutF	* Rhodobacter sphaeroides 2.4.1 Site: position = -41 score = 4.84514 sequence = AATTTGTGTGCACATAAT Gene: RSP_2933: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Paracoccus denitrificans PD1222 Site: position = -41 score = 4.39773 sequence = TCTATGTCTAAACTTATT Site: position = -64 score = 4.39773 sequence = TCTATGTCTAAACTTATT Gene: Pden_0709: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	* Oceanicola granulosus HTCC2516 Site: position = -41 score = 4.48907 sequence = GTTATGTCTGCACATAAC Gene: OG2516_07752: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	* Roseovarius nubinhibens ISM Site: position = -95 score = 5.1679 sequence = ATTATGTCCAGACATAAC Gene: ISM_02740: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Roseovarius sp. 217 Site: position = -42 score = 4.07831 sequence = AATATGATTAAGCATATT Gene: ROS217_15950: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Sulfitobacter sp. EE-36	* Silicibacter TM1040 Site: position = -26 score = 5.17492 sequence = GTTATGTCTATACATAAG Gene: TM1040_3003: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Silicibacter pomeroyi DSS-3 Gene: SPO2194: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Roseobacter sp. MED193 Site: position = -30 score = 5.33833 sequence = CATATGTCTAGACATAAA Gene: MED193_01665: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Hyphomonas neptunium ATCC 15444 Site: position = -40 score = 6.19847 sequence = AATATGTATAGACATAAT Gene: HNE_2394: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Oceanicaulis alexandrii HTCC2633	Formiminoglutamic iminohydrolase (EC 3.5.3.13)
hutG2	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633 Gene: OA2633_11059: Formiminoglutamase (EC 3.5.3.8)	Formiminoglutamase (EC 3.5.3.8)
hutC	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2932: Histidine utilization repressor, GntR family	Paracoccus denitrificans PD1222 Gene: Pden_0708: Histidine utilization repressor, GntR family	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	2 Roseovarius sp. 217* Gene: ROS217_15955: Histidine utilization repressor, GntR family Site: position = -187 score = 6.19847 sequence = ATTATGTCTATACATATT Gene: ROS217_11791: Histidine utilization repressor, GntR family	Sulfitobacter sp. EE-36	* Silicibacter TM1040 Site: position = -119 score = 5.25013 sequence = AATATGTAGGTACATATT Gene: TM1040_3642: Histidine utilization repressor, GntR family	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444 Gene: HNE_2393: Histidine utilization repressor, GntR family	* Oceanicaulis alexandrii HTCC2633 Site: position = -75 score = 6.22479 sequence = AATATGTCTATACATATT Gene: OA2633_11039: Histidine utilization repressor, GntR family	Histidine utilization repressor, GntR family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HutC - Rhodobacterales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --