Regulog HutC - Pseudomonadaceae

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:	repressor
Biological process:	Histidine utilization
Effector:	cis-Urocanic acid
Phylum:	Proteobacteria/gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 22 sites [see more]

Member of regulog collections

By taxonomy - Pseudomonadaceae
By trascription factor - HutC
By TF family - GntR/Others
By effector - cis-Urocanic acid
By pathway - Histidine utilization

Statistics of regulated genes
Genome	Genes	Operons
Pseudomonas aeruginosa PAO1	13	3
Pseudomonas entomophila L48	9	4
Pseudomonas putida KT2440	8	3
Pseudomonas syringae pv. tomato str. DC3000	12	3
Pseudomonas fluorescens Pf-5	13	3
Pseudomonas mendocina ymp	6	2
Pseudomonas stutzeri A1501
Azotobacter vinelandii AvOP

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
hutC	* Pseudomonas aeruginosa PAO1 Site: position = -77 score = 5.40882 sequence = TTATTTGTATATACATATAC Gene: PA5105: Histidine utilization repressor, GntR family	* Pseudomonas entomophila L48 Site: position = -88 score = 5.24889 sequence = CAACTTGTATATACATATAC Gene: PSEEN5099: Histidine utilization repressor, GntR family	* Pseudomonas putida KT2440 Site: position = -88 score = 5.45516 sequence = TAACTTGTATATACATATAC Gene: PP5035: Histidine utilization repressor, GntR family	* Pseudomonas syringae pv. tomato str. DC3000 Site: position = -142 score = 5.25468 sequence = TAATTTGTATATACATATAC Gene: PSPTO5172: Histidine utilization repressor, GntR family	* Pseudomonas fluorescens Pf-5 Site: position = -85 score = 5.40882 sequence = TTATTTGTATATACATATAC Gene: PFL_0399: Histidine utilization repressor, GntR family	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Histidine utilization repressor, GntR family
hutD	Pseudomonas aeruginosa PAO1 Gene: PA5104: Conserved hypothetical protein related to histidine degradation	Pseudomonas entomophila L48 Gene: PSEEN5098: Conserved hypothetical protein related to histidine degradation	Pseudomonas putida KT2440 Gene: PP5034: Conserved hypothetical protein related to histidine degradation	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO5173: Conserved hypothetical protein related to histidine degradation	Pseudomonas fluorescens Pf-5 Gene: PFL_0400: Conserved hypothetical protein related to histidine degradation	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Conserved hypothetical protein related to histidine degradation

CRON 2.
hutF	* Pseudomonas aeruginosa PAO1 Site: position = -43 score = 5.37873 sequence = GTATATGTATATACAAATAA Gene: PA5106: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Pseudomonas entomophila L48 Site: position = -41 score = 5.21446 sequence = GTATATGTATATACAAGTTG Gene: PSEEN5100: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Pseudomonas putida KT2440 Site: position = -40 score = 5.43985 sequence = GTATATGTATATACAAGTTA Gene: PP5036: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Pseudomonas syringae pv. tomato str. DC3000 Site: position = -41 score = 5.04775 sequence = GTATATGTATATACAAATTA Gene: PSPTO5171: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	* Pseudomonas fluorescens Pf-5 Site: position = -42 score = 5.37873 sequence = GTATATGTATATACAAATAA Gene: PFL_0398: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP Gene: Avin_26300: Formiminoglutamic iminohydrolase (EC 3.5.3.13)	Formiminoglutamic iminohydrolase (EC 3.5.3.13)

CRON 3.
hutD	Pseudomonas aeruginosa PAO1	Pseudomonas entomophila L48	Pseudomonas putida KT2440	Pseudomonas syringae pv. tomato str. DC3000	Pseudomonas fluorescens Pf-5	* Pseudomonas mendocina ymp Site: position = -212 score = 4.60639 sequence = TGTTTTGTATATACAATATG Site: position = -27 score = 4.23414 sequence = GACCATGTATATACATTTGG Gene: Pmen_4074: Conserved hypothetical protein related to histidine degradation	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Conserved hypothetical protein related to histidine degradation

CRON 4.
hutU	* Pseudomonas aeruginosa PAO1 Site: position = -121 score = 5.86309 sequence = ATACTTGTATGTACAAGCAT Gene: PA5100: Urocanate hydratase (EC 4.2.1.49)	* Pseudomonas entomophila L48 Site: position = -84 score = 6.4688 sequence = ATGCTTGTACATACAAGTAA Gene: PSEEN5097: Urocanate hydratase (EC 4.2.1.49)	* Pseudomonas putida KT2440 Site: position = -82 score = 6.4688 sequence = ATGCTTGTACATACAAGTAA Gene: PP5033: Urocanate hydratase (EC 4.2.1.49)	* Pseudomonas syringae pv. tomato str. DC3000 Site: position = -10 score = 4.60975 sequence = TTGATTGCATATGCTTGTAT Site: position = 0 score = 5.88365 sequence = ATGCTTGTATGTACAAGTAG Gene: PSPTO5270: Urocanate hydratase (EC 4.2.1.49)	* Pseudomonas fluorescens Pf-5 Site: position = -86 score = 6.10904 sequence = ATGCTTGTATGTACAAGTAA Site: position = -96 score = 4.60975 sequence = TTGATTGCATATGCTTGTAT Gene: PFL_0401: Urocanate hydratase (EC 4.2.1.49)	Pseudomonas mendocina ymp Gene: Pmen_4070: Urocanate hydratase (EC 4.2.1.49)	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP Gene: Avin_26180: Urocanate hydratase (EC 4.2.1.49)	Urocanate hydratase (EC 4.2.1.49)
COG1457 (CodB)	Pseudomonas aeruginosa PAO1 Gene: PA5099: Permease, cytosine/purines, uracil, thiamine, allantoin family protein	* Pseudomonas entomophila L48 Site: position = -101 score = 5.13845 sequence = AGACTTGTATATACATGCTC Gene: PSEEN3026: Permease, cytosine/purines, uracil, thiamine, allantoin family protein	Pseudomonas putida KT2440	Pseudomonas syringae pv. tomato str. DC3000	Pseudomonas fluorescens Pf-5 Gene: PFL_0402: Permease, cytosine/purines, uracil, thiamine, allantoin family protein	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Permease, cytosine/purines, uracil, thiamine, allantoin family protein
hutX	Pseudomonas aeruginosa PAO1 Gene: PA5096: Histidine ABC transporter, histidine-binding protein (TC 3.A.1)	Pseudomonas entomophila L48 Gene: PSEEN2601: Histidine ABC transporter, histidine-binding protein (TC 3.A.1)	Pseudomonas putida KT2440 Gene: PP3558: Histidine ABC transporter, histidine-binding protein (TC 3.A.1)	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO5271: Histidine ABC transporter, histidine-binding protein (TC 3.A.1)	Pseudomonas fluorescens Pf-5 Gene: PFL_0403: Histidine ABC transporter, histidine-binding protein (TC 3.A.1)	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Histidine ABC transporter, histidine-binding protein (TC 3.A.1)
hutW	Pseudomonas aeruginosa PAO1 Gene: PA5095: Histidine ABC transporter, permease protein (TC 3.A.1)	Pseudomonas entomophila L48 Gene: PSEEN2602: Histidine ABC transporter, permease protein (TC 3.A.1)	Pseudomonas putida KT2440 Gene: PP3559: Histidine ABC transporter, permease protein (TC 3.A.1)	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO5272: Histidine ABC transporter, permease protein (TC 3.A.1)	Pseudomonas fluorescens Pf-5 Gene: PFL_0404: Histidine ABC transporter, permease protein (TC 3.A.1)	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Histidine ABC transporter, permease protein (TC 3.A.1)
hutV	Pseudomonas aeruginosa PAO1 Gene: PA5094: Histidine ABC transporter, ATP-binding protein	Pseudomonas entomophila L48 Gene: PSEEN2603: Histidine ABC transporter, ATP-binding protein	Pseudomonas putida KT2440	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO5273: Histidine ABC transporter, ATP-binding protein	Pseudomonas fluorescens Pf-5 Gene: PFL_0405: Histidine ABC transporter, ATP-binding protein	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Histidine ABC transporter, ATP-binding protein
hutH2	Pseudomonas aeruginosa PAO1 Gene: PA5093: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas entomophila L48 Gene: PSEEN2604: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas putida KT2440	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO5274: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas fluorescens Pf-5 Gene: PFL_0406: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Histidine ammonia-lyase (EC 4.3.1.3)
hutH	Pseudomonas aeruginosa PAO1 Gene: PA5098: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas entomophila L48 Gene: PSEEN5096: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas putida KT2440 Gene: PP5032: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO5275: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas fluorescens Pf-5 Gene: PFL_0407: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas mendocina ymp Gene: Pmen_4069: Histidine ammonia-lyase (EC 4.3.1.3)	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP Gene: Avin_26290: Histidine ammonia-lyase (EC 4.3.1.3)	Histidine ammonia-lyase (EC 4.3.1.3)
hisT	Pseudomonas aeruginosa PAO1 Gene: PA5097: Histidine transport protein (permease)	Pseudomonas entomophila L48 Gene: PSEEN5095: Histidine transport protein (permease)	Pseudomonas putida KT2440 Gene: PP5031: Histidine transport protein (permease)	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO5276: Histidine transport protein (permease)	Pseudomonas fluorescens Pf-5 Gene: PFL_0408: Histidine transport protein (permease)	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Histidine transport protein (permease)
hutI	Pseudomonas aeruginosa PAO1 Gene: PA5092: Imidazolonepropionase (EC 3.5.2.7)	Pseudomonas entomophila L48 Gene: PSEEN5094: Imidazolonepropionase (EC 3.5.2.7)	Pseudomonas putida KT2440 Gene: PP5030: Imidazolonepropionase (EC 3.5.2.7)	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO5277: Imidazolonepropionase (EC 3.5.2.7)	Pseudomonas fluorescens Pf-5 Gene: PFL_0409: Imidazolonepropionase (EC 3.5.2.7)	* Pseudomonas mendocina ymp Site: position = -220 score = 3.80286 sequence = CCAAATGTATATACATGGTC Site: position = -35 score = 4.43945 sequence = CATATTGTATATACAAAACA Gene: Pmen_4073: Imidazolonepropionase (EC 3.5.2.7)	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP Gene: Avin_26160: Imidazolonepropionase (EC 3.5.2.7)	Imidazolonepropionase (EC 3.5.2.7)
hutG	Pseudomonas aeruginosa PAO1 Gene: PA5091: N-formylglutamate deformylase (EC 3.5.1.68)	Pseudomonas entomophila L48 Gene: PSEEN5093: N-formylglutamate deformylase (EC 3.5.1.68)	Pseudomonas putida KT2440 Gene: PP5029: N-formylglutamate deformylase (EC 3.5.1.68)	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO5278: N-formylglutamate deformylase (EC 3.5.1.68)	Pseudomonas fluorescens Pf-5 Gene: PFL_0410: N-formylglutamate deformylase (EC 3.5.1.68)	Pseudomonas mendocina ymp	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP Gene: Avin_26150: N-formylglutamate deformylase (EC 3.5.1.68)	N-formylglutamate deformylase (EC 3.5.1.68)
hutG2	Pseudomonas aeruginosa PAO1 Gene: PA3175: Formiminoglutamase (EC 3.5.3.8)	Pseudomonas entomophila L48	Pseudomonas putida KT2440	Pseudomonas syringae pv. tomato str. DC3000	Pseudomonas fluorescens Pf-5 Gene: PFL_0349: Formiminoglutamase (EC 3.5.3.8)	Pseudomonas mendocina ymp Gene: Pmen_4072: Formiminoglutamase (EC 3.5.3.8)	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Formiminoglutamase (EC 3.5.3.8)
COG3314	Pseudomonas aeruginosa PAO1	Pseudomonas entomophila L48	Pseudomonas putida KT2440	Pseudomonas syringae pv. tomato str. DC3000	Pseudomonas fluorescens Pf-5	Pseudomonas mendocina ymp Gene: Pmen_4071: Predicted histidine uptake transporter	Pseudomonas stutzeri A1501	Azotobacter vinelandii AvOP	Predicted histidine uptake transporter

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HutC - Pseudomonadaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --