The Glycine riboswitch, is a highly conserved RNA structure that was originally identified upstream of the glycine cleavage system genes gcvT-gcvPA-gcvPB in numerous bacterial species [15096624]. The Bacillus subtilis gcvT motif was then demonstrated to serve as a glycine-dependent riboswitch that activate gene expression upon binding of glycine [15472076]. Glycine riboswitch is a genetic ?on? switch that functions as an antiterminator. Glycine riboswitches usually consist of two binding domains with similar structures in tandem. The tandem riboswitch structure promotes a positive cooperative response to increasing concentrations of glycine [18042658]. more

The solved crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions in the glycine riboswitch [21439473].