Regulog Glycine - Clostridiaceae

Properties
Regulator type:	RNA regulatory element
Name:	Glycine
RFAM:	RF00504
Regulation mode:
Biological process:	Glycine metabolism
Effector:	Glycine
Phylum:	Firmicutes

Member of regulog collections

By taxonomy - Clostridiaceae
By RNA motif - Glycine
By effector - Glycine
By pathway - Glycine metabolism

Statistics of regulated genes
Genome	Genes	Operons
Clostridium kluyveri DSM 555	7	3
Clostridium sp. SS2/1	1	1
Clostridium cellulolyticum H10	2	1
Clostridium phytofermentans ISDg
Clostridium tetani E88	2	2
Clostridium acetobutylicum ATCC 824	1	1
Clostridium botulinum A str. ATCC 3502	8	1
Clostridium novyi NT	1	1
Clostridium perfringens ATCC 13124	1	1
Clostridium difficile 630	8	3
Clostridium beijerincki NCIMB 8052	2	2
Clostridium sp. OhILAs	12	2
Clostridium sp. L2-50
Clostridium scindens ATCC 35704	11	2
Clostridium nexile DSM 1787	1	1
Clostridium leptum DSM 753	1	1
Clostridium hiranonis DSM 13275	12	3
Clostridium butyricum 5521	1	1
Clostridium bolteae ATCC BAA-613	10	3
Clostridium bartlettii DSM 16795	2	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																					Function

CRON 1.
glyP	Clostridium kluyveri DSM 555	* Clostridium sp. SS2/1 Site: position = -216 score = 61.45 sequence = AGAAATGAACTCTGG... Gene: CLOSS21_00738: Sodium/glycine symporter GlyP	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	* Clostridium tetani E88 Site: position = -100 score = 72.39 sequence = TGGACGAAACTCTGG... Site: position = -186 score = 35.32 sequence = GATGAAGGTAATAGG... Gene: CTC01975: Sodium/glycine symporter GlyP	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	* Clostridium novyi NT Site: position = -261 score = 32.82 sequence = GATGAAGATAGCGGG... Site: position = -174 score = 66.31 sequence = TGGACGAGCCTCTGG... Gene: NT01CX_2425: Sodium/glycine symporter GlyP	* Clostridium perfringens ATCC 13124 Site: position = -168 score = 72.69 sequence = TGGACGAGCCTCTGG... Site: position = -242 score = 48.54 sequence = GATGAAGGTAATGGG... Gene: CPF_1672: Sodium/glycine symporter GlyP	* Clostridium difficile 630 Site: position = -277 score = 65.62 sequence = TACGGAACTCTGGAG... Site: position = -358 score = 34.92 sequence = AAGATTTTATAGAAG... Gene: CD2276: Sodium/glycine symporter GlyP	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	* Clostridium leptum DSM 753 Site: position = -122 score = 58.65 sequence = GGCGACTCTCTGGAG... Gene: CLOLEP_01924: Sodium/glycine symporter GlyP	Clostridium hiranonis DSM 13275	* Clostridium butyricum 5521 Site: position = -425 score = 46.55 sequence = GATGAAGATGGTGGG... Site: position = -327 score = 56.78 sequence = GCCTCTGGAGAGACT... Gene: CBY_0150: Sodium/glycine symporter GlyP	Clostridium bolteae ATCC BAA-613	* Clostridium bartlettii DSM 16795 Site: position = -264 score = 67.56 sequence = TAGGATACTCTGGAG... Site: position = -349 score = 38.76 sequence = GAAACTTTACAGAAG... Gene: CLOBAR_02646: Sodium/glycine symporter GlyP	Sodium/glycine symporter GlyP

CRON 2.
potE	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	2 Clostridium difficile 630 Gene: CD2465: Amino acid permease family protein Gene: CD1555: Amino acid permease family protein	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	* Clostridium scindens ATCC 35704 Site: position = -198 score = 30.19 sequence = GAAGTAGCGAGGAAG... Site: position = -91 score = 48.45 sequence = GATGGGACTCTGGAA... Gene: CLOSCI_00442: Amino acid permease family protein	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	3 Clostridium bartlettii DSM 16795* Gene: CLOBAR_00193: Amino acid permease family protein Gene: CLOBAR_02017: Amino acid permease family protein Site: position = -266 score = 47.09 sequence = TGAAATTTATGGGAG... Gene: CLOBAR_00195: Amino acid permease family protein	Amino acid permease family protein

CRON 3.
pfoR	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO0612: Perfringolysin O regulator protein PfoR	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704 Gene: CLOSCI_00036: Perfringolysin O regulator protein PfoR	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00466: Perfringolysin O regulator protein PfoR	Clostridium butyricum 5521	* Clostridium bolteae ATCC BAA-613 Site: position = -386 score = 49.23 sequence = CGGACGGGACTCTGG... Site: position = -463 score = 49.83 sequence = GTTGATGAATTCGGG... Gene: CLOBOL_00277: Perfringolysin O regulator protein PfoR	Clostridium bartlettii DSM 16795	Perfringolysin O regulator protein PfoR

CRON 4.
COG0697	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	2 Clostridium tetani E88* Site: position = -252 score = 57.3 sequence = TGAAGAGTATAAGAG... Gene: CTC01813: Permease of the drug/metabolite transporter (DMT) superfamily Gene: CTC01502: Permease of the drug/metabolite transporter (DMT) superfamily	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO1334: Permease of the drug/metabolite transporter (DMT) superfamily	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_0320: Permease of the drug/metabolite transporter (DMT) superfamily	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_01070: Permease of the drug/metabolite transporter (DMT) superfamily	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Permease of the drug/metabolite transporter (DMT) superfamily

CRON 5.
glyA2	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	* Clostridium bolteae ATCC BAA-613 Site: position = -349 score = 47.83 sequence = TGATGGATTCGGGAG... Site: position = -272 score = 34.04 sequence = GACGAAACTCTGGAA... Gene: CLOBOL_05294: Serine hydroxymethyltransferase (EC 2.1.2.1)	Clostridium bartlettii DSM 16795	Serine hydroxymethyltransferase (EC 2.1.2.1)
gcvT	* Clostridium kluyveri DSM 555 Site: position = -128 score = 34.1 sequence = TTGACGAAACTCTGG... Site: position = -213 score = 55.8 sequence = AATGATAAATTTAGG... Gene: CKL_1774: Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10)	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO0696: Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	* Clostridium sp. OhILAs Site: position = -468 score = 49.38 sequence = TGAAAATAACGAGAG... Site: position = -370 score = 57.87 sequence = GATGAATCTCTGGAG... Gene: Clos_0065: Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10)	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	2 Clostridium bolteae ATCC BAA-613* Gene: CLOBOL_05295: Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Site: position = -125 score = 39.84 sequence = CGGACGATACTCTGG... Site: position = -265 score = 39.65 sequence = GAAGATGGATTCGGG... Gene: CLOBOL_01537: Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10)	Clostridium bartlettii DSM 16795	Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10)
gcvH	Clostridium kluyveri DSM 555 Gene: CKL_1773: Glycine cleavage system H protein	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Glycine cleavage system H protein	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO0697: Glycine cleavage system H protein	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0066: Glycine cleavage system H protein	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	2 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_05296: Glycine cleavage system H protein Gene: CLOBOL_01536: Glycine cleavage system H protein	Clostridium bartlettii DSM 16795	Glycine cleavage system H protein
gcvP1	Clostridium kluyveri DSM 555 Gene: CKL_1772: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2)	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO0698: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	* Clostridium difficile 630 Site: position = -213 score = 41.99 sequence = GATGGGACTCTGGAG... Site: position = -313 score = 53.0 sequence = TGAGATTAGCGAGAG... Gene: CD1657: Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) / Glycine cleavage system H protein / Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0067: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2)	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	3 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_05297: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) Gene: CLOBOL_06282: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) Gene: CLOBOL_01535: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2)	Clostridium bartlettii DSM 16795	Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2)
gcvP2	Clostridium kluyveri DSM 555 Gene: CKL_1771: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2)	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO0699: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD1658: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0068: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2)	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	3 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_05298: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2) Gene: CLOBOL_06283: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2) Gene: CLOBOL_01534: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2)	Clostridium bartlettii DSM 16795	Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2)

CRON 6.
grdX	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	* Clostridium botulinum A str. ATCC 3502 Site: position = -159 score = 38.94 sequence = GACAAAACTCTGGAA... Site: position = -239 score = 20.82 sequence = TATCCTTATAGGATA... Gene: CBO1255: putative glycine reductase complex component	Clostridium novyi NT	Clostridium perfringens ATCC 13124	* Clostridium difficile 630 Site: position = -215 score = 47.13 sequence = GATGAAGAGTATGGG... Gene: CD2357: putative glycine reductase complex component	Clostridium beijerincki NCIMB 8052	* Clostridium sp. OhILAs Site: position = -194 score = 40.5 sequence = GACGGTACTCTGAAA... Site: position = -298 score = 52.62 sequence = AGAAGAGTGCGGGAG... Gene: Clos_0953: putative glycine reductase complex component	Clostridium sp. L2-50	* Clostridium scindens ATCC 35704 Site: position = -205 score = 58.51 sequence = ATGATGTTTCTCAAG... Gene: CLOSCI_00776: putative glycine reductase complex component	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	* Clostridium hiranonis DSM 13275 Site: position = -185 score = 33.99 sequence = TGAAGCGTATAGGAG... Gene: CLOHIR_00161: putative glycine reductase complex component	Clostridium butyricum 5521	2 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01011: putative glycine reductase complex component Gene: CLOBOL_01874: putative glycine reductase complex component	Clostridium bartlettii DSM 16795	putative glycine reductase complex component
grdE	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO1256: Glycine reductase component B (EC 1.21.4.2)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD2354: Glycine reductase component B (EC 1.21.4.2)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0956: Glycine reductase component B (EC 1.21.4.2)	Clostridium sp. L2-50	Clostridium scindens ATCC 35704 Gene: CLOSCI_00775: Glycine reductase component B (EC 1.21.4.2)	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00164: Glycine reductase component B (EC 1.21.4.2)	Clostridium butyricum 5521	2 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01012: Glycine reductase component B (EC 1.21.4.2) Gene: CLOBOL_01873: Glycine reductase component B (EC 1.21.4.2)	Clostridium bartlettii DSM 16795	Glycine reductase component B (EC 1.21.4.2)
grdB	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO1257: Glycine reductase complex component B gamma subunit	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD2351: Glycine reductase complex component B gamma subunit	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0958: Glycine reductase complex component B gamma subunit	Clostridium sp. L2-50	2 Clostridium scindens ATCC 35704 Gene: CLOSCI_00774: Glycine reductase complex component B gamma subunit Gene: CLOSCI_00773: Glycine reductase complex component B gamma subunit	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	2 Clostridium hiranonis DSM 13275 Gene: CLOHIR_00167: Glycine reductase complex component B gamma subunit Gene: CLOHIR_00168: Glycine reductase complex component B gamma subunit	Clostridium butyricum 5521	4 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01871: Glycine reductase complex component B gamma subunit Gene: CLOBOL_01872: Glycine reductase complex component B gamma subunit Gene: CLOBOL_01014: Glycine reductase complex component B gamma subunit Gene: CLOBOL_01013: Glycine reductase complex component B gamma subunit	Clostridium bartlettii DSM 16795	Glycine reductase complex component B gamma subunit
trxB	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO1259: Thioredoxin reductase (EC 1.8.1.9)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD2356: Thioredoxin reductase (EC 1.8.1.9)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0954: Thioredoxin reductase (EC 1.8.1.9)	Clostridium sp. L2-50	Clostridium scindens ATCC 35704 Gene: CLOSCI_00772: Thioredoxin reductase (EC 1.8.1.9)	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00162: Thioredoxin reductase (EC 1.8.1.9)	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01870: Thioredoxin reductase (EC 1.8.1.9)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02651: Thioredoxin reductase (EC 1.8.1.9)	Thioredoxin reductase (EC 1.8.1.9)
trxA	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO1260: Thioredoxin	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD2355: Thioredoxin	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0955: Thioredoxin	Clostridium sp. L2-50	Clostridium scindens ATCC 35704 Gene: CLOSCI_00771: Thioredoxin	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00163: Thioredoxin	Clostridium butyricum 5521	2 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01869: Thioredoxin Gene: CLOBOL_03144: Thioredoxin	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02650: Thioredoxin	Thioredoxin
grdA	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO1261: Glycine reductase complex protein A	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD2352: Glycine reductase complex protein A	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0957: Glycine reductase complex protein A	Clostridium sp. L2-50	2 Clostridium scindens ATCC 35704 Gene: CLOSCI_00770: Glycine reductase complex protein A Gene: CLOSCI_00769: Glycine reductase complex protein A	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	2 Clostridium hiranonis DSM 13275 Gene: CLOHIR_00165: Glycine reductase complex protein A Gene: CLOHIR_00166: Glycine reductase complex protein A	Clostridium butyricum 5521	4 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01867: Glycine reductase complex protein A Gene: CLOBOL_01868: Glycine reductase complex protein A Gene: CLOBOL_03143: Glycine reductase complex protein A Gene: CLOBOL_03142: Glycine reductase complex protein A	Clostridium bartlettii DSM 16795	Glycine reductase complex protein A
grdC	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO1263: Glycine reductase component C chain 1	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD2349: Glycine reductase component C chain 1	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0959: Glycine reductase component C chain 1	Clostridium sp. L2-50	Clostridium scindens ATCC 35704 Gene: CLOSCI_00768: Glycine reductase component C chain 1	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00169: Glycine reductase component C chain 1	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01866: Glycine reductase component C chain 1	Clostridium bartlettii DSM 16795	Glycine reductase component C chain 1
grdD	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO1264: Glycine reductase component C chain 2	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD2348: Glycine reductase component C chain 2	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs Gene: Clos_0960: Glycine reductase component C chain 2	Clostridium sp. L2-50	Clostridium scindens ATCC 35704 Gene: CLOSCI_00767: Glycine reductase component C chain 2	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00170: Glycine reductase component C chain 2	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01865: Glycine reductase component C chain 2	Clostridium bartlettii DSM 16795	Glycine reductase component C chain 2

CRON 7.
serC	Clostridium kluyveri DSM 555 Gene: CKL_3817: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Clostridium sp. SS2/1	* Clostridium cellulolyticum H10 Site: position = -323 score = 45.46 sequence = TGATTGTTGTGGGAG... Site: position = -244 score = 58.85 sequence = GACGGACCTCTGGAG... Gene: Ccel_1188: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Clostridium phytofermentans ISDg	Clostridium tetani E88 Gene: CTC00695: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Clostridium acetobutylicum ATCC 824 Gene: CAC0014: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Clostridium botulinum A str. ATCC 3502 Gene: CBO1126: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Clostridium novyi NT Gene: NT01CX_0729: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Clostridium perfringens ATCC 13124 Gene: CPF_0060: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Clostridium difficile 630 Gene: CD0994: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521 Gene: CBY_3790: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795 Gene: CLOBAR_01071: Serine--pyruvate aminotransferase (EC 2.6.1.-)	Serine--pyruvate aminotransferase (EC 2.6.1.-)
serA	Clostridium kluyveri DSM 555 Gene: CKL_3816: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10 Gene: Ccel_1189: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium phytofermentans ISDg	Clostridium tetani E88 Gene: CTC00694: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium acetobutylicum ATCC 824 Gene: CAC0015: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium botulinum A str. ATCC 3502 Gene: CBO1127: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium novyi NT Gene: NT01CX_0728: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium perfringens ATCC 13124 Gene: CPF_0061: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium difficile 630 Gene: CD0995: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4927: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521 Gene: CBY_3791: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795 Gene: CLOBAR_01070: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)	D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)

CRON 8.
gcvR	* Clostridium kluyveri DSM 555 Site: position = -229 score = 61.37 sequence = TGGACGAACCTCTGG... Gene: CKL_0776: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium sp. SS2/1 Gene: CLOSS21_02622: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium cellulolyticum H10 Gene: Ccel_1723: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium phytofermentans ISDg Gene: null: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824 Gene: CAC0478: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT Gene: NT01CX_0174: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium perfringens ATCC 13124 Gene: CPF_1747: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium difficile 630 Gene: CD2627: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2351: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium sp. OhILAs	Clostridium sp. L2-50 Gene: CLOL250_00210: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787 Gene: CLONEX_01555: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521 Gene: CBY_3159: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_02936: ACT domain containing transcriptional regulators, related to gcvR of E.coli	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02783: ACT domain containing transcriptional regulators, related to gcvR of E.coli	ACT domain containing transcriptional regulators, related to gcvR of E.coli
COG2848	Clostridium kluyveri DSM 555 Gene: CKL_0775: hypothetical protein	Clostridium sp. SS2/1 Gene: CLOSS21_02623: hypothetical protein	Clostridium cellulolyticum H10 Gene: Ccel_1722: hypothetical protein	Clostridium phytofermentans ISDg Gene: null: hypothetical protein	Clostridium tetani E88 Gene: CTC01034: hypothetical protein	Clostridium acetobutylicum ATCC 824 Gene: CAC0479: hypothetical protein	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT Gene: NT01CX_0175: hypothetical protein	Clostridium perfringens ATCC 13124 Gene: CPF_1748: hypothetical protein	Clostridium difficile 630 Gene: CD2626: hypothetical protein	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2352: hypothetical protein	Clostridium sp. OhILAs	Clostridium sp. L2-50 Gene: CLOL250_00209: hypothetical protein	Clostridium scindens ATCC 35704 Gene: CLOSCI_00641: hypothetical protein	Clostridium nexile DSM 1787 Gene: CLONEX_01556: hypothetical protein	Clostridium leptum DSM 753 Gene: CLOLEP_03314: hypothetical protein	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521 Gene: CBY_3160: hypothetical protein	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_02935: hypothetical protein	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02782: hypothetical protein	hypothetical protein

CRON 9.
alsT	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	* Clostridium nexile DSM 1787 Site: position = -187 score = 51.25 sequence = TTAAAAAAACTCTGG... Gene: CLONEX_04109: Na+/alanine symporter	Clostridium leptum DSM 753	* Clostridium hiranonis DSM 13275 Site: position = -204 score = 63.37 sequence = TTAGGAACTCTGGAG... Gene: CLOHIR_02272: Na+/alanine symporter	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_06470: Na+/alanine symporter	Clostridium bartlettii DSM 16795	Na+/alanine symporter

CRON 10.
COG2860	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10 Gene: Ccel_3364: membrane protein of unknown function UPF0126	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	* Clostridium beijerincki NCIMB 8052 Site: position = -155 score = 39.1 sequence = CTGACGAAACTCTGG... Site: position = -237 score = 48.39 sequence = TGTGACGAATTTGGG... Gene: Cbei_2529: membrane protein of unknown function UPF0126	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	membrane protein of unknown function UPF0126

CRON 11.
COG1748	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10 Gene: Ccel_1128: Carboxynorspermidine dehydrogenase family, COG1748	Clostridium phytofermentans ISDg Gene: null: Carboxynorspermidine dehydrogenase family, COG1748	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4409: Carboxynorspermidine dehydrogenase family, COG1748	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	2 Clostridium nexile DSM 1787 Gene: CLONEX_02167: Carboxynorspermidine dehydrogenase family, COG1748 Gene: CLONEX_02165: Carboxynorspermidine dehydrogenase family, COG1748	Clostridium leptum DSM 753 Gene: CLOLEP_01502: Carboxynorspermidine dehydrogenase family, COG1748	* Clostridium hiranonis DSM 13275 Site: position = -318 score = 31.41 sequence = TGAGGACTGCATTAG... Site: position = -217 score = 27.54 sequence = GACGATACTTTGGAG... Gene: CLOHIR_00302: Carboxynorspermidine dehydrogenase family, COG1748	Clostridium butyricum 5521 Gene: CBY_4120: Carboxynorspermidine dehydrogenase family, COG1748	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Carboxynorspermidine dehydrogenase family, COG1748

CRON 12.
aroP	* Clostridium kluyveri DSM 555 Site: position = -373 score = 51.76 sequence = ATCCTTGGAGAGACT... Site: position = -469 score = 38.66 sequence = GATGAAAATAGTGGG... Gene: CKL_3526: D-serine/D-alanine/glycine transporter	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	* Clostridium acetobutylicum ATCC 824 Site: position = -222 score = 53.73 sequence = ACCCTTGGAGAGACT... Site: position = -317 score = 40.71 sequence = GATGAAGTTAGCGGG... Gene: CAC1472: D-serine/D-alanine/glycine transporter	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	* Clostridium beijerincki NCIMB 8052 Site: position = -220 score = 52.62 sequence = ACCTTGGAGAGACTC... Site: position = -316 score = 47.22 sequence = GATGAAGATAGCGGG... Gene: Cbei_3972: D-serine/D-alanine/glycine transporter	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	D-serine/D-alanine/glycine transporter