Statistics of regulated genes

Genome	Genes	Operons
Haloarcula marismortui ATCC 43049	12	7
Halobacterium salinarum R1	32	7
Halobacterium sp. NRC-1	32	7
Haloferax volcanii DS2	13	3
Halomicrobium mukohataei DSM 12286	31	10
Haloquadratum walsbyi DSM 16790	23	8
Halorhabdus utahensis DSM 12940	13	3
Halorubrum lacusprofundi ATCC 49239	24	9
Haloterrigena turkmenica DSM 5511	13	7
Natrialba magadii ATCC 43099	8	5
Natronomonas pharaonis DSM 2160	27	9

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes												Function
CRON 1.
cbiT	* Haloarcula marismortui ATCC 43049 Site: position = -46 score = 5.7005 sequence = AATACAACCAAAATTGTTTT Gene: rrnAC2998: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	* Halobacterium salinarum R1 Site: position = -45 score = 5.63854 sequence = AATACAATCAAAATTGTTTT Gene: OE3207F: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	* Halobacterium sp. NRC-1 Site: position = -45 score = 5.63854 sequence = AATACAATCAAAATTGTTTT Gene: VNG1550G: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	* Haloferax volcanii DS2 Site: position = -123 score = 5.10688 sequence = AGAACAAGCGAGATTGTGTT Site: position = -150 score = 5.04933 sequence = AAACCAAGCACAGTTGTAAA Site: position = -47 score = 5.43003 sequence = ACAACAAGCACAATTGTTTT Gene: HVO_B0062: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	* Halomicrobium mukohataei DSM 12286 Site: position = -46 score = 5.69222 sequence = AAAACAACCAAAATTGTTTT Gene: Hmuk_1874: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	* Haloquadratum walsbyi DSM 16790 Site: position = -47 score = 5.3072 sequence = AGAGCAAGCGTAATTGTTTT Site: position = -113 score = 5.53781 sequence = AAAACAATTTTGCTTGTACT Gene: HQ1834A: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Halorhabdus utahensis DSM 12940	* Halorubrum lacusprofundi ATCC 49239 Site: position = -46 score = 5.04216 sequence = AGCTCAACCAAAATTGTTTT Gene: Hlac_3478: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	* Haloterrigena turkmenica DSM 5511 Site: position = -46 score = 4.94547 sequence = ATACCAAACAAAATTGTTTT Site: position = -66 score = 4.38438 sequence = TGAGCAAGCGAACTTGCCTT Gene: Htur_0996: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Natrialba magadii ATCC 43099	* Natronomonas pharaonis DSM 2160 Site: position = -46 score = 5.29007 sequence = AGCACAACCAAAATTGTTTT Gene: NP1124A: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
cbiL	Haloarcula marismortui ATCC 43049 Gene: rrnAC3000: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Halobacterium salinarum R1 Gene: OE3209F: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Halobacterium sp. NRC-1 Gene: VNG1551G: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Haloferax volcanii DS2 Gene: HVO_B0061: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1873: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Haloquadratum walsbyi DSM 16790 Gene: HQ1833A: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3477: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Haloterrigena turkmenica DSM 5511 Gene: Htur_0995: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1122A: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
cbiF	Haloarcula marismortui ATCC 43049 Gene: rrnAC3001: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Halobacterium salinarum R1 Gene: OE3212F: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Halobacterium sp. NRC-1 Gene: VNG1553G: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Haloferax volcanii DS2 Gene: HVO_B0060: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1872: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Haloquadratum walsbyi DSM 16790 Gene: HQ1832A: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3476: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Haloterrigena turkmenica DSM 5511 Gene: Htur_0994: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1120A: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
cbiG	Haloarcula marismortui ATCC 43049 Gene: rrnAC3003: Cobalamin biosynthesis protein CbiG	Halobacterium salinarum R1 Gene: OE3213F: Cobalamin biosynthesis protein CbiG	Halobacterium sp. NRC-1 Gene: VNG1554G: Cobalamin biosynthesis protein CbiG	Haloferax volcanii DS2 Gene: HVO_B0059: Cobalamin biosynthesis protein CbiG	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1871: Cobalamin biosynthesis protein CbiG	*2 Haloquadratum walsbyi DSM 16790 Gene: HQ1831A: Cobalamin biosynthesis protein CbiG Site: position = -107 score = 5.31393 sequence = AAGACAACCGTAATTGTTTT Gene: HQ3035A: Cobalamin biosynthesis protein CbiG	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3475: Cobalamin biosynthesis protein CbiG	Haloterrigena turkmenica DSM 5511 Gene: Htur_0993: Cobalamin biosynthesis protein CbiG	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1118A: Cobalamin biosynthesis protein CbiG	Cobalamin biosynthesis protein CbiG
cbiH	*2 Haloarcula marismortui ATCC 43049 Site: position = -20 score = 5.53781 sequence = AGTACAAGCACAATTGTTTT Gene: rrnAC3005: Cobalt-precorrin-3b C17-methyltransferase Gene: rrnAC3008: Cobalt-precorrin-3b C17-methyltransferase	2 Halobacterium salinarum R1 Gene: OE3214F: Cobalt-precorrin-3b C17-methyltransferase Gene: OE3216F: Cobalt-precorrin-3b C17-methyltransferase	2 Halobacterium sp. NRC-1 Gene: VNG1555G: Cobalt-precorrin-3b C17-methyltransferase Gene: VNG1557G: Cobalt-precorrin-3b C17-methyltransferase	2 Haloferax volcanii DS2 Gene: HVO_B0057: Cobalt-precorrin-3b C17-methyltransferase Gene: HVO_B0058: Cobalt-precorrin-3b C17-methyltransferase	2 Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1869: Cobalt-precorrin-3b C17-methyltransferase Gene: Hmuk_1870: Cobalt-precorrin-3b C17-methyltransferase	2 Haloquadratum walsbyi DSM 16790 Gene: HQ3034A: Cobalt-precorrin-3b C17-methyltransferase Gene: HQ3033A: Cobalt-precorrin-3b C17-methyltransferase	Halorhabdus utahensis DSM 12940	2 Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3473: Cobalt-precorrin-3b C17-methyltransferase Gene: Hlac_3474: Cobalt-precorrin-3b C17-methyltransferase	2 Haloterrigena turkmenica DSM 5511 Gene: Htur_0992: Cobalt-precorrin-3b C17-methyltransferase Gene: Htur_0991: Cobalt-precorrin-3b C17-methyltransferase	Natrialba magadii ATCC 43099	*2 Natronomonas pharaonis DSM 2160 Gene: NP1114A: Cobalt-precorrin-3b C17-methyltransferase Site: position = -101 score = 5.23884 sequence = ACAACAAGCACAATTGTTAT Gene: NP1116A: Cobalt-precorrin-3b C17-methyltransferase	Cobalt-precorrin-3b C17-methyltransferase
VNG1558H	Haloarcula marismortui ATCC 43049 Gene: rrnAC3009: conserved cobalamin operon protein	Halobacterium salinarum R1 Gene: OE3219F: conserved cobalamin operon protein	Halobacterium sp. NRC-1 Gene: VNG1558H: conserved cobalamin operon protein	Haloferax volcanii DS2 Gene: HVO_B0056: conserved cobalamin operon protein	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1868: conserved cobalamin operon protein	Haloquadratum walsbyi DSM 16790 Gene: HQ1830A: conserved cobalamin operon protein	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3472: conserved cobalamin operon protein	Haloterrigena turkmenica DSM 5511 Gene: Htur_0990: conserved cobalamin operon protein	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1112A: conserved cobalamin operon protein	conserved cobalamin operon protein
VNG1559H	Haloarcula marismortui ATCC 43049 Gene: rrnAC3010: conserved cobalamin operon protein	Halobacterium salinarum R1 Gene: OE3218F: conserved cobalamin operon protein	Halobacterium sp. NRC-1 Gene: VNG1559H: conserved cobalamin operon protein	Haloferax volcanii DS2 Gene: HVO_B0055: conserved cobalamin operon protein	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1867: conserved cobalamin operon protein	Haloquadratum walsbyi DSM 16790 Gene: HQ3032B: conserved cobalamin operon protein	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3471: conserved cobalamin operon protein	Haloterrigena turkmenica DSM 5511 Gene: Htur_0989: conserved cobalamin operon protein	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1110A: conserved cobalamin operon protein	conserved cobalamin operon protein
cbiK	Haloarcula marismortui ATCC 43049 Gene: rrnAC3011: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis	Halobacterium salinarum R1 Gene: OE3221F: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis	Halobacterium sp. NRC-1 Gene: VNG1561Cm: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis	Haloferax volcanii DS2 Gene: HVO_B0054: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1866: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis	Haloquadratum walsbyi DSM 16790 Gene: HQ3032A: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3470: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis	Haloterrigena turkmenica DSM 5511 Gene: Htur_0988: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1108A: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis	Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis
VNG1562H	Haloarcula marismortui ATCC 43049 Gene: rrnAC3012: conserved cobalamin operon protein	Halobacterium salinarum R1 Gene: OE3224F: conserved cobalamin operon protein	Halobacterium sp. NRC-1 Gene: VNG1562H: conserved cobalamin operon protein	Haloferax volcanii DS2 Gene: HVO_B0053: conserved cobalamin operon protein	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1865: conserved cobalamin operon protein	Haloquadratum walsbyi DSM 16790 Gene: HQ3031A: conserved cobalamin operon protein	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3469: conserved cobalamin operon protein	Haloterrigena turkmenica DSM 5511 Gene: Htur_0987: conserved cobalamin operon protein	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1106A: conserved cobalamin operon protein	conserved cobalamin operon protein
cobT	Haloarcula marismortui ATCC 43049 Gene: rrnAC1101: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	*2 Halobacterium salinarum R1 Gene: OE3227F: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Site: position = -120 score = 4.77874 sequence = AACCCAACTGTGGTTGCATA Gene: OE3242F: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	*2 Halobacterium sp. NRC-1 Gene: VNG1564H: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Site: position = -219 score = 4.77874 sequence = AACCCAACTGTGGTTGCATA Gene: VNG1572C: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Haloferax volcanii DS2 Gene: HVO_0590: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_2245: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Haloquadratum walsbyi DSM 16790 Gene: HQ1408A: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Halorhabdus utahensis DSM 12940 Gene: Huta_2498: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0230: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Haloterrigena turkmenica DSM 5511 Gene: Htur_2836: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Natrialba magadii ATCC 43099 Gene: Nmag_0990: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	* Natronomonas pharaonis DSM 2160 Site: position = -33 score = 4.10747 sequence = GGTTCAAGTACACTTGTCCA Site: position = -97 score = 4.37519 sequence = ACAGCAATTCGGCTTGTACA Site: position = -117 score = 5.40741 sequence = TAATCAAGTATAGTTGTATT Gene: NP0736A: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
cbiA	Haloarcula marismortui ATCC 43049 Gene: rrnAC1102: Cobyrinic acid A,C-diamide synthase	Halobacterium salinarum R1 Gene: OE3243F: Cobyrinic acid A,C-diamide synthase	Halobacterium sp. NRC-1 Gene: VNG1573G: Cobyrinic acid A,C-diamide synthase	Haloferax volcanii DS2 Gene: HVO_A0487: Cobyrinic acid A,C-diamide synthase	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1855: Cobyrinic acid A,C-diamide synthase	Haloquadratum walsbyi DSM 16790 Gene: HQ1829A: Cobyrinic acid A,C-diamide synthase	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0231: Cobyrinic acid A,C-diamide synthase	Haloterrigena turkmenica DSM 5511 Gene: Htur_0999: Cobyrinic acid A,C-diamide synthase	* Natrialba magadii ATCC 43099 Site: position = -115 score = 4.42529 sequence = AGTTCAAGTACAGTTGTGTG Gene: Nmag_3175: Cobyrinic acid A,C-diamide synthase	Natronomonas pharaonis DSM 2160 Gene: NP0738A: Cobyrinic acid A,C-diamide synthase	Cobyrinic acid A,C-diamide synthase
btuR	Haloarcula marismortui ATCC 43049 Gene: rrnAC1936: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Halobacterium salinarum R1 Gene: OE3245F: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Halobacterium sp. NRC-1 Gene: VNG1574G: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Haloferax volcanii DS2 Gene: HVO_A0488: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_0139: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Haloquadratum walsbyi DSM 16790 Gene: HQ1405A: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Halorhabdus utahensis DSM 12940 Gene: Huta_2501: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0237: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Haloterrigena turkmenica DSM 5511 Gene: Htur_5207: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Natrialba magadii ATCC 43099 Gene: Nmag_3073: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Natronomonas pharaonis DSM 2160 Gene: NP4974A: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
cbiP	Haloarcula marismortui ATCC 43049 Gene: rrnAC1938: Cobyric acid synthase	Halobacterium salinarum R1 Gene: OE3246F: Cobyric acid synthase	Halobacterium sp. NRC-1 Gene: VNG1576G: Cobyric acid synthase	Haloferax volcanii DS2 Gene: HVO_A0553: Cobyric acid synthase	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1854: Cobyric acid synthase	Haloquadratum walsbyi DSM 16790 Gene: HQ1404A: Cobyric acid synthase	Halorhabdus utahensis DSM 12940 Gene: Huta_2504: Cobyric acid synthase	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0238: Cobyric acid synthase	Haloterrigena turkmenica DSM 5511 Gene: Htur_5212: Cobyric acid synthase	Natrialba magadii ATCC 43099 Gene: Nmag_3068: Cobyric acid synthase	Natronomonas pharaonis DSM 2160 Gene: NP5126A: Cobyric acid synthase	Cobyric acid synthase
VNG1577C	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1 Gene: OE3249F: conserved cobalamine operon protein, HAD family hydrolase	Halobacterium sp. NRC-1 Gene: VNG1577C: conserved cobalamine operon protein, HAD family hydrolase	Haloferax volcanii DS2 Gene: HVO_0586: conserved cobalamine operon protein, HAD family hydrolase	* Halomicrobium mukohataei DSM 12286 Site: position = -32 score = 4.59199 sequence = AGTTCAAGTGTGCTTGCGGT Gene: Hmuk_0145: conserved cobalamine operon protein, HAD family hydrolase	Haloquadratum walsbyi DSM 16790 Gene: HQ1412A: conserved cobalamine operon protein, HAD family hydrolase	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0642: conserved cobalamine operon protein, HAD family hydrolase	Haloterrigena turkmenica DSM 5511 Gene: Htur_2832: conserved cobalamine operon protein, HAD family hydrolase	Natrialba magadii ATCC 43099 Gene: Nmag_0986: conserved cobalamine operon protein, HAD family hydrolase	Natronomonas pharaonis DSM 2160 Gene: NP5310A: conserved cobalamine operon protein, HAD family hydrolase	conserved cobalamine operon protein, HAD family hydrolase
cbiB	Haloarcula marismortui ATCC 43049 Gene: rrnAC1930: Adenosylcobinamide-phosphate synthase	Halobacterium salinarum R1 Gene: OE3253F: Adenosylcobinamide-phosphate synthase	Halobacterium sp. NRC-1 Gene: VNG1578H: Adenosylcobinamide-phosphate synthase	Haloferax volcanii DS2 Gene: HVO_0587: Adenosylcobinamide-phosphate synthase	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_0144: Adenosylcobinamide-phosphate synthase	Haloquadratum walsbyi DSM 16790 Gene: HQ1411A: Adenosylcobinamide-phosphate synthase	Halorhabdus utahensis DSM 12940 Gene: Huta_2495: Adenosylcobinamide-phosphate synthase	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0232: Adenosylcobinamide-phosphate synthase	Haloterrigena turkmenica DSM 5511 Gene: Htur_2833: Adenosylcobinamide-phosphate synthase	Natrialba magadii ATCC 43099 Gene: Nmag_0987: Adenosylcobinamide-phosphate synthase	Natronomonas pharaonis DSM 2160 Gene: NP5308A: Adenosylcobinamide-phosphate synthase	Adenosylcobinamide-phosphate synthase
cobS	Haloarcula marismortui ATCC 43049 Gene: rrnAC1931: Cobalamin synthase	Halobacterium salinarum R1 Gene: OE3255F: Cobalamin synthase	Halobacterium sp. NRC-1 Gene: VNG1580H: Cobalamin synthase	Haloferax volcanii DS2 Gene: HVO_0588: Cobalamin synthase	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_0143: Cobalamin synthase	Haloquadratum walsbyi DSM 16790 Gene: HQ1410A: Cobalamin synthase	Halorhabdus utahensis DSM 12940 Gene: Huta_2496: Cobalamin synthase	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0233: Cobalamin synthase	Haloterrigena turkmenica DSM 5511 Gene: Htur_2834: Cobalamin synthase	Natrialba magadii ATCC 43099 Gene: Nmag_0988: Cobalamin synthase	Natronomonas pharaonis DSM 2160 Gene: NP5306A: Cobalamin synthase	Cobalamin synthase
cobY	Haloarcula marismortui ATCC 43049 Gene: rrnAC1932: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Halobacterium salinarum R1 Gene: OE3257F: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Halobacterium sp. NRC-1 Gene: VNG1581C: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Haloferax volcanii DS2 Gene: HVO_0589: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_0142: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Haloquadratum walsbyi DSM 16790 Gene: HQ1409A: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Halorhabdus utahensis DSM 12940 Gene: Huta_2497: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0234: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Haloterrigena turkmenica DSM 5511 Gene: Htur_2835: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Natrialba magadii ATCC 43099 Gene: Nmag_0989: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Natronomonas pharaonis DSM 2160 Gene: NP5304A: Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
cobD	Haloarcula marismortui ATCC 43049 Gene: rrnAC1934: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Halobacterium salinarum R1 Gene: OE3259F: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Halobacterium sp. NRC-1 Gene: VNG1582G: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	2 Haloferax volcanii DS2 Gene: HVO_0593: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Gene: HVO_0591: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_0141: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Haloquadratum walsbyi DSM 16790 Gene: HQ1407A: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Halorhabdus utahensis DSM 12940 Gene: Huta_2499: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0235: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Haloterrigena turkmenica DSM 5511 Gene: Htur_2837: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Natrialba magadii ATCC 43099 Gene: Nmag_0991: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Natronomonas pharaonis DSM 2160 Gene: NP5302A: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
cbiZ	Haloarcula marismortui ATCC 43049 Gene: rrnAC1935: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Halobacterium salinarum R1 Gene: OE3261F: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Halobacterium sp. NRC-1 Gene: VNG1583C: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Haloferax volcanii DS2 Gene: HVO_0592: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_0140: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Haloquadratum walsbyi DSM 16790 Gene: HQ1406A: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Halorhabdus utahensis DSM 12940 Gene: Huta_2500: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0236: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Haloterrigena turkmenica DSM 5511 Gene: Htur_2838: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Natrialba magadii ATCC 43099 Gene: Nmag_0992: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Natronomonas pharaonis DSM 2160 Gene: NP5300A: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Adenosylcobinamide amidohydrolase (EC 3.5.1.90)
btuF	Haloarcula marismortui ATCC 43049 Gene: rrnAC3375: Vitamin B12 ABC transporter, B12-binding component BtuF	Halobacterium salinarum R1 Gene: OE2951R: Vitamin B12 ABC transporter, B12-binding component BtuF	Halobacterium sp. NRC-1 Gene: VNG1369G: Vitamin B12 ABC transporter, B12-binding component BtuF	Haloferax volcanii DS2 Gene: HVO_1110: Vitamin B12 ABC transporter, B12-binding component BtuF	* Halomicrobium mukohataei DSM 12286 Site: position = -60 score = 4.06726 sequence = GTTCCAACCACAGTTGGGAT Gene: Hmuk_2791: Vitamin B12 ABC transporter, B12-binding component BtuF	* Haloquadratum walsbyi DSM 16790 Site: position = -64 score = 4.64993 sequence = TATACAAACGCACTTGCAGT Gene: HQ1628A: Vitamin B12 ABC transporter, B12-binding component BtuF	* Halorhabdus utahensis DSM 12940 Site: position = -59 score = 4.60461 sequence = ACGACAAGTTGAGTTGCATT Gene: Huta_2494: Vitamin B12 ABC transporter, B12-binding component BtuF	* Halorubrum lacusprofundi ATCC 49239 Site: position = -58 score = 4.28481 sequence = TCTCCAACAAAACTTGTAGT Gene: Hlac_0880: Vitamin B12 ABC transporter, B12-binding component BtuF	* Haloterrigena turkmenica DSM 5511 Site: position = -58 score = 4.70745 sequence = GATCCAACCACGGTTGGTTT Gene: Htur_1830: Vitamin B12 ABC transporter, B12-binding component BtuF	*2 Natrialba magadii ATCC 43099 Site: position = -58 score = 4.89006 sequence = AATGCAACTCTGATTGCAAT Gene: Nmag_1837: Vitamin B12 ABC transporter, B12-binding component BtuF Site: position = -58 score = 4.9868 sequence = TGTGCAAGCATGATTGCTTT Gene: Nmag_3605: Vitamin B12 ABC transporter, B12-binding component BtuF	* Natronomonas pharaonis DSM 2160 Site: position = -57 score = 4.1954 sequence = GCTGCAACTGGGCTTGGTTT Gene: NP3814A: Vitamin B12 ABC transporter, B12-binding component BtuF	Vitamin B12 ABC transporter, B12-binding component BtuF
CRON 2.
chlID	* Haloarcula marismortui ATCC 43049 Site: position = -9 score = 5.86458 sequence = AATACAAGTATGGTTGTATT Gene: rrnAC3018: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	* Halobacterium salinarum R1 Site: position = -9 score = 5.45308 sequence = ATTACAACTATGGTTGATTT Gene: OE3229R: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	* Halobacterium sp. NRC-1 Site: position = -9 score = 5.45308 sequence = ATTACAACTATGGTTGATTT Gene: VNG1565G: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	Haloferax volcanii DS2 Gene: HVO_B0051: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	* Halomicrobium mukohataei DSM 12286 Site: position = -9 score = 5.52886 sequence = AATACAAGCATGATTGATTT Gene: Hmuk_1860: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	* Haloquadratum walsbyi DSM 16790 Site: position = -18 score = 4.15721 sequence = AGTGCAAAAAAGGTTGATAT Gene: HQ2295A: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	Halorhabdus utahensis DSM 12940	* Halorubrum lacusprofundi ATCC 49239 Site: position = -9 score = 5.40043 sequence = ACTACAACCATGGTTGATTT Gene: Hlac_3462: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	* Haloterrigena turkmenica DSM 5511 Site: position = -9 score = 4.60058 sequence = AGCGCAACTATGGTTGCAGA Gene: Htur_1006: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	Natrialba magadii ATCC 43099	* Natronomonas pharaonis DSM 2160 Site: position = -29 score = 4.01304 sequence = TGATAAACTCCGGTTGTTCT Site: position = -9 score = 4.64701 sequence = AATACAACCGTGATTGACAA Gene: NP1094A: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis
cbtB	* Haloarcula marismortui ATCC 43049 Site: position = -39 score = 5.12809 sequence = TTTACAATCTTACTTGTTCT Gene: rrnAC3016: Cobalt transporter subunit CbtB, putative	Halobacterium salinarum R1	Halobacterium sp. NRC-1	* Haloferax volcanii DS2 Site: position = -142 score = 5.43003 sequence = AAAACAATTGTGCTTGTTGT Site: position = -66 score = 5.10688 sequence = AACACAATCTCGCTTGTTCT Site: position = -39 score = 5.04933 sequence = TTTACAACTGTGCTTGGTTT Gene: HVO_B0063: Cobalt transporter subunit CbtB, putative	* Halomicrobium mukohataei DSM 12286 Site: position = -38 score = 4.73694 sequence = TTTACAATCTAGTTTGTACT Gene: Hmuk_1861: Cobalt transporter subunit CbtB, putative	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940	* Halorubrum lacusprofundi ATCC 49239 Site: position = -39 score = 4.91175 sequence = TTTACAAGCTCAGTTGTGTT Gene: Hlac_3463: Cobalt transporter subunit CbtB, putative	* Haloterrigena turkmenica DSM 5511 Site: position = -37 score = 5.33734 sequence = TTTACAACTATACTTGTTCT Gene: Htur_5160: Cobalt transporter subunit CbtB, putative	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1096A: Cobalt transporter subunit CbtB, putative	Cobalt transporter subunit CbtB, putative
cbtA	* Haloarcula marismortui ATCC 43049 Site: position = -245 score = 5.12809 sequence = TTTACAATCTTACTTGTTCT Gene: rrnAC3015: Predicted cobalt transporter CbtA	Halobacterium salinarum R1	Halobacterium sp. NRC-1	* Haloferax volcanii DS2 Site: position = -227 score = 5.04933 sequence = TTTACAACTGTGCTTGGTTT Gene: HVO_B0064: Predicted cobalt transporter CbtA	* Halomicrobium mukohataei DSM 12286 Site: position = -229 score = 4.73694 sequence = TTTACAATCTAGTTTGTACT Gene: Hmuk_1862: Predicted cobalt transporter CbtA	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940	* Halorubrum lacusprofundi ATCC 49239 Site: position = -229 score = 4.91175 sequence = TTTACAAGCTCAGTTGTGTT Gene: Hlac_3464: Predicted cobalt transporter CbtA	* Haloterrigena turkmenica DSM 5511 Site: position = -229 score = 5.33734 sequence = TTTACAACTATACTTGTTCT Gene: Htur_5161: Predicted cobalt transporter CbtA	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1098A: Predicted cobalt transporter CbtA	Predicted cobalt transporter CbtA
cbiX_2	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1	Halobacterium sp. NRC-1	Haloferax volcanii DS2 Gene: HVO_B0065: conserved cobalamin cluster protein CbiX 2 (probable ferredoxin-like iron-sulfur protein)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1863: conserved cobalamin cluster protein CbiX 2 (probable ferredoxin-like iron-sulfur protein)	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3465: conserved cobalamin cluster protein CbiX 2 (probable ferredoxin-like iron-sulfur protein)	Haloterrigena turkmenica DSM 5511 Gene: Htur_5162: conserved cobalamin cluster protein CbiX 2 (probable ferredoxin-like iron-sulfur protein)	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1100A: conserved cobalamin cluster protein CbiX 2 (probable ferredoxin-like iron-sulfur protein)	conserved cobalamin cluster protein CbiX 2 (probable ferredoxin-like iron-sulfur protein)
CRON 3.
cobN	* Haloarcula marismortui ATCC 43049 Site: position = -46 score = 5.86458 sequence = AATACAACCATACTTGTATT Gene: rrnAC3019: CobN component of cobalt chelatase involved in B12 biosynthesis	* Halobacterium salinarum R1 Site: position = -45 score = 5.45308 sequence = AAATCAACCATAGTTGTAAT Gene: OE3230F: CobN component of cobalt chelatase involved in B12 biosynthesis	* Halobacterium sp. NRC-1 Site: position = -240 score = 5.45308 sequence = AAATCAACCATAGTTGTAAT Gene: VNG1566G: CobN component of cobalt chelatase involved in B12 biosynthesis	Haloferax volcanii DS2 Gene: HVO_B0050: CobN component of cobalt chelatase involved in B12 biosynthesis	* Halomicrobium mukohataei DSM 12286 Site: position = -45 score = 5.52886 sequence = AAATCAATCATGCTTGTATT Gene: Hmuk_1859: CobN component of cobalt chelatase involved in B12 biosynthesis	* Haloquadratum walsbyi DSM 16790 Site: position = -45 score = 4.15721 sequence = ATATCAACCTTTTTTGCACT Gene: HQ2296A: CobN component of cobalt chelatase involved in B12 biosynthesis	Halorhabdus utahensis DSM 12940	* Halorubrum lacusprofundi ATCC 49239 Site: position = -45 score = 5.40043 sequence = AAATCAACCATGGTTGTAGT Gene: Hlac_3461: CobN component of cobalt chelatase involved in B12 biosynthesis	* Haloterrigena turkmenica DSM 5511 Site: position = -45 score = 4.60058 sequence = TCTGCAACCATAGTTGCGCT Gene: Htur_1005: CobN component of cobalt chelatase involved in B12 biosynthesis	Natrialba magadii ATCC 43099	* Natronomonas pharaonis DSM 2160 Site: position = -45 score = 4.64701 sequence = TTGTCAATCACGGTTGTATT Site: position = -25 score = 4.01304 sequence = AGAACAACCGGAGTTTATCA Gene: NP1092A: CobN component of cobalt chelatase involved in B12 biosynthesis	CobN component of cobalt chelatase involved in B12 biosynthesis
cbiC	Haloarcula marismortui ATCC 43049 Gene: rrnAC3020: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Halobacterium salinarum R1 Gene: OE3237F: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Halobacterium sp. NRC-1 Gene: VNG1567G: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Haloferax volcanii DS2 Gene: HVO_B0049: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1858: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Haloquadratum walsbyi DSM 16790 Gene: HQ2297A: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3460: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Haloterrigena turkmenica DSM 5511 Gene: Htur_1004: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1090A: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
cbiJ	Haloarcula marismortui ATCC 43049 Gene: rrnAC3021: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Halobacterium salinarum R1 Gene: OE3238F: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Halobacterium sp. NRC-1 Gene: VNG1568G: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Haloferax volcanii DS2 Gene: HVO_B0048: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1857: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	* Haloquadratum walsbyi DSM 16790 Site: position = -236 score = 4.25711 sequence = GTTGCAACCCCGGTTGGATT Gene: HQ2298A: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_3459: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Haloterrigena turkmenica DSM 5511 Gene: Htur_1003: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP1088A: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
CRON 4.
cbiD-II	* Haloarcula marismortui ATCC 43049 Site: position = -37 score = 5.40567 sequence = AAAACAACTCAGCTTGTTTT Gene: rrnAC3023: B12 biosynthesis-related protein, possible CbiD equivalent	* Halobacterium salinarum R1 Site: position = -44 score = 4.77874 sequence = TATGCAACCACAGTTGGGTT Gene: OE3239R: B12 biosynthesis-related protein, possible CbiD equivalent	* Halobacterium sp. NRC-1 Site: position = -44 score = 4.77874 sequence = TATGCAACCACAGTTGGGTT Gene: VNG1570H: B12 biosynthesis-related protein, possible CbiD equivalent	Haloferax volcanii DS2	* Halomicrobium mukohataei DSM 12286 Site: position = -36 score = 4.99638 sequence = AGTACAACTACACTTGTACC Site: position = -56 score = 4.749 sequence = ATAGCAAGCACAATTGGTGT Gene: Hmuk_1856: B12 biosynthesis-related protein, possible CbiD equivalent	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940	* Halorubrum lacusprofundi ATCC 49239 Site: position = -33 score = 4.41593 sequence = AGATAAAGTATAGTTGAACT Gene: Hlac_3458: B12 biosynthesis-related protein, possible CbiD equivalent	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	* Natronomonas pharaonis DSM 2160 Site: position = -27 score = 5.40741 sequence = AATACAACTATACTTGATTA Site: position = -47 score = 4.37519 sequence = TGTACAAGCCGAATTGCTGT Gene: NP0734A: B12 biosynthesis-related protein, possible CbiD equivalent	B12 biosynthesis-related protein, possible CbiD equivalent
CRON 5.
btuC	Haloarcula marismortui ATCC 43049 Gene: rrnAC3374: Vitamin B12 ABC transporter, permease component BtuC	Halobacterium salinarum R1 Gene: OE2952F: Vitamin B12 ABC transporter, permease component BtuC	Halobacterium sp. NRC-1 Gene: VNG1370G: Vitamin B12 ABC transporter, permease component BtuC	Haloferax volcanii DS2 Gene: HVO_1111: Vitamin B12 ABC transporter, permease component BtuC	* Halomicrobium mukohataei DSM 12286 Site: position = -21 score = 4.06726 sequence = ATCCCAACTGTGGTTGGAAC Gene: Hmuk_2792: Vitamin B12 ABC transporter, permease component BtuC	* Haloquadratum walsbyi DSM 16790 Site: position = -26 score = 4.64993 sequence = ACTGCAAGTGCGTTTGTATA Gene: HQ1627A: Vitamin B12 ABC transporter, permease component BtuC	* Halorhabdus utahensis DSM 12940 Site: position = -1 score = 4.60461 sequence = AATGCAACTCAACTTGTCGT Gene: Huta_2493: Vitamin B12 ABC transporter, permease component BtuC	* Halorubrum lacusprofundi ATCC 49239 Site: position = -24 score = 4.28481 sequence = ACTACAAGTTTTGTTGGAGA Gene: Hlac_0881: Vitamin B12 ABC transporter, permease component BtuC	* Haloterrigena turkmenica DSM 5511 Site: position = -21 score = 4.70745 sequence = AAACCAACCGTGGTTGGATC Gene: Htur_1831: Vitamin B12 ABC transporter, permease component BtuC	* Natrialba magadii ATCC 43099 Site: position = -22 score = 4.9868 sequence = AAAGCAATCATGCTTGCACA Gene: Nmag_3606: Vitamin B12 ABC transporter, permease component BtuC	* Natronomonas pharaonis DSM 2160 Site: position = -21 score = 4.1954 sequence = AAACCAAGCCCAGTTGCAGC Gene: NP3816A: Vitamin B12 ABC transporter, permease component BtuC	Vitamin B12 ABC transporter, permease component BtuC
btuD	Haloarcula marismortui ATCC 43049 Gene: rrnAC3372: Vitamin B12 ABC transporter, ATPase component BtuD	Halobacterium salinarum R1 Gene: OE2955F: Vitamin B12 ABC transporter, ATPase component BtuD	Halobacterium sp. NRC-1 Gene: VNG1371Gm: Vitamin B12 ABC transporter, ATPase component BtuD	Haloferax volcanii DS2 Gene: HVO_1112: Vitamin B12 ABC transporter, ATPase component BtuD	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_2793: Vitamin B12 ABC transporter, ATPase component BtuD	Haloquadratum walsbyi DSM 16790 Gene: HQ1626A: Vitamin B12 ABC transporter, ATPase component BtuD	Halorhabdus utahensis DSM 12940 Gene: Huta_2492: Vitamin B12 ABC transporter, ATPase component BtuD	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_0882: Vitamin B12 ABC transporter, ATPase component BtuD	Haloterrigena turkmenica DSM 5511 Gene: Htur_1832: Vitamin B12 ABC transporter, ATPase component BtuD	Natrialba magadii ATCC 43099 Gene: Nmag_3607: Vitamin B12 ABC transporter, ATPase component BtuD	Natronomonas pharaonis DSM 2160 Gene: NP3818A: Vitamin B12 ABC transporter, ATPase component BtuD	Vitamin B12 ABC transporter, ATPase component BtuD
CRON 6.
nrdR	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1	Halobacterium sp. NRC-1	Haloferax volcanii DS2	* Halomicrobium mukohataei DSM 12286 Site: position = -136 score = 4.90606 sequence = TAATCAAGTCTAATTGTACT Gene: Hmuk_3351: Ribonucleotide reductase transcriptional regulator NrdR	Haloquadratum walsbyi DSM 16790	* Halorhabdus utahensis DSM 12940 Site: position = -133 score = 5.10158 sequence = AGTACAACTGAACTTGGACT Gene: Huta_2339: Ribonucleotide reductase transcriptional regulator NrdR	* Halorubrum lacusprofundi ATCC 49239 Site: position = -136 score = 5.46877 sequence = AATACAAGTTTAGTTGTGTT Gene: Hlac_2946: Ribonucleotide reductase transcriptional regulator NrdR	Haloterrigena turkmenica DSM 5511	* Natrialba magadii ATCC 43099 Site: position = -136 score = 3.99336 sequence = AACACAAGTGAATTTTCACT Gene: Nmag_2658: Ribonucleotide reductase transcriptional regulator NrdR	* Natronomonas pharaonis DSM 2160 Site: position = -117 score = 4.259 sequence = ACACCAATTTTATTTGGAAA Site: position = -137 score = 4.95164 sequence = AAATCAAGTTCATTTGTACT Gene: NP6162A: Ribonucleotide reductase transcriptional regulator NrdR	Ribonucleotide reductase transcriptional regulator NrdR
NP6164A	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1	Halobacterium sp. NRC-1	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP6164A: hypothetical protein	hypothetical protein
nrdB2	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1	Halobacterium sp. NRC-1	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_3350: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_2945: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP6166A: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
nrdA2	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1	Halobacterium sp. NRC-1	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_3349: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_2944: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP6168A: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
nrdA1	Haloarcula marismortui ATCC 43049	* Halobacterium salinarum R1 Site: position = -153 score = 4.85074 sequence = TGATCAACTTAGATTGTACT Site: position = -133 score = 4.62208 sequence = TCTACAAGTTTAGTTGGTAA Gene: OE4346R: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Halobacterium sp. NRC-1 Site: position = -153 score = 4.85074 sequence = TGATCAACTTAGATTGTACT Site: position = -133 score = 4.62208 sequence = TCTACAAGTTTAGTTGGTAA Gene: VNG2384G: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940 Gene: Huta_2338: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099 Gene: Nmag_2657: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Natronomonas pharaonis DSM 2160	Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
nrdB1	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1 Gene: OE4345R: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Halobacterium sp. NRC-1 Gene: VNG2383G: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940 Gene: Huta_2337: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099 Gene: Nmag_2656: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Natronomonas pharaonis DSM 2160	Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
CRON 7.
cbiM	Haloarcula marismortui ATCC 43049	* Halobacterium salinarum R1 Site: position = -69 score = 5.23546 sequence = AATACAAATTCAGTTGTTCT Gene: OE3319R: Substrate-specific component CbiM of cobalt ECF transporter	* Halobacterium sp. NRC-1 Site: position = -69 score = 5.23546 sequence = AATACAAATTCAGTTGTTCT Gene: VNG1635G: Substrate-specific component CbiM of cobalt ECF transporter	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286	* Haloquadratum walsbyi DSM 16790 Site: position = -126 score = 5.3072 sequence = AAAACAATTACGCTTGCTCT Site: position = -60 score = 5.53781 sequence = AGTACAAGCAAAATTGTTTT Gene: HQ1835A: Substrate-specific component CbiM of cobalt ECF transporter	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160	Substrate-specific component CbiM of cobalt ECF transporter
cbiN	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1 Gene: OE3318R: Additional substrate-specific component CbiN of cobalt ECF transporter	Halobacterium sp. NRC-1 Gene: VNG1634G: Additional substrate-specific component CbiN of cobalt ECF transporter	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286	Haloquadratum walsbyi DSM 16790 Gene: HQ1836A: Additional substrate-specific component CbiN of cobalt ECF transporter	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160	Additional substrate-specific component CbiN of cobalt ECF transporter
cbiQ	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1 Gene: OE3317R: Transmembrane component CbiQ of energizing module of cobalt ECF transporter	Halobacterium sp. NRC-1 Gene: VNG1632G: Transmembrane component CbiQ of energizing module of cobalt ECF transporter	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286	Haloquadratum walsbyi DSM 16790 Gene: HQ1837A: Transmembrane component CbiQ of energizing module of cobalt ECF transporter	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160	Transmembrane component CbiQ of energizing module of cobalt ECF transporter
cbiO	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1 Gene: OE3315R: ATPase component CbiO of energizing module of cobalt ECF transporter	Halobacterium sp. NRC-1 Gene: VNG1631G: ATPase component CbiO of energizing module of cobalt ECF transporter	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286	Haloquadratum walsbyi DSM 16790 Gene: HQ1838A: ATPase component CbiO of energizing module of cobalt ECF transporter	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160	ATPase component CbiO of energizing module of cobalt ECF transporter

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