Regulog TPP - Clostridiaceae

Properties
Regulator type:	RNA regulatory element
Name:	TPP
RFAM:	RF00059
Regulation mode:
Biological process:	Thiamine biosynthesis
Effector:	Thiamine pyrophosphate
Phylum:	Firmicutes

Member of regulog collections

By taxonomy - Clostridiaceae
By RNA motif - TPP
By effector - Thiamine pyrophosphate
By pathway - Thiamine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Clostridium kluyveri DSM 555	11	5
Clostridium sp. SS2/1	2	2
Clostridium cellulolyticum H10	5	2
Clostridium phytofermentans ISDg	1	1
Clostridium tetani E88	10	3
Clostridium acetobutylicum ATCC 824	14	5
Clostridium botulinum A str. ATCC 3502	9	4
Clostridium novyi NT	5	3
Clostridium perfringens ATCC 13124	12	5
Clostridium difficile 630	12	3
Clostridium beijerincki NCIMB 8052	12	4
Clostridium sp. OhILAs	6	3
Clostridium sp. L2-50	1	1
Clostridium scindens ATCC 35704	7	3
Clostridium nexile DSM 1787	11	4
Clostridium leptum DSM 753	5	2
Clostridium hiranonis DSM 13275	9	2
Clostridium butyricum 5521	9	3
Clostridium bolteae ATCC BAA-613	8	3
Clostridium bartlettii DSM 16795	6	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																					Function

CRON 1.
thiW	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1 Gene: CLOSS21_01030: Substrate-specific component ThiW of predicted thiazole ECF transporter	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	* Clostridium tetani E88 Site: position = -203 score = 70.66 sequence = AATAAAGTTTCAGGG... Gene: CTC01754: Substrate-specific component ThiW of predicted thiazole ECF transporter	Clostridium acetobutylicum ATCC 824	* Clostridium botulinum A str. ATCC 3502 Site: position = -410 score = 54.67 sequence = AATTTTTCAAAAGGG... Gene: CBO2254: Substrate-specific component ThiW of predicted thiazole ECF transporter	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	* Clostridium beijerincki NCIMB 8052 Site: position = -301 score = 68.15 sequence = ATTGAATAACTAGGG... Gene: Cbei_4491: Substrate-specific component ThiW of predicted thiazole ECF transporter	Clostridium sp. OhILAs Gene: Clos_0767: Substrate-specific component ThiW of predicted thiazole ECF transporter	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	* Clostridium nexile DSM 1787 Site: position = -166 score = 66.31 sequence = CAAAAACATAGGGGA... Gene: CLONEX_00816: Substrate-specific component ThiW of predicted thiazole ECF transporter	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	* Clostridium butyricum 5521 Site: position = -200 score = 67.64 sequence = TAGATAACTAGGGGA... Gene: CBY_1699: Substrate-specific component ThiW of predicted thiazole ECF transporter	* Clostridium bolteae ATCC BAA-613 Site: position = -118 score = 60.62 sequence = CTAAATGACAACAGG... Gene: CLOBOL_04495: Substrate-specific component ThiW of predicted thiazole ECF transporter	Clostridium bartlettii DSM 16795	Substrate-specific component ThiW of predicted thiazole ECF transporter
thiD	* Clostridium kluyveri DSM 555 Site: position = -169 score = 80.45 sequence = AATAGTTTTGTGGGG... Gene: CKL_2919: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Clostridium sp. SS2/1 Site: position = -271 score = 56.02 sequence = TAAAAACAGGGAGCT... Gene: CLOSS21_01710: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Clostridium cellulolyticum H10 Site: position = -409 score = 59.42 sequence = GTACTAGTTGCGGGG... Site: position = -216 score = 58.84 sequence = TAAAAATTTGTGGGG... Gene: Ccel_1992: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Clostridium phytofermentans ISDg	Clostridium tetani E88 Gene: CTC01753: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Clostridium acetobutylicum ATCC 824 Gene: CAC3095: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	2 Clostridium botulinum A str. ATCC 3502* Gene: CBO0771: Phosphomethylpyrimidine kinase (EC 2.7.4.7) Site: position = -409 score = 71.26 sequence = CCTTATGTTGTGGGG... Gene: CBO0451: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Clostridium novyi NT Site: position = -275 score = 77.16 sequence = TTAAGTTGCAGGGGT... Gene: NT01CX_0246: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Clostridium perfringens ATCC 13124 Site: position = -184 score = 74.0 sequence = AAAAAATAGCTAGGG... Gene: CPF_1545: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Clostridium difficile 630 Site: position = -191 score = 66.85 sequence = AAAATAGCTAGGGGA... Gene: CD1599: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4490: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Clostridium sp. OhILAs Site: position = -426 score = 68.36 sequence = AATGGAACACTGGGA... Gene: Clos_2695: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Clostridium sp. L2-50 Gene: CLOL250_00263: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Clostridium scindens ATCC 35704 Gene: CLOSCI_03985: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	2 Clostridium nexile DSM 1787 Gene: CLONEX_00819: Phosphomethylpyrimidine kinase (EC 2.7.4.7) Gene: CLONEX_00626: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00636: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Clostridium butyricum 5521 Gene: CBY_1700: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Clostridium bolteae ATCC BAA-613 Site: position = -253 score = 51.79 sequence = TTGTAAATAAACGGG... Gene: CLOBOL_02869: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Clostridium bartlettii DSM 16795 Site: position = -297 score = 64.4 sequence = ATTAAAGTGCTAGGG... Gene: CLOBAR_02041: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Phosphomethylpyrimidine kinase (EC 2.7.4.7)
thiM	Clostridium kluyveri DSM 555 Gene: CKL_2918: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium sp. SS2/1 Gene: CLOSS21_01933: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium cellulolyticum H10 Gene: Ccel_1990: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium phytofermentans ISDg	Clostridium tetani E88 Gene: CTC01752: Hydroxyethylthiazole kinase (EC 2.7.1.50)	* Clostridium acetobutylicum ATCC 824 Site: position = -196 score = 53.4 sequence = TAATATTTTTCAGGG... Gene: CAC3096: Hydroxyethylthiazole kinase (EC 2.7.1.50)	2 Clostridium botulinum A str. ATCC 3502 Gene: CBO2253: Hydroxyethylthiazole kinase (EC 2.7.1.50) Gene: CBO0450: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium novyi NT Gene: NT01CX_0247: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium perfringens ATCC 13124 Gene: CPF_1544: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium difficile 630 Gene: CD1600: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4488: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium sp. OhILAs Gene: Clos_2694: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium sp. L2-50 Gene: CLOL250_00266: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium scindens ATCC 35704 Gene: CLOSCI_03982: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium nexile DSM 1787 Gene: CLONEX_00817: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium leptum DSM 753	* Clostridium hiranonis DSM 13275 Site: position = -175 score = 55.95 sequence = AAAATCAAGCAGGGG... Gene: CLOHIR_00634: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium butyricum 5521 Gene: CBY_1702: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_04494: Hydroxyethylthiazole kinase (EC 2.7.1.50)	2 Clostridium bartlettii DSM 16795 Gene: CLOBAR_02040: Hydroxyethylthiazole kinase (EC 2.7.1.50) Gene: CLOBAR_00057: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Hydroxyethylthiazole kinase (EC 2.7.1.50)
thiE	2 Clostridium kluyveri DSM 555 Gene: CKL_1635: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CKL_2917: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium sp. SS2/1 Gene: CLOSS21_01932: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CLOSS21_00147: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Clostridium cellulolyticum H10 Gene: Ccel_1989: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Clostridium phytofermentans ISDg	2 Clostridium tetani E88 Gene: CTC01746: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CTC01751: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium acetobutylicum ATCC 824 Gene: CAC0495: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CAC2920: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Clostridium botulinum A str. ATCC 3502 Gene: CBO0449: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium novyi NT Gene: NT01CX_0248: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: NT01CX_1504: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium perfringens ATCC 13124 Gene: CPF_1852: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CPF_1543: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium difficile 630 Gene: CD1706: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CD1601: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium beijerincki NCIMB 8052 Gene: Cbei_0648: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: Cbei_4487: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Clostridium sp. OhILAs Gene: Clos_2693: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium sp. L2-50 Gene: CLOL250_00265: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CLOL250_02990: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium scindens ATCC 35704 Gene: CLOSCI_03983: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CLOSCI_02954: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium nexile DSM 1787 Gene: CLONEX_00818: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CLONEX_00627: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Clostridium leptum DSM 753	2 Clostridium hiranonis DSM 13275 Gene: CLOHIR_00430: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CLOHIR_00635: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	2 Clostridium butyricum 5521 Gene: CBY_3722: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CBY_1703: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_04493: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	3 Clostridium bartlettii DSM 16795 Gene: CLOBAR_02037: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CLOBAR_00058: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CLOBAR_01602: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
thiF	Clostridium kluyveri DSM 555 Gene: CKL_1638: Sulfur carrier protein adenylyltransferase ThiF	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88 Gene: CTC01750: Sulfur carrier protein adenylyltransferase ThiF	Clostridium acetobutylicum ATCC 824 Gene: CAC2923: Sulfur carrier protein adenylyltransferase ThiF	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT Gene: NT01CX_1503: Sulfur carrier protein adenylyltransferase ThiF	Clostridium perfringens ATCC 13124 Gene: CPF_1855: Sulfur carrier protein adenylyltransferase ThiF	Clostridium difficile 630 Gene: CD1703: Sulfur carrier protein adenylyltransferase ThiF	* Clostridium beijerincki NCIMB 8052 Site: position = -294 score = 76.65 sequence = TAAAAGGCTAGGGGT... Gene: Cbei_0647: Sulfur carrier protein adenylyltransferase ThiF	Clostridium sp. OhILAs	Clostridium sp. L2-50 Gene: CLOL250_02987: Sulfur carrier protein adenylyltransferase ThiF	Clostridium scindens ATCC 35704 Gene: CLOSCI_02951: Sulfur carrier protein adenylyltransferase ThiF	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00427: Sulfur carrier protein adenylyltransferase ThiF	Clostridium butyricum 5521 Gene: CBY_3726: Sulfur carrier protein adenylyltransferase ThiF	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795 Gene: CLOBAR_01599: Sulfur carrier protein adenylyltransferase ThiF	Sulfur carrier protein adenylyltransferase ThiF
thiG	Clostridium kluyveri DSM 555 Gene: CKL_1637: Thiazole biosynthesis protein ThiG	2 Clostridium sp. SS2/1 Gene: CLOSS21_02633: Thiazole biosynthesis protein ThiG Gene: CLOSS21_00758: Thiazole biosynthesis protein ThiG	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88 Gene: CTC01749: Thiazole biosynthesis protein ThiG	Clostridium acetobutylicum ATCC 824 Gene: CAC2922: Thiazole biosynthesis protein ThiG	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT Gene: NT01CX_1437: Thiazole biosynthesis protein ThiG	Clostridium perfringens ATCC 13124 Gene: CPF_1854: Thiazole biosynthesis protein ThiG	Clostridium difficile 630 Gene: CD1704: Thiazole biosynthesis protein ThiG	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1519: Thiazole biosynthesis protein ThiG	Clostridium sp. OhILAs	Clostridium sp. L2-50 Gene: CLOL250_02988: Thiazole biosynthesis protein ThiG	Clostridium scindens ATCC 35704 Gene: CLOSCI_02952: Thiazole biosynthesis protein ThiG	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00428: Thiazole biosynthesis protein ThiG	Clostridium butyricum 5521 Gene: CBY_3724: Thiazole biosynthesis protein ThiG	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795 Gene: CLOBAR_01600: Thiazole biosynthesis protein ThiG	Thiazole biosynthesis protein ThiG
thiH	Clostridium kluyveri DSM 555 Gene: CKL_1636: Thiazole biosynthesis protein ThiH	Clostridium sp. SS2/1 Gene: CLOSS21_00757: Thiazole biosynthesis protein ThiH	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88 Gene: CTC01748: Thiazole biosynthesis protein ThiH	Clostridium acetobutylicum ATCC 824 Gene: CAC2921: Thiazole biosynthesis protein ThiH	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT Gene: NT01CX_1438: Thiazole biosynthesis protein ThiH	Clostridium perfringens ATCC 13124 Gene: CPF_1853: Thiazole biosynthesis protein ThiH	Clostridium difficile 630 Gene: CD1705: Thiazole biosynthesis protein ThiH	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1520: Thiazole biosynthesis protein ThiH	Clostridium sp. OhILAs	Clostridium sp. L2-50 Gene: CLOL250_02989: Thiazole biosynthesis protein ThiH	Clostridium scindens ATCC 35704 Gene: CLOSCI_02953: Thiazole biosynthesis protein ThiH	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00429: Thiazole biosynthesis protein ThiH	Clostridium butyricum 5521 Gene: CBY_3723: Thiazole biosynthesis protein ThiH	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795 Gene: CLOBAR_01601: Thiazole biosynthesis protein ThiH	Thiazole biosynthesis protein ThiH
thiC	* Clostridium kluyveri DSM 555 Site: position = -241 score = 55.89 sequence = ATATTATGTGCAGGG... Gene: CKL_1776: Thiamine biosynthesis protein ThiC	* Clostridium sp. SS2/1 Site: position = -246 score = 59.87 sequence = GTAACTGAAATGGGA... Gene: CLOSS21_02770: Thiamine biosynthesis protein ThiC	Clostridium cellulolyticum H10 Gene: Ccel_1991: Thiamine biosynthesis protein ThiC	Clostridium phytofermentans ISDg	* Clostridium tetani E88 Site: position = -204 score = 73.8 sequence = AATAAATTTAGGGGA... Gene: CTC00828: Thiamine biosynthesis protein ThiC	* Clostridium acetobutylicum ATCC 824 Site: position = -242 score = 55.94 sequence = ATATTTTAGCTAGGG... Gene: CAC3014: Thiamine biosynthesis protein ThiC	Clostridium botulinum A str. ATCC 3502 Gene: CBO2911: Thiamine biosynthesis protein ThiC	* Clostridium novyi NT Site: position = -202 score = 62.89 sequence = ATCGTTTGCGGGGGA... Gene: NT01CX_0092: Thiamine biosynthesis protein ThiC	* Clostridium perfringens ATCC 13124 Site: position = -253 score = 78.81 sequence = GTAAGTGCTAGGGGT... Gene: CPF_0670: Thiamine biosynthesis protein ThiC	* Clostridium difficile 630 Site: position = -252 score = 70.78 sequence = ATTAGAGCTAGGGGC... Gene: CD1702: Thiamine biosynthesis protein ThiC	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4489: Thiamine biosynthesis protein ThiC	* Clostridium sp. OhILAs Site: position = -258 score = 71.75 sequence = TAAGTTAGAAGGGGA... Gene: Clos_0766: Thiamine biosynthesis protein ThiC	* Clostridium sp. L2-50 Site: position = -199 score = 58.48 sequence = TTATATATTCAGGGA... Gene: CLOL250_01568: Thiamine biosynthesis protein ThiC	* Clostridium scindens ATCC 35704 Site: position = -234 score = 57.85 sequence = AGGAACAACAGGGGT... Gene: CLOSCI_03456: Thiamine biosynthesis protein ThiC	Clostridium nexile DSM 1787 Gene: CLONEX_00820: Thiamine biosynthesis protein ThiC	Clostridium leptum DSM 753	* Clostridium hiranonis DSM 13275 Site: position = -275 score = 57.48 sequence = ATCGATGCTAGGGGC... Gene: CLOHIR_00425: Thiamine biosynthesis protein ThiC	Clostridium butyricum 5521 Gene: CBY_1701: Thiamine biosynthesis protein ThiC	Clostridium bolteae ATCC BAA-613	* Clostridium bartlettii DSM 16795 Site: position = -291 score = 48.61 sequence = GAAATATATACAGGG... Gene: CLOBAR_02453: Thiamine biosynthesis protein ThiC	Thiamine biosynthesis protein ThiC
thiS	* Clostridium kluyveri DSM 555 Site: position = -318 score = 66.59 sequence = TAATATCTTTAAGGG... Gene: CKL_1639: thiamine biosynthesis protein ThiS	Clostridium sp. SS2/1 Gene: CLOSS21_00759: thiamine biosynthesis protein ThiS	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	* Clostridium acetobutylicum ATCC 824 Site: position = -212 score = 73.82 sequence = AATATAGTTAACGGG... Gene: CAC2924: thiamine biosynthesis protein ThiS	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT Gene: NT01CX_1502: thiamine biosynthesis protein ThiS	* Clostridium perfringens ATCC 13124 Site: position = -232 score = 70.24 sequence = AAGATATTGCTAGGG... Gene: CPF_1856: thiamine biosynthesis protein ThiS	Clostridium difficile 630 Gene: CD1702A: thiamine biosynthesis protein ThiS	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1518: thiamine biosynthesis protein ThiS	Clostridium sp. OhILAs	Clostridium sp. L2-50 Gene: CLOL250_02986: thiamine biosynthesis protein ThiS	* Clostridium scindens ATCC 35704 Site: position = -319 score = 58.83 sequence = AAATTGAACAGGGGA... Gene: CLOSCI_02950: thiamine biosynthesis protein ThiS	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00426: thiamine biosynthesis protein ThiS	Clostridium butyricum 5521 Gene: CBY_3727: thiamine biosynthesis protein ThiS	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795 Gene: CLOBAR_01598: thiamine biosynthesis protein ThiS	thiamine biosynthesis protein ThiS
COG0084	Clostridium kluyveri DSM 555 Gene: CKL_2678: TatD-related deoxyribonuclease, COG0084	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	* Clostridium acetobutylicum ATCC 824 Site: position = -156 score = 72.29 sequence = TTTAGTGCTAGGGGT... Gene: CAC1397: TatD-related deoxyribonuclease, COG0084	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	TatD-related deoxyribonuclease, COG0084
COG0011	Clostridium kluyveri DSM 555 Gene: CKL_0450: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824 Gene: CAC1398: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Clostridium botulinum A str. ATCC 3502 Gene: CBO2910: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_1754: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	* Clostridium nexile DSM 1787 Site: position = -226 score = 67.07 sequence = GAAAAGAAATCAGGG... Gene: CLONEX_00344: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	* Clostridium leptum DSM 753 Site: position = -199 score = 59.95 sequence = ATAGAATACCGGGGT... Gene: CLOLEP_00999: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00449: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Clostridium butyricum 5521	* Clostridium bolteae ATCC BAA-613 Site: position = -189 score = 61.04 sequence = ACAATGAAAAGGGGT... Gene: CLOBOL_05155: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00056: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family
thiX	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Thiamin ABC transporter, transmembrane component	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824 Gene: CAC1399: Thiamin ABC transporter, transmembrane component	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	* Clostridium difficile 630 Site: position = -496 score = 52.74 sequence = ATAATATATTTCGGG... Gene: CD1980: Thiamin ABC transporter, transmembrane component	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2090: Thiamin ABC transporter, transmembrane component	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787 Gene: CLONEX_00343: Thiamin ABC transporter, transmembrane component	Clostridium leptum DSM 753 Gene: CLOLEP_01000: Thiamin ABC transporter, transmembrane component	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00450: Thiamin ABC transporter, transmembrane component	Clostridium butyricum 5521 Gene: CBY_0915: Thiamin ABC transporter, transmembrane component	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_05156: Thiamin ABC transporter, transmembrane component	Clostridium bartlettii DSM 16795	Thiamin ABC transporter, transmembrane component
thiY	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Thiamin ABC transporter, substrate-binding component	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824 Gene: CAC1400: Thiamin ABC transporter, substrate-binding component	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD1979: Thiamin ABC transporter, substrate-binding component	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2091: Thiamin ABC transporter, substrate-binding component	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787 Gene: CLONEX_00340: Thiamin ABC transporter, substrate-binding component	Clostridium leptum DSM 753 Gene: CLOLEP_01001: Thiamin ABC transporter, substrate-binding component	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00451: Thiamin ABC transporter, substrate-binding component	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_05157: Thiamin ABC transporter, substrate-binding component	Clostridium bartlettii DSM 16795	Thiamin ABC transporter, substrate-binding component
thiZ	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Thiamin ABC transporter, ATPase component	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824 Gene: CAC1401: Thiamin ABC transporter, ATPase component	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD1978: Thiamin ABC transporter, ATPase component	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2089: Thiamin ABC transporter, ATPase component	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787 Gene: CLONEX_00339: Thiamin ABC transporter, ATPase component	Clostridium leptum DSM 753 Gene: CLOLEP_01002: Thiamin ABC transporter, ATPase component	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00452: Thiamin ABC transporter, ATPase component	Clostridium butyricum 5521 Gene: CBY_0916: Thiamin ABC transporter, ATPase component	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_05158: Thiamin ABC transporter, ATPase component	Clostridium bartlettii DSM 16795	Thiamin ABC transporter, ATPase component
tenA	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -321 score = 70.98 sequence = ACTTTATAGCTAGGG... Gene: CPF_2870: Thiaminase II (EC 3.5.99.2)	Clostridium difficile 630	* Clostridium beijerincki NCIMB 8052 Site: position = -189 score = 72.39 sequence = ACGAGCACTAGGGGA... Gene: Cbei_2088: Thiaminase II (EC 3.5.99.2)	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	* Clostridium nexile DSM 1787 Site: position = -163 score = 49.66 sequence = TGTGTTTGCGAGGGA... Site: position = -323 score = 70.88 sequence = TACTCAAGCAGGGGG... Gene: CLONEX_00625: Thiaminase II (EC 3.5.99.2)	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	* Clostridium butyricum 5521 Site: position = -248 score = 76.09 sequence = CAAAAATAACTAGGG... Gene: CBY_0917: Thiaminase II (EC 3.5.99.2)	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02039: Thiaminase II (EC 3.5.99.2)	Thiaminase II (EC 3.5.99.2)
thiT	* Clostridium kluyveri DSM 555 Site: position = -164 score = 76.2 sequence = CTTAATGCTAGGGGT... Gene: CKL_2038: Substrate-specific component ThiT of thiamin ECF transporter	Clostridium sp. SS2/1	* Clostridium cellulolyticum H10 Site: position = -198 score = 64.37 sequence = ATATTGAAAGGGGAG... Gene: Ccel_2120: Substrate-specific component ThiT of thiamin ECF transporter	* Clostridium phytofermentans ISDg Site: position = -145 score = 71.84 sequence = ATTGTATTGCTGGGG... Gene: null: Substrate-specific component ThiT of thiamin ECF transporter	* Clostridium tetani E88 Site: position = -193 score = 65.14 sequence = AATGTAGTGCTAGGG... Gene: CTC00254: Substrate-specific component ThiT of thiamin ECF transporter	* Clostridium acetobutylicum ATCC 824 Site: position = -201 score = 72.79 sequence = ATATGTGCTAGGGGT... Gene: CAC2928: Substrate-specific component ThiT of thiamin ECF transporter	* Clostridium botulinum A str. ATCC 3502 Site: position = -160 score = 78.18 sequence = TTAAGTGCTAGGGGT... Gene: CBO0556: Substrate-specific component ThiT of thiamin ECF transporter	* Clostridium novyi NT Site: position = -317 score = 70.37 sequence = TTTTTAACTAGGGGT... Gene: NT01CX_1441: Substrate-specific component ThiT of thiamin ECF transporter	2 Clostridium perfringens ATCC 13124* Gene: CPF_2869: Substrate-specific component ThiT of thiamin ECF transporter Site: position = -194 score = 77.04 sequence = TCATGTGCTAGGGGT... Gene: CPF_1622: Substrate-specific component ThiT of thiamin ECF transporter	Clostridium difficile 630	* Clostridium beijerincki NCIMB 8052 Site: position = -157 score = 71.95 sequence = TATAATGTGCTAGGG... Gene: Cbei_0066: Substrate-specific component ThiT of thiamin ECF transporter	* Clostridium sp. OhILAs Site: position = -182 score = 61.7 sequence = TATTTATCGCTAGGG... Gene: Clos_0240: Substrate-specific component ThiT of thiamin ECF transporter	Clostridium sp. L2-50	* Clostridium scindens ATCC 35704 Site: position = -188 score = 57.06 sequence = ATAAGACCCATATGG... Gene: CLOSCI_02958: Substrate-specific component ThiT of thiamin ECF transporter	* Clostridium nexile DSM 1787 Site: position = -38 score = 59.97 sequence = CAATTTGCTAGGGGA... Gene: CLONEX_00550: Substrate-specific component ThiT of thiamin ECF transporter	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	* Clostridium butyricum 5521 Site: position = -186 score = 70.17 sequence = AAGTGTGCTAGGGGT... Gene: CBY_0451: Substrate-specific component ThiT of thiamin ECF transporter	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02038: Substrate-specific component ThiT of thiamin ECF transporter	Substrate-specific component ThiT of thiamin ECF transporter
purF2	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	* Clostridium botulinum A str. ATCC 3502 Site: position = -191 score = 75.69 sequence = TATGTAAATGCAGGG... Gene: CBO2913: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Amidophosphoribosyltransferase (EC 2.4.2.14)

CRON 2.
ykoF	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	* Clostridium leptum DSM 753 Site: position = -291 score = 63.34 sequence = TAGAATTCTAGGGGG... Gene: CLOLEP_00018: Additional substrate-binding component of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Additional substrate-binding component of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine

CRON 3.
CKL_2891	* Clostridium kluyveri DSM 555 Site: position = -191 score = 66.14 sequence = ATAACGGACAGGGGA... Gene: CKL_2891: hypothetical protein	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	hypothetical protein