Regulog Zur - Corynebacteriaceae

Properties
Regulator type:	Transcription factor
Regulator family:	FUR
Regulation mode:	repressor
Biological process:	Zinc homeostasis
Effector:	Zinc ion, (Zn2+)
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 38 sites [see more]

Member of regulog collections

By taxonomy - Corynebacteriaceae
By trascription factor - Zur
By TF family - FUR
By effector - Zinc ion, (Zn2+)
By pathway - Zinc homeostasis

Statistics of regulated genes
Genome	Genes	Operons
Corynebacterium amycolatum SK46	9	3
Corynebacterium aurimucosum ATCC 700975	8	4
Corynebacterium diphtheriae NCTC 13129	10	6
Corynebacterium efficiens YS-314	3	1
Corynebacterium glutamicum ATCC 13032	10	7
Corynebacterium jeikeium K411	9	3
Corynebacterium kroppenstedtii DSM 44385	4	2
Corynebacterium urealyticum DSM 7109	12	4

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
yciC	* Corynebacterium amycolatum SK46 Site: position = -36 score = 5.42229 sequence = TATTGATAAGCATTTTCAGTA Gene: CORAM0001_0703: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	* Corynebacterium aurimucosum ATCC 700975 Site: position = -25 score = 5.96824 sequence = TGATGAAAACCGTTATCATTA Gene: cauri_0148: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	* Corynebacterium diphtheriae NCTC 13129 Site: position = -25 score = 5.10612 sequence = AAGTGAAAACGGTATCCATTA Gene: DIP1486: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Corynebacterium efficiens YS-314	* Corynebacterium glutamicum ATCC 13032 Site: position = -79 score = 6.05065 sequence = TATTGAAAACAATTTCCATTA Site: position = -34 score = 5.27347 sequence = TATTGAAAATGATTCCCAAAA Gene: cg0794: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	* Corynebacterium jeikeium K411 Site: position = -40 score = 5.2288 sequence = TGATGAAAACAGGTTGCAATA Gene: jk1292: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	* Corynebacterium kroppenstedtii DSM 44385 Site: position = -164 score = 5.09335 sequence = TATTGACATTGTGTATCATTA Gene: ckrop_1235: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Corynebacterium urealyticum DSM 7109	Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family

CRON 2.
znuA	* Corynebacterium amycolatum SK46 Site: position = -85 score = 5.40811 sequence = AAAGGACAACTGTTTTCAATA Gene: CORAM0001_1250: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Corynebacterium aurimucosum ATCC 700975 Site: position = -39 score = 5.08166 sequence = ATTTGACAACAATTTTCACTA Gene: cauri_2206: Zinc ABC transporter, periplasmic-binding protein ZnuA	Corynebacterium diphtheriae NCTC 13129	* Corynebacterium efficiens YS-314 Site: position = 1 score = 5.77025 sequence = TGTTGACAATCGTTTCCAATA Gene: CE2512: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Corynebacterium glutamicum ATCC 13032 Site: position = -38 score = 5.43721 sequence = TGTTGACATCCTTTTTCAATA Gene: cg2911: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Corynebacterium jeikeium K411 Site: position = 40 score = 4.99347 sequence = TgAaGAAAATGgTTgcCAaTt Gene: jk0328: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Corynebacterium kroppenstedtii DSM 44385 Site: position = -38 score = 5.05233 sequence = AATTGACATCATATTTCATTA Gene: ckrop_0347: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Corynebacterium urealyticum DSM 7109 Site: position = -43 score = 5.0514 sequence = TATTGCAATCTGTTCCCATTA Gene: cur_1662: Zinc ABC transporter, periplasmic-binding protein ZnuA	Zinc ABC transporter, periplasmic-binding protein ZnuA
znuC	Corynebacterium amycolatum SK46 Gene: CORAM0001_1251: Zinc ABC transporter, ATP-binding protein ZnuC	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_2207: Zinc ABC transporter, ATP-binding protein ZnuC	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE2513: Zinc ABC transporter, ATP-binding protein ZnuC	Corynebacterium glutamicum ATCC 13032 Gene: cg2912: Zinc ABC transporter, ATP-binding protein ZnuC	Corynebacterium jeikeium K411 Gene: jk0327: Zinc ABC transporter, ATP-binding protein ZnuC	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_0346: Zinc ABC transporter, ATP-binding protein ZnuC	Corynebacterium urealyticum DSM 7109 Gene: cur_1663: Zinc ABC transporter, ATP-binding protein ZnuC	Zinc ABC transporter, ATP-binding protein ZnuC
znuB	Corynebacterium amycolatum SK46 Gene: CORAM0001_1252: Zinc ABC transporter, inner membrane permease protein ZnuB	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_2208: Zinc ABC transporter, inner membrane permease protein ZnuB	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE2514: Zinc ABC transporter, inner membrane permease protein ZnuB	Corynebacterium glutamicum ATCC 13032 Gene: cg2913: Zinc ABC transporter, inner membrane permease protein ZnuB	Corynebacterium jeikeium K411 Gene: jk0326: Zinc ABC transporter, inner membrane permease protein ZnuB	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_0345: Zinc ABC transporter, inner membrane permease protein ZnuB	Corynebacterium urealyticum DSM 7109 Gene: cur_1664: Zinc ABC transporter, inner membrane permease protein ZnuB	Zinc ABC transporter, inner membrane permease protein ZnuB

CRON 3.
adhA	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	* Corynebacterium diphtheriae NCTC 13129 Site: position = -37 score = 5.47802 sequence = TATTGAAAATAGGTACCATTA Gene: DIP2114: Zn-dependent alcohol dehydrogenase( EC:1.1.1.1 )	Corynebacterium efficiens YS-314 Gene: CE0053: Zn-dependent alcohol dehydrogenase( EC:1.1.1.1 )	* Corynebacterium glutamicum ATCC 13032 Site: position = -317 score = 5.69017 sequence = AATTGAAAAACATTTCCATTA Gene: cg3107: Zn-dependent alcohol dehydrogenase( EC:1.1.1.1 )	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	* Corynebacterium urealyticum DSM 7109 Site: position = -98 score = 4.7507 sequence = TAATGGGAACTATACTCATTA Gene: cur_1829: Zn-dependent alcohol dehydrogenase( EC:1.1.1.1 )	Zn-dependent alcohol dehydrogenase( EC:1.1.1.1 )

CRON 4.
mntA	* Corynebacterium amycolatum SK46 Site: position = -143 score = 4.36576 sequence = GGTTGAAAATGCTTGTCGTTA Gene: CORAM0001_0534: putative manganese ABC transporter, substrate-binding protein	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0615: putative manganese ABC transporter, substrate-binding protein	Corynebacterium efficiens YS-314	* Corynebacterium glutamicum ATCC 13032 Site: position = -40 score = 5.31441 sequence = TATTGACAAAGAGTGCCATTA Site: position = 4 score = 5.26642 sequence = TACTGAAAGACATTTTCAATA Gene: cg0041: putative manganese ABC transporter, substrate-binding protein	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	* Corynebacterium urealyticum DSM 7109 Site: position = -128 score = 5.2542 sequence = TAATGGAAAACAGTGCCATTA Gene: cur_1147: putative manganese ABC transporter, substrate-binding protein	putative manganese ABC transporter, substrate-binding protein
mntB	Corynebacterium amycolatum SK46 Gene: CORAM0001_0535: putative manganese ABC transporter, ATP-binding protein	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0616: putative manganese ABC transporter, ATP-binding protein	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109 Gene: cur_1146: putative manganese ABC transporter, ATP-binding protein	putative manganese ABC transporter, ATP-binding protein
mntC	Corynebacterium amycolatum SK46 Gene: CORAM0001_0536: putative manganese ABC transporter, permease component	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0617: putative manganese ABC transporter, permease component	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109 Gene: cur_1145: putative manganese ABC transporter, permease component	putative manganese ABC transporter, permease component
mntD	Corynebacterium amycolatum SK46 Gene: CORAM0001_0537: putative manganese ABC transporter, permease component 2	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0618: putative manganese ABC transporter, permease component 2	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109 Gene: cur_1144: putative manganese ABC transporter, permease component 2	putative manganese ABC transporter, permease component 2
mntR	Corynebacterium amycolatum SK46 Gene: CORAM0001_0538: Manganese-dependent transcriptional regulator MntR	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0619: Manganese-dependent transcriptional regulator MntR	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	Manganese-dependent transcriptional regulator MntR
sapD	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1145: putative surface-anchored protein	2 Corynebacterium diphtheriae NCTC 13129* Site: position = -68 score = 5.24989 sequence = AATTGACATCGGATTCCAATA Site: position = -30 score = 4.41734 sequence = AATTGCAAATCTAAATCAATA Gene: DIP1724: putative surface-anchored protein Gene: DIP0443: putative surface-anchored protein	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	* Corynebacterium jeikeium K411 Site: position = -75 score = 4.37991 sequence = GTTTGAAAATGGTTGCCACTT Site: position = -42 score = 4.23974 sequence = TAATGAAAACTAGACTCATTG Gene: jk1856: putative surface-anchored protein	Corynebacterium kroppenstedtii DSM 44385	* Corynebacterium urealyticum DSM 7109 Site: position = -160 score = 5.05348 sequence = AAAGGAAAACCATTGCCAATT Site: position = -103 score = 5.03567 sequence = ACTTGAAAATGGCTGTCATTA Gene: cur_0291: putative surface-anchored protein	putative surface-anchored protein
troA	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1144: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Corynebacterium diphtheriae NCTC 13129 Site: position = -69 score = 4.93391 sequence = TAATGAAAATGATTGTGATGT Gene: DIP0438: Zinc ABC transporter, periplasmic-binding protein ZnuA	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411 Gene: jk1855: Zinc ABC transporter, periplasmic-binding protein ZnuA	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109 Gene: cur_0292: Zinc ABC transporter, periplasmic-binding protein ZnuA	Zinc ABC transporter, periplasmic-binding protein ZnuA
DIP0439	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0439: Putative membrane protein	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411 Gene: jk1854: Putative membrane protein	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	Putative membrane protein
DIP0440	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1143: putative ABC transport system, ATP-binding protein	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0440: putative ABC transport system, ATP-binding protein	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411 Gene: jk1853: putative ABC transport system, ATP-binding protein	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109 Gene: cur_0293: putative ABC transport system, ATP-binding protein	putative ABC transport system, ATP-binding protein
DIP0441	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1142: putative ABC transport system, permease protein	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0441: putative ABC transport system, permease protein	Corynebacterium efficiens YS-314	* Corynebacterium glutamicum ATCC 13032 Site: position = -25 score = 5.85691 sequence = TAATGATAACGGTTATCATTT Site: position = -19 score = 4.20691 sequence = TAACGGTTATCATTTTCAAAT Gene: cg0042: putative ABC transport system, permease protein	Corynebacterium jeikeium K411 Gene: jk1852: putative ABC transport system, permease protein	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109 Gene: cur_0294: putative ABC transport system, permease protein	putative ABC transport system, permease protein
cmrA	Corynebacterium amycolatum SK46	* Corynebacterium aurimucosum ATCC 700975 Site: position = -116 score = 4.44234 sequence = AATTGAACCCTGTTTCCACTA Site: position = -67 score = 4.36061 sequence = TAACGGGACTGAATTCCATTA Gene: cauri_1146: hypothetical protein	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	hypothetical protein
cg0040	Corynebacterium amycolatum SK46	* Corynebacterium aurimucosum ATCC 700975 Site: position = -39 score = 4.8146 sequence = TATTGCTATTGATTTTCACTT Gene: cauri_0852: putative secreted protein	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032 Gene: cg0040: putative secreted protein	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	putative secreted protein
DIP0442	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	* Corynebacterium diphtheriae NCTC 13129 Site: position = -84 score = 4.95415 sequence = TATTGGTTATCTTTTTCATTT Gene: DIP0442: Putative membrane protein	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	Putative membrane protein
znuC2	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314	* Corynebacterium glutamicum ATCC 13032 Site: position = -25 score = 5.85691 sequence = AAATGATAACCGTTATCATTA Gene: cg0043: zinc ABC transporter, ATP-binding protein	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	zinc ABC transporter, ATP-binding protein

CRON 5.
cg0795	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314	* Corynebacterium glutamicum ATCC 13032 Site: position = -105 score = 5.27347 sequence = TTTTGGGAATCATTTTCAATA Site: position = -60 score = 6.05065 sequence = TAATGGAAATTGTTTTCAATA Gene: cg0795: FAD-dependent pyridine nucleotide-disulphide oxidoreductase	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	FAD-dependent pyridine nucleotide-disulphide oxidoreductase

CRON 6.
cmra	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	* Corynebacterium diphtheriae NCTC 13129 Site: position = -2 score = 5.32765 sequence = TAATGAAAATAATTACCGATA Gene: DIP2325: putative surface-anchored protein	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	putative surface-anchored protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog Zur - Corynebacteriaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --