Regulog MetR - Enterobacteriales

Properties
Regulator type:	Transcription factor
Regulator family:	LysR
Regulation mode:	repressor (activator)
Biological process:	Methionine biosynthesis
Effector:	Homocysteine
Phylum:	Proteobacteria/Gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 140 sites [see more]

Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - MetR
By TF family - LysR
By effector - Homocysteine
By pathway - Methionine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Escherichia coli str. K-12 substr. MG1655	8	8
Salmonella typhimurium LT2	8	8
Citrobacter koseri ATCC BAA-895	11	10
Klebsiella pneumoniae subsp. pneumoniae MGH 78578	12	11
Enterobacter sp. 638	11	10
Erwinia amylovora ATCC 49946	7	7
Yersinia pestis KIM	7	7
Serratia proteamaculans 568	11	10
Erwinia carotovora subsp. atroseptica SCRI1043	9	8
Edwardsiella tarda EIB202	5	5
Proteus mirabilis HI4320	9	9
Photorhabdus luminescens subsp. laumondii TTO1	6	6

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
metE	* Escherichia coli str. K-12 substr. MG1655 Site: position = -238 score = 4.85051 sequence = ATGAAAGTCCTTCAC Gene: b3829: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Salmonella typhimurium LT2 Site: position = -250 score = 4.85051 sequence = ATGAAAGTCCTTCAC Gene: STM3965: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Citrobacter koseri ATCC BAA-895 Site: position = -250 score = 4.85051 sequence = ATGAAAGTCCTTCAC Gene: CKO_00171: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -249 score = 4.85051 sequence = ATGAAAGTCCTTCAC Gene: KPN_04325: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Enterobacter sp. 638 Site: position = -249 score = 4.85051 sequence = ATGAAAGTCCTTCAC Gene: Ent638_3967: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Erwinia amylovora ATCC 49946 Site: position = -152 score = 4.69451 sequence = ATGAGAGTCCTTCAC Gene: EAM_0198: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Yersinia pestis KIM Site: position = -92 score = 4.69451 sequence = ATGAGAGTCCTTCAC Gene: y0442: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Serratia proteamaculans 568 Site: position = -107 score = 4.69451 sequence = ATGAGAGTCCTTCAC Gene: Spro_0242: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -106 score = 4.69451 sequence = ATGAGAGTCCTTCAC Gene: ECA0181: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Edwardsiella tarda EIB202 Site: position = -125 score = 4.4802 sequence = ATGAGAAACCCTCAG Gene: ETAE_0142: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Proteus mirabilis HI4320 Site: position = -109 score = 4.6362 sequence = ATGAGAAACCTTCAG Site: position = -87 score = 4.04576 sequence = ATGAAAAATTTGCGC Gene: PMI3529: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -110 score = 4.6362 sequence = ATGAGAAACCTTCAG Gene: plu4420: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)

CRON 2.
metA	* Escherichia coli str. K-12 substr. MG1655 Site: position = -111 score = 4.50089 sequence = TTGAAACTTTCTCAC Gene: b4013: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Salmonella typhimurium LT2 Site: position = -111 score = 4.75431 sequence = GTGAAACTTTCTCAC Gene: STM4182: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Citrobacter koseri ATCC BAA-895 Site: position = -111 score = 4.75431 sequence = GTGAAACTTTCTCAC Gene: CKO_03907: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -111 score = 4.8154 sequence = GTGAAATTTTCTCAC Gene: KPN_04394: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Enterobacter sp. 638 Site: position = -111 score = 4.75431 sequence = GTGAAACTTTCTCAC Gene: Ent638_0217: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Erwinia amylovora ATCC 49946 Site: position = -110 score = 4.73569 sequence = ATGAAACATTTTCAA Gene: EAM_0250: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Yersinia pestis KIM Site: position = -109 score = 4.83298 sequence = ATGAAACATTTTCAG Gene: y0013: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Serratia proteamaculans 568 Site: position = -108 score = 4.98911 sequence = ATGAAACATTTTCAC Gene: Spro_4504: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -112 score = 4.91031 sequence = GTGAAACATTTTCAC Gene: ECA3992: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Edwardsiella tarda EIB202 Site: position = -113 score = 4.82431 sequence = ATGAAAATTTCTCAA Gene: ETAE_3190: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Proteus mirabilis HI4320 Site: position = -102 score = 4.78338 sequence = ATGAATATTCTTCAT Gene: PMI2765: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -112 score = 4.71055 sequence = ATGAAATAATTTCAG Gene: plu4397: Homoserine O-succinyltransferase (EC 2.3.1.46)	Homoserine O-succinyltransferase (EC 2.3.1.46)

CRON 3.
glyA	* Escherichia coli str. K-12 substr. MG1655 Site: position = -217 score = 4.81196 sequence = GTGAAAAATTTGCAT Gene: b2551: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Salmonella typhimurium LT2 Site: position = -215 score = 4.62439 sequence = GTGAAAAATCTGCAT Gene: STM2555: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Citrobacter koseri ATCC BAA-895 Site: position = -209 score = 4.62439 sequence = GTGAAAAATCTGCAT Gene: CKO_00237: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -216 score = 4.7032 sequence = ATGAAGAATTTGCAT Gene: KPN_02876: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Enterobacter sp. 638 Site: position = -214 score = 4.56237 sequence = ATGAAAAATGTGCAT Gene: Ent638_3036: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Erwinia amylovora ATCC 49946 Site: position = -213 score = 3.77555 sequence = ATGAGGATCATGCAA Gene: EAM_2497: Serine hydroxymethyltransferase (EC 2.1.2.1)	Yersinia pestis KIM Gene: y1322: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Serratia proteamaculans 568 Site: position = -218 score = 4.36367 sequence = ATGAAAAAACCGCAT Gene: Spro_3638: Serine hydroxymethyltransferase (EC 2.1.2.1)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA3250: Serine hydroxymethyltransferase (EC 2.1.2.1)	Edwardsiella tarda EIB202 Gene: ETAE_2821: Serine hydroxymethyltransferase (EC 2.1.2.1)	Proteus mirabilis HI4320 Gene: PMI1867: Serine hydroxymethyltransferase (EC 2.1.2.1)	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu3291: Serine hydroxymethyltransferase (EC 2.1.2.1)	Serine hydroxymethyltransferase (EC 2.1.2.1)

CRON 4.
metE2	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	* Citrobacter koseri ATCC BAA-895 Site: position = -149 score = 4.19287 sequence = GTGAATTTATTTCAA Site: position = -129 score = 3.63028 sequence = ATGAATTTTTCTCGG Site: position = -180 score = 4.09218 sequence = ATGAAAAAGCGTCAC Gene: CKO_01563: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -152 score = 4.98031 sequence = TTGAAAATTTTTCAT Site: position = -132 score = 4.20681 sequence = ATGAAATATTCTCGT Gene: KPN_01615: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Enterobacter sp. 638 Site: position = -152 score = 4.44582 sequence = ATGAATAAAATTCAT Site: position = -191 score = 3.79617 sequence = ATGAACATTTTGCGT Site: position = -132 score = 3.63028 sequence = ATGAATTTTTCTCGG Gene: Ent638_1987: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Erwinia amylovora ATCC 49946 Site: position = -163 score = 4.39648 sequence = ATGAATTTTTCTCAG Site: position = -143 score = 3.65345 sequence = ATGAAATTTTGTCGT Gene: EAM_0952: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Yersinia pestis KIM	* Serratia proteamaculans 568 Site: position = -177 score = 4.45478 sequence = ATGAATTTCTCTCAC Site: position = -157 score = 4.10485 sequence = ATGAAAATTCTTCTA Gene: Spro_1044: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -202 score = 4.36702 sequence = ATGAATTTTATTCAC Site: position = -182 score = 3.94775 sequence = GTGAAAATTCTTCCA Site: position = -82 score = 3.86223 sequence = GGGCAAATATTTCAT Gene: ECA1113: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)

CRON 5.
metR	* Escherichia coli str. K-12 substr. MG1655 Site: position = -13 score = 4.85051 sequence = GTGAAGGACTTTCAT Site: position = -34 score = 3.70416 sequence = GCGCAAATTATTCAT Gene: b3828: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Salmonella typhimurium LT2 Site: position = -13 score = 4.85051 sequence = GTGAAGGACTTTCAT Gene: STM3964: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Citrobacter koseri ATCC BAA-895 Site: position = -13 score = 4.85051 sequence = GTGAAGGACTTTCAT Gene: CKO_00170: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -217 score = 3.95288 sequence = AAGAAAAAATCTCAA Site: position = -13 score = 4.85051 sequence = GTGAAGGACTTTCAT Gene: KPN_04324: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Enterobacter sp. 638 Site: position = -13 score = 4.85051 sequence = GTGAAGGACTTTCAT Gene: Ent638_3968: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Erwinia amylovora ATCC 49946 Site: position = -35 score = 3.62536 sequence = GCGCAAAATATTCAC Site: position = -13 score = 4.69451 sequence = GTGAAGGACTCTCAT Gene: EAM_0197: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Yersinia pestis KIM Site: position = -13 score = 4.69451 sequence = GTGAAGGACTCTCAT Gene: y0441: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Serratia proteamaculans 568 Site: position = -174 score = 4.17474 sequence = CTGAGCTTTTTTCAG Site: position = -13 score = 4.69451 sequence = GTGAAGGACTCTCAT Gene: Spro_0241: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -173 score = 3.75297 sequence = CTGCGCTTTTTTCAG Site: position = -13 score = 4.69451 sequence = GTGAAGGACTCTCAT Gene: ECA0180: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Edwardsiella tarda EIB202	* Proteus mirabilis HI4320 Site: position = -35 score = 4.04576 sequence = GCGCAAATTTTTCAT Site: position = -13 score = 4.6362 sequence = CTGAAGGTTTCTCAT Gene: PMI3528: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -207 score = 4.0766 sequence = CTGAGAAATTTTCCC Site: position = -13 score = 4.6362 sequence = CTGAAGGTTTCTCAT Gene: plu4421: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family

CRON 6.
metF	* Escherichia coli str. K-12 substr. MG1655 Site: position = -295 score = 3.68776 sequence = ATGAAATATATTGAA Site: position = -156 score = 4.70651 sequence = CTGAAGTTTTTTCAT Site: position = 0 score = 4.56581 sequence = ATGAGCTTTTTTCAC Gene: b3941: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Salmonella typhimurium LT2 Site: position = -156 score = 4.26763 sequence = ATGAAGAAAATTCAA Site: position = -136 score = 4.39244 sequence = CTGAATATTCCTCAT Site: position = 0 score = 4.56581 sequence = ATGAGCTTTTTTCAC Gene: STM4105: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Citrobacter koseri ATCC BAA-895 Site: position = -136 score = 4.15763 sequence = CTGAGTATTCCTCAC Site: position = -156 score = 4.37639 sequence = TTGAATTTTTTTCAC Site: position = 0 score = 4.56581 sequence = ATGAGCTTTTTTCAC Gene: CKO_03051: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = 0 score = 4.56581 sequence = ATGAGCTTTTTTCAC Site: position = -155 score = 4.80062 sequence = ATGAACTTTTTTCAT Gene: KPN_04239: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Enterobacter sp. 638 Site: position = 0 score = 4.56581 sequence = ATGAGCTTTTTTCAC Site: position = -136 score = 4.32684 sequence = CTGAACATTCCTCAC Site: position = -156 score = 4.70279 sequence = ATGAACTTCTTTCAT Gene: Ent638_4033: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Erwinia amylovora ATCC 49946 Site: position = -146 score = 4.55051 sequence = CTGAAATTTCCTCAT Site: position = 0 score = 3.87812 sequence = ATGAGTTTTTTCCAT Gene: EAM_0135: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Yersinia pestis KIM Site: position = 0 score = 4.55261 sequence = ATGAGTTTTTTTCAC Site: position = -148 score = 3.84118 sequence = GTGAATATTAATCAT Site: position = -172 score = 3.6353 sequence = ATATGAATTTTTCAC Gene: y0304: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Serratia proteamaculans 568 Site: position = 0 score = 4.55261 sequence = ATGAGTTTTTTTCAC Site: position = -139 score = 3.83921 sequence = GTGAGGATTAATCAT Site: position = -161 score = 4.18567 sequence = GTGAAATTCTTTCTC Gene: Spro_4784: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -136 score = 3.76041 sequence = GTGAGTAATCATCAC Site: position = -156 score = 4.80062 sequence = ATGAACTTTTTTCAT Site: position = 0 score = 4.56581 sequence = ATGAGCTTTTTTCAC Gene: ECA4244: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Edwardsiella tarda EIB202 Site: position = -161 score = 3.78005 sequence = CTGACGCTTTCTCAT Site: position = -140 score = 3.80959 sequence = CTGACGTTTCTTCAT Site: position = 0 score = 4.55261 sequence = ATGAGTTTTTTTCAC Gene: ETAE_3485: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Proteus mirabilis HI4320 Site: position = 0 score = 3.85645 sequence = ATGAGCTTTTATCAC Site: position = -163 score = 4.11163 sequence = TTGAATTATCCTCAT Site: position = -185 score = 4.2851 sequence = ATGAAATTTTCTCTT Gene: PMI2932: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = 0 score = 4.55261 sequence = ATGAGTTTTTTTCAC Site: position = -167 score = 4.46977 sequence = GTGAATATTCCTCAC Site: position = -189 score = 3.78628 sequence = ATGAATTTTTTTCCG Gene: plu4754: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)

CRON 7.
hmp	* Escherichia coli str. K-12 substr. MG1655 Site: position = -125 score = 4.81196 sequence = ATGCAAATTTTTCAC Gene: b2552: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	* Salmonella typhimurium LT2 Site: position = -124 score = 4.62439 sequence = ATGCAGATTTTTCAC Gene: STM2556: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	* Citrobacter koseri ATCC BAA-895 Site: position = -125 score = 4.62439 sequence = ATGCAGATTTTTCAC Gene: CKO_00235: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -124 score = 4.7032 sequence = ATGCAAATTCTTCAT Gene: KPN_02877: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	* Enterobacter sp. 638 Site: position = -103 score = 4.56237 sequence = ATGCACATTTTTCAT Gene: Ent638_3037: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	Erwinia amylovora ATCC 49946	* Yersinia pestis KIM Site: position = -149 score = 4.48154 sequence = ATGTGAATTTTTCAT Gene: y1321: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	* Serratia proteamaculans 568 Site: position = -169 score = 4.36367 sequence = ATGCGGTTTTTTCAT Gene: Spro_3639: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA3251: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	Edwardsiella tarda EIB202 Gene: ETAE_2822: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	* Proteus mirabilis HI4320 Site: position = -23 score = 4.50107 sequence = CTGAATATTTTTCAG Gene: PMI1868: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -25 score = 4.12243 sequence = TTGAAAGAAATTCAG Gene: plu3292: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)	Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)

CRON 8.
metH	* Escherichia coli str. K-12 substr. MG1655 Site: position = -109 score = 4.3124 sequence = TTGAACAAATCTCAT Gene: b4019: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Salmonella typhimurium LT2 Site: position = -93 score = 4.34858 sequence = CTGAACATGTCTCAT Gene: STM4188.S: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Citrobacter koseri ATCC BAA-895 Site: position = -50 score = 4.34858 sequence = CTGAACATGTCTCAT Gene: CKO_03902: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -106 score = 4.34858 sequence = CTGAACATGTCTCAT Gene: KPN_04399: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Enterobacter sp. 638 Site: position = -105 score = 4.50472 sequence = GTGAACATGTCTCAT Gene: Ent638_0222: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	Erwinia amylovora ATCC 49946	* Yersinia pestis KIM Site: position = -116 score = 4.34475 sequence = CTGAAAAAGTCTCAA Gene: y0020: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Serratia proteamaculans 568 Site: position = -166 score = 4.49154 sequence = CTGAAAAACTCTCAA Gene: Spro_4490: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -98 score = 4.67697 sequence = CTGAAAAAGTCTCAT Gene: ECA3987: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Edwardsiella tarda EIB202 Site: position = -138 score = 4.39213 sequence = ATGAAAAAGCCTCAA Gene: ETAE_0200: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Proteus mirabilis HI4320 Site: position = -191 score = 3.72879 sequence = CTGTATATTTTTCAA Site: position = -129 score = 4.9799 sequence = GTGAAAATCTCTCAT Gene: PMI2758: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	Photorhabdus luminescens subsp. laumondii TTO1	5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)

CRON 9.
luxS	* Escherichia coli str. K-12 substr. MG1655 Site: position = -81 score = 4.2107 sequence = ATGCGCGTCTTTCAT Gene: b2687: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Salmonella typhimurium LT2 Site: position = -80 score = 4.2107 sequence = ATGCGCGTCTTTCAT Gene: STM2817: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Citrobacter koseri ATCC BAA-895 Site: position = -81 score = 4.1319 sequence = ATGCGCGTCTTTCAC Gene: CKO_04036: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -83 score = 4.2107 sequence = ATGCGCGTCTTTCAT Gene: KPN_03018: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Enterobacter sp. 638 Site: position = -83 score = 4.2107 sequence = ATGCGCGTCTTTCAT Gene: Ent638_3167: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Erwinia amylovora ATCC 49946 Site: position = -51 score = 3.81349 sequence = TCGAGAAAGTTTCAT Gene: EAM_2633: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Yersinia pestis KIM Site: position = -103 score = 4.1319 sequence = ATGCGCGTCTTTCAC Gene: y0888: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Serratia proteamaculans 568 Site: position = -101 score = 4.1319 sequence = ATGCGCGTCTTTCAC Gene: Spro_0848: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -92 score = 3.97577 sequence = ATGCGCGTCTTTCAG Gene: ECA3362: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Edwardsiella tarda EIB202 Site: position = -89 score = 4.2107 sequence = ATGCGCGTCTTTCAT Gene: ETAE_2854: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Proteus mirabilis HI4320 Site: position = -281 score = 4.87518 sequence = ATGAGAGAATTTCAT Gene: PMI0379: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -56 score = 5.06791 sequence = ATGAAAAAGTTTCAT Gene: plu1253: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS

CRON 10.
metQ2	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -98 score = 3.89477 sequence = ATGAAATCCTCTCAA Gene: KPN_02168: Methionine ABC transporter substrate-binding protein	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1966: Methionine ABC transporter substrate-binding protein	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	2 Proteus mirabilis HI4320* Site: position = -208 score = 5.12901 sequence = ATGAAAATATTTCAT Gene: PMI3020: Methionine ABC transporter substrate-binding protein Site: position = -184 score = 3.68776 sequence = TTGAATTATTTTTAT Gene: PMI1247: Methionine ABC transporter substrate-binding protein	Photorhabdus luminescens subsp. laumondii TTO1	Methionine ABC transporter substrate-binding protein

CRON 11.
PF08908	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	* Citrobacter koseri ATCC BAA-895 Site: position = -182 score = 4.22872 sequence = ATGAATATGACTCAT Gene: CKO_02940: Protein of unknown function DUF1852	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -192 score = 4.23995 sequence = ATGAGGATGGCTCAT Gene: KPN_02153: Protein of unknown function DUF1852	* Enterobacter sp. 638 Site: position = -186 score = 4.59788 sequence = ATGAAGAAACCTCAT Gene: Ent638_2112: Protein of unknown function DUF1852	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	* Serratia proteamaculans 568 Site: position = -183 score = 4.38275 sequence = ATGAATATGCCTCAT Gene: Spro_3175: Protein of unknown function DUF1852	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -181 score = 4.44582 sequence = ATGAATATAATTCAT Site: position = -161 score = 3.68118 sequence = ATGAAATTAACTCTC Gene: ECA3125: Protein of unknown function DUF1852	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Protein of unknown function DUF1852
metE2-2	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895 Gene: CKO_02941: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_02152: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Enterobacter sp. 638 Gene: Ent638_2113: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_3176: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA3126: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog MetR - Enterobacteriales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --