Regulog NiaR - Clostridia-3

Properties
Regulator type:	Transcription factor
Regulator family:	NiaR
Regulation mode:	repressor
Biological process:	NAD biosynthesis
Effector:	Niacin
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 18 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-3
By TF family - NiaR
By effector - Niacin
By pathway - NAD biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Bacteroides pectinophilus ATCC 43243	1	1
Blautia hansenii DSM 20583	2	1
Bryantella formatexigens DSM 14469	1	1
Clostridiales bacterium 1_7_47_FAA
Clostridium bolteae ATCC BAA-613	4	1
Clostridium nexile DSM 1787	5	2
Clostridium scindens ATCC 35704	5	2
Dorea formicigenerans ATCC 27755	3	1
Dorea longicatena DSM 13814	4	2
Eubacterium eligens ATCC 27750	4	1
Eubacterium rectale ATCC 33656	4	2
Roseburia intestinalis L1-82	1	1
Ruminococcus gnavus ATCC 29149	4	1
Ruminococcus lactaris ATCC 29176	4	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes															Function

CRON 1.
niaY	* Bacteroides pectinophilus ATCC 43243 Site: position = -45 score = 5.37441 sequence = ATCATCTGACAAGACAGTTGAC Site: position = -33 score = 5.30768 sequence = GACAGTTGACATTACAGCTGTA Gene: BACPEC_00421: Predicted nicotinate-regulated transporter NiaY	Blautia hansenii DSM 20583 Gene: BLAHAN_00635: Predicted nicotinate-regulated transporter NiaY	* Bryantella formatexigens DSM 14469 Site: position = -42 score = 5.62962 sequence = TGCAGGTGACAAGACACTTGAC Gene: BRYFOR_01996: Predicted nicotinate-regulated transporter NiaY	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	* Clostridium nexile DSM 1787 Site: position = -47 score = 5.84505 sequence = TGCTAGTGACAAGACACATGTA Gene: CLONEX_03876: Predicted nicotinate-regulated transporter NiaY	* Clostridium scindens ATCC 35704 Site: position = -53 score = 5.91121 sequence = TTCAAATGACAAGACAGTTGTA Gene: CLOSCI_02252: Predicted nicotinate-regulated transporter NiaY	Dorea formicigenerans ATCC 27755	* Dorea longicatena DSM 13814 Site: position = -98 score = 6.36318 sequence = GACATGTGACAAGACACATGTA Gene: DORLON_02159: Predicted nicotinate-regulated transporter NiaY	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_02018: Predicted nicotinate-regulated transporter NiaY	Predicted nicotinate-regulated transporter NiaY

CRON 2.
nadA	Bacteroides pectinophilus ATCC 43243	* Blautia hansenii DSM 20583 Site: position = -256 score = 6.23992 sequence = AACAACTGTCTTGTCACTTGTA Gene: BLAHAN_02639: Quinolinate synthetase (EC 4.1.99.-)	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA	* Clostridium bolteae ATCC BAA-613 Site: position = -108 score = 5.10874 sequence = CCTATATGTCTTGTCACATGTA Gene: CLOBOL_03914: Quinolinate synthetase (EC 4.1.99.-)	* Clostridium nexile DSM 1787 Site: position = -3 score = 6.02303 sequence = AGCATGTGTCTTGTCACCTGTA Gene: CLONEX_03264: Quinolinate synthetase (EC 4.1.99.-)	* Clostridium scindens ATCC 35704 Site: position = -10 score = 5.26456 sequence = CTTATCTGTCTTGTCATATGTA Gene: CLOSCI_01553: Quinolinate synthetase (EC 4.1.99.-)	* Dorea formicigenerans ATCC 27755 Site: position = -47 score = 4.86463 sequence = ACTTACTGTCTTGTCACATGTA Gene: DORFOR_01504: Quinolinate synthetase (EC 4.1.99.-)	Dorea longicatena DSM 13814 Gene: DORLON_00278: Quinolinate synthetase (EC 4.1.99.-)	* Eubacterium eligens ATCC 27750 Site: position = -102 score = 6.45869 sequence = TACAACTGTCTTGTCACATGTA Gene: EUBELI_01431: Quinolinate synthetase (EC 4.1.99.-)	* Eubacterium rectale ATCC 33656 Site: position = -173 score = 6.32847 sequence = TACAACTGACAAGACACCTGTA Gene: EUBREC_1033: Quinolinate synthetase (EC 4.1.99.-)	2 Roseburia intestinalis L1-82* Site: position = -69 score = 6.20911 sequence = AACATGTGTCTTGTCATATGTA Gene: ROSINTL182_03917: Quinolinate synthetase (EC 4.1.99.-) Gene: ROSINTL182_03918: Quinolinate synthetase (EC 4.1.99.-)	* Ruminococcus gnavus ATCC 29149 Site: position = -94 score = 6.16344 sequence = CACAACTGTCTTGTCACATGTA Gene: RUMGNA_03804: Quinolinate synthetase (EC 4.1.99.-)	* Ruminococcus lactaris ATCC 29176 Site: position = -57 score = 6.19748 sequence = AACATCTGTCTTGTCACCTGTA Gene: RUMLAC_00642: Quinolinate synthetase (EC 4.1.99.-)	Quinolinate synthetase (EC 4.1.99.-)
nadB	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583 Gene: BLAHAN_02638: L-aspartate oxidase (EC 1.4.3.16)	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_03915: L-aspartate oxidase (EC 1.4.3.16)	Clostridium nexile DSM 1787 Gene: CLONEX_03263: L-aspartate oxidase (EC 1.4.3.16)	Clostridium scindens ATCC 35704 Gene: CLOSCI_01552: L-aspartate oxidase (EC 1.4.3.16)	Dorea formicigenerans ATCC 27755 Gene: DORFOR_01505: L-aspartate oxidase (EC 1.4.3.16)	* Dorea longicatena DSM 13814 Site: position = -123 score = 6.11465 sequence = AACAATTGTCTTGTCACATGTA Gene: DORLON_01089: L-aspartate oxidase (EC 1.4.3.16)	Eubacterium eligens ATCC 27750 Gene: EUBELI_01430: L-aspartate oxidase (EC 1.4.3.16)	* Eubacterium rectale ATCC 33656 Site: position = -129 score = 6.32847 sequence = TACAGGTGTCTTGTCAGTTGTA Gene: EUBREC_1034: L-aspartate oxidase (EC 1.4.3.16)	Roseburia intestinalis L1-82 Gene: ROSINTL182_03919: L-aspartate oxidase (EC 1.4.3.16)	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_03805: L-aspartate oxidase (EC 1.4.3.16)	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_00641: L-aspartate oxidase (EC 1.4.3.16)	L-aspartate oxidase (EC 1.4.3.16)
nadC	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583 Gene: BLAHAN_02635: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_03916: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium nexile DSM 1787 Gene: CLONEX_03262: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium scindens ATCC 35704 Gene: CLOSCI_01551: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Dorea formicigenerans ATCC 27755 Gene: DORFOR_01506: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Dorea longicatena DSM 13814 Gene: DORLON_01088: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Eubacterium eligens ATCC 27750 Gene: EUBELI_01429: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Eubacterium rectale ATCC 33656 Gene: EUBREC_1035: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Roseburia intestinalis L1-82 Gene: ROSINTL182_03920: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_03806: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_00640: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)
niaR	Bacteroides pectinophilus ATCC 43243 Gene: BACPEC_00422: NAD biosynthesis transcription regulator, HTH_11 family	Blautia hansenii DSM 20583 Gene: BLAHAN_02634: NAD biosynthesis transcription regulator, HTH_11 family	Bryantella formatexigens DSM 14469 Gene: BRYFOR_01997: NAD biosynthesis transcription regulator, HTH_11 family	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100010440: NAD biosynthesis transcription regulator, HTH_11 family	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_03917: NAD biosynthesis transcription regulator, HTH_11 family	Clostridium nexile DSM 1787 Gene: CLONEX_03261: NAD biosynthesis transcription regulator, HTH_11 family	Clostridium scindens ATCC 35704 Gene: CLOSCI_01550: NAD biosynthesis transcription regulator, HTH_11 family	Dorea formicigenerans ATCC 27755 Gene: DORFOR_02387: NAD biosynthesis transcription regulator, HTH_11 family	Dorea longicatena DSM 13814 Gene: DORLON_01087: NAD biosynthesis transcription regulator, HTH_11 family	Eubacterium eligens ATCC 27750 Gene: EUBELI_01428: NAD biosynthesis transcription regulator, HTH_11 family	Eubacterium rectale ATCC 33656 Gene: EUBREC_1036: NAD biosynthesis transcription regulator, HTH_11 family	Roseburia intestinalis L1-82 Gene: ROSINTL182_03921: NAD biosynthesis transcription regulator, HTH_11 family	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_03807: NAD biosynthesis transcription regulator, HTH_11 family	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_00639: NAD biosynthesis transcription regulator, HTH_11 family	NAD biosynthesis transcription regulator, HTH_11 family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NiaR - Clostridia-3

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --