Regulog Zur - Bifidobacteriaceae

Properties
Regulator type:	Transcription factor
Regulator family:	FUR
Regulation mode:	repressor
Biological process:	Zinc homeostasis
Effector:	Zinc ion, (Zn2+)
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 33 sites [see more]

Member of regulog collections

By taxonomy - Bifidobacteriaceae
By trascription factor - Zur
By TF family - FUR
By effector - Zinc ion, (Zn2+)
By pathway - Zinc homeostasis

Statistics of regulated genes
Genome	Genes	Operons
Bifidobacterium adolescentis ATCC 15703	4	3
Bifidobacterium angulatum DSM 20098	4	3
Bifidobacterium animalis subsp. lactis AD011	4	3
Bifidobacterium bifidum NCIMB 41171	5	4
Bifidobacterium breve DSM 20213	6	5
Bifidobacterium dentium Bd1	10	4
Bifidobacterium gallicum DSM 20093	3	2
Bifidobacterium longum NCC2705	2	2
Bifidobacterium longum subsp. infantis ATCC 15697	7	5
Gardnerella vaginalis 409-05	6	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes											Function

CRON 1.
rpmB2	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	* Bifidobacterium bifidum NCIMB 41171 Site: position = 14 score = 5.57917 sequence = TTTTGATAATGATTATCATTA Gene: BbifN4_010100006411: LSU ribosomal protein L28p	Bifidobacterium breve DSM 20213	* Bifidobacterium dentium Bd1 Site: position = -37 score = 6.14112 sequence = TATTGATAATGATTATCATTA Gene: BDP_1883: LSU ribosomal protein L28p	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	* Bifidobacterium longum subsp. infantis ATCC 15697 Site: position = -37 score = 5.22909 sequence = ATTTGATAATGGTTATCATTA Gene: Blon_1965: LSU ribosomal protein L28p	Gardnerella vaginalis 409-05	LSU ribosomal protein L28p
rpmG2	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1 Gene: BDP_1882: LSU ribosomal protein L33p	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697 Gene: Blon_1966: LSU ribosomal protein L33p	Gardnerella vaginalis 409-05	LSU ribosomal protein L33p
rpsN2	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	* Bifidobacterium breve DSM 20213 Site: position = -19 score = 5.71551 sequence = TATTGAGAATTATTATCATTT Gene: BIFBRE_00822: SSU ribosomal protein S14p	Bifidobacterium dentium Bd1 Gene: BDP_1881: SSU ribosomal protein S14p	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	Gardnerella vaginalis 409-05	SSU ribosomal protein S14p
rpmJ2	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1 Gene: BDP_1879: LSU ribosomal protein L36p	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	Gardnerella vaginalis 409-05	LSU ribosomal protein L36p
BDP_1880	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1 Gene: BDP_1880: hypothetical protein	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	Gardnerella vaginalis 409-05	hypothetical protein
zinT	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	* Bifidobacterium animalis subsp. lactis AD011 Site: position = -60 score = 5.99025 sequence = TATTGAGAACGATTCCCAATA Site: position = -92 score = 6.23234 sequence = TATTGAGAATCGTTCTCATTT Gene: BLA_0171: Candidate zinc-binding lipoprotein ZinT	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1 Gene: BDP_1878: Candidate zinc-binding lipoprotein ZinT	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	Gardnerella vaginalis 409-05	Candidate zinc-binding lipoprotein ZinT

CRON 2.
zur	Bifidobacterium adolescentis ATCC 15703 Gene: BAD_0517: Zinc uptake regulation protein ZUR	Bifidobacterium angulatum DSM 20098 Gene: BIFANG_00962: Zinc uptake regulation protein ZUR	Bifidobacterium animalis subsp. lactis AD011 Gene: BLA_1123: Zinc uptake regulation protein ZUR	Bifidobacterium bifidum NCIMB 41171 Gene: BbifN4_010100006451: Zinc uptake regulation protein ZUR	2 Bifidobacterium breve DSM 20213* Site: position = -45 score = 5.08654 sequence = TAACGATAATGAATATCATTT Gene: BIFBRE_00816: Zinc uptake regulation protein ZUR Gene: BIFBRE_00810: Zinc uptake regulation protein ZUR	Bifidobacterium dentium Bd1 Gene: BDP_0716: Zinc uptake regulation protein ZUR	Bifidobacterium gallicum DSM 20093 Gene: BIFGAL_01073: Zinc uptake regulation protein ZUR	Bifidobacterium longum NCC2705 Gene: BL1128: Zinc uptake regulation protein ZUR	2 Bifidobacterium longum subsp. infantis ATCC 15697* Gene: Blon_1979: Zinc uptake regulation protein ZUR Site: position = -45 score = 5.08654 sequence = TAACGATAATGAATATCATTT Gene: Blon_1974: Zinc uptake regulation protein ZUR	Gardnerella vaginalis 409-05 Gene: HMPREF0424_1040: Zinc uptake regulation protein ZUR	Zinc uptake regulation protein ZUR

CRON 3.
HMPREF0424_1241	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	* Gardnerella vaginalis 409-05 Site: position = -117 score = 5.55319 sequence = TAATGAGAATCATTATTATTA Gene: HMPREF0424_1241: surface-anchored protein domain protein	surface-anchored protein domain protein
HMPREF0424_1240	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	Gardnerella vaginalis 409-05 Gene: HMPREF0424_1240: surface-anchored protein domain protein	surface-anchored protein domain protein
HMPREF0424_1239	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	Gardnerella vaginalis 409-05 Gene: HMPREF0424_1239: putative ABC transporter-associated repeat protein	putative ABC transporter-associated repeat protein
znuA3	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	Gardnerella vaginalis 409-05 Gene: HMPREF0424_1238: Zinc ABC transporter, periplasmic-binding protein ZnuA	Zinc ABC transporter, periplasmic-binding protein ZnuA
znuC3	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	Gardnerella vaginalis 409-05 Gene: HMPREF0424_1237: Zinc ABC transporter, ATP-binding protein ZnuC	Zinc ABC transporter, ATP-binding protein ZnuC
znuB3	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705	Bifidobacterium longum subsp. infantis ATCC 15697	Gardnerella vaginalis 409-05 Gene: HMPREF0424_1236: Zinc ABC transporter, inner membrane permease protein ZnuB	Zinc ABC transporter, inner membrane permease protein ZnuB

CRON 4.
czcD	* Bifidobacterium adolescentis ATCC 15703 Site: position = -60 score = 5.89065 sequence = TATTGAGAAGCGGTTTCAATA Gene: BAD_1116: Cobalt-zinc-cadmium resistance protein CzcD	* Bifidobacterium angulatum DSM 20098 Site: position = -42 score = 5.50982 sequence = TACTGAGAAGCAGTCTCATCT Gene: BIFANG_00989: Cobalt-zinc-cadmium resistance protein CzcD	Bifidobacterium animalis subsp. lactis AD011 Gene: BLA_0791: Cobalt-zinc-cadmium resistance protein CzcD	* Bifidobacterium bifidum NCIMB 41171 Site: position = -57 score = 4.72026 sequence = TATTGAAAATGATTGTAGGAA Gene: BbifN4_010100002259: Cobalt-zinc-cadmium resistance protein CzcD	* Bifidobacterium breve DSM 20213 Site: position = -211 score = 5.47246 sequence = AAATGAGAAGCGGTTTCAACA Gene: BIFBRE_01806: Cobalt-zinc-cadmium resistance protein CzcD	* Bifidobacterium dentium Bd1 Site: position = -128 score = 5.65097 sequence = TATTGAGAAGCGATTTCAGTT Gene: BDP_1557: Cobalt-zinc-cadmium resistance protein CzcD	Bifidobacterium gallicum DSM 20093 Gene: BIFGAL_00304: Cobalt-zinc-cadmium resistance protein CzcD	* Bifidobacterium longum NCC2705 Site: position = -42 score = 5.37576 sequence = AAATGAGAAGCGGTTTCAACT Gene: BL1309: Cobalt-zinc-cadmium resistance protein CzcD	* Bifidobacterium longum subsp. infantis ATCC 15697 Site: position = -42 score = 5.65494 sequence = TATTGAGAAGCGGTTTCAACT Gene: Blon_0841: Cobalt-zinc-cadmium resistance protein CzcD	Gardnerella vaginalis 409-05 Gene: HMPREF0424_0669: Cobalt-zinc-cadmium resistance protein CzcD	Cobalt-zinc-cadmium resistance protein CzcD

CRON 5.
znuC	* Bifidobacterium adolescentis ATCC 15703 Site: position = -65 score = 6.59119 sequence = TATTGAGAATGATTGTCAACA Gene: BAD_0671: Zinc ABC transporter, ATP-binding protein ZnuC	* Bifidobacterium angulatum DSM 20098 Site: position = -27 score = 5.93778 sequence = TATTGAAAACGATTGTCAGCA Gene: BIFANG_01134: Zinc ABC transporter, ATP-binding protein ZnuC	* Bifidobacterium animalis subsp. lactis AD011 Site: position = -100 score = 6.73021 sequence = TATTGAGAATGATTGTCAATA Gene: BLA_1501: Zinc ABC transporter, ATP-binding protein ZnuC	* Bifidobacterium bifidum NCIMB 41171 Site: position = -101 score = 5.77441 sequence = TAATGAGAATGATTGTCATAG Gene: BbifN4_010100003314: Zinc ABC transporter, ATP-binding protein ZnuC	* Bifidobacterium breve DSM 20213 Site: position = -43 score = 6.28976 sequence = TATTGAGAACGATTGTCAGCA Gene: BIFBRE_01043: Zinc ABC transporter, ATP-binding protein ZnuC	* Bifidobacterium dentium Bd1 Site: position = -68 score = 6.43906 sequence = TATTGAGAATGGTTGTCAACA Gene: BDP_0897: Zinc ABC transporter, ATP-binding protein ZnuC	* Bifidobacterium gallicum DSM 20093 Site: position = -103 score = 6.04165 sequence = AAATGGGAATGATTGTCAATA Gene: BIFGAL_00364: Zinc ABC transporter, ATP-binding protein ZnuC	Bifidobacterium longum NCC2705 Gene: BL0995: Zinc ABC transporter, ATP-binding protein ZnuC	* Bifidobacterium longum subsp. infantis ATCC 15697 Site: position = -43 score = 6.28976 sequence = TATTGAGAACGATTGTCAGCA Gene: Blon_1757: Zinc ABC transporter, ATP-binding protein ZnuC	Gardnerella vaginalis 409-05	Zinc ABC transporter, ATP-binding protein ZnuC
znuB	Bifidobacterium adolescentis ATCC 15703 Gene: BAD_0670: Zinc ABC transporter, inner membrane permease protein ZnuB	Bifidobacterium angulatum DSM 20098 Gene: BIFANG_01133: Zinc ABC transporter, inner membrane permease protein ZnuB	Bifidobacterium animalis subsp. lactis AD011 Gene: BLA_1502: Zinc ABC transporter, inner membrane permease protein ZnuB	Bifidobacterium bifidum NCIMB 41171 Gene: BbifN4_010100003309: Zinc ABC transporter, inner membrane permease protein ZnuB	Bifidobacterium breve DSM 20213 Gene: BIFBRE_01042: Zinc ABC transporter, inner membrane permease protein ZnuB	Bifidobacterium dentium Bd1 Gene: BDP_0896: Zinc ABC transporter, inner membrane permease protein ZnuB	Bifidobacterium gallicum DSM 20093 Gene: BIFGAL_00365: Zinc ABC transporter, inner membrane permease protein ZnuB	Bifidobacterium longum NCC2705 Gene: BL0996: Zinc ABC transporter, inner membrane permease protein ZnuB	Bifidobacterium longum subsp. infantis ATCC 15697 Gene: Blon_1758: Zinc ABC transporter, inner membrane permease protein ZnuB	Gardnerella vaginalis 409-05	Zinc ABC transporter, inner membrane permease protein ZnuB

CRON 6.
znuA	* Bifidobacterium adolescentis ATCC 15703 Site: position = -27 score = 6.10909 sequence = TGTTGAGAATCATTCTCAGTT Gene: BAD_0282: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Bifidobacterium angulatum DSM 20098 Site: position = -150 score = 5.7589 sequence = TACTGATAACGGTTCTCATTT Gene: BIFANG_00140: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Bifidobacterium animalis subsp. lactis AD011 Site: position = -100 score = 6.15275 sequence = TATTGAGAACGATTCTCACTT Gene: BLA_0332: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Bifidobacterium bifidum NCIMB 41171 Site: position = -89 score = 6.04699 sequence = TAATGATAATAAATCTCAATA Gene: BbifN4_010100006401: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Bifidobacterium breve DSM 20213 Site: position = -287 score = 6.1442 sequence = AAATGATAATAATTCTCAATA Gene: BIFBRE_00824: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Bifidobacterium dentium Bd1 Site: position = -67 score = 6.06726 sequence = TGTTGAGAATCATTCTCATTT Gene: BDP_0392: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Bifidobacterium gallicum DSM 20093 Site: position = -285 score = 5.92483 sequence = TACTGATAATCATTATCAATT Gene: BIFGAL_00753: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Bifidobacterium longum NCC2705 Site: position = -112 score = 6.1442 sequence = AAATGATAATAATTCTCAATA Gene: BL1126: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Bifidobacterium longum subsp. infantis ATCC 15697 Site: position = -113 score = 6.1442 sequence = AAATGATAATAATTCTCAATA Gene: Blon_1963: Zinc ABC transporter, periplasmic-binding protein ZnuA	Gardnerella vaginalis 409-05	Zinc ABC transporter, periplasmic-binding protein ZnuA

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog Zur - Bifidobacteriaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --