Regulog CblR - Thermococcales

Properties
Regulator type:	Transcription factor
Regulator family:
Regulation mode:
Biological process:	Cobalamin biosynthesis
Effector:
Phylum:	Euryarchaeota
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 82 sites [see more]

Member of regulog collections

By taxonomy - Thermococcales
By trascription factor - CblR
By pathway - Cobalamin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Pyrococcus abyssi GE5	16	10
Pyrococcus furiosus DSM 3638	22	10
Pyrococcus horikoshii OT3	18	10
Thermococcus gammatolerans EJ3	26	14
Thermococcus kodakaraensis KOD1	20	11
Thermococcus onnurineus NA1	22	13
Thermococcus sibiricus MM 739	8	6

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes								Function

CRON 1.
meaB	* Pyrococcus abyssi GE5 Site: position = -26 score = 5.54965 sequence = TTGGATAAATTCTCCAG Gene: PAB2398: GTP-dependent assembly of methylmalonyl-CoA mutase	* Pyrococcus furiosus DSM 3638 Site: position = -26 score = 5.54965 sequence = TTGGATAATTTCTCCAG Gene: PF1947: GTP-dependent assembly of methylmalonyl-CoA mutase	* Pyrococcus horikoshii OT3 Site: position = -26 score = 5.54965 sequence = TTGGATAATTTCTCCAG Gene: PH0274: GTP-dependent assembly of methylmalonyl-CoA mutase	* Thermococcus gammatolerans EJ3 Site: position = -25 score = 5.54965 sequence = TTGGATAATTTCTCCAG Gene: TGAM_1930: GTP-dependent assembly of methylmalonyl-CoA mutase	* Thermococcus kodakaraensis KOD1 Site: position = -27 score = 4.98773 sequence = CTGGATGATTAATCCAG Gene: TK0329: GTP-dependent assembly of methylmalonyl-CoA mutase	* Thermococcus onnurineus NA1 Site: position = -26 score = 5.41445 sequence = TTGGATAATTTGTCCGA Gene: TON_1075: GTP-dependent assembly of methylmalonyl-CoA mutase	* Thermococcus sibiricus MM 739 Site: position = -17 score = 5.75444 sequence = TTGGATAATTAATCCAA Gene: TSIB_1401: GTP-dependent assembly of methylmalonyl-CoA mutase	GTP-dependent assembly of methylmalonyl-CoA mutase
mceE	Pyrococcus abyssi GE5 Gene: PAB2438: Methylmalonyl-CoA epimerase (EC 5.1.99.1)	Pyrococcus furiosus DSM 3638 Gene: PF1948: Methylmalonyl-CoA epimerase (EC 5.1.99.1)	Pyrococcus horikoshii OT3 Gene: PH0272: Methylmalonyl-CoA epimerase (EC 5.1.99.1)	Thermococcus gammatolerans EJ3 Gene: TGAM_1929: Methylmalonyl-CoA epimerase (EC 5.1.99.1)	Thermococcus kodakaraensis KOD1 Gene: TK0330: Methylmalonyl-CoA epimerase (EC 5.1.99.1)	Thermococcus onnurineus NA1 Gene: TON_1074: Methylmalonyl-CoA epimerase (EC 5.1.99.1)	Thermococcus sibiricus MM 739 Gene: TSIB_1400: Methylmalonyl-CoA epimerase (EC 5.1.99.1)	Methylmalonyl-CoA epimerase (EC 5.1.99.1)

CRON 2.
mutB_C	* Pyrococcus abyssi GE5 Site: position = -72 score = 5.05534 sequence = TGGGATAATATATCCAT Gene: PAB2187: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Pyrococcus furiosus DSM 3638 Site: position = -78 score = 5.14126 sequence = TAGGATAAAATGTCCAA Gene: PF1946: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Pyrococcus horikoshii OT3 Site: position = -61 score = 4.94022 sequence = CGGGATAAAATATCCAT Gene: PH0275: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Thermococcus gammatolerans EJ3 Site: position = -77 score = 5.09035 sequence = GTGGACAAAAAATCCAA Gene: TGAM_1931: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Thermococcus kodakaraensis KOD1 Site: position = -87 score = 5.52924 sequence = CTGGACAAAATATCCAA Gene: TK0328: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Thermococcus onnurineus NA1 Site: position = -87 score = 5.52924 sequence = CTGGACAAAATATCCAA Gene: TON_1076: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Thermococcus sibiricus MM 739 Site: position = -87 score = 5.65647 sequence = ATGGATAAAATATCCAA Gene: TSIB_1402: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)	B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)

CRON 3.
mutB_N	* Pyrococcus abyssi GE5 Site: position = -81 score = 5.32731 sequence = TTAGATAATTTATCCAA Gene: PAB1800: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal	* Pyrococcus furiosus DSM 3638 Site: position = -83 score = 4.64086 sequence = GTGGATAAAAAAGCCAG Gene: PF1477: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal	* Pyrococcus horikoshii OT3 Site: position = -77 score = 4.87505 sequence = TTGAACAAAATGTCCAA Gene: PH1306: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal	* Thermococcus gammatolerans EJ3 Site: position = -87 score = 5.34267 sequence = CTGGACTTTTTATCCAA Gene: TGAM_1685: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal	* Thermococcus kodakaraensis KOD1 Site: position = -89 score = 5.6419 sequence = ATGGACAATTTATCCAA Gene: TK1149: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal	* Thermococcus onnurineus NA1 Site: position = -88 score = 5.52924 sequence = CTGGACAATATATCCAA Gene: TON_1110: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal	* Thermococcus sibiricus MM 739 Site: position = -88 score = 5.52924 sequence = CTGGATAAAATGTCCAA Gene: TSIB_0812: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal	Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal

CRON 4.
TON_1664	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638	Pyrococcus horikoshii OT3	Thermococcus gammatolerans EJ3	Thermococcus kodakaraensis KOD1	* Thermococcus onnurineus NA1 Site: position = -29 score = 5.06159 sequence = GCGGATAAAATATCCAA Gene: TON_1664: anion transporter	Thermococcus sibiricus MM 739	anion transporter
sucD	* Pyrococcus abyssi GE5 Site: position = -62 score = 5.6134 sequence = TTGGATATTTAATCCAA Gene: PAB1230: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)	* Pyrococcus furiosus DSM 3638 Site: position = -71 score = 5.6134 sequence = TTGGATATTTAATCCAA Gene: PF0233: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)	* Pyrococcus horikoshii OT3 Site: position = -63 score = 5.45779 sequence = TTGGATATTTAGTCCAA Gene: PH1928: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)	* Thermococcus gammatolerans EJ3 Site: position = -67 score = 5.51298 sequence = ATGGATAAAATATCCAT Gene: TGAM_0218: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)	* Thermococcus kodakaraensis KOD1 Site: position = -69 score = 5.18538 sequence = ATGGATATAAAATCCAT Gene: TK1880: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)	Thermococcus onnurineus NA1 Gene: TON_1665: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)	Thermococcus sibiricus MM 739 Gene: TSIB_1965: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)	Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)

CRON 5.
cobS	Pyrococcus abyssi GE5 Gene: PAB2320: Cobalamin-5-phosphate synthase	2 Pyrococcus furiosus DSM 3638* Gene: PF0837: Cobalamin-5-phosphate synthase Site: position = -25 score = 5.14933 sequence = TTGGATTAATTAGCCAG Gene: PF0836: Cobalamin-5-phosphate synthase	Pyrococcus horikoshii OT3 Gene: PH0373: Cobalamin-5-phosphate synthase	Thermococcus gammatolerans EJ3 Gene: TGAM_0538: Cobalamin-5-phosphate synthase	Thermococcus kodakaraensis KOD1 Gene: TK0857: Cobalamin-5-phosphate synthase	Thermococcus onnurineus NA1 Gene: TON_0684: Cobalamin-5-phosphate synthase	Thermococcus sibiricus MM 739	Cobalamin-5-phosphate synthase
PAB7298	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638 Gene: PF0838: Function Code: 16.1 Conserved Hypothetical	Pyrococcus horikoshii OT3	Thermococcus gammatolerans EJ3	Thermococcus kodakaraensis KOD1	Thermococcus onnurineus NA1	Thermococcus sibiricus MM 739	hypothetical protein
PF0839	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638 Gene: PF0839: Function Code: 16.1 Conserved Hypothetical	Pyrococcus horikoshii OT3	Thermococcus gammatolerans EJ3	Thermococcus kodakaraensis KOD1	Thermococcus onnurineus NA1	Thermococcus sibiricus MM 739	Function Code: 16.1 Conserved Hypothetical
cobY	Pyrococcus abyssi GE5 Gene: PAB2323: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	2 Pyrococcus furiosus DSM 3638 Gene: PF0841: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62) Gene: PF0840: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Pyrococcus horikoshii OT3 Gene: PH0372: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Thermococcus gammatolerans EJ3	Thermococcus kodakaraensis KOD1 Gene: TK0856: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Thermococcus onnurineus NA1 Gene: TON_0686: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Thermococcus sibiricus MM 739 Gene: TSIB_2027: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)	Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
PF0841.1n	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638 Gene: PF0841.1n: hypothetical protein	Pyrococcus horikoshii OT3	Thermococcus gammatolerans EJ3	Thermococcus kodakaraensis KOD1	Thermococcus onnurineus NA1	Thermococcus sibiricus MM 739	hypothetical protein
PAB3017	Pyrococcus abyssi GE5 Gene: PAB3017: hypothetical protein	Pyrococcus furiosus DSM 3638	Pyrococcus horikoshii OT3 Gene: PH0373.1n: hypothetical protein	Thermococcus gammatolerans EJ3	* Thermococcus kodakaraensis KOD1 Site: position = -42 score = 5.05018 sequence = ATGGATAAAAACTCCAT Gene: TK0862: hypothetical protein	* Thermococcus onnurineus NA1 Site: position = -41 score = 4.6169 sequence = AAGGATAAAACATCCAA Gene: TON_0681: hypothetical protein	Thermococcus sibiricus MM 739	hypothetical protein
PH0375	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638	* Pyrococcus horikoshii OT3 Site: position = -41 score = 5.05018 sequence = ATGGATAAAAACTCCAT Gene: PH0375: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71	Thermococcus gammatolerans EJ3	Thermococcus kodakaraensis KOD1 Gene: TK0861: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71	Thermococcus onnurineus NA1 Gene: TON_0682: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71	Thermococcus sibiricus MM 739	conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
TGAM_0541	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638	Pyrococcus horikoshii OT3	Thermococcus gammatolerans EJ3 Gene: TGAM_0541: hypothetical protein	Thermococcus kodakaraensis KOD1 Gene: TK0860: hypothetical protein	Thermococcus onnurineus NA1	Thermococcus sibiricus MM 739	hypothetical protein
TGAM_0540	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638	Pyrococcus horikoshii OT3	Thermococcus gammatolerans EJ3 Gene: TGAM_0540: hypothetical protein	Thermococcus kodakaraensis KOD1 Gene: TK0859: hypothetical protein	Thermococcus onnurineus NA1	Thermococcus sibiricus MM 739	hypothetical protein
cobZ	* Pyrococcus abyssi GE5 Site: position = -48 score = 4.98725 sequence = TTGGATAAAAGCTCCAA Gene: PAB2319: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)	Pyrococcus furiosus DSM 3638 Gene: PF0294: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)	Pyrococcus horikoshii OT3 Gene: PH0374: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)	Thermococcus gammatolerans EJ3 Gene: TGAM_0539: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)	Thermococcus kodakaraensis KOD1 Gene: TK0858: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)	Thermococcus onnurineus NA1 Gene: TON_0683: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)	Thermococcus sibiricus MM 739	Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
PAB0415	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638 Gene: PF0295: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71	Pyrococcus horikoshii OT3	* Thermococcus gammatolerans EJ3 Site: position = -41 score = 4.84376 sequence = ATGGATAAAAGCTCCAA Gene: TGAM_0542: N-type ATP pyrophosphatase, putative	Thermococcus kodakaraensis KOD1	Thermococcus onnurineus NA1	Thermococcus sibiricus MM 739	conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
cbiB	* Pyrococcus abyssi GE5 Site: position = -31 score = 4.98725 sequence = TTGGAGCTTTTATCCAA Gene: PAB0025: Adenosylcobinamide-phosphate synthase	* Pyrococcus furiosus DSM 3638 Site: position = -19 score = 5.06159 sequence = GCGGATAAAATATCCAA Gene: PF0296: Adenosylcobinamide-phosphate synthase	* Pyrococcus horikoshii OT3 Site: position = -23 score = 5.05018 sequence = ATGGAGTTTTTATCCAT Gene: PH0376: Adenosylcobinamide-phosphate synthase	Thermococcus gammatolerans EJ3 Gene: TGAM_0544: Adenosylcobinamide-phosphate synthase	Thermococcus kodakaraensis KOD1	Thermococcus onnurineus NA1 Gene: TON_0679: Adenosylcobinamide-phosphate synthase	Thermococcus sibiricus MM 739	Adenosylcobinamide-phosphate synthase
cobD	Pyrococcus abyssi GE5 Gene: PAB0026: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Pyrococcus furiosus DSM 3638 Gene: PF0293: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Pyrococcus horikoshii OT3 Gene: PH0377: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Thermococcus gammatolerans EJ3 Gene: TGAM_0545: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Thermococcus kodakaraensis KOD1	Thermococcus onnurineus NA1 Gene: TON_0678: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Thermococcus sibiricus MM 739	L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
TGAM_0543	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638	Pyrococcus horikoshii OT3	* Thermococcus gammatolerans EJ3 Site: position = 0 score = 4.84376 sequence = TTGGAGCTTTTATCCAT Gene: TGAM_0543: Uracil-DNA glycosylase superfamily protein	Thermococcus kodakaraensis KOD1	* Thermococcus onnurineus NA1 Site: position = -18 score = 4.6169 sequence = TTGGATGTTTTATCCTT Gene: TON_0680: Uracil-DNA glycosylase superfamily protein	Thermococcus sibiricus MM 739	Uracil-DNA glycosylase superfamily protein
btuF	* Pyrococcus abyssi GE5 Site: position = -30 score = 4.83212 sequence = CTGGACGAATAATCCAG Gene: PAB0349: Vitamin B12 ABC transporter, B12-binding component BtuF	* Pyrococcus furiosus DSM 3638 Site: position = -29 score = 5.21796 sequence = TTGGATGATTAATCCAA Site: position = -72 score = 5.6134 sequence = TTGGATTTTTTATCCAA Gene: PF1774: Vitamin B12 ABC transporter, B12-binding component BtuF	* Pyrococcus horikoshii OT3 Site: position = -74 score = 5.3143 sequence = TTGGACTTTTTATCCAT Site: position = -29 score = 5.06235 sequence = TTGGACGAATAATCCAA Gene: PH1659: Vitamin B12 ABC transporter, B12-binding component BtuF	* Thermococcus gammatolerans EJ3 Site: position = -17 score = 5.36859 sequence = CTGGACAATTAATCCAG Site: position = -65 score = 4.96684 sequence = TTGGACGTTATATCCAA Gene: TGAM_0480: Vitamin B12 ABC transporter, B12-binding component BtuF	* Thermococcus kodakaraensis KOD1 Site: position = -26 score = 4.99766 sequence = CCGGACAAATAATCCAG Site: position = -73 score = 4.61789 sequence = TTGGCCGTTTTATCCAA Gene: TK0865: Vitamin B12 ABC transporter, B12-binding component BtuF	* Thermococcus onnurineus NA1 Site: position = -73 score = 5.01088 sequence = ATGGCCAAAATATCCAA Site: position = -26 score = 5.34022 sequence = ATGGACAAATAATCCAG Gene: TON_0546: Vitamin B12 ABC transporter, B12-binding component BtuF	* Thermococcus sibiricus MM 739 Site: position = 56 score = 5.64436 sequence = TTGGACAAAATATCCAA Gene: TSIB_1577: Vitamin B12 ABC transporter, B12-binding component BtuF	Vitamin B12 ABC transporter, B12-binding component BtuF

CRON 6.
nrdD	* Pyrococcus abyssi GE5 Site: position = 58 score = 5.47236 sequence = TTGGATTTAATATCCAA Gene: PAB2337: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Pyrococcus furiosus DSM 3638 Site: position = -99 score = 5.16649 sequence = ATGGATATTTTAGCCAA Site: position = -29 score = 5.64436 sequence = TTGGACAAAATATCCAA Gene: PF1971: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Pyrococcus horikoshii OT3 Site: position = -28 score = 5.64436 sequence = TTGGACAAAATATCCAA Site: position = -99 score = 5.79996 sequence = TTGGATATTTTATCCAA Gene: PH0021: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Thermococcus gammatolerans EJ3 Site: position = -17 score = 5.82589 sequence = TTGGATAATTTATCCAG Gene: TGAM_0161: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Thermococcus kodakaraensis KOD1 Site: position = -35 score = 5.82589 sequence = TTGGATAAATTATCCAG Site: position = -127 score = 5.941 sequence = TTGGATAATTTATCCAA Gene: TK2298: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Thermococcus onnurineus NA1 Site: position = -27 score = 5.82589 sequence = TTGGATAAATTATCCAG Gene: TON_1870: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Thermococcus sibiricus MM 739	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG	Pyrococcus abyssi GE5 Gene: PAB2338: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Pyrococcus furiosus DSM 3638 Gene: PF1972: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Pyrococcus horikoshii OT3 Gene: PH0020: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Thermococcus gammatolerans EJ3 Gene: TGAM_0160: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Thermococcus kodakaraensis KOD1 Gene: TK2299: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Thermococcus onnurineus NA1 Gene: TON_1871: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Thermococcus sibiricus MM 739	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)

CRON 7.
cobT	* Pyrococcus abyssi GE5 Site: position = -27 score = 4.98725 sequence = TTGGATAAAACCTCCAA Gene: PAB2326: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	* Pyrococcus furiosus DSM 3638 Site: position = -27 score = 5.32641 sequence = ATGGATAAAAAATCCAT Gene: PF0303: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	* Pyrococcus horikoshii OT3 Site: position = -19 score = 5.04355 sequence = TTGGACAAAATTTCCAT Gene: PH0034: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	* Thermococcus gammatolerans EJ3 Site: position = -27 score = 4.85461 sequence = CTGGATAAAAACTCCAC Gene: TGAM_0534: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	* Thermococcus kodakaraensis KOD1 Site: position = -27 score = 4.97523 sequence = CTGGATAAAAAGTCCAC Gene: TK0853: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	* Thermococcus onnurineus NA1 Site: position = -27 score = 4.84376 sequence = TTGGATAAAACCTCCAT Gene: TON_0688: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Thermococcus sibiricus MM 739	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)

CRON 8.
btuC	* Pyrococcus abyssi GE5 Site: position = -19 score = 4.99803 sequence = ATGGAATATTTGTCCAA Gene: PAB1535: Vitamin B12 ABC transporter, permease component BtuC	* Pyrococcus furiosus DSM 3638 Site: position = -19 score = 4.65153 sequence = TTGGCATATTTGTCCAA Gene: PF0503: Vitamin B12 ABC transporter, permease component BtuC	* Pyrococcus horikoshii OT3 Site: position = -20 score = 4.4397 sequence = GTGGCATATTTATCCAA Gene: PH0790: Vitamin B12 ABC transporter, permease component BtuC	* Thermococcus gammatolerans EJ3 Site: position = -20 score = 4.95132 sequence = CTGGACAAAAACTCCAG Gene: TGAM_2054: Vitamin B12 ABC transporter, permease component BtuC	* Thermococcus kodakaraensis KOD1 Site: position = -20 score = 5.07195 sequence = CTGGACAAAAAGTCCAG Gene: TK2209: Vitamin B12 ABC transporter, permease component BtuC	* Thermococcus onnurineus NA1 Site: position = -21 score = 4.86394 sequence = GTGGACAAATAATCCAC Gene: TON_1424: Vitamin B12 ABC transporter, permease component BtuC	* Thermococcus sibiricus MM 739 Site: position = -24 score = 5.63932 sequence = TTGGATAAATAATCCAG Gene: TSIB_1460: Vitamin B12 ABC transporter, permease component BtuC	Vitamin B12 ABC transporter, permease component BtuC
btuD	Pyrococcus abyssi GE5 Gene: PAB1536: Vitamin B12 ABC transporter, ATPase component BtuD	Pyrococcus furiosus DSM 3638 Gene: PF0502: Vitamin B12 ABC transporter, ATPase component BtuD	Pyrococcus horikoshii OT3 Gene: PH0791: Vitamin B12 ABC transporter, ATPase component BtuD	Thermococcus gammatolerans EJ3 Gene: TGAM_2053: Vitamin B12 ABC transporter, ATPase component BtuD	Thermococcus kodakaraensis KOD1 Gene: TK2208: Vitamin B12 ABC transporter, ATPase component BtuD	Thermococcus onnurineus NA1 Gene: TON_1425: Vitamin B12 ABC transporter, ATPase component BtuD	Thermococcus sibiricus MM 739 Gene: TSIB_1459: Vitamin B12 ABC transporter, ATPase component BtuD	Vitamin B12 ABC transporter, ATPase component BtuD

CRON 9.
nrdJ	Pyrococcus abyssi GE5 Gene: PAB1057: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Pyrococcus furiosus DSM 3638 Gene: PF0440: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Pyrococcus horikoshii OT3 Gene: PH0363: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	* Thermococcus gammatolerans EJ3 Site: position = -187 score = 5.27096 sequence = ATGGACAAATTATCCGA Gene: TGAM_0422: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	* Thermococcus kodakaraensis KOD1 Site: position = -198 score = 4.99031 sequence = ATGGATAATTCGTCCAG Gene: TK1736: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	* Thermococcus onnurineus NA1 Site: position = -186 score = 5.41445 sequence = TTGGATAATTTGTCCGA Gene: TON_1816: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	* Thermococcus sibiricus MM 739 Site: position = -185 score = 5.42903 sequence = TTGGATAAAATATCCGA Gene: TSIB_1142: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing

CRON 10.
btuR	Pyrococcus abyssi GE5 Gene: PAB2289: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Pyrococcus furiosus DSM 3638 Gene: PF2038: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Pyrococcus horikoshii OT3 Gene: PH0075: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	* Thermococcus gammatolerans EJ3 Site: position = -27 score = 4.9848 sequence = TTGGAGGATTTATCCAT Gene: TGAM_0096: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	* Thermococcus kodakaraensis KOD1 Site: position = -28 score = 5.11197 sequence = CTGGAGATTATGTCCAA Gene: TK2130: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	* Thermococcus onnurineus NA1 Site: position = -31 score = 4.41015 sequence = CTGGCGATTATATCCAC Gene: TON_1529: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Thermococcus sibiricus MM 739 Gene: TSIB_0909: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Cob(I)alamin adenosyltransferase (EC 2.5.1.17)

CRON 11.
cbiP	Pyrococcus abyssi GE5	Pyrococcus furiosus DSM 3638 Gene: PF0301: Cobyrinic acid ac-diamide synthase	Pyrococcus horikoshii OT3	* Thermococcus gammatolerans EJ3 Site: position = -44 score = 4.85461 sequence = GTGGAGTTTTTATCCAG Gene: TGAM_0535: Cobyrinic acid ac-diamide synthase	Thermococcus kodakaraensis KOD1 Gene: TK0854: Cobyrinic acid ac-diamide synthase	* Thermococcus onnurineus NA1 Site: position = -58 score = 4.84376 sequence = ATGGAGGTTTTATCCAA Gene: TON_0687: Cobyrinic acid ac-diamide synthase	Thermococcus sibiricus MM 739	Cobyrinic acid ac-diamide synthase

CRON 12.
mmdA	Pyrococcus abyssi GE5 Gene: PAB1769: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)	Pyrococcus furiosus DSM 3638 Gene: PF0671: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)	Pyrococcus horikoshii OT3 Gene: PH1287: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)	* Thermococcus gammatolerans EJ3 Site: position = -98 score = 5.05051 sequence = GTGGACAAATTATCCAC Gene: TGAM_2026: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)	Thermococcus kodakaraensis KOD1 Gene: TK1622: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)	Thermococcus onnurineus NA1 Gene: TON_0041: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)	Thermococcus sibiricus MM 739 Gene: TSIB_1534: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)	Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
mmdD	Pyrococcus abyssi GE5 Gene: PAB1770: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)	Pyrococcus furiosus DSM 3638 Gene: PF0672: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)	Pyrococcus horikoshii OT3 Gene: PH1285: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)	Thermococcus gammatolerans EJ3 Gene: TGAM_2027: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)	Thermococcus kodakaraensis KOD1 Gene: TK1623: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)	Thermococcus onnurineus NA1 Gene: TON_0040: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)	Thermococcus sibiricus MM 739 Gene: TSIB_1535: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)	Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
mmdC	Pyrococcus abyssi GE5 Gene: PAB1771: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase	Pyrococcus furiosus DSM 3638 Gene: PF0673: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase	Pyrococcus horikoshii OT3 Gene: PH1284: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase	Thermococcus gammatolerans EJ3 Gene: TGAM_2028: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase	Thermococcus kodakaraensis KOD1 Gene: TK1624: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase	Thermococcus onnurineus NA1 Gene: TON_0039: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase	Thermococcus sibiricus MM 739 Gene: TSIB_1536: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase	Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
mmdB	Pyrococcus abyssi GE5 Gene: PAB1772: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)	Pyrococcus furiosus DSM 3638 Gene: PF0674: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)	Pyrococcus horikoshii OT3 Gene: PH1283: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)	Thermococcus gammatolerans EJ3 Gene: TGAM_2029: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)	Thermococcus kodakaraensis KOD1 Gene: TK1625: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)	Thermococcus onnurineus NA1 Gene: TON_0038: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)	Thermococcus sibiricus MM 739 Gene: TSIB_1537: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)	Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CblR - Thermococcales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --