Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of CblR in Thermococcus gammatolerans EJ3

Properties
Regulator type: Transcription factor
TF locus tag:
Regulator family:
Regulation mode:
Biological process: Cobalamin biosynthesis
Effector:
Regulog: CblR - Thermococcales
Statistics of regulated genes:
- Genes 26
- Operons 14
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 82 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function
Position: -77
Score: 5.1
Sequence: GTGGACAAAAAATCCAA
Locus tag: TGAM_1931
Name: mutB_C
Funciton: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
TGAM_1931
mutB_C
B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
Position: -27
Score: 5
Sequence: TTGGAGGATTTATCCAT
Locus tag: TGAM_0096
Name: btuR
Funciton: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
TGAM_0096
btuR
Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
Position: -98
Score: 5.1
Sequence: GTGGACAAATTATCCAC
Locus tag: TGAM_2026
Name: mmdA
Funciton: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
Locus tag: TGAM_2027
Name: mmdD
Funciton: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
Locus tag: TGAM_2028
Name: mmdC
Funciton: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
Locus tag: TGAM_2029
Name: mmdB
Funciton: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
TGAM_2026
mmdA
Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
TGAM_2027
mmdD
Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
TGAM_2028
mmdC
Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
TGAM_2029
mmdB
Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
Position: -44
Score: 4.9
Sequence: GTGGAGTTTTTATCCAG
Locus tag: TGAM_0535
Name: cbiP
Funciton: Cobyrinic acid ac-diamide synthase
TGAM_0535
cbiP
Cobyrinic acid ac-diamide synthase
Position: -65
Score: 5
Sequence: TTGGACGTTATATCCAA
Position: -17
Score: 5.4
Sequence: CTGGACAATTAATCCAG
Locus tag: TGAM_0480
Name: btuF
Funciton: Vitamin B12 ABC transporter, B12-binding component BtuF
TGAM_0480
btuF
Vitamin B12 ABC transporter, B12-binding component BtuF
Position: -41
Score: 4.8
Sequence: ATGGATAAAAGCTCCAA
Locus tag: TGAM_0542
Name: null
Funciton: N-type ATP pyrophosphatase, putative
Locus tag: TGAM_0541
Name: null
Funciton: hypothetical protein
Locus tag: TGAM_0540
Name: null
Funciton: hypothetical protein
Locus tag: TGAM_0539
Name: cobZ
Funciton: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
Locus tag: TGAM_0538
Name: cobS
Funciton: Cobalamin-5-phosphate synthase
TGAM_0542
N-type ATP pyrophosphatase, putative
TGAM_0541
hypothetical protein
TGAM_0540
hypothetical protein
TGAM_0539
cobZ
Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
TGAM_0538
cobS
Cobalamin-5-phosphate synthase
Position: 0
Score: 4.8
Sequence: TTGGAGCTTTTATCCAT
Locus tag: TGAM_0543
Name: TGAM_0543
Funciton: Uracil-DNA glycosylase superfamily protein
Locus tag: TGAM_0544
Name: cbiB
Funciton: Adenosylcobinamide-phosphate synthase
Locus tag: TGAM_0545
Name: cobD
Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
TGAM_0543
TGAM_0543
Uracil-DNA glycosylase superfamily protein
TGAM_0544
cbiB
Adenosylcobinamide-phosphate synthase
TGAM_0545
cobD
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
Position: -17
Score: 5.8
Sequence: TTGGATAATTTATCCAG
Locus tag: TGAM_0161
Name: nrdD
Funciton: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
Locus tag: TGAM_0160
Name: nrdG
Funciton: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
TGAM_0161
nrdD
Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
TGAM_0160
nrdG
Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
Position: -187
Score: 5.3
Sequence: ATGGACAAATTATCCGA
Locus tag: TGAM_0422
Name: nrdJ
Funciton: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
TGAM_0422
nrdJ
Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
Position: -20
Score: 5
Sequence: CTGGACAAAAACTCCAG
Locus tag: TGAM_2054
Name: btuC
Funciton: Vitamin B12 ABC transporter, permease component BtuC
Locus tag: TGAM_2053
Name: btuD
Funciton: Vitamin B12 ABC transporter, ATPase component BtuD
TGAM_2054
btuC
Vitamin B12 ABC transporter, permease component BtuC
TGAM_2053
btuD
Vitamin B12 ABC transporter, ATPase component BtuD
Position: -27
Score: 4.9
Sequence: CTGGATAAAAACTCCAC
Locus tag: TGAM_0534
Name: cobT
Funciton: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
TGAM_0534
cobT
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
Position: -25
Score: 5.5
Sequence: TTGGATAATTTCTCCAG
Locus tag: TGAM_1930
Name: meaB
Funciton: GTP-dependent assembly of methylmalonyl-CoA mutase
Locus tag: TGAM_1929
Name: mceE
Funciton: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
TGAM_1930
meaB
GTP-dependent assembly of methylmalonyl-CoA mutase
TGAM_1929
mceE
Methylmalonyl-CoA epimerase (EC 5.1.99.1)
Position: -87
Score: 5.3
Sequence: CTGGACTTTTTATCCAA
Locus tag: TGAM_1685
Name: mutB_N
Funciton: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
TGAM_1685
mutB_N
Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
Position: -67
Score: 5.5
Sequence: ATGGATAAAATATCCAT
Locus tag: TGAM_0218
Name: sucD
Funciton: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
TGAM_0218
sucD
Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
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