Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of CblR in Thermococcus gammatolerans EJ3

Properties
Regulator type: Transcription factor
TF locus tag:
Regulator family:
Regulation mode:
Biological process: Cobalamin biosynthesis
Effector:
Regulog: CblR - Thermococcales
Statistics of regulated genes:
- Genes 26
- Operons 14
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 82 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -77
Score: 5.1
Sequence: GTGGACAAAAAATCCAA
Locus tag: TGAM_1931
Name: mutB_C
Funciton: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
mutB_C
B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)

Position: -27
Score: 5
Sequence: TTGGAGGATTTATCCAT
Locus tag: TGAM_0096
Name: btuR
Funciton: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
btuR
Cob(I)alamin adenosyltransferase (EC 2.5.1.17)

Position: -98
Score: 5.1
Sequence: GTGGACAAATTATCCAC
Locus tag: TGAM_2026
Name: mmdA
Funciton: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
Locus tag: TGAM_2027
Name: mmdD
Funciton: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
Locus tag: TGAM_2028
Name: mmdC
Funciton: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
Locus tag: TGAM_2029
Name: mmdB
Funciton: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
mmdA
Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
mmdD
Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
mmdC
Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
mmdB
Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)

Position: -44
Score: 4.9
Sequence: GTGGAGTTTTTATCCAG
Locus tag: TGAM_0535
Name: cbiP
Funciton: Cobyrinic acid ac-diamide synthase
cbiP
Cobyrinic acid ac-diamide synthase

Position: -65
Score: 5
Sequence: TTGGACGTTATATCCAA
Position: -17
Score: 5.4
Sequence: CTGGACAATTAATCCAG
Locus tag: TGAM_0480
Name: btuF
Funciton: Vitamin B12 ABC transporter, B12-binding component BtuF
btuF
Vitamin B12 ABC transporter, B12-binding component BtuF

Position: -41
Score: 4.8
Sequence: ATGGATAAAAGCTCCAA
Locus tag: TGAM_0542
Name: null
Funciton: N-type ATP pyrophosphatase, putative
Locus tag: TGAM_0541
Name: null
Funciton: hypothetical protein
Locus tag: TGAM_0540
Name: null
Funciton: hypothetical protein
Locus tag: TGAM_0539
Name: cobZ
Funciton: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
Locus tag: TGAM_0538
Name: cobS
Funciton: Cobalamin-5-phosphate synthase
N-type ATP pyrophosphatase, putative
hypothetical protein
hypothetical protein
cobZ
Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
cobS
Cobalamin-5-phosphate synthase

Position: 0
Score: 4.8
Sequence: TTGGAGCTTTTATCCAT
Locus tag: TGAM_0543
Name: TGAM_0543
Funciton: Uracil-DNA glycosylase superfamily protein
Locus tag: TGAM_0544
Name: cbiB
Funciton: Adenosylcobinamide-phosphate synthase
Locus tag: TGAM_0545
Name: cobD
Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
TGAM_0543
Uracil-DNA glycosylase superfamily protein
cbiB
Adenosylcobinamide-phosphate synthase
cobD
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)

Position: -17
Score: 5.8
Sequence: TTGGATAATTTATCCAG
Locus tag: TGAM_0161
Name: nrdD
Funciton: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
Locus tag: TGAM_0160
Name: nrdG
Funciton: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
nrdD
Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG
Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)

Position: -187
Score: 5.3
Sequence: ATGGACAAATTATCCGA
Locus tag: TGAM_0422
Name: nrdJ
Funciton: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
nrdJ
Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing

Position: -20
Score: 5
Sequence: CTGGACAAAAACTCCAG
Locus tag: TGAM_2054
Name: btuC
Funciton: Vitamin B12 ABC transporter, permease component BtuC
Locus tag: TGAM_2053
Name: btuD
Funciton: Vitamin B12 ABC transporter, ATPase component BtuD
btuC
Vitamin B12 ABC transporter, permease component BtuC
btuD
Vitamin B12 ABC transporter, ATPase component BtuD

Position: -27
Score: 4.9
Sequence: CTGGATAAAAACTCCAC
Locus tag: TGAM_0534
Name: cobT
Funciton: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
cobT
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)

Position: -25
Score: 5.5
Sequence: TTGGATAATTTCTCCAG
Locus tag: TGAM_1930
Name: meaB
Funciton: GTP-dependent assembly of methylmalonyl-CoA mutase
Locus tag: TGAM_1929
Name: mceE
Funciton: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
meaB
GTP-dependent assembly of methylmalonyl-CoA mutase
mceE
Methylmalonyl-CoA epimerase (EC 5.1.99.1)

Position: -87
Score: 5.3
Sequence: CTGGACTTTTTATCCAA
Locus tag: TGAM_1685
Name: mutB_N
Funciton: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
mutB_N
Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal

Position: -67
Score: 5.5
Sequence: ATGGATAAAATATCCAT
Locus tag: TGAM_0218
Name: sucD
Funciton: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
sucD
Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
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