Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of CblR in Pyrococcus furiosus DSM 3638

Properties
Regulator type: Transcription factor
TF locus tag:
Regulator family:
Regulation mode:
Biological process: Cobalamin biosynthesis
Effector:
Regulog: CblR - Thermococcales
Statistics of regulated genes:
- Genes 22
- Operons 10
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 82 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -26
Score: 5.5
Sequence: TTGGATAATTTCTCCAG
Locus tag: PF1947
Name: meaB
Funciton: GTP-dependent assembly of methylmalonyl-CoA mutase
Locus tag: PF1948
Name: mceE
Funciton: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
meaB
GTP-dependent assembly of methylmalonyl-CoA mutase
mceE
Methylmalonyl-CoA epimerase (EC 5.1.99.1)

Position: -83
Score: 4.6
Sequence: GTGGATAAAAAAGCCAG
Locus tag: PF1477
Name: mutB_N
Funciton: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
mutB_N
Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal

Position: -25
Score: 5.1
Sequence: TTGGATTAATTAGCCAG
Locus tag: PF0836
Name: cobS
Funciton: Cobalamin-5-phosphate synthase
Locus tag: PF0837
Name: cobS
Funciton: Cobalamin-5-phosphate synthase
Locus tag: PF0838
Name: null
Funciton: Function Code: 16.1 Conserved Hypothetical
Locus tag: PF0839
Name: null
Funciton: Function Code: 16.1 Conserved Hypothetical
Locus tag: PF0840
Name: cobY
Funciton: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
Locus tag: PF0841
Name: cobY
Funciton: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
Locus tag: PF0841.1n
Name: null
Funciton: hypothetical protein
cobS
Cobalamin-5-phosphate synthase
cobS
Cobalamin-5-phosphate synthase
Function Code: 16.1 Conserved Hypothetical
Function Code: 16.1 Conserved Hypothetical
cobY
Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
cobY
Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
hypothetical protein

Position: -71
Score: 5.6
Sequence: TTGGATATTTAATCCAA
Locus tag: PF0233
Name: sucD
Funciton: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
sucD
Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)

Position: -27
Score: 5.3
Sequence: ATGGATAAAAAATCCAT
Locus tag: PF0303
Name: cobT
Funciton: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
cobT
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)

Position: -99
Score: 5.2
Sequence: ATGGATATTTTAGCCAA
Position: -29
Score: 5.6
Sequence: TTGGACAAAATATCCAA
Locus tag: PF1971
Name: nrdD
Funciton: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
Locus tag: PF1972
Name: nrdG
Funciton: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
nrdD
Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG
Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)

Position: -19
Score: 4.7
Sequence: TTGGCATATTTGTCCAA
Locus tag: PF0503
Name: btuC
Funciton: Vitamin B12 ABC transporter, permease component BtuC
Locus tag: PF0502
Name: btuD
Funciton: Vitamin B12 ABC transporter, ATPase component BtuD
btuC
Vitamin B12 ABC transporter, permease component BtuC
btuD
Vitamin B12 ABC transporter, ATPase component BtuD

Position: -78
Score: 5.1
Sequence: TAGGATAAAATGTCCAA
Locus tag: PF1946
Name: mutB_C
Funciton: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
mutB_C
B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)

Position: -19
Score: 5.1
Sequence: GCGGATAAAATATCCAA
Locus tag: PF0296
Name: cbiB
Funciton: Adenosylcobinamide-phosphate synthase
Locus tag: PF0295
Name: null
Funciton: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
Locus tag: PF0294
Name: cobZ
Funciton: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
Locus tag: PF0293
Name: cobD
Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
cbiB
Adenosylcobinamide-phosphate synthase
conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
cobZ
Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
cobD
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)

Position: -72
Score: 5.6
Sequence: TTGGATTTTTTATCCAA
Position: -29
Score: 5.2
Sequence: TTGGATGATTAATCCAA
Locus tag: PF1774
Name: btuF
Funciton: Vitamin B12 ABC transporter, B12-binding component BtuF
btuF
Vitamin B12 ABC transporter, B12-binding component BtuF
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Regulated Genes [ Tab delimited format ] DOWNLOAD
Regulatory Sites [ FASTA format ] DOWNLOAD