Regulon of CblR in Thermococcus onnurineus NA1

Properties
Regulator type:	Transcription factor
TF locus tag:
Regulator family:
Regulation mode:
Biological process:	Cobalamin biosynthesis
Effector:
Regulog:	CblR - Thermococcales
Statistics of regulated genes:
- Genes	22
- Operons	13
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 82 sites [see more]

Member of regulog collections

By taxonomy - Thermococcales
By trascription factor - CblR
By pathway - Cobalamin biosynthesis

Regulated operons
	Locus Tag	Name	Function
Position: -31 Score: 4.4 Sequence: CTGGCGATTATATCCAC Locus tag: TON_1529 Name: btuR Funciton: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
	TON_1529	btuR	Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
Position: -58 Score: 4.8 Sequence: ATGGAGGTTTTATCCAA Locus tag: TON_0687 Name: cbiP Funciton: Cobyrinic acid ac-diamide synthase
	TON_0687	cbiP	Cobyrinic acid ac-diamide synthase
Position: -87 Score: 5.5 Sequence: CTGGACAAAATATCCAA Locus tag: TON_1076 Name: mutB_C Funciton: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
	TON_1076	mutB_C	B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
Position: -41 Score: 4.6 Sequence: AAGGATAAAACATCCAA Locus tag: TON_0681 Name: null Funciton: hypothetical protein Locus tag: TON_0682 Name: null Funciton: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71 Locus tag: TON_0683 Name: cobZ Funciton: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73) Locus tag: TON_0684 Name: cobS Funciton: Cobalamin-5-phosphate synthase
	TON_0681		hypothetical protein
	TON_0682		conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
	TON_0683	cobZ	Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
	TON_0684	cobS	Cobalamin-5-phosphate synthase
Position: -21 Score: 4.9 Sequence: GTGGACAAATAATCCAC Locus tag: TON_1424 Name: btuC Funciton: Vitamin B12 ABC transporter, permease component BtuC Locus tag: TON_1425 Name: btuD Funciton: Vitamin B12 ABC transporter, ATPase component BtuD
	TON_1424	btuC	Vitamin B12 ABC transporter, permease component BtuC
	TON_1425	btuD	Vitamin B12 ABC transporter, ATPase component BtuD
Position: -186 Score: 5.4 Sequence: TTGGATAATTTGTCCGA Locus tag: TON_1816 Name: nrdJ Funciton: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
	TON_1816	nrdJ	Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
Position: -27 Score: 5.8 Sequence: TTGGATAAATTATCCAG Locus tag: TON_1870 Name: nrdD Funciton: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Locus tag: TON_1871 Name: nrdG Funciton: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
	TON_1870	nrdD	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
	TON_1871	nrdG	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
Position: -27 Score: 4.8 Sequence: TTGGATAAAACCTCCAT Locus tag: TON_0688 Name: cobT Funciton: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
	TON_0688	cobT	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
Position: -26 Score: 5.4 Sequence: TTGGATAATTTGTCCGA Locus tag: TON_1075 Name: meaB Funciton: GTP-dependent assembly of methylmalonyl-CoA mutase Locus tag: TON_1074 Name: mceE Funciton: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
	TON_1075	meaB	GTP-dependent assembly of methylmalonyl-CoA mutase
	TON_1074	mceE	Methylmalonyl-CoA epimerase (EC 5.1.99.1)
Position: -73 Score: 5 Sequence: ATGGCCAAAATATCCAA Position: -26 Score: 5.3 Sequence: ATGGACAAATAATCCAG Locus tag: TON_0546 Name: btuF Funciton: Vitamin B12 ABC transporter, B12-binding component BtuF
	TON_0546	btuF	Vitamin B12 ABC transporter, B12-binding component BtuF
Position: -18 Score: 4.6 Sequence: TTGGATGTTTTATCCTT Locus tag: TON_0680 Name: TGAM_0543 Funciton: Uracil-DNA glycosylase superfamily protein Locus tag: TON_0679 Name: cbiB Funciton: Adenosylcobinamide-phosphate synthase Locus tag: TON_0678 Name: cobD Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
	TON_0680	TGAM_0543	Uracil-DNA glycosylase superfamily protein
	TON_0679	cbiB	Adenosylcobinamide-phosphate synthase
	TON_0678	cobD	L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
Position: -88 Score: 5.5 Sequence: CTGGACAATATATCCAA Locus tag: TON_1110 Name: mutB_N Funciton: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
	TON_1110	mutB_N	Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
Position: -29 Score: 5.1 Sequence: GCGGATAAAATATCCAA Locus tag: TON_1664 Name: null Funciton: anion transporter Locus tag: TON_1665 Name: sucD Funciton: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
	TON_1664		anion transporter
	TON_1665	sucD	Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of CblR in Thermococcus onnurineus NA1

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --