Regulon of CblR in Pyrococcus horikoshii OT3

Properties
Regulator type:	Transcription factor
TF locus tag:
Regulator family:
Regulation mode:
Biological process:	Cobalamin biosynthesis
Effector:
Regulog:	CblR - Thermococcales
Statistics of regulated genes:
- Genes	18
- Operons	10
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 82 sites [see more]

Member of regulog collections

By taxonomy - Thermococcales
By trascription factor - CblR
By pathway - Cobalamin biosynthesis

Regulated operons
	Locus Tag	Name	Function
Position: -99 Score: 5.8 Sequence: TTGGATATTTTATCCAA Position: -28 Score: 5.6 Sequence: TTGGACAAAATATCCAA Locus tag: PH0021 Name: nrdD Funciton: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Locus tag: PH0020 Name: nrdG Funciton: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
	PH0021	nrdD	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
	PH0020	nrdG	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
Position: -41 Score: 5.1 Sequence: ATGGATAAAAACTCCAT Locus tag: PH0375 Name: null Funciton: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71 Locus tag: PH0374 Name: cobZ Funciton: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73) Locus tag: PH0373.1n Name: null Funciton: hypothetical protein Locus tag: PH0373 Name: cobS Funciton: Cobalamin-5-phosphate synthase Locus tag: PH0372 Name: cobY Funciton: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
	PH0375		conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
	PH0374	cobZ	Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
	PH0373.1n		hypothetical protein
	PH0373	cobS	Cobalamin-5-phosphate synthase
	PH0372	cobY	Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
Position: -23 Score: 5.1 Sequence: ATGGAGTTTTTATCCAT Locus tag: PH0376 Name: cbiB Funciton: Adenosylcobinamide-phosphate synthase Locus tag: PH0377 Name: cobD Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
	PH0376	cbiB	Adenosylcobinamide-phosphate synthase
	PH0377	cobD	L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
Position: -26 Score: 5.5 Sequence: TTGGATAATTTCTCCAG Locus tag: PH0274 Name: meaB Funciton: GTP-dependent assembly of methylmalonyl-CoA mutase Locus tag: PH0272 Name: mceE Funciton: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
	PH0274	meaB	GTP-dependent assembly of methylmalonyl-CoA mutase
	PH0272	mceE	Methylmalonyl-CoA epimerase (EC 5.1.99.1)
Position: -19 Score: 5 Sequence: TTGGACAAAATTTCCAT Locus tag: PH0034 Name: cobT Funciton: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
	PH0034	cobT	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
Position: -20 Score: 4.4 Sequence: GTGGCATATTTATCCAA Locus tag: PH0790 Name: btuC Funciton: Vitamin B12 ABC transporter, permease component BtuC Locus tag: PH0791 Name: btuD Funciton: Vitamin B12 ABC transporter, ATPase component BtuD
	PH0790	btuC	Vitamin B12 ABC transporter, permease component BtuC
	PH0791	btuD	Vitamin B12 ABC transporter, ATPase component BtuD
Position: -74 Score: 5.3 Sequence: TTGGACTTTTTATCCAT Position: -29 Score: 5.1 Sequence: TTGGACGAATAATCCAA Locus tag: PH1659 Name: btuF Funciton: Vitamin B12 ABC transporter, B12-binding component BtuF
	PH1659	btuF	Vitamin B12 ABC transporter, B12-binding component BtuF
Position: -77 Score: 4.9 Sequence: TTGAACAAAATGTCCAA Locus tag: PH1306 Name: mutB_N Funciton: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
	PH1306	mutB_N	Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
Position: -61 Score: 4.9 Sequence: CGGGATAAAATATCCAT Locus tag: PH0275 Name: mutB_C Funciton: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
	PH0275	mutB_C	B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
Position: -63 Score: 5.5 Sequence: TTGGATATTTAGTCCAA Locus tag: PH1928 Name: sucD Funciton: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
	PH1928	sucD	Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of CblR in Pyrococcus horikoshii OT3

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --