Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulog MetR - Pseudomonadaceae

Properties
Regulator type: Transcription factor
Regulator family: LysR
Regulation mode: repressor (activator)
Biological process: Methionine biosynthesis
Effector: Homocysteine
Phylum: Proteobacteria/Gamma
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 44 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Pseudomonas aeruginosa PAO1 3 3
Pseudomonas entomophila L48 10 6
Pseudomonas putida KT2440 11 6
Pseudomonas syringae pv. tomato str. DC3000 3 3
Pseudomonas fluorescens Pf-5 6 4
Pseudomonas mendocina ymp 3 3
Pseudomonas stutzeri A1501 3 3
Azotobacter vinelandii AvOP 2 2
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
metE
*
Pseudomonas aeruginosa PAO1

Site:
position = -69
score = 5.3414
sequence = ATTGAGTTTGTCTCATG

Gene: PA1927: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Pseudomonas entomophila L48

Site:
position = -72
score = 4.63937
sequence = TATGAGTTTGTCTCACC

Site:
position = -92
score = 4.79486
sequence = CTTGAGTTCATCTCAAA

Gene: PSEEN4639: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Pseudomonas putida KT2440
*
Pseudomonas syringae pv. tomato str. DC3000

Site:
position = -64
score = 5.49577
sequence = AATGAGTTTGTCTCATG

Gene: PSPTO4179: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Pseudomonas fluorescens Pf-5

Site:
position = -69
score = 4.78913
sequence = AATGAGTTTGTCTCACC

Gene: PFL_2404: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Pseudomonas mendocina ymp

Site:
position = -71
score = 4.88928
sequence = CTTGAGTTTGTCTCACT

Site:
position = -102
score = 3.84182
sequence = CATGAGTAAATCTTTAG

Gene: Pmen_1683: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Pseudomonas stutzeri A1501

Site:
position = -73
score = 4.84051
sequence = CGTGAGTTTGTTTCATT

Gene: PST_2850: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Azotobacter vinelandii AvOP

Site:
position = -66
score = 4.94923
sequence = TCTGAGTTTGTCTCATG

Gene: Avin_13980: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
CRON 2.
metH
*
Pseudomonas aeruginosa PAO1

Site:
position = -258
score = 5.02531
sequence = AATGAGCCAGACTCATT

Site:
position = -95
score = 5.04783
sequence = CTTGAATGAAATTCATG

Gene: PA1843: 5-methyltetrahydrofolate--homocysteine methyltransferase, B12-dependent (EC 2.1.1.13)
*
Pseudomonas entomophila L48

Site:
position = -98
score = 4.84722
sequence = CATGAAGGAAATTCATG

Gene: PSEEN3382: 5-methyltetrahydrofolate--homocysteine methyltransferase, B12-dependent (EC 2.1.1.13)
*
Pseudomonas putida KT2440

Site:
position = -98
score = 4.42872
sequence = CATGAGCAGTTTTCATG

Gene: PP2375: 5-methyltetrahydrofolate--homocysteine methyltransferase, B12-dependent (EC 2.1.1.13)
*
Pseudomonas syringae pv. tomato str. DC3000

Site:
position = -99
score = 4.91633
sequence = CATGAATGATTTTCATG

Gene: PSPTO2732: 5-methyltetrahydrofolate--homocysteine methyltransferase, B12-dependent (EC 2.1.1.13)
*
Pseudomonas fluorescens Pf-5

Site:
position = -96
score = 4.87133
sequence = CATGAGCGATATTCATG

Gene: PFL_3662: 5-methyltetrahydrofolate--homocysteine methyltransferase, B12-dependent (EC 2.1.1.13)
*
Pseudomonas mendocina ymp

Site:
position = -97
score = 5.2022
sequence = CATGAATGAAATTCATG

Gene: Pmen_2159: 5-methyltetrahydrofolate--homocysteine methyltransferase, B12-dependent (EC 2.1.1.13)
*
Pseudomonas stutzeri A1501

Site:
position = -96
score = 4.17972
sequence = CCTGAATAATCTTCATG

Gene: PST_2223: 5-methyltetrahydrofolate--homocysteine methyltransferase, B12-dependent (EC 2.1.1.13)
 
Azotobacter vinelandii AvOP

Gene: Avin_29240: 5-methyltetrahydrofolate--homocysteine methyltransferase, B12-dependent (EC 2.1.1.13)
5-methyltetrahydrofolate--homocysteine methyltransferase, B12-dependent (EC 2.1.1.13)
 
CRON 3.
dsbC
 
Pseudomonas aeruginosa PAO1

Gene: PA3737: Thiol:disulfide interchange protein DsbC
*
Pseudomonas entomophila L48

Site:
position = -158
score = 4.72561
sequence = GATGAATGATATTCATG

Gene: PSEEN4253: Thiol:disulfide interchange protein DsbC
*
Pseudomonas putida KT2440

Site:
position = -119
score = 4.66181
sequence = GATGAATGTTTTTCATG

Gene: PP1469: Thiol:disulfide interchange protein DsbC
 
Pseudomonas syringae pv. tomato str. DC3000

Gene: PSPTO1479: Thiol:disulfide interchange protein DsbC
 
Pseudomonas fluorescens Pf-5

Gene: PFL_1102: Thiol:disulfide interchange protein DsbC
 
Pseudomonas mendocina ymp

Gene: Pmen_3395: Thiol:disulfide interchange protein DsbC
 
Pseudomonas stutzeri A1501

Gene: PST_1196: Thiol:disulfide interchange protein DsbC
 
Azotobacter vinelandii AvOP

Gene: Avin_39500: Thiol:disulfide interchange protein DsbC
Thiol:disulfide interchange protein DsbC
hom
 
Pseudomonas aeruginosa PAO1

Gene: PA3736: Homoserine dehydrogenase (EC 1.1.1.3)
 
Pseudomonas entomophila L48

Gene: PSEEN4252: Homoserine dehydrogenase (EC 1.1.1.3)
 
Pseudomonas putida KT2440

Gene: PP1470: Homoserine dehydrogenase (EC 1.1.1.3)
 
Pseudomonas syringae pv. tomato str. DC3000

Gene: PSPTO1480: Homoserine dehydrogenase (EC 1.1.1.3)
 
Pseudomonas fluorescens Pf-5

Gene: PFL_1103: Homoserine dehydrogenase (EC 1.1.1.3)
 
Pseudomonas mendocina ymp

Gene: Pmen_3394: Homoserine dehydrogenase (EC 1.1.1.3)
 
Pseudomonas stutzeri A1501

Gene: PST_1198: Homoserine dehydrogenase (EC 1.1.1.3)
 
Azotobacter vinelandii AvOP

Gene: Avin_39490: Homoserine dehydrogenase (EC 1.1.1.3)
Homoserine dehydrogenase (EC 1.1.1.3)
thrC
 
Pseudomonas aeruginosa PAO1

Gene: PA3735: Threonine synthase (EC 4.2.3.1)
 
Pseudomonas entomophila L48

Gene: PSEEN4251: Threonine synthase (EC 4.2.3.1)
 2
Pseudomonas putida KT2440

Gene: PP0662: Threonine synthase (EC 4.2.3.1)

Gene: PP1471: Threonine synthase (EC 4.2.3.1)
 
Pseudomonas syringae pv. tomato str. DC3000

Gene: PSPTO1481: Threonine synthase (EC 4.2.3.1)
 2
Pseudomonas fluorescens Pf-5

Gene: PFL_3811: Threonine synthase (EC 4.2.3.1)

Gene: PFL_1104: Threonine synthase (EC 4.2.3.1)
 
Pseudomonas mendocina ymp

Gene: Pmen_3393: Threonine synthase (EC 4.2.3.1)
 
Pseudomonas stutzeri A1501

Gene: PST_1199: Threonine synthase (EC 4.2.3.1)
 
Azotobacter vinelandii AvOP

Gene: Avin_39480: Threonine synthase (EC 4.2.3.1)
Threonine synthase (EC 4.2.3.1)
 
CRON 4.
PF08908
 
Pseudomonas aeruginosa PAO1
*
Pseudomonas entomophila L48

Site:
position = -215
score = 4.52096
sequence = CATGAGTAAAACTAAAT

Site:
position = -184
score = 5.36119
sequence = AATGAGTTTGTCTCATT

Gene: PSEEN2746: Protein of unknown function DUF1852
*
Pseudomonas putida KT2440

Site:
position = -66
score = 4.07584
sequence = CTTCAATATCATTCATG

Site:
position = -76
score = 3.93143
sequence = TGTGAAATAACTTCAAT

Gene: PP2699: Protein of unknown function DUF1852
 
Pseudomonas syringae pv. tomato str. DC3000
*
Pseudomonas fluorescens Pf-5

Site:
position = -190
score = 4.4133
sequence = CATGAATGTGACTAAAG

Site:
position = -169
score = 4.14045
sequence = GGTGAAATCAATTCATT

Gene: PFL_3510: Protein of unknown function DUF1852
 
Pseudomonas mendocina ymp
 
Pseudomonas stutzeri A1501
 
Azotobacter vinelandii AvOP
Protein of unknown function DUF1852
metE2
 
Pseudomonas aeruginosa PAO1
 
Pseudomonas entomophila L48

Gene: PSEEN2747: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
*2
Pseudomonas putida KT2440

Gene: PP2698: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)

Site:
position = -72
score = 5.20682
sequence = AATGAGTTTGTCTCAAT

Site:
position = -92
score = 4.04495
sequence = CTTGGGTTCATCTCAAA

Gene: PP4637: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
Pseudomonas syringae pv. tomato str. DC3000
 
Pseudomonas fluorescens Pf-5

Gene: PFL_3511: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
Pseudomonas mendocina ymp
 
Pseudomonas stutzeri A1501
 
Azotobacter vinelandii AvOP
Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
PF01613
 
Pseudomonas aeruginosa PAO1
 
Pseudomonas entomophila L48

Gene: PSEEN2748: Flavin reductase-like, FMN-binding
 
Pseudomonas putida KT2440

Gene: PP2697: Flavin reductase-like, FMN-binding
 
Pseudomonas syringae pv. tomato str. DC3000
 
Pseudomonas fluorescens Pf-5

Gene: PFL_3512: Flavin reductase-like, FMN-binding
 
Pseudomonas mendocina ymp
 
Pseudomonas stutzeri A1501
 
Azotobacter vinelandii AvOP
Flavin reductase-like, FMN-binding
metR
*
Pseudomonas aeruginosa PAO1

Site:
position = -59
score = 4.93711
sequence = TATGAGACAAACTCAAC

Gene: PA3587: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Pseudomonas entomophila L48

Site:
position = -57
score = 4.8446
sequence = CATGAGGGAAACTCAAC

Site:
position = 17
score = 3.83443
sequence = CCTGAAAACCCTTCATG

Gene: PSEEN1184: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*2
Pseudomonas putida KT2440

Site:
position = 17
score = 3.83443
sequence = CCTGAAAACCCTTCATG

Site:
position = -57
score = 5.25573
sequence = CATGAGAGAAACTCAAT

Gene: PP1063: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family

Gene: PP2696: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Pseudomonas syringae pv. tomato str. DC3000

Site:
position = -59
score = 5.49577
sequence = CATGAGACAAACTCATT

Gene: PSPTO4180: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Pseudomonas fluorescens Pf-5

Site:
position = -26
score = 3.79305
sequence = CACAAAATTTACTCATG

Site:
position = -57
score = 5.22145
sequence = CATGAGACAAACTCAAC

Gene: PFL_4890: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Pseudomonas mendocina ymp

Site:
position = -115
score = 4.88928
sequence = AGTGAGACAAACTCAAG

Site:
position = -84
score = 3.84182
sequence = CTAAAGATTTACTCATG

Gene: Pmen_1682: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Pseudomonas stutzeri A1501

Site:
position = -89
score = 4.38781
sequence = GATGAGCCTCGCTCATC

Gene: PST_2852: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Azotobacter vinelandii AvOP

Site:
position = -58
score = 4.94923
sequence = CATGAGACAAACTCAGA

Gene: Avin_13970: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
 
CRON 5.
metF2
 
Pseudomonas aeruginosa PAO1
*
Pseudomonas entomophila L48

Site:
position = -104
score = 3.85
sequence = AACGAAAATGTCTCAAC

Site:
position = -236
score = 4.63937
sequence = GGTGAGACAAACTCATA

Site:
position = -216
score = 4.79486
sequence = TTTGAGATGAACTCAAG

Gene: PSEEN4641: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
*
Pseudomonas putida KT2440

Site:
position = -172
score = 5.20682
sequence = ATTGAGACAAACTCATT

Site:
position = -152
score = 4.04495
sequence = TTTGAGATGAACCCAAG

Gene: PP4638: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Pseudomonas syringae pv. tomato str. DC3000
 
Pseudomonas fluorescens Pf-5
 
Pseudomonas mendocina ymp
 
Pseudomonas stutzeri A1501
 
Azotobacter vinelandii AvOP
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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