Regulog MetJ - Vibrionales

Properties
Regulator type:	Transcription factor
Regulator family:	MetJ
Regulation mode:	repressor
Biological process:	Methionine metabolism; Methionine biosynthesis
Effector:	S-adenosylmethionine
Phylum:	Proteobacteria/Gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 218 sites [see more]

Member of regulog collections

By taxonomy - Vibrionales
By trascription factor - MetJ
By TF family - MetJ
By effector - S-adenosylmethionine
By pathway - Methionine metabolism
By pathway - Methionine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Vibrio cholerae O1 biovar eltor str. N16961	14	11
Vibrio vulnificus CMCP6	17	12
Vibrio harveyi ATCC BAA-1116	18	13
Vibrio parahaemolyticus RIMD 2210633	18	13
Vibrio shilonii AK1	15	12
Vibrio splendidus LGP32	16	11
Vibrio fischeri ES114	16	11
Vibrio salmonicida LFI1238	15	10
Vibrio angustum S14	18	12
Photobacterium profundum SS9	16	11

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes											Function

CRON 1.
metK	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -131 score = 6.83359 sequence = AGCCGTCT-(0)-AGATGTAG Site: position = -123 score = 5.79378 sequence = AGATGTAG-(0)-AAACGCCT Gene: VC0472: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Vibrio vulnificus CMCP6 Site: position = -98 score = 7.21097 sequence = AGACGTCT-(0)-AGATGTAG Gene: VV1_1536: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Vibrio harveyi ATCC BAA-1116 Site: position = -97 score = 7.21097 sequence = AGACGTCT-(0)-AGATGTAG Gene: VIBHAR_03568: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -97 score = 7.21097 sequence = AGACGTCT-(0)-AGATGTAG Gene: VP2606: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Vibrio shilonii AK1 Site: position = -92 score = 7.21097 sequence = AGACGTCT-(0)-AGATGTAG Gene: VSAK1_07864: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Vibrio splendidus LGP32 Site: position = -129 score = 6.83359 sequence = AGCCGTCT-(0)-AGATGTAG Gene: VS_2655: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Vibrio fischeri ES114 Site: position = -68 score = 6.46241 sequence = AAACGTAT-(0)-AGACTTAT Site: position = -100 score = 6.61782 sequence = AGACGTCT-(0)-AGATGGAA Gene: VF_0439: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Vibrio salmonicida LFI1238 Site: position = -101 score = 5.74843 sequence = GGCCGTCT-(0)-AGATGGAA Site: position = -69 score = 6.46241 sequence = AAACGTAT-(0)-AGACTTAT Gene: VSAL_I0552: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Vibrio angustum S14 Site: position = -107 score = 6.74581 sequence = AGACGTCT-(0)-AGACGGAA Gene: VAS14_20221: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Photobacterium profundum SS9 Site: position = -126 score = 6.55798 sequence = AGCCGTCT-(0)-AGACGGAG Gene: PBPRA3134: S-adenosylmethionine synthetase (EC 2.5.1.6)	S-adenosylmethionine synthetase (EC 2.5.1.6)

CRON 2.
metR	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -85 score = 7.40921 sequence = AGCCATCT-(0)-AGATGTTT Gene: VC1706: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Vibrio vulnificus CMCP6 Site: position = -197 score = 7.11408 sequence = AGATGTCT-(0)-GGATGGCT Site: position = -82 score = 7.9863 sequence = AGACGTCT-(0)-AGATGTTT Gene: VV1_2218: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Vibrio harveyi ATCC BAA-1116 Site: position = -203 score = 7.11408 sequence = AGATGTCT-(0)-GGATGGCT Site: position = -82 score = 8.11428 sequence = AGACGTCT-(0)-AGACGTTT Gene: VIBHAR_02773: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -259 score = 8.11428 sequence = AGACGTCT-(0)-AGACGTTT Gene: VP1976: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Vibrio shilonii AK1 Site: position = -178 score = 6.61389 sequence = AGCAGTCT-(0)-GGATGGCT Site: position = -73 score = 7.49428 sequence = GGACGTCT-(0)-AGATGTTT Gene: VSAK1_00947: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Vibrio splendidus LGP32 Site: position = -89 score = 7.42256 sequence = GGACATCT-(0)-AGACGTTT Site: position = -210 score = 6.68391 sequence = AGGCGTCT-(0)-GGATGGCT Gene: VS_1144: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Vibrio fischeri ES114 Site: position = -84 score = 7.60892 sequence = AGCCGTCT-(0)-AGATGTTT Site: position = -205 score = 6.63723 sequence = AGCCGTTT-(0)-GGATGGCT Gene: VF_1722: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Vibrio salmonicida LFI1238 Site: position = -205 score = 6.63723 sequence = AGCCGTTT-(0)-GGATGGCT Site: position = -84 score = 7.60892 sequence = AGCCGTCT-(0)-AGATGTTT Gene: VSAL_I0860: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Vibrio angustum S14 Site: position = -87 score = 6.20313 sequence = AGACGTTT-(0)-AGCCATCT Site: position = -79 score = 7.40921 sequence = AGCCATCT-(0)-AGATGTTT Gene: VAS14_04738: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Photobacterium profundum SS9 Site: position = -232 score = 6.18058 sequence = AGCGGTAT-(0)-GGATGGCT Site: position = -82 score = 7.9863 sequence = AGACGTCT-(0)-AGATGTTT Gene: PBPRA1378: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family

CRON 3.
csd	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -34 score = 5.47411 sequence = GGGCATAT-(0)-GGATGTTT Gene: VC1184: Cysteine desulfurase (EC 2.8.1.7)	* Vibrio vulnificus CMCP6 Site: position = -43 score = 5.09717 sequence = GGTCATAT-(0)-GGATGTGT Gene: VV1_2808: Cysteine desulfurase (EC 2.8.1.7)	* Vibrio harveyi ATCC BAA-1116 Site: position = -217 score = 5.3487 sequence = ATCCATCA-(0)-AGATGGTT Gene: VIBHAR_02028: Cysteine desulfurase (EC 2.8.1.7)	Vibrio parahaemolyticus RIMD 2210633 Gene: VP1253: Cysteine desulfurase (EC 2.8.1.7)	* Vibrio shilonii AK1 Site: position = -247 score = 5.00389 sequence = GTACATCA-(0)-AGATGGAT Gene: VSAK1_06235: Cysteine desulfurase (EC 2.8.1.7)	Vibrio splendidus LGP32 Gene: VS_1192: Cysteine desulfurase (EC 2.8.1.7)	* Vibrio fischeri ES114 Site: position = -43 score = 5.69707 sequence = GGGCATAT-(0)-GGACGTTT Gene: VF_A0768: Cysteine desulfurase (EC 2.8.1.7)	* Vibrio salmonicida LFI1238 Site: position = -112 score = 6.25112 sequence = GGACATAT-(0)-GGATGTTT Gene: VSAL_II0879: Cysteine desulfurase (EC 2.8.1.7)	* Vibrio angustum S14 Site: position = -217 score = 5.96561 sequence = ATACATCA-(0)-AGATGGCT Gene: VAS14_13649: Cysteine desulfurase (EC 2.8.1.7)	Photobacterium profundum SS9 Gene: PBPRB1853: Cysteine desulfurase (EC 2.8.1.7)	Cysteine desulfurase (EC 2.8.1.7)

CRON 4.
btuB	Vibrio cholerae O1 biovar eltor str. N16961	* Vibrio vulnificus CMCP6 Site: position = -222 score = 6.82975 sequence = GGAAGTAT-(0)-AGATGGCT Gene: VV1_1173: TonB-dependent outer membrane transporter for vitamin B12	* Vibrio harveyi ATCC BAA-1116 Site: position = -231 score = 6.89284 sequence = AGCAATCT-(0)-AGATGGCT Gene: VIBHAR_00261: TonB-dependent outer membrane transporter for vitamin B12	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -231 score = 6.89284 sequence = AGCAATCT-(0)-AGATGGCT Gene: VP2938: TonB-dependent outer membrane transporter for vitamin B12	* Vibrio shilonii AK1 Site: position = -321 score = 4.84841 sequence = ATATGGCT-(0)-GGATATCT Gene: VSAK1_13281: TonB-dependent outer membrane transporter for vitamin B12	* Vibrio splendidus LGP32 Site: position = -215 score = 6.95255 sequence = GGATGTAT-(0)-AGATGGCT Gene: VS_2998: TonB-dependent outer membrane transporter for vitamin B12	Vibrio fischeri ES114	Vibrio salmonicida LFI1238	Vibrio angustum S14	Photobacterium profundum SS9 Gene: PBPRA3464: TonB-dependent outer membrane transporter for vitamin B12	TonB-dependent outer membrane transporter for vitamin B12

CRON 5.
metH	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -66 score = 7.8467 sequence = AGACGTCT-(0)-AGATTTCT Gene: VC0390: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Vibrio vulnificus CMCP6 Site: position = -67 score = 7.32611 sequence = AGACGTCT-(0)-AGACTCCT Gene: VV1_1423: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Vibrio harveyi ATCC BAA-1116 Site: position = -66 score = 7.32611 sequence = AGACGTCT-(0)-AGACTCCT Gene: VIBHAR_03712: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -66 score = 7.32611 sequence = AGACGTCT-(0)-AGACTCCT Gene: VP2717: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Vibrio shilonii AK1 Site: position = -73 score = 6.92388 sequence = AGATTTTT-(0)-AGACGTCT Site: position = -65 score = 7.8467 sequence = AGACGTCT-(0)-AGATTTCT Gene: VSAK1_04630: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Vibrio splendidus LGP32 Site: position = -66 score = 7.32611 sequence = AGACGTCT-(0)-AGACTCCT Gene: VS_0315: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Vibrio fischeri ES114 Site: position = -69 score = 7.8467 sequence = AGACGTCT-(0)-AGATTTCT Gene: VF_0337: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Vibrio salmonicida LFI1238 Site: position = -68 score = 7.8467 sequence = AGACGTCT-(0)-AGATTTCT Gene: VSAL_I0442: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Vibrio angustum S14 Site: position = -12 score = 5.17489 sequence = GGATGTAG-(0)-TGACGTGT Gene: VAS14_19426: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Photobacterium profundum SS9 Site: position = -77 score = 6.68465 sequence = AGGTATTT-(0)-AGACGTCT Site: position = -69 score = 7.23711 sequence = AGACGTCT-(0)-AGATTTCC Gene: PBPRA3294: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)

CRON 6.
metQ2	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6	Vibrio harveyi ATCC BAA-1116	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -36 score = 7.47529 sequence = AGCCGTAT-(0)-GGACGTCT Gene: VP0379: Methionine ABC transporter substrate-binding protein	Vibrio shilonii AK1	Vibrio splendidus LGP32	Vibrio fischeri ES114	Vibrio salmonicida LFI1238	Vibrio angustum S14	Photobacterium profundum SS9	Methionine ABC transporter substrate-binding protein

CRON 7.
metA	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -30 score = 6.09088 sequence = ATAAGTCT-(0)-GGATGTTT Site: position = -22 score = 6.56808 sequence = GGATGTTT-(0)-AGACGTCC Gene: VC1611: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Vibrio vulnificus CMCP6 Site: position = -43 score = 7.97616 sequence = AGATGTAT-(0)-AGACGTCT Site: position = -51 score = 5.56801 sequence = ATAGGTTT-(0)-AGATGTAT Gene: VV1_2772: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Vibrio harveyi ATCC BAA-1116 Site: position = -44 score = 7.97616 sequence = AGATGTAT-(0)-AGACGTCT Gene: VIBHAR_02491: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -45 score = 7.85335 sequence = AGAAGTAT-(0)-AGACGTCT Gene: VP1751: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Vibrio shilonii AK1 Site: position = -40 score = 5.93524 sequence = AGACGTCC-(0)-AGATGACC Site: position = -48 score = 7.36657 sequence = AGATGTAT-(0)-AGACGTCC Gene: VSAK1_06879: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Vibrio splendidus LGP32 Site: position = -33 score = 6.56259 sequence = AGACGTCT-(0)-ACATATCT Site: position = -41 score = 7.97616 sequence = AGATGTAT-(0)-AGACGTCT Gene: VS_1677: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Vibrio fischeri ES114 Site: position = -40 score = 7.2264 sequence = AGAAGTAT-(0)-AGACGTAT Gene: VF_2063: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Vibrio salmonicida LFI1238 Site: position = -45 score = 6.96548 sequence = AGACGTAT-(0)-AGAATGCT Site: position = -53 score = 6.44107 sequence = AGGAGTAT-(0)-AGACGTAT Gene: VSAL_I2499: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Vibrio angustum S14 Site: position = -39 score = 6.1592 sequence = AGACGGCT-(0)-AAACATCT Site: position = -47 score = 6.65126 sequence = GGAAGTTT-(0)-AGACGGCT Gene: VAS14_19416: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Photobacterium profundum SS9 Site: position = -45 score = 7.92461 sequence = AGATATCT-(0)-AGACGTCT Site: position = -37 score = 7.10576 sequence = AGACGTCT-(0)-AAACATCT Gene: PBPRA0369: Homoserine O-succinyltransferase (EC 2.3.1.46)	Homoserine O-succinyltransferase (EC 2.3.1.46)

CRON 8.
metJ	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -108 score = 6.02571 sequence = AGACGTCA-(0)-ACACTTCT Site: position = -100 score = 6.9173 sequence = ACACTTCT-(0)-AGACGTCT Site: position = -92 score = 7.34652 sequence = AGACGTCT-(0)-ACATGTCT Gene: VC2682: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Vibrio vulnificus CMCP6 Site: position = -108 score = 6.02571 sequence = AGACGTCA-(0)-ACACTTCT Site: position = -100 score = 6.9173 sequence = ACACTTCT-(0)-AGACGTCT Site: position = -92 score = 7.72544 sequence = AGACGTCT-(0)-ATATGTCT Gene: VV1_1362: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Vibrio harveyi ATCC BAA-1116 Site: position = -110 score = 6.02571 sequence = AGACGTCA-(0)-ACACTTCT Site: position = -102 score = 6.9173 sequence = ACACTTCT-(0)-AGACGTCT Site: position = -94 score = 7.72544 sequence = AGACGTCT-(0)-ATATGTCT Gene: VIBHAR_00050: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -92 score = 7.72544 sequence = AGACGTCT-(0)-ATATGTCT Site: position = -108 score = 6.02571 sequence = AGACGTCA-(0)-ACACTTCT Site: position = -100 score = 6.9173 sequence = ACACTTCT-(0)-AGACGTCT Gene: VP2766: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Vibrio shilonii AK1 Site: position = -111 score = 6.02571 sequence = AGACGTCA-(0)-ACACTTCT Site: position = -103 score = 6.9173 sequence = ACACTTCT-(0)-AGACGTCT Site: position = -95 score = 7.72544 sequence = AGACGTCT-(0)-ATATGTCT Gene: VSAK1_09478: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Vibrio splendidus LGP32 Site: position = -107 score = 5.41612 sequence = AGACGTCA-(0)-ACACTTCC Site: position = -91 score = 7.23343 sequence = GGACGTCT-(0)-ATATGTCT Gene: VS_2895: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Vibrio fischeri ES114 Site: position = -108 score = 6.02571 sequence = AGACGTCA-(0)-ACACTTCT Site: position = -100 score = 6.9173 sequence = ACACTTCT-(0)-AGACGTCT Site: position = -92 score = 7.72544 sequence = AGACGTCT-(0)-ATATGTCT Gene: VF_2268: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Vibrio salmonicida LFI1238 Site: position = -109 score = 6.40463 sequence = AGACGTCA-(0)-ATACTTCT Site: position = -101 score = 6.79489 sequence = ATACTTCT-(0)-AGACGTCT Site: position = -93 score = 6.94152 sequence = AGACGTCT-(0)-ATATATCT Gene: VSAL_I2746: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Vibrio angustum S14 Site: position = -215 score = 7.23343 sequence = GGACGTCT-(0)-ATATGTCT Site: position = -223 score = 6.98474 sequence = ACACATCT-(0)-GGACGTCT Site: position = -231 score = 5.74658 sequence = AGACGTCA-(0)-ACACATCT Gene: VAS14_21447: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Photobacterium profundum SS9 Site: position = -106 score = 5.41612 sequence = AGACGTCA-(0)-ACACTTCC Site: position = -90 score = 7.72544 sequence = AGACGTCT-(0)-ATATGTCT Gene: PBPRA0260: S-adenosylmethionine-responsive transcriptional repressor MetJ	S-adenosylmethionine-responsive transcriptional repressor MetJ

CRON 9.
mtsA	Vibrio cholerae O1 biovar eltor str. N16961	* Vibrio vulnificus CMCP6 Site: position = -181 score = 5.64371 sequence = AGACATCC-(0)-AGACAGAT Gene: VV21534: Substrate-specific component MtsA of methionine-regulated ECF transporter	* Vibrio harveyi ATCC BAA-1116 Site: position = -244 score = 5.26633 sequence = AGCCATCC-(0)-AGACAGAT Gene: VIBHAR_05109: Substrate-specific component MtsA of methionine-regulated ECF transporter	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -252 score = 5.26633 sequence = AGCCATCC-(0)-AGACAGAT Gene: VPA1481: Substrate-specific component MtsA of methionine-regulated ECF transporter	Vibrio shilonii AK1	* Vibrio splendidus LGP32 Site: position = -177 score = 4.69651 sequence = AGACCACT-(0)-AAACGGTC Gene: VS_II0189: Substrate-specific component MtsA of methionine-regulated ECF transporter	* Vibrio fischeri ES114 Site: position = -96 score = 6.64405 sequence = AGCCGTCT-(0)-AGATGTAA Site: position = -104 score = 6.35665 sequence = AAACATAT-(0)-AGCCGTCT Gene: VF_1566: Substrate-specific component MtsA of methionine-regulated ECF transporter	* Vibrio salmonicida LFI1238 Site: position = -92 score = 6.64405 sequence = AGCCGTCT-(0)-AGATGTAA Gene: VSAL_I1988: Substrate-specific component MtsA of methionine-regulated ECF transporter	* Vibrio angustum S14 Site: position = -303 score = 7.02143 sequence = AGACGTCT-(0)-AGATGTAA Gene: VAS14_04448: Substrate-specific component MtsA of methionine-regulated ECF transporter	* Photobacterium profundum SS9 Site: position = -239 score = 6.61782 sequence = AGACGTCT-(0)-AGATGGAA Gene: PBPRA2239: Substrate-specific component MtsA of methionine-regulated ECF transporter	Substrate-specific component MtsA of methionine-regulated ECF transporter
mtsB	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6 Gene: VV21533: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_05108: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Vibrio parahaemolyticus RIMD 2210633 Gene: VPA1482: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Vibrio shilonii AK1	Vibrio splendidus LGP32 Gene: VS_II0188: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Vibrio fischeri ES114 Gene: VF_1565: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Vibrio salmonicida LFI1238 Gene: VSAL_I1989: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Vibrio angustum S14 Gene: VAS14_04453: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Photobacterium profundum SS9 Gene: PBPRA2240: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
mtsC	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6 Gene: VV21532: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_05107: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Vibrio parahaemolyticus RIMD 2210633 Gene: VPA1483: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Vibrio shilonii AK1	Vibrio splendidus LGP32 Gene: VS_II0187: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Vibrio fischeri ES114 Gene: VF_1564: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Vibrio salmonicida LFI1238 Gene: VSAL_I1990: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Vibrio angustum S14 Gene: VAS14_04458: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Photobacterium profundum SS9 Gene: PBPRA2241: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter

CRON 10.
metT	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -79 score = 6.71387 sequence = GGACGTCT-(0)-AGACTGTT Site: position = -87 score = 6.69901 sequence = GGATGTTT-(0)-GGACGTCT Gene: VCA0193: Methionine transporter MetT, NhaC antiporter family	Vibrio vulnificus CMCP6	* Vibrio harveyi ATCC BAA-1116 Site: position = -76 score = 7.6007 sequence = AGACGTCT-(0)-AGACGTTG Site: position = -84 score = 7.44776 sequence = AGCCATTT-(0)-AGACGTCT Gene: VIBHAR_01104: Methionine transporter MetT, NhaC antiporter family	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -21 score = 7.44776 sequence = AGCCATTT-(0)-AGACGTCT Site: position = -13 score = 7.6007 sequence = AGACGTCT-(0)-AGACGTTG Gene: VP0632: Methionine transporter MetT, NhaC antiporter family	* Vibrio shilonii AK1 Site: position = -83 score = 6.85446 sequence = GGACATTT-(0)-GGACGTCT Site: position = -75 score = 7.10869 sequence = GGACGTCT-(0)-AGACGTTG Site: position = -67 score = 5.94788 sequence = AGACGTTG-(0)-ACATGTCT Gene: VSAK1_25825: Methionine transporter MetT, NhaC antiporter family	* Vibrio splendidus LGP32 Site: position = -75 score = 7.6007 sequence = AGACGTCT-(0)-AGACGTTG Site: position = -83 score = 6.7475 sequence = GGGCGTTT-(0)-AGACGTCT Gene: VS_II1202: Methionine transporter MetT, NhaC antiporter family	Vibrio fischeri ES114	Vibrio salmonicida LFI1238	* Vibrio angustum S14 Site: position = -78 score = 7.47271 sequence = AGACGTCT-(0)-AGATGTTG Site: position = -86 score = 7.66969 sequence = AGATGTTT-(0)-AGACGTCT Gene: VAS14_16434: Methionine transporter MetT, NhaC antiporter family	* Photobacterium profundum SS9 Site: position = -85 score = 7.17767 sequence = GGATGTTT-(0)-AGACGTCT Site: position = -77 score = 7.14326 sequence = AGACGTCT-(0)-AGAAGTTG Gene: PBPRA2837: Methionine transporter MetT, NhaC antiporter family	Methionine transporter MetT, NhaC antiporter family

CRON 11.
mmuM	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_05821: Homocysteine S-methyltransferase (EC 2.1.1.10)	Vibrio parahaemolyticus RIMD 2210633	Vibrio shilonii AK1 Gene: VSAK1_01497: Homocysteine S-methyltransferase (EC 2.1.1.10)	Vibrio splendidus LGP32 Gene: VS_II0079: Homocysteine S-methyltransferase (EC 2.1.1.10)	Vibrio fischeri ES114	Vibrio salmonicida LFI1238	* Vibrio angustum S14 Site: position = -18 score = 6.86933 sequence = AGCAGTAT-(0)-GGATGTCT Gene: VAS14_13164: Homocysteine S-methyltransferase (EC 2.1.1.10)	Photobacterium profundum SS9	Homocysteine S-methyltransferase (EC 2.1.1.10)

CRON 12.
metB	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -175 score = 6.5891 sequence = AGAAGTGT-(0)-TGACGTCT Site: position = -191 score = 7.64808 sequence = AGACATGT-(0)-AGACGTCT Site: position = -183 score = 7.43751 sequence = AGACGTCT-(0)-AGAAGTGT Gene: VC2683: Cystathionine gamma-synthase (EC 2.5.1.48)	* Vibrio vulnificus CMCP6 Site: position = -135 score = 8.13161 sequence = AGACATAT-(0)-AGACGTCT Site: position = -119 score = 6.5891 sequence = AGAAGTGT-(0)-TGACGTCT Site: position = -127 score = 7.43751 sequence = AGACGTCT-(0)-AGAAGTGT Gene: VV1_1364: Cystathionine gamma-synthase (EC 2.5.1.48)	* Vibrio harveyi ATCC BAA-1116 Site: position = -143 score = 7.43751 sequence = AGACGTCT-(0)-AGAAGTGT Site: position = -151 score = 8.13161 sequence = AGACATAT-(0)-AGACGTCT Site: position = -135 score = 6.5891 sequence = AGAAGTGT-(0)-TGACGTCT Gene: VIBHAR_00049: Cystathionine gamma-synthase (EC 2.5.1.48)	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -135 score = 6.5891 sequence = AGAAGTGT-(0)-TGACGTCT Site: position = -143 score = 7.43751 sequence = AGACGTCT-(0)-AGAAGTGT Site: position = -151 score = 8.13161 sequence = AGACATAT-(0)-AGACGTCT Gene: VP2765: Cystathionine gamma-synthase (EC 2.5.1.48)	* Vibrio shilonii AK1 Site: position = -180 score = 8.13161 sequence = AGACATAT-(0)-AGACGTCT Site: position = -164 score = 6.5891 sequence = AGAAGTGT-(0)-TGACGTCT Site: position = -172 score = 7.43751 sequence = AGACGTCT-(0)-AGAAGTGT Gene: VSAK1_09473: Cystathionine gamma-synthase (EC 2.5.1.48)	* Vibrio splendidus LGP32 Site: position = -89 score = 6.13726 sequence = AGACGTCC-(0)-GGAAGTGT Site: position = -97 score = 7.52203 sequence = AGACATAT-(0)-AGACGTCC Site: position = -81 score = 6.09709 sequence = GGAAGTGT-(0)-TGACGTCT Gene: VS_2894: Cystathionine gamma-synthase (EC 2.5.1.48)	* Vibrio fischeri ES114 Site: position = -256 score = 6.5891 sequence = AGAAGTGT-(0)-TGACGTCT Site: position = -272 score = 8.13161 sequence = AGACATAT-(0)-AGACGTCT Site: position = -264 score = 7.43751 sequence = AGACGTCT-(0)-AGAAGTGT Gene: VF_2267: Cystathionine gamma-synthase (EC 2.5.1.48)	* Vibrio salmonicida LFI1238 Site: position = -94 score = 7.07263 sequence = AGAAGTAT-(0)-TGACGTCT Site: position = -102 score = 7.39509 sequence = AGACGTCT-(0)-AGAAGTAT Site: position = -110 score = 7.77645 sequence = AGATATAT-(0)-AGACGTCT Gene: VSAL_I2747: Cystathionine gamma-synthase (EC 2.5.1.48)	* Vibrio angustum S14 Site: position = -89 score = 6.71191 sequence = AGATGTGT-(0)-TGACGTCT Site: position = -97 score = 6.94537 sequence = AGACGTCC-(0)-AGATGTGT Site: position = -105 score = 7.52203 sequence = AGACATAT-(0)-AGACGTCC Gene: VAS14_21442: Cystathionine gamma-synthase (EC 2.5.1.48)	* Photobacterium profundum SS9 Site: position = -90 score = 6.09709 sequence = GGAAGTGT-(0)-TGACGTCT Site: position = -98 score = 6.95886 sequence = AGACGTCT-(0)-GGAAGTGT Site: position = -106 score = 8.13161 sequence = AGACATAT-(0)-AGACGTCT Gene: PBPRA0261: Cystathionine gamma-synthase (EC 2.5.1.48)	Cystathionine gamma-synthase (EC 2.5.1.48)
metL	Vibrio cholerae O1 biovar eltor str. N16961 Gene: VC2684: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Vibrio vulnificus CMCP6 Gene: VV1_1365: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_00048: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Vibrio parahaemolyticus RIMD 2210633 Gene: VP2764: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Vibrio shilonii AK1 Gene: VSAK1_09468: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Vibrio splendidus LGP32 Gene: VS_2893: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Vibrio fischeri ES114 Gene: VF_2266: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Vibrio salmonicida LFI1238 Gene: VSAL_I2748: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Vibrio angustum S14 Gene: VAS14_21437: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Photobacterium profundum SS9 Gene: PBPRA0262: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)

CRON 13.
metE	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -79 score = 6.29688 sequence = AGCCATCC-(0)-AGACATCT Gene: VC1704: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Vibrio vulnificus CMCP6 Site: position = -255 score = 7.54261 sequence = AAACATCT-(0)-AGACGTCT Site: position = -140 score = 6.29688 sequence = AGCCATCC-(0)-AGACATCT Gene: VV1_2219: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Vibrio harveyi ATCC BAA-1116 Site: position = -198 score = 7.74233 sequence = AAACGTCT-(0)-AGACGTCT Site: position = -77 score = 6.29688 sequence = AGCCATCC-(0)-AGACATCT Gene: VIBHAR_02772: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -81 score = 6.29688 sequence = AGCCATCC-(0)-AGACATCT Site: position = -210 score = 6.2111 sequence = GGATATGT-(0)-AAACGTCT Site: position = -202 score = 7.74233 sequence = AAACGTCT-(0)-AGACGTCT Gene: VP1974: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Vibrio shilonii AK1 Site: position = -148 score = 5.62689 sequence = GGATGTGT-(0)-AAACATCT Site: position = -140 score = 6.93303 sequence = AAACATCT-(0)-AGACGTCC Site: position = -35 score = 6.17241 sequence = AGCCATCC-(0)-AGACTGCT Gene: VSAK1_00952: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Vibrio splendidus LGP32 Site: position = -208 score = 7.00475 sequence = AAACGTCT-(0)-AGATGTCC Site: position = -87 score = 6.43223 sequence = AGCCATCC-(0)-AGACGCCT Gene: VS_1145: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Vibrio fischeri ES114 Site: position = -152 score = 7.13901 sequence = AAACATCT-(0)-AGACGGCT Site: position = -31 score = 6.0874 sequence = AGCCATCC-(0)-AAACGGCT Gene: VF_1721: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Vibrio salmonicida LFI1238	Vibrio angustum S14	* Photobacterium profundum SS9 Site: position = -196 score = 5.50408 sequence = GGAAGTGT-(0)-AAACATCT Site: position = -188 score = 7.54261 sequence = AAACATCT-(0)-AGACGTCT Gene: PBPRA1379: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)

CRON 14.
metF	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -66 score = 7.35605 sequence = AGCCATAT-(0)-AGACGTCT Site: position = -58 score = 7.2236 sequence = AGACGTCT-(0)-AAACGTCA Gene: VC2685: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Vibrio vulnificus CMCP6 Site: position = -66 score = 7.33362 sequence = AGACGTCT-(0)-AAACGTCG Site: position = -74 score = 7.25019 sequence = GGACATAT-(0)-AGACGTCT Gene: VV1_1366: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Vibrio harveyi ATCC BAA-1116 Site: position = -72 score = 7.67109 sequence = AGACATAT-(0)-AGACGTCT Site: position = -64 score = 7.33362 sequence = AGACGTCT-(0)-AAACGTCG Gene: VIBHAR_00047: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -70 score = 7.67109 sequence = AGACATAT-(0)-AGACGTCT Site: position = -62 score = 7.33362 sequence = AGACGTCT-(0)-AAACGTCG Gene: VP2763: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Vibrio shilonii AK1 Site: position = -98 score = 7.2236 sequence = AGACGTCT-(0)-AAACGTCA Site: position = -106 score = 7.67109 sequence = AGACATAT-(0)-AGACGTCT Gene: VSAK1_09463: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Vibrio splendidus LGP32	* Vibrio fischeri ES114 Site: position = -86 score = 7.67109 sequence = AGACATAT-(0)-AGACGTCT Gene: VF_2309: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Vibrio salmonicida LFI1238 Site: position = -84 score = 7.15084 sequence = AGACATAT-(0)-AGACGTCC Site: position = -76 score = 5.63489 sequence = AGACGTCC-(0)-AAACATGA Gene: VSAL_I2762: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Vibrio angustum S14	* Photobacterium profundum SS9 Site: position = -82 score = 7.67109 sequence = AGACATAT-(0)-AGACGTCT Site: position = -74 score = 7.12247 sequence = AGACGTCT-(0)-AAACGGTT Gene: PBPRA0263: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)

CRON 15.
metN	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -107 score = 6.14026 sequence = AGACGTAA-(0)-AAATATCT Site: position = -123 score = 6.84017 sequence = AACCATTT-(0)-AGACGTCT Site: position = -115 score = 7.11232 sequence = AGACGTCT-(0)-AGACGTAA Gene: VC0907: Methionine ABC transporter ATP-binding protein	* Vibrio vulnificus CMCP6 Site: position = -114 score = 7.11232 sequence = AGACGTCT-(0)-AGACGTAA Site: position = -106 score = 6.14026 sequence = AGACGTAA-(0)-AAATATCT Site: position = -122 score = 6.98444 sequence = GAACGTTT-(0)-AGACGTCT Gene: VV1_0292: Methionine ABC transporter ATP-binding protein	* Vibrio harveyi ATCC BAA-1116 Site: position = -153 score = 7.08138 sequence = ATACATTT-(0)-AGACGTCT Site: position = -145 score = 7.11232 sequence = AGACGTCT-(0)-AGACGTAA Site: position = -137 score = 6.14026 sequence = AGACGTAA-(0)-AAATATCT Gene: VIBHAR_01202: Methionine ABC transporter ATP-binding protein	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -153 score = 7.08138 sequence = ATACATTT-(0)-AGACGTCT Site: position = -145 score = 7.11232 sequence = AGACGTCT-(0)-AGACGTAA Site: position = -137 score = 6.14026 sequence = AGACGTAA-(0)-AAATATCT Gene: VP0706: Methionine ABC transporter ATP-binding protein	* Vibrio shilonii AK1 Site: position = -123 score = 6.75284 sequence = TGCCGTTT-(0)-AGACGTCT Site: position = -115 score = 7.11232 sequence = AGACGTCT-(0)-AGACGTAA Site: position = -107 score = 6.14026 sequence = AGACGTAA-(0)-AAATATCT Gene: VSAK1_10548: Methionine ABC transporter ATP-binding protein	* Vibrio splendidus LGP32 Site: position = -114 score = 6.79728 sequence = AGCCGTCT-(0)-AGACGTAA Site: position = -106 score = 6.14026 sequence = AGACGTAA-(0)-AAATATCT Gene: VS_2382: Methionine ABC transporter ATP-binding protein	* Vibrio fischeri ES114 Site: position = -70 score = 7.11232 sequence = AGACGTCT-(0)-AGACGTAA Site: position = -62 score = 6.14026 sequence = AGACGTAA-(0)-AAATATCT Gene: VF_0686: Methionine ABC transporter ATP-binding protein	* Vibrio salmonicida LFI1238 Site: position = -179 score = 6.44855 sequence = ATACGTTT-(0)-AGCCGTCT Site: position = -171 score = 6.79728 sequence = AGCCGTCT-(0)-AGACGTAA Site: position = -163 score = 6.14026 sequence = AGACGTAA-(0)-AAATATCT Gene: VSAL_I0886: Methionine ABC transporter ATP-binding protein	* Vibrio angustum S14 Site: position = -172 score = 7.00833 sequence = AGCCATTT-(0)-GGACGTCT Site: position = -164 score = 5.80845 sequence = GGACGTCT-(0)-AGCCGTAA Site: position = -156 score = 5.39568 sequence = AGCCGTAA-(0)-AAATAGCT Gene: VAS14_21086: Methionine ABC transporter ATP-binding protein	* Photobacterium profundum SS9 Site: position = -161 score = 5.03914 sequence = TTACGTTT-(0)-AGCCATCT Site: position = -153 score = 5.66418 sequence = AGCCATCT-(0)-AGCCGTAA Site: position = -121 score = 5.45211 sequence = AGCCATCC-(0)-AGACACCC Gene: PBPRA2940: Methionine ABC transporter ATP-binding protein	Methionine ABC transporter ATP-binding protein
metI	Vibrio cholerae O1 biovar eltor str. N16961 Gene: VC0906: Methionine ABC transporter permease protein	Vibrio vulnificus CMCP6 Gene: VV1_0293: Methionine ABC transporter permease protein	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_01201: Methionine ABC transporter permease protein	Vibrio parahaemolyticus RIMD 2210633 Gene: VP0705: Methionine ABC transporter permease protein	Vibrio shilonii AK1 Gene: VSAK1_10553: Methionine ABC transporter permease protein	Vibrio splendidus LGP32 Gene: VS_2383: Methionine ABC transporter permease protein	Vibrio fischeri ES114 Gene: VF_0685: Methionine ABC transporter permease protein	Vibrio salmonicida LFI1238 Gene: VSAL_I0887: Methionine ABC transporter permease protein	Vibrio angustum S14 Gene: VAS14_21081: Methionine ABC transporter permease protein	Photobacterium profundum SS9 Gene: PBPRA2941: Methionine ABC transporter permease protein	Methionine ABC transporter permease protein
metQ	Vibrio cholerae O1 biovar eltor str. N16961 Gene: VC0905: Methionine ABC transporter substrate-binding protein	Vibrio vulnificus CMCP6 Gene: VV1_0294: Methionine ABC transporter substrate-binding protein	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_01200: Methionine ABC transporter substrate-binding protein	Vibrio parahaemolyticus RIMD 2210633 Gene: VP0704: Methionine ABC transporter substrate-binding protein	Vibrio shilonii AK1 Gene: VSAK1_10558: Methionine ABC transporter substrate-binding protein	Vibrio splendidus LGP32 Gene: VS_2384: Methionine ABC transporter substrate-binding protein	Vibrio fischeri ES114 Gene: VF_0684: Methionine ABC transporter substrate-binding protein	Vibrio salmonicida LFI1238 Gene: VSAL_I0888: Methionine ABC transporter substrate-binding protein	Vibrio angustum S14 Gene: VAS14_21076: Methionine ABC transporter substrate-binding protein	Photobacterium profundum SS9 Gene: PBPRA2942: Methionine ABC transporter substrate-binding protein	Methionine ABC transporter substrate-binding protein

CRON 16.
metE	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6	Vibrio harveyi ATCC BAA-1116	Vibrio parahaemolyticus RIMD 2210633	Vibrio shilonii AK1	Vibrio splendidus LGP32	Vibrio fischeri ES114	Vibrio salmonicida LFI1238	2 Vibrio angustum S14* Site: position = -163 score = 6.58796 sequence = AGATGGCT-(0)-AAACGTCT Site: position = -171 score = 7.01103 sequence = AAACATCT-(0)-AGATGGCT Gene: VAS14_04733: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Gene: VAS14_04728: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Photobacterium profundum SS9	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog MetJ - Vibrionales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --