Regulog FlpA - Lactobacillaceae

Properties
Regulator type:	Transcription factor
Regulator family:	CRP
Regulation mode:	activator (repressor)
Biological process:	Heavy metal resistance
Effector:	Oxygen
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 32 sites [see more]

Member of regulog collections

By taxonomy - Lactobacillaceae
By TF family - CRP
By effector - Oxygen
By pathway - Heavy metal resistance

Statistics of regulated genes
Genome	Genes	Operons
Lactobacillus acidophilus NCFM	4	2
Lactobacillus brevis ATCC 367
Lactobacillus casei ATCC 334	4	2
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	2	1
Lactobacillus fermentum IFO 3956	7	4
Lactobacillus helveticus DPC 4571
Lactobacillus johnsonii NCC 533	2	2
Lactobacillus plantarum WCFS1	5	4
Lactobacillus reuteri JCM 1112	3	2
Lactobacillus rhamnosus GG	2	2
Lactobacillus sakei subsp. sakei 23K	4	2
Lactobacillus salivarius subsp. salivarius UCC118	4	4
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	4	2
Oenococcus oeni PSU-1	3	2
Pediococcus pentosaceus ATCC 25745	4	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
copZ	* Lactobacillus acidophilus NCFM Site: position = -81 score = 5.97169 sequence = AAATTGACGATCATCAAGTT Gene: LBA0542: Copper chaperone	Lactobacillus brevis ATCC 367 Gene: LVIS_0693: Copper chaperone	* Lactobacillus casei ATCC 334 Site: position = -76 score = 5.3869 sequence = AACTTGACGACGATCAAGGA Gene: LSEI_0071: Copper chaperone	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0428: Copper chaperone	2 Lactobacillus fermentum IFO 3956* Site: position = -68 score = 5.07974 sequence = AAGTTGATGAGGATCAATTA Gene: LAF_1701: Copper chaperone Site: position = -91 score = 4.76427 sequence = AAGTTGATAGAAAACAATTT Gene: LAF_1466: Copper chaperone	Lactobacillus helveticus DPC 4571	* Lactobacillus johnsonii NCC 533 Site: position = -82 score = 5.97169 sequence = AAATTGACGATCATCAAGTT Gene: LJ1695: Copper chaperone	* Lactobacillus plantarum WCFS1 Site: position = -75 score = 5.95664 sequence = TTCTTGACGGCCGTCAAGTT Gene: lp_3442: Copper chaperone	* Lactobacillus reuteri JCM 1112 Site: position = -69 score = 5.67517 sequence = AAATTGATGATAATCAATTT Gene: LAR_1340: Copper chaperone	* Lactobacillus rhamnosus GG Site: position = -76 score = 6.0267 sequence = AACTTGACGGCCATCAAGGT Gene: LGG_00083: Copper chaperone	* Lactobacillus sakei subsp. sakei 23K Site: position = -79 score = 6.09395 sequence = AACTTGATGGCGATCAATTT Gene: LSA1783: Copper chaperone	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -129 score = 5.89238 sequence = AACTTGATATGCGTCAATTT Gene: LSL_1784: Copper chaperone	* Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Site: position = -66 score = 5.17102 sequence = TAATTGATCTATATCAAGTA Gene: LEUM_A04: Copper chaperone	* Oenococcus oeni PSU-1 Site: position = -126 score = 5.95664 sequence = TTCTTGACGGCCGTCAAGTT Gene: OEOE_0354: Copper chaperone	* Pediococcus pentosaceus ATCC 25745 Site: position = -75 score = 5.71126 sequence = AAATTGACCTACGTCAATTT Gene: PEPE_0409: Copper chaperone	Copper chaperone
LAF_1465	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1465: Hypothetical protein	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Hypothetical protein
flpA	2 Lactobacillus acidophilus NCFM Gene: LBA1969: Heavy metal resistance transcriptional regulator FlpA, Crp family Gene: LBA0544: Heavy metal resistance transcriptional regulator FlpA, Crp family	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334 Gene: LSEI_0073: Heavy metal resistance transcriptional regulator FlpA, Crp family	2 Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0159: Heavy metal resistance transcriptional regulator FlpA, Crp family Gene: LBUL_0430: Heavy metal resistance transcriptional regulator FlpA, Crp family	2 Lactobacillus fermentum IFO 3956 Gene: LAF_1699: Heavy metal resistance transcriptional regulator FlpA, Crp family Gene: LAF_1464: Heavy metal resistance transcriptional regulator FlpA, Crp family	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533 Gene: LJ1693: Heavy metal resistance transcriptional regulator FlpA, Crp family	2 Lactobacillus plantarum WCFS1* Site: position = -31 score = 5.27792 sequence = AAATTGACATAAATCAAGAA Gene: lp_1442: Heavy metal resistance transcriptional regulator FlpA, Crp family Site: position = -142 score = 5.95664 sequence = AACTTGACGGCCGTCAAGAA Gene: lp_3444: Heavy metal resistance transcriptional regulator FlpA, Crp family	2 Lactobacillus reuteri JCM 1112 Gene: LAR_0962: Heavy metal resistance transcriptional regulator FlpA, Crp family Gene: LAR_1338: Heavy metal resistance transcriptional regulator FlpA, Crp family	Lactobacillus rhamnosus GG Gene: LGG_00085: Heavy metal resistance transcriptional regulator FlpA, Crp family	Lactobacillus sakei subsp. sakei 23K Gene: LSA1781: Heavy metal resistance transcriptional regulator FlpA, Crp family	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -89 score = 5.61331 sequence = TTCTTGATGTGCATCAATTT Gene: LSL_1782: Heavy metal resistance transcriptional regulator FlpA, Crp family	2 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_A06: Heavy metal resistance transcriptional regulator FlpA, Crp family Gene: LEUM_2066: Heavy metal resistance transcriptional regulator FlpA, Crp family	* Oenococcus oeni PSU-1 Site: position = -142 score = 5.95664 sequence = AACTTGACGGCCGTCAAGAA Gene: OEOE_0355: Heavy metal resistance transcriptional regulator FlpA, Crp family	* Pediococcus pentosaceus ATCC 25745 Site: position = -74 score = 5.71126 sequence = AAATTGACGTAGGTCAATTT Gene: PEPE_0408: Heavy metal resistance transcriptional regulator FlpA, Crp family	Heavy metal resistance transcriptional regulator FlpA, Crp family
dps	Lactobacillus acidophilus NCFM Gene: LBA0543: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Lactobacillus brevis ATCC 367 Gene: LVIS_0692: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Lactobacillus casei ATCC 334 Gene: LSEI_0072: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	* Lactobacillus fermentum IFO 3956 Site: position = -298 score = 5.07974 sequence = AAGTTGATGAGGATCAATTA Gene: LAF_1700: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_3441: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	* Lactobacillus reuteri JCM 1112 Site: position = -298 score = 5.67517 sequence = AAATTGATGATAATCAATTT Gene: LAR_1339: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Lactobacillus rhamnosus GG Gene: LGG_00084: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Lactobacillus sakei subsp. sakei 23K Gene: LSA1782: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -118 score = 5.54699 sequence = TTCTTGATGAGCGTCAATTT Gene: LSL_1781: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_A05: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Oenococcus oeni PSU-1 Gene: OEOE_0353: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0410: Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)	Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)
cadA	* Lactobacillus acidophilus NCFM Site: position = -75 score = 5.38156 sequence = ATCTTGATAACAGTCAAGTC Gene: LBA0541: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	Lactobacillus brevis ATCC 367 Gene: LVIS_0691: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	* Lactobacillus casei ATCC 334 Site: position = -68 score = 4.83265 sequence = AAGTTGATCACCGTCAAGGC Gene: LSEI_0070: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	* Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -77 score = 5.25894 sequence = ATCTTGATAGAAATCAATTG Gene: LBUL_0427: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	* Lactobacillus fermentum IFO 3956 Site: position = -69 score = 5.20176 sequence = CTCTTGATTCCGATCAATTT Gene: LAF_1702: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	Lactobacillus helveticus DPC 4571	* Lactobacillus johnsonii NCC 533 Site: position = -75 score = 5.22225 sequence = ATCTTGATAATAGTCAAGTC Gene: LJ1696: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	* Lactobacillus plantarum WCFS1 Site: position = -78 score = 6.14076 sequence = AACTTGACGCCTATCAAGTT Gene: lp_3435: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	Lactobacillus reuteri JCM 1112	* Lactobacillus rhamnosus GG Site: position = -68 score = 5.34234 sequence = AAATTGATCCCGGTCAAGGT Gene: LGG_00082: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	* Lactobacillus sakei subsp. sakei 23K Site: position = -75 score = 6.27702 sequence = AACTTGATGGCTATCAAGTT Gene: LSA1784: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -210 score = 5.61847 sequence = AACTTGATAGCCATAAATTT Site: position = -88 score = 5.7445 sequence = AACTTGATGTCAGTCAATTA Gene: LSL_1786: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	* Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Site: position = -76 score = 6.32516 sequence = AACTTGATGGACGTCAAGTT Gene: LEUM_A03: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0411: Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)	Lead, cadmium, zinc and mercury transporting ATPase (EC:3.6.3.-)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog FlpA - Lactobacillaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --