Regulog LiuR - Various betaproteobacteria

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	repressor
Biological process:	Branched-chain amino acid degradation
Effector:
Phylum:	Proteobacteria/beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 31 sites [see more]

Member of regulog collections

By trascription factor - LiuR
By taxonomy - Various betaproteobacteria
By TF family - MerR
By pathway - Branched-chain amino acid degradation

Statistics of regulated genes
Genome	Genes	Operons
Azoarcus sp. EbN1	2	2
Thauera sp. MZ1T	18	6
Dechloromonas aromatica RCB	16	1
Nitrosomonas europaea ATCC 19718
Nitrosospira multiformis ATCC 25196
Thiobacillus denitrificans
Chromobacterium violaceum ATCC 12472	21	6
Neisseria meningitidis MC58
Laribacter hongkongensis HLHK9	17	4
Methylobacillus flagellatus KT
Methylotenera mobilis JLW8
Methylophilales bacterium HTCC2181

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
Tmz1t_2954	Azoarcus sp. EbN1	* Thauera sp. MZ1T Site: position = -33 score = 5.92737 sequence = GTTGACGCGAACGTAAAC Site: position = -153 score = 5.48106 sequence = GTTGACGCAAACGTCAAT Site: position = -159 score = 5.18368 sequence = GTTTACGTTGACGCAAAC Gene: Tmz1t_2954: 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
badI	Azoarcus sp. EbN1 Gene: ebA1954: 2-ketocyclohexanecarboxyl-CoA hydrolase (EC 4.1.3.36)	Thauera sp. MZ1T Gene: Tmz1t_2953: 2-ketocyclohexanecarboxyl-CoA hydrolase (EC 4.1.3.36)	Dechloromonas aromatica RCB Gene: Daro_1616: 2-ketocyclohexanecarboxyl-CoA hydrolase (EC 4.1.3.36)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	2-ketocyclohexanecarboxyl-CoA hydrolase (EC 4.1.3.36)
Tmz1t_2952	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_2952: cyclohexa-1,5-dienecarbonyl-CoA hydratase	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	cyclohexa-1,5-dienecarbonyl-CoA hydratase
Tmz1t_2951	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_2951: benzoyl-CoA reductase, subunit C	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	benzoyl-CoA reductase, subunit C
Tmz1t_2950	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_2950: benzoyl-CoA reductase, subunit B	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	benzoyl-CoA reductase, subunit B
Tmz1t_2949	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_2949: benzoyl-CoA reductase, subunit A	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	benzoyl-CoA reductase, subunit A
Tmz1t_2948	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_2948: benzoyl-CoA reductase, subunit D	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	benzoyl-CoA reductase, subunit D
Tmz1t_2947	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_2947: 4Fe-4S ferredoxin iron-sulfur binding domain protein	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	4Fe-4S ferredoxin iron-sulfur binding domain protein
Tmz1t_2946	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_2946: GCN5-related N-acetyltransferase	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	GCN5-related N-acetyltransferase
Tmz1t_2945	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_2945: GCN5-related N-acetyltransferase	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	GCN5-related N-acetyltransferase

CRON 2.
lcfA	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_3365: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Dechloromonas aromatica RCB Gene: Daro_0249: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	* Laribacter hongkongensis HLHK9 Site: position = -62 score = 5.39433 sequence = GTTTACGTTCACGTAAAT Gene: LHK_00209: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
livG	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_3364: Branched-chain amino acid ABC transport system, ATP-binding protein LivG	Dechloromonas aromatica RCB Gene: Daro_0250: Branched-chain amino acid ABC transport system, ATP-binding protein LivG	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00210: Branched-chain amino acid ABC transport system, ATP-binding protein LivG	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Branched-chain amino acid ABC transport system, ATP-binding protein LivG
livH	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_3363: Branched-chain amino acid ABC transport system, permease protein LivH	Dechloromonas aromatica RCB Gene: Daro_0251: Branched-chain amino acid ABC transport system, permease protein LivH	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00211: Branched-chain amino acid ABC transport system, permease protein LivH	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Branched-chain amino acid ABC transport system, permease protein LivH
livM	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_3362: Branched-chain amino acid ABC transport system, permease protein LivM	Dechloromonas aromatica RCB Gene: Daro_0252: Branched-chain amino acid ABC transport system, permease protein LivM	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00212: Branched-chain amino acid ABC transport system, permease protein LivM	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Branched-chain amino acid ABC transport system, permease protein LivM
livK	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_0253: Branched-chain amino acid ABC transport system, substrate-binding protein LivK	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00213: Branched-chain amino acid ABC transport system, substrate-binding protein LivK	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Branched-chain amino acid ABC transport system, substrate-binding protein LivK
livF	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_3360: Branched-chain amino acid ABC transport system, ATP-binding protein LivF	Dechloromonas aromatica RCB Gene: Daro_0254: Branched-chain amino acid ABC transport system, ATP-binding protein LivF	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00214: Branched-chain amino acid ABC transport system, ATP-binding protein LivF	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Branched-chain amino acid ABC transport system, ATP-binding protein LivF
paaK	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_3359: Putative phenylacetate-CoA ligase	Dechloromonas aromatica RCB Gene: Daro_0255: Putative phenylacetate-CoA ligase	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00215: Putative phenylacetate-CoA ligase	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Putative phenylacetate-CoA ligase
ivdB	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2085: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00216: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
ivdC	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2084: Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00217: Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12)
ivdE	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2083: Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00218: Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17)
ivdD	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2082: 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00219: 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)
ivdF	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2081: 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_00220: 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31)
ivdG	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -60 score = 5.46161 sequence = GTTGACGTAAACGTCAAG Site: position = -66 score = 6.08613 sequence = GTTGACGTTGACGTAAAC Gene: CV2086: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	Neisseria meningitidis MC58	* Laribacter hongkongensis HLHK9 Site: position = -54 score = 4.82897 sequence = GTTAACGTAAACGTATAT Site: position = -60 score = 6.59853 sequence = ATTGACGTTAACGTAAAC Gene: LHK_00208: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)

CRON 3.
CV0303	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -262 score = 6.22769 sequence = GTTGACGTAAACGTAAAC Site: position = -268 score = 5.81331 sequence = TTTGACGTTGACGTAAAC Gene: CV0303: Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits
CV0302	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV0302: hypothetical protein	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	hypothetical protein

CRON 4.
aacS2	Azoarcus sp. EbN1 Gene: ebA4661: Acetoacetyl-CoA synthetase (EC 6.2.1.16) / Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Thauera sp. MZ1T Gene: Tmz1t_0752: Acetoacetyl-CoA synthetase (EC 6.2.1.16) / Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -54 score = 5.77229 sequence = ATTTACGTTTACGTAATC Site: position = -48 score = 4.75894 sequence = GTTTACGTAATCGTCAAT Gene: CV1780: Acetoacetyl-CoA synthetase (EC 6.2.1.16) / Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Acetoacetyl-CoA synthetase (EC 6.2.1.16) / Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)

CRON 5.
paaH	* Azoarcus sp. EbN1 Site: position = -78 score = 5.89612 sequence = GTTGACGTTGACGTCAAC Gene: ebA5126: Short-chain dehydrogenase/reductase SDR	* Thauera sp. MZ1T Site: position = -84 score = 5.70491 sequence = ATTGACGCCTACGTCAAC Gene: Tmz1t_1274: Short-chain dehydrogenase/reductase SDR	Dechloromonas aromatica RCB Gene: Daro_0710: Short-chain dehydrogenase/reductase SDR	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Short-chain dehydrogenase/reductase SDR

CRON 6.
paaI	Azoarcus sp. EbN1	* Thauera sp. MZ1T Site: position = -59 score = 5.5039 sequence = GATTACGTTAACGTTAAC Gene: Tmz1t_0730: Phenylacetic acid degradation-related protein	* Dechloromonas aromatica RCB Site: position = -45 score = 5.4159 sequence = GTTAACGTAAACGTAAAT Site: position = -51 score = 6.54321 sequence = GTTGACGTTAACGTAAAC Gene: Daro_0101: Phenylacetic acid degradation-related protein	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Phenylacetic acid degradation-related protein
liuA	Azoarcus sp. EbN1 Gene: ebA4656: Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)	Thauera sp. MZ1T Gene: Tmz1t_0748: Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)	Dechloromonas aromatica RCB Gene: Daro_0100: Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -80 score = 6.45935 sequence = ATTGACGCTTACGTAAAC Site: position = -74 score = 5.25036 sequence = GCTTACGTAAACGTAAGC Gene: CV1766: Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)	Neisseria meningitidis MC58	* Laribacter hongkongensis HLHK9 Site: position = -80 score = 6.08613 sequence = GTTGACGTTCACGTAAAC Gene: LHK_02055: Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)
cah	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_0731: Carbonic anhydrase (EC 4.2.1.1)	Dechloromonas aromatica RCB Gene: Daro_0099: Carbonic anhydrase (EC 4.2.1.1)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Carbonic anhydrase (EC 4.2.1.1)
ivdA	Azoarcus sp. EbN1 Gene: ebA3639: Acetyl-CoA C-acyltransferase (EC 2.3.1.16)	Thauera sp. MZ1T Gene: Tmz1t_0732: Acetyl-CoA C-acyltransferase (EC 2.3.1.16)	Dechloromonas aromatica RCB Gene: Daro_0098: Acetyl-CoA C-acyltransferase (EC 2.3.1.16)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2088: Acetyl-CoA C-acyltransferase (EC 2.3.1.16)	Neisseria meningitidis MC58	* Laribacter hongkongensis HLHK9 Site: position = -33 score = 5.10584 sequence = GTTTCCGTTTACGTAAAA Gene: LHK_00206: Acetyl-CoA C-acyltransferase (EC 2.3.1.16)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Acetyl-CoA C-acyltransferase (EC 2.3.1.16)
Daro_0097	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_0097: Permease of the drug/metabolite transporter (DMT) superfamily	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Permease of the drug/metabolite transporter (DMT) superfamily
ivdC	Azoarcus sp. EbN1 Gene: ebA3640: Isovaleryl-CoA dehydrogenase (EC 1.3.99.10); Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2)	Thauera sp. MZ1T Gene: Tmz1t_0733: Isovaleryl-CoA dehydrogenase (EC 1.3.99.10); Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2)	Dechloromonas aromatica RCB Gene: Daro_0096: Isovaleryl-CoA dehydrogenase (EC 1.3.99.10); Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Isovaleryl-CoA dehydrogenase (EC 1.3.99.10); Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2)
Daro_0095	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_0095: Protein of unknown function DUF88	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Protein of unknown function DUF88
Daro_0094	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_0094: 2-hydroxychromene-2-carboxylate isomerase	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	2-hydroxychromene-2-carboxylate isomerase
Daro_0093	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_0093: Lysine decarboxylase family	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Lysine decarboxylase family
liuB	Azoarcus sp. EbN1 Gene: ebA4657: Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)	Thauera sp. MZ1T Gene: Tmz1t_0749: Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)	Dechloromonas aromatica RCB Gene: Daro_0092: Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV1764: Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_02056: Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)
Daro_0091	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_0091: Transcriptional regulator	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Transcriptional regulator
liuC	Azoarcus sp. EbN1 Gene: ebA3642: Methylglutaconyl-CoA hydratase (EC 4.2.1.18)	Thauera sp. MZ1T Gene: Tmz1t_0750: Methylglutaconyl-CoA hydratase (EC 4.2.1.18)	Dechloromonas aromatica RCB Gene: Daro_0090: Methylglutaconyl-CoA hydratase (EC 4.2.1.18)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV1763: Methylglutaconyl-CoA hydratase (EC 4.2.1.18)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Methylglutaconyl-CoA hydratase (EC 4.2.1.18)
liuD	Azoarcus sp. EbN1 Gene: ebA4659: Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)	Thauera sp. MZ1T Gene: Tmz1t_0751: Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)	Dechloromonas aromatica RCB Gene: Daro_0089: Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV1762: Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_02057: Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)
Daro_0088	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_0088: 5-enolpyruvylshikimate-3-phosphate synthase	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	5-enolpyruvylshikimate-3-phosphate synthase
fabG	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_2236: 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)	Dechloromonas aromatica RCB Gene: Daro_0087: 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)
liuE	Azoarcus sp. EbN1 Gene: ebA4662: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	Thauera sp. MZ1T Gene: Tmz1t_0753: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	Dechloromonas aromatica RCB Gene: Daro_0086: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV1759: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_02058: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)
CV1765	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV1765: hypothetical protein	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	hypothetical protein
CV1761	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV1761: FOG: TPR repeat protein	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	FOG: TPR repeat protein
CV1760	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV1760: probable transcriptional regulator (AraC/XylS family)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	probable transcriptional regulator (AraC/XylS family)
aacS	Azoarcus sp. EbN1 Gene: ebA4666: Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16)	Thauera sp. MZ1T Gene: Tmz1t_1658: Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16)	Dechloromonas aromatica RCB Gene: Daro_0177: Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV1758: Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_02059: Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16)
liuR	Azoarcus sp. EbN1 Gene: ebA3634: Predicted transcriptional regulator LiuR of leucine degradation pathway, MerR family	* Thauera sp. MZ1T Site: position = -135 score = 6.23303 sequence = GTTGACGTTTACGTTAGC Gene: Tmz1t_2996: Predicted transcriptional regulator LiuR of leucine degradation pathway, MerR family	Dechloromonas aromatica RCB Gene: Daro_0102: Predicted transcriptional regulator LiuR of leucine degradation pathway, MerR family	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	2 Chromobacterium violaceum ATCC 12472* Site: position = -87 score = 5.47325 sequence = GTTTACGTCAACGTCAAC Site: position = -93 score = 6.35749 sequence = CTTGACGTTTACGTCAAC Gene: CV2087: Predicted transcriptional regulator LiuR of leucine degradation pathway, MerR family Site: position = -75 score = 4.95429 sequence = GATTACGTAAACGTAAAT Site: position = -81 score = 6.09447 sequence = ATTGACGATTACGTAAAC Gene: CV1779: Predicted transcriptional regulator LiuR of leucine degradation pathway, MerR family	Neisseria meningitidis MC58	* Laribacter hongkongensis HLHK9 Site: position = -116 score = 5.59504 sequence = ATATACGTTTACGTTAAC Site: position = -110 score = 5.66139 sequence = GTTTACGTTAACGTCAAT Gene: LHK_00207: Predicted transcriptional regulator LiuR of leucine degradation pathway, MerR family	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Predicted transcriptional regulator LiuR of leucine degradation pathway, MerR family

CRON 7.
ebA6516	Azoarcus sp. EbN1 Gene: ebA6516: Enoyl-CoA hydratase (EC 4.2.1.17)	* Thauera sp. MZ1T Site: position = -66 score = 5.2622 sequence = GTTGACGTTAACGTTGCC Gene: Tmz1t_2272: Enoyl-CoA hydratase (EC 4.2.1.17)	Dechloromonas aromatica RCB Gene: Daro_0558: Enoyl-CoA hydratase (EC 4.2.1.17)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Enoyl-CoA hydratase (EC 4.2.1.17)

CRON 8.
acsA	* Azoarcus sp. EbN1 Site: position = -202 score = 5.27766 sequence = CATGACGTTGACGTCAAC Gene: ebA1206: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases	* Thauera sp. MZ1T Site: position = -84 score = 4.96721 sequence = GTTAACGTCAACGTAAAA Gene: Tmz1t_1162: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog LiuR - Various betaproteobacteria

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --