Regulog Zur - Clostridia-1

Properties
Regulator type:	Transcription factor
Regulator family:	FUR
Regulation mode:	repressor
Biological process:	Zinc homeostasis
Effector:	Zinc ion, (Zn2+)
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 46 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-1
By trascription factor - Zur
By TF family - FUR
By effector - Zinc ion, (Zn2+)
By pathway - Zinc homeostasis

Statistics of regulated genes
Genome	Genes	Operons
Clostridium acetobutylicum ATCC 824	9	5
Clostridium beijerincki NCIMB 8052	10	6
Clostridium botulinum A str. ATCC 3502	6	4
Clostridium butyricum 5521	5	4
Clostridium kluyveri DSM 555	9	5
Clostridium novyi NT	9	4
Clostridium perfringens ATCC 13124	10	6
Clostridium tetani E88	8	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
feoA	Clostridium acetobutylicum ATCC 824 Gene: CAC1029: ferrous iron transport protein A	* Clostridium beijerincki NCIMB 8052 Site: position = -168 score = 5.41213 sequence = TCATTGAAAATCATTTTCAATGA Site: position = -112 score = 5.41561 sequence = TTAATTAAAATCATTATCAATTG Gene: Cbei_4198: ferrous iron transport protein A	Clostridium botulinum A str. ATCC 3502 Gene: CBO1028: ferrous iron transport protein A	* Clostridium butyricum 5521 Site: position = -88 score = 6.39161 sequence = ATATTGAAAATTATTTGCATTTA Gene: CBY_1468: ferrous iron transport protein A	Clostridium kluyveri DSM 555 Gene: CKL_1603: ferrous iron transport protein A	* Clostridium novyi NT Site: position = -87 score = 5.58284 sequence = TAAATGAATTTCATTTTCAATTG Gene: NT01CX_2431: ferrous iron transport protein A	Clostridium perfringens ATCC 13124 Gene: CPF_1127: ferrous iron transport protein A	Clostridium tetani E88	ferrous iron transport protein A
feoA2	Clostridium acetobutylicum ATCC 824 Gene: CAC1030: Ferrous iron transport protein A	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4197: Ferrous iron transport protein A	Clostridium botulinum A str. ATCC 3502 Gene: CBO1029: Ferrous iron transport protein A	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_1602: Ferrous iron transport protein A	Clostridium novyi NT Gene: NT01CX_2430: Ferrous iron transport protein A	Clostridium perfringens ATCC 13124 Gene: CPF_1126: Ferrous iron transport protein A	Clostridium tetani E88	Ferrous iron transport protein A
feoB	Clostridium acetobutylicum ATCC 824 Gene: CAC1031: Ferrous iron transport protein B	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4196: Ferrous iron transport protein B	Clostridium botulinum A str. ATCC 3502 Gene: CBO1030: Ferrous iron transport protein B	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_1601: Ferrous iron transport protein B	Clostridium novyi NT Gene: NT01CX_2429: Ferrous iron transport protein B	Clostridium perfringens ATCC 13124 Gene: CPF_1125: Ferrous iron transport protein B	Clostridium tetani E88 Gene: CTC01207: Ferrous iron transport protein B	Ferrous iron transport protein B
CPF_1128	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -85 score = 5.58303 sequence = CAATTGAAAATAATTATCAAATT Gene: CPF_1128: conserved hypothetical protein	Clostridium tetani E88	conserved hypothetical protein

CRON 2.
yciC	Clostridium acetobutylicum ATCC 824	2 Clostridium beijerincki NCIMB 8052 Gene: Cbei_2463: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Gene: Cbei_1816: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Clostridium botulinum A str. ATCC 3502	2 Clostridium butyricum 5521 Gene: CBY_1124: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Gene: CBY_0946: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	* Clostridium kluyveri DSM 555 Site: position = -79 score = 6.43225 sequence = TAAATGCTAATAATTTGCATTTA Gene: CKL_2453: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	* Clostridium novyi NT Site: position = -57 score = 6.27686 sequence = TTAGTGCAAATGATTTGCATTTG Gene: NT01CX_2391: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Clostridium perfringens ATCC 13124 Gene: CPF_0043: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	* Clostridium tetani E88 Site: position = -34 score = 6.84999 sequence = TAAATGCAAATCATTTGCATTTA Gene: CTC00941: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family
yciC2	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1817: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_0945: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_2390: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Clostridium perfringens ATCC 13124 Gene: CPF_0044: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Clostridium tetani E88 Gene: CTC00940: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family	Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family
CAC1592	Clostridium acetobutylicum ATCC 824 Gene: CAC1592: ABC transporter, permease protein	3 Clostridium beijerincki NCIMB 8052* Gene: Cbei_1818: ABC transporter, permease protein Site: position = -33 score = 5.5006 sequence = TAAATGCAAATACATTGCAACAA Gene: Cbei_3261: ABC transporter, permease protein Gene: Cbei_4662: ABC transporter, permease protein	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_0944: ABC transporter, permease protein	Clostridium kluyveri DSM 555 Gene: CKL_2452: ABC transporter, permease protein	Clostridium novyi NT Gene: NT01CX_2389: ABC transporter, permease protein	Clostridium perfringens ATCC 13124 Gene: CPF_0045: ABC transporter, permease protein	Clostridium tetani E88 Gene: CTC00939: ABC transporter, permease protein	ABC transporter, permease protein
CAC1591	Clostridium acetobutylicum ATCC 824 Gene: CAC1591: ABC transporter, substrate-binding protein	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_2451: ABC transporter, substrate-binding protein	Clostridium novyi NT Gene: NT01CX_2388: ABC transporter, substrate-binding protein	Clostridium perfringens ATCC 13124	Clostridium tetani E88 Gene: CTC00938: ABC transporter, substrate-binding protein	ABC transporter, substrate-binding protein
znuA	* Clostridium acetobutylicum ATCC 824 Site: position = -45 score = 6.35347 sequence = TTAATGCAAATTATTTGCAAGTA Gene: CAC1593: Zinc ABC transporter, periplasmic-binding protein ZnuA	2 Clostridium beijerincki NCIMB 8052* Site: position = -34 score = 5.61723 sequence = CAAATGCAAATCGTATGCATGTG Gene: Cbei_4668: Zinc ABC transporter, periplasmic-binding protein ZnuA Site: position = -34 score = 5.11485 sequence = CAAATGCAAATCAGATGCAAACT Gene: Cbei_0477: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Clostridium botulinum A str. ATCC 3502 Site: position = -86 score = 6.38262 sequence = TAAATGCAAATAGTTTGCAATAA Gene: CBO1363: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Clostridium butyricum 5521 Site: position = -33 score = 5.88934 sequence = CAAATGCAAATCATATGCAAAAT Gene: CBY_3975: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Clostridium kluyveri DSM 555 Site: position = -53 score = 5.92987 sequence = TAGATGCAAACCATTTGCATCTA Gene: CKL_3051: Zinc ABC transporter, periplasmic-binding protein ZnuA	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -32 score = 5.57449 sequence = ATAATGCGAATCATTTGCAAACA Gene: CPF_2413: Zinc ABC transporter, periplasmic-binding protein ZnuA	* Clostridium tetani E88 Site: position = -105 score = 5.93972 sequence = TACTTGCAAATAGTTTGCAATAT Site: position = -40 score = 6.06906 sequence = TAAATGCAAACGATTTGCAAAAG Gene: CTC02360: Zinc ABC transporter, periplasmic-binding protein ZnuA	Zinc ABC transporter, periplasmic-binding protein ZnuA
zupT	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3818: zinc transporter ZupT	Clostridium kluyveri DSM 555	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -55 score = 5.9405 sequence = TAATTGAAAATAATTATCAATTG Gene: CPF_0717: zinc transporter ZupT	Clostridium tetani E88	zinc transporter ZupT

CRON 3.
znuC	* Clostridium acetobutylicum ATCC 824 Site: position = -81 score = 6.30751 sequence = TACTTGCAAATGATTTGCATTAT Gene: CAC2877: Zinc ABC transporter, ATP-binding protein ZnuC	* Clostridium beijerincki NCIMB 8052 Site: position = -60 score = 6.39388 sequence = CTATTGCAAATTATTTGCATTTG Gene: Cbei_4334: Zinc ABC transporter, ATP-binding protein ZnuC	* Clostridium botulinum A str. ATCC 3502 Site: position = -157 score = 6.38262 sequence = TTATTGCAAACTATTTGCATTTA Gene: CBO1362: Zinc ABC transporter, ATP-binding protein ZnuC	* Clostridium butyricum 5521 Site: position = -128 score = 6.04486 sequence = ATATTGCAAATCATTTGCAGATA Gene: CBY_3660: Zinc ABC transporter, ATP-binding protein ZnuC	* Clostridium kluyveri DSM 555 Site: position = -112 score = 5.76846 sequence = TATTTGCAAATCACTTGCAACTA Gene: CKL_2905: Zinc ABC transporter, ATP-binding protein ZnuC	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -74 score = 6.19453 sequence = AAAATGCAAATTATTTGCACTTG Gene: CPF_1709: Zinc ABC transporter, ATP-binding protein ZnuC	* Clostridium tetani E88 Site: position = -38 score = 5.93972 sequence = ATATTGCAAACTATTTGCAAGTA Site: position = -103 score = 6.06906 sequence = CTTTTGCAAATCGTTTGCATTTA Gene: CTC02361: Zinc ABC transporter, ATP-binding protein ZnuC	Zinc ABC transporter, ATP-binding protein ZnuC
znuB	Clostridium acetobutylicum ATCC 824 Gene: CAC2878: Zinc ABC transporter, inner membrane permease protein ZnuB	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4335: Zinc ABC transporter, inner membrane permease protein ZnuB	Clostridium botulinum A str. ATCC 3502 Gene: CBO1361: Zinc ABC transporter, inner membrane permease protein ZnuB	Clostridium butyricum 5521 Gene: CBY_3661: Zinc ABC transporter, inner membrane permease protein ZnuB	Clostridium kluyveri DSM 555 Gene: CKL_2906: Zinc ABC transporter, inner membrane permease protein ZnuB	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_1710: Zinc ABC transporter, inner membrane permease protein ZnuB	Clostridium tetani E88 Gene: CTC02362: Zinc ABC transporter, inner membrane permease protein ZnuB	Zinc ABC transporter, inner membrane permease protein ZnuB
zur	* Clostridium acetobutylicum ATCC 824 Site: position = -108 score = 4.77343 sequence = TTTATTAAAACCATTTTCTTTTA Gene: CAC2634: Zinc homeostasis transcriptional regulator Zur, Fur family	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1336: Zinc homeostasis transcriptional regulator Zur, Fur family	Clostridium botulinum A str. ATCC 3502 Gene: CBO3220: Zinc homeostasis transcriptional regulator Zur, Fur family	Clostridium butyricum 5521 Gene: CBY_0017: Zinc homeostasis transcriptional regulator Zur, Fur family	Clostridium kluyveri DSM 555 Gene: CKL_3342: Zinc homeostasis transcriptional regulator Zur, Fur family	Clostridium novyi NT Gene: NT01CX_0363: Zinc homeostasis transcriptional regulator Zur, Fur family	Clostridium perfringens ATCC 13124 Gene: CPF_1420: Zinc homeostasis transcriptional regulator Zur, Fur family	* Clostridium tetani E88 Site: position = -89 score = 4.92665 sequence = ATATTGAATAGCATTTGAAAATA Gene: CTC02363: Zinc homeostasis transcriptional regulator Zur, Fur family	Zinc homeostasis transcriptional regulator Zur, Fur family

CRON 4.
rpsD2	2 Clostridium acetobutylicum ATCC 824* Site: position = -111 score = 5.40737 sequence = CAAATGAAAAATATTCTCATTTA Site: position = -193 score = 5.35974 sequence = TAATTGATAATTATTATCATATG Gene: CAC1478: SSU ribosomal protein S4p paralog Gene: CAC1594: SSU ribosomal protein S4p paralog	Clostridium beijerincki NCIMB 8052	* Clostridium botulinum A str. ATCC 3502 Site: position = -92 score = 5.84578 sequence = ATATTGAAAATCATTTTCAGTTT Gene: CBO3405: SSU ribosomal protein S4p paralog	* Clostridium butyricum 5521 Site: position = -101 score = 5.62275 sequence = AAAATGATAATGAATTTCATTTA Site: position = -95 score = 5.11667 sequence = ATAATGAATTTCATTTACATTTA Gene: CBY_3339: SSU ribosomal protein S4p paralog	* Clostridium kluyveri DSM 555 Site: position = -152 score = 5.78945 sequence = ATATTGAACATCATTTTCAATTA Gene: CKL_2190: SSU ribosomal protein S4p paralog	Clostridium novyi NT Gene: NT01CX_2339: SSU ribosomal protein S4p paralog	* Clostridium perfringens ATCC 13124 Site: position = -81 score = 5.84592 sequence = ATAATGATAATCATTTTCAATAA Gene: CPF_2668: SSU ribosomal protein S4p paralog	Clostridium tetani E88	SSU ribosomal protein S4p paralog

CRON 5.
fld	* Clostridium acetobutylicum ATCC 824 Site: position = -51 score = 5.09462 sequence = ATAATGAAAATCAATATCAACAA Gene: CAC0587: Flavodoxin	* Clostridium beijerincki NCIMB 8052 Site: position = -53 score = 5.61085 sequence = TAATTGAGAATGATTTTCAAAAT Gene: Cbei_2410: Flavodoxin	* Clostridium botulinum A str. ATCC 3502 Site: position = -78 score = 5.20863 sequence = TAAATGAAATTGATTCTCACTTT Gene: CBO0346: Flavodoxin	Clostridium butyricum 5521	* Clostridium kluyveri DSM 555 Site: position = -56 score = 5.7145 sequence = TATATGATAATGATTTTCATTAT Gene: CKL_2165: Flavodoxin	* Clostridium novyi NT Site: position = -40 score = 5.23497 sequence = AATATGAAAATGATAATCAATAT Site: position = -34 score = 5.16087 sequence = AAAATGATAATCAATATCAATAA Gene: NT01CX_2337: Flavodoxin	* Clostridium perfringens ATCC 13124 Site: position = -54 score = 5.97432 sequence = TAATTGAAATTGATTTTCATTAA Site: position = -121 score = 5.99146 sequence = TTATTGAAAATTATTATCATTTA Gene: CPF_0625: Flavodoxin	Clostridium tetani E88 Gene: CTC00430: Flavodoxin	Flavodoxin
CAC0588	Clostridium acetobutylicum ATCC 824 Gene: CAC0588: conserved hypothetical protein	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2411: conserved hypothetical protein	Clostridium botulinum A str. ATCC 3502 Gene: CBO0347: conserved hypothetical protein	Clostridium butyricum 5521 Gene: CBY_0737: conserved hypothetical protein	Clostridium kluyveri DSM 555 Gene: CKL_2164: conserved hypothetical protein	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_0624: conserved hypothetical protein	Clostridium tetani E88 Gene: CTC00782: conserved hypothetical protein	conserved hypothetical protein

CRON 6.
znuA2	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -175 score = 4.99181 sequence = TATATGAAAAACATTGTCATTAT Site: position = -42 score = 6.3804 sequence = TTTTTGCAAATGATTTGCATTTT Gene: NT01CX_0482: Zinc ABC transporter, periplasmic-binding protein ZnuA	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Zinc ABC transporter, periplasmic-binding protein ZnuA

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog Zur - Clostridia-1

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --