Regulog Cobalamin - Deinococcus-Thermus

Properties
Regulator type:	RNA regulatory element
Name:	Cobalamin
RFAM:	RF00174
Regulation mode:
Biological process:	Cobalamin biosynthesis
Effector:	Adenosylcobalamin
Phylum:	Deinococcus-Thermus

Member of regulog collections

By taxonomy - Deinococcus-Thermus
By RNA motif - Cobalamin
By effector - Adenosylcobalamin
By pathway - Cobalamin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Deinococcus radiodurans R1	10	2
Deinococcus geothermalis DSM 11300	24	2
Deinococcus deserti VCD115	20	2
Thermus thermophilus HB27	24	3
Thermus aquaticus Y51MC23	18	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes						Function

CRON 1.
btuF	* Deinococcus radiodurans R1 Site: position = -84 score = 17.62 sequence = GGGAAAGTCCGGTTT... Gene: DR2588: Vitamin B12 ABC transporter, B12-binding component BtuF	* Deinococcus geothermalis DSM 11300 Site: position = -244 score = 21.57 sequence = GGGAAAGACCGGTGA... Gene: Dgeo_0025: Vitamin B12 ABC transporter, B12-binding component BtuF	* Deinococcus deserti VCD115 Site: position = -274 score = 25.48 sequence = GGAAGCAGGTGAAGA... Gene: Deide_02140: Vitamin B12 ABC transporter, B12-binding component BtuF	* Thermus thermophilus HB27 Site: position = -291 score = 60.52 sequence = CCAGGTCCCGTAGCC... Gene: TTC0390: Vitamin B12 ABC transporter, B12-binding component BtuF	* Thermus aquaticus Y51MC23 Site: position = -291 score = 55.74 sequence = CAGGTCCCGTTTGCC... Gene: TaqDRAFT_5534: Vitamin B12 ABC transporter, B12-binding component BtuF	Vitamin B12 ABC transporter, B12-binding component BtuF
btuC	Deinococcus radiodurans R1 Gene: DR2589: Vitamin B12 ABC transporter, permease component	Deinococcus geothermalis DSM 11300 Gene: Dgeo_0024: Vitamin B12 ABC transporter, permease component	Deinococcus deserti VCD115 Gene: Deide_02150: Vitamin B12 ABC transporter, permease component	Thermus thermophilus HB27 Gene: TTC0391: Vitamin B12 ABC transporter, permease component	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5535: Vitamin B12 ABC transporter, permease component	Vitamin B12 ABC transporter, permease component
btuD	Deinococcus radiodurans R1 Gene: DR2590: Vitamin B12 ABC transporter, ATP-binding component	Deinococcus geothermalis DSM 11300 Gene: Dgeo_0023: Vitamin B12 ABC transporter, ATP-binding component	Deinococcus deserti VCD115 Gene: Deide_02160: Vitamin B12 ABC transporter, ATP-binding component	Thermus thermophilus HB27 Gene: TTC0392: Vitamin B12 ABC transporter, ATP-binding component	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5536: Vitamin B12 ABC transporter, ATP-binding component	Vitamin B12 ABC transporter, ATP-binding component
COG3411	Deinococcus radiodurans R1 Gene: DR2591: Thioredoxin domain protein	Deinococcus geothermalis DSM 11300 Gene: Dgeo_0022: Thioredoxin domain protein	Deinococcus deserti VCD115 Gene: Deide_02170: Thioredoxin domain protein	Thermus thermophilus HB27 Gene: TTC0393: Thioredoxin domain protein	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5537: Thioredoxin domain protein	Thioredoxin domain protein

CRON 2.
achX	Deinococcus radiodurans R1 Gene: DRB0106: Acyl-CoA hydrolase (EC 3.1.2.20)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_1772: Acyl-CoA hydrolase (EC 3.1.2.20)	Deinococcus deserti VCD115	* Thermus thermophilus HB27 Site: position = -240 score = 35.57 sequence = GGAAGTCCGGTGAAA... Gene: TTP0160: Acyl-CoA hydrolase (EC 3.1.2.20)	* Thermus aquaticus Y51MC23 Site: position = -260 score = 37.4 sequence = GGAAGTCCGGTGCAA... Gene: TaqDRAFT_3194: Acyl-CoA hydrolase (EC 3.1.2.20)	Acyl-CoA hydrolase (EC 3.1.2.20)
nrdB	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0161: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3195: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
nrdA	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0162: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3196: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)

CRON 3.
btuF	* Deinococcus radiodurans R1 Site: position = -100 score = 13.78 sequence = GGGGAAGCCCGGTGA... Gene: DRB0007: Vitamin B12 ABC transporter, B12-binding component BtuF	* Deinococcus geothermalis DSM 11300 Site: position = -259 score = 35.03 sequence = CCGGCTTCTGCTATC... Gene: Dgeo_2363: Vitamin B12 ABC transporter, B12-binding component BtuF	* Deinococcus deserti VCD115 Site: position = -242 score = 41.15 sequence = GGAAGTCCGGTGAGA... Gene: Deide_2p01550: Vitamin B12 ABC transporter, B12-binding component BtuF	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Vitamin B12 ABC transporter, B12-binding component BtuF
btuR	Deinococcus radiodurans R1 Gene: DRB0008: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2362: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Deinococcus deserti VCD115 Gene: Deide_2p01560: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Thermus thermophilus HB27 Gene: TTP0002: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3284: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)	Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
cbiE	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2361: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Deinococcus deserti VCD115 Gene: Deide_2p01570: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
cbiXC	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2360: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Deinococcus deserti VCD115 Gene: Deide_2p01580: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
cbiD	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2359: Cobalt-precorrin-6 synthase, anaerobic	Deinococcus deserti VCD115 Gene: Deide_2p01590: Cobalt-precorrin-6 synthase, anaerobic	Thermus thermophilus HB27 Gene: TTP0008: Cobalt-precorrin-6 synthase, anaerobic	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5284: Cobalt-precorrin-6 synthase, anaerobic	Cobalt-precorrin-6 synthase, anaerobic
cbiL	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2358: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Deinococcus deserti VCD115 Gene: Deide_2p01600: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Thermus thermophilus HB27 Gene: TTP0011: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5281: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
cbiF	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2357: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Deinococcus deserti VCD115 Gene: Deide_2p01610: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Thermus thermophilus HB27 Gene: TTP0012: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5280: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
cbiG	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2356: Cobalamin biosynthesis protein CbiG	Deinococcus deserti VCD115 Gene: Deide_2p01620: Cobalamin biosynthesis protein CbiG	Thermus thermophilus HB27 Gene: TTP0014: Cobalamin biosynthesis protein CbiG	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5278: Cobalamin biosynthesis protein CbiG	Cobalamin biosynthesis protein CbiG
cbiHJ	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2355: Cobalt-precorrin-3b C17-methyltransferase / Cobalt-precorrin-6x reductase (EC 1.3.1.54)	Deinococcus deserti VCD115 Gene: Deide_2p01630: Cobalt-precorrin-3b C17-methyltransferase / Cobalt-precorrin-6x reductase (EC 1.3.1.54)	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Cobalt-precorrin-3b C17-methyltransferase / Cobalt-precorrin-6x reductase (EC 1.3.1.54)
cobW	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2354: Cobalamin synthesis protein	Deinococcus deserti VCD115 Gene: Deide_2p01640: Cobalamin synthesis protein	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Cobalamin synthesis protein
hoxN	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2353: HoxN/HupN/NixA family cobalt transporter	Deinococcus deserti VCD115 Gene: Deide_2p01650: HoxN/HupN/NixA family cobalt transporter	* Thermus thermophilus HB27 Site: position = -209 score = 45.89 sequence = AGGGGGAAGACCGGT... Gene: TTP0007: HoxN/HupN/NixA family cobalt transporter	* Thermus aquaticus Y51MC23 Site: position = -204 score = 42.11 sequence = AAAGGGGGAAGACCG... Gene: TaqDRAFT_5285: HoxN/HupN/NixA family cobalt transporter	HoxN/HupN/NixA family cobalt transporter
cobN	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2352: Cobaltochelatase, CobN subunit	Deinococcus deserti VCD115 Gene: Deide_2p01670: Cobaltochelatase, CobN subunit	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Cobaltochelatase, CobN subunit
Dgeo_2351	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2351: Methyltransferase type 11	Deinococcus deserti VCD115	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Methyltransferase type 11
chlID	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2350: Cobalt chelatase, ChlI subunit / Cobalt chelatase, ChlD subunit	Deinococcus deserti VCD115 Gene: Deide_2p01680: Cobalt chelatase, ChlI subunit / Cobalt chelatase, ChlD subunit	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Cobalt chelatase, ChlI subunit / Cobalt chelatase, ChlD subunit
cbiA	Deinococcus radiodurans R1 Gene: DRB0009: Cobyrinic acid a,c-diamide synthase	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2349: Cobyrinic acid a,c-diamide synthase	Deinococcus deserti VCD115 Gene: Deide_2p01690: Cobyrinic acid a,c-diamide synthase	Thermus thermophilus HB27 Gene: TTP0001: Cobyrinic acid a,c-diamide synthase	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3286: Cobyrinic acid a,c-diamide synthase	Cobyrinic acid a,c-diamide synthase
cbiB	Deinococcus radiodurans R1 Gene: DRB0010: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2348: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)	Deinococcus deserti VCD115 Gene: Deide_2p01700: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)	Thermus thermophilus HB27 Gene: TTP0019: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3278: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)	Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)
cobD	Deinococcus radiodurans R1 Gene: DRB0011: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2875: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0022: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3274: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
cbiP	Deinococcus radiodurans R1 Gene: DRB0012: Cobyric acid synthase	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2874: Cobyric acid synthase	Deinococcus deserti VCD115 Gene: Deide_2p01820: Cobyric acid synthase	Thermus thermophilus HB27 Gene: TTP0023: Cobyric acid synthase / Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3272: Cobyric acid synthase / Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Cobyric acid synthase
cobU	Deinococcus radiodurans R1 Gene: DRA0020: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2873: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Deinococcus deserti VCD115 Gene: Deide_2p01830: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
cobT	Deinococcus radiodurans R1 Gene: DRA0240: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2872: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Deinococcus deserti VCD115 Gene: Deide_2p01840: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)	Thermus thermophilus HB27	Thermus aquaticus Y51MC23	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
cbiC	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0009: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5283: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
cbiET	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0010: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5282: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
cbiH	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0013: Cobalt-precorrin-3b C17-methyltransferase	2 Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5279: Cobalt-precorrin-3b C17-methyltransferase Gene: TaqDRAFT_5224: Cobalt-precorrin-3b C17-methyltransferase	Cobalt-precorrin-3b C17-methyltransferase
cbiX	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0015: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5277: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
DUF3209	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0016: Hypothetical protein implicated in coenzyme B12 biosynthesis	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5276: Hypothetical protein implicated in coenzyme B12 biosynthesis	Hypothetical protein implicated in coenzyme B12 biosynthesis
cobA	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0017: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_5275: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)	Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
bluB	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115 Gene: Deide_2p01660: Cob(II)yrinic acid a,c-diamide reductase	Thermus thermophilus HB27 Gene: TTP0018: Cob(II)yrinic acid a,c-diamide reductase	Thermus aquaticus Y51MC23	Cob(II)yrinic acid a,c-diamide reductase
TTP0020	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0020: HEPN domain-containing nucleotidyltransferase	Thermus aquaticus Y51MC23	HEPN domain-containing nucleotidyltransferase
TTP0021	Deinococcus radiodurans R1	Deinococcus geothermalis DSM 11300	Deinococcus deserti VCD115	Thermus thermophilus HB27 Gene: TTP0021: Nucleotidyltransferase	Thermus aquaticus Y51MC23	Nucleotidyltransferase

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog Cobalamin - Deinococcus-Thermus

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --