Regulog MetR - Oceanospirillales/Alteromonadales

Properties
Regulator type:	Transcription factor
Regulator family:	LysR
Regulation mode:	repressor (activator)
Biological process:	Methionine biosynthesis
Effector:	Homocysteine
Phylum:	Proteobacteria/Gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 46 sites [see more]

Member of regulog collections

By taxonomy - Oceanospirillales/Alteromonadales
By trascription factor - MetR
By TF family - LysR
By effector - Homocysteine
By pathway - Methionine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Hahella chejuensis KCTC 2396	2	2
Marinobacter aqueolei	2	2
Marinobacter sp. ELB17	2	2
Oceanobacter sp. RED65	5	3
Oceanospirillum sp. MED92	3	2
Marinomonas sp. MWYL1	5	2
Saccharophagus degradans 2-40	2	2
Teredinibacter turnerae T7901	2	2
Cellvibrio japonicus Ueda107	2	2
Chromohalobacter salexigens DSM 3043	3	3
Reinekea sp. MED297	2	2
Alcanivorax borkumensis SK2	2	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
metE	* Hahella chejuensis KCTC 2396 Site: position = -91 score = 4.57699 sequence = ATGAATTTATTTAAT Site: position = -70 score = 4.50915 sequence = ATGAAATATTAACAT Gene: HCH_01174: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Marinobacter aqueolei Site: position = -104 score = 4.61489 sequence = GTGAATCTTTTTCAT Site: position = -83 score = 4.05719 sequence = GTGAAATAATACCAT Gene: Maqu_0809: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Marinobacter sp. ELB17 Site: position = -67 score = 4.90154 sequence = GTGAATAGAATTCAT Site: position = -46 score = 4.06 sequence = GTGAAATAATACCAT Gene: MELB17_19821: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Oceanobacter sp. RED65	Oceanospirillum sp. MED92	Marinomonas sp. MWYL1	* Saccharophagus degradans 2-40 Site: position = -62 score = 4.20008 sequence = ATCAATTTTATTCAC Site: position = -93 score = 5.22028 sequence = ATGATTAAAATTCAT Gene: Sde_0638: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Teredinibacter turnerae T7901 Site: position = -81 score = 4.50915 sequence = ATGAAATAATACCAT Site: position = -102 score = 5.35351 sequence = ATGAATTGTATTCAT Gene: TERTU_4688: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Cellvibrio japonicus Ueda107 Site: position = -138 score = 4.65204 sequence = ATTAATTAAATTCAT Gene: CJA_2448: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Chromohalobacter salexigens DSM 3043 Site: position = -163 score = 4.29234 sequence = ATGAGTGCCGTTCAT Gene: Csal_0672: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Reinekea sp. MED297 Site: position = -102 score = 5.02378 sequence = ATGAATTTTACTCAT Site: position = -81 score = 4.58421 sequence = ATGAATTAATACCAT Gene: MED297_11745: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Alcanivorax borkumensis SK2 Site: position = -230 score = 4.39374 sequence = ATGAATGCCTTTCCT Site: position = -147 score = 4.39751 sequence = TTGAGAAAAATTCAT Gene: ABO_0861: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)

CRON 2.
PF08908	Hahella chejuensis KCTC 2396	Marinobacter aqueolei	Marinobacter sp. ELB17	* Oceanobacter sp. RED65 Site: position = -86 score = 4.19905 sequence = ATGAGATAAAATCAA Site: position = -76 score = 4.57699 sequence = ATCAATTTTTTTCAT Gene: RED65_13432: Protein of unknown function DUF1852	* Oceanospirillum sp. MED92 Site: position = -188 score = 4.37853 sequence = ATGAATAAATATAAT Site: position = -167 score = 4.72811 sequence = ATGAAAAGGTATCAT Gene: MED92_05643: Protein of unknown function DUF1852	* Marinomonas sp. MWYL1 Site: position = -169 score = 5.41874 sequence = ATGAATAATATTCAT Site: position = -149 score = 4.02578 sequence = TTAAAATAAATTCAT Gene: Mmwyl1_0387: Protein of unknown function DUF1852	Saccharophagus degradans 2-40	Teredinibacter turnerae T7901	Cellvibrio japonicus Ueda107	Chromohalobacter salexigens DSM 3043	Reinekea sp. MED297	Alcanivorax borkumensis SK2	Protein of unknown function DUF1852
metE2	Hahella chejuensis KCTC 2396	Marinobacter aqueolei	Marinobacter sp. ELB17	Oceanobacter sp. RED65 Gene: RED65_13427: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Oceanospirillum sp. MED92 Gene: MED92_05638: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Marinomonas sp. MWYL1 Gene: Mmwyl1_0388: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Saccharophagus degradans 2-40	Teredinibacter turnerae T7901	Cellvibrio japonicus Ueda107	* Chromohalobacter salexigens DSM 3043 Site: position = -41 score = 4.75254 sequence = ATGAACGTCATTCAT Gene: Csal_1563: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Reinekea sp. MED297	Alcanivorax borkumensis SK2	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)

CRON 3.
metH	Hahella chejuensis KCTC 2396	Marinobacter aqueolei	Marinobacter sp. ELB17	2 Oceanobacter sp. RED65* Gene: RED65_09024: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Site: position = -106 score = 4.40734 sequence = ATGAGTAGTATTCAA Gene: RED65_09029: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Oceanospirillum sp. MED92 Site: position = -129 score = 4.31029 sequence = ATGACCAATTTTCAT Gene: MED92_04362: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	Marinomonas sp. MWYL1 Gene: Mmwyl1_2169: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	Saccharophagus degradans 2-40	Teredinibacter turnerae T7901	Cellvibrio japonicus Ueda107	Chromohalobacter salexigens DSM 3043	Reinekea sp. MED297	Alcanivorax borkumensis SK2	5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)

CRON 4.
glyA	Hahella chejuensis KCTC 2396	Marinobacter aqueolei	Marinobacter sp. ELB17	Oceanobacter sp. RED65	Oceanospirillum sp. MED92 Gene: MED92_08642: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Marinomonas sp. MWYL1 Site: position = -95 score = 4.79334 sequence = ATGATCTTTTTTCAT Gene: Mmwyl1_2283: Serine hydroxymethyltransferase (EC 2.1.2.1)	Saccharophagus degradans 2-40	Teredinibacter turnerae T7901	Cellvibrio japonicus Ueda107	Chromohalobacter salexigens DSM 3043	Reinekea sp. MED297	Alcanivorax borkumensis SK2	Serine hydroxymethyltransferase (EC 2.1.2.1)
gcvH	Hahella chejuensis KCTC 2396	Marinobacter aqueolei	Marinobacter sp. ELB17	Oceanobacter sp. RED65	Oceanospirillum sp. MED92 Gene: MED92_08647: Glycine cleavage system H protein	Marinomonas sp. MWYL1 Gene: Mmwyl1_2284: Glycine cleavage system H protein	Saccharophagus degradans 2-40	Teredinibacter turnerae T7901	Cellvibrio japonicus Ueda107	Chromohalobacter salexigens DSM 3043	Reinekea sp. MED297	Alcanivorax borkumensis SK2	Glycine cleavage system H protein
gcvP	Hahella chejuensis KCTC 2396	Marinobacter aqueolei	Marinobacter sp. ELB17	Oceanobacter sp. RED65	Oceanospirillum sp. MED92 Gene: MED92_08652: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)	Marinomonas sp. MWYL1 Gene: Mmwyl1_2285: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)	Saccharophagus degradans 2-40	Teredinibacter turnerae T7901	Cellvibrio japonicus Ueda107	Chromohalobacter salexigens DSM 3043	Reinekea sp. MED297	Alcanivorax borkumensis SK2	Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)

CRON 5.
metR	* Hahella chejuensis KCTC 2396 Site: position = -47 score = 4.50915 sequence = ATGTTAATATTTCAT Site: position = -26 score = 4.57699 sequence = ATTAAATAAATTCAT Gene: HCH_01175: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Marinobacter aqueolei Site: position = -21 score = 4.05719 sequence = ATGGTATTATTTCAC Site: position = 0 score = 4.61489 sequence = ATGAAAAAGATTCAC Gene: Maqu_0810: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Marinobacter sp. ELB17 Site: position = -44 score = 4.90154 sequence = ATGAATTCTATTCAC Site: position = -65 score = 4.05719 sequence = ATGGTATTATTTCAC Gene: MELB17_19816: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Oceanobacter sp. RED65 Site: position = -29 score = 3.68523 sequence = CTGTATCTCATTCAT Site: position = -53 score = 3.61864 sequence = ATGAATATTCCTAAT Gene: RED65_10519: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Oceanospirillum sp. MED92 Gene: MED92_02289: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Marinomonas sp. MWYL1 Gene: Mmwyl1_3390: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Saccharophagus degradans 2-40 Site: position = -13 score = 5.22028 sequence = ATGAATTTTAATCAT Site: position = -44 score = 4.20008 sequence = GTGAATAAAATTGAT Gene: Sde_0637: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Teredinibacter turnerae T7901 Site: position = 0 score = 4.50915 sequence = ATGGTATTATTTCAT Site: position = 21 score = 5.35351 sequence = ATGAATACAATTCAT Gene: TERTU_4689: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Cellvibrio japonicus Ueda107 Site: position = -84 score = 4.65204 sequence = ATGAATTTAATTAAT Site: position = -115 score = 3.98024 sequence = ATGAATCAAACTGAT Gene: CJA_2446: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Chromohalobacter salexigens DSM 3043 Site: position = -20 score = 4.29234 sequence = ATGAACGGCACTCAT Site: position = -139 score = 3.8959 sequence = ATGAGTGACTTTCAG Gene: Csal_0671: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Reinekea sp. MED297 Site: position = -84 score = 4.58421 sequence = ATGGTATTAATTCAT Site: position = -63 score = 5.02378 sequence = ATGAGTAAAATTCAT Gene: MED297_11750: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Alcanivorax borkumensis SK2 Site: position = -96 score = 4.39751 sequence = ATGAATTTTTCTCAA Site: position = -13 score = 4.39374 sequence = AGGAAAGGCATTCAT Gene: ABO_0862: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog MetR - Oceanospirillales/Alteromonadales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --