Regulog PerR - Lactobacillaceae

Properties
Regulator type:	Transcription factor
Regulator family:	FUR
Regulation mode:	repressor
Biological process:	Manganese homeostasis; Oxidative stress response; Iron homeostasis
Effector:	Iron ion, (Fe2+); Manganese ion, (Mn2+); Hydrogen peroxide
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 49 sites [see more]

Member of regulog collections

By taxonomy - Lactobacillaceae
By TF family - FUR
By effector - Iron ion, (Fe2+)
By effector - Manganese ion, (Mn2+)
By effector - Hydrogen peroxide
By pathway - Manganese homeostasis
By pathway - Oxidative stress response
By pathway - Iron homeostasis

Statistics of regulated genes
Genome	Genes	Operons
Lactobacillus acidophilus NCFM
Lactobacillus brevis ATCC 367	7	6
Lactobacillus casei ATCC 334	7	5
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
Lactobacillus fermentum IFO 3956	6	4
Lactobacillus helveticus DPC 4571
Lactobacillus johnsonii NCC 533
Lactobacillus plantarum WCFS1	8	6
Lactobacillus reuteri JCM 1112	6	4
Lactobacillus rhamnosus GG	6	4
Lactobacillus sakei subsp. sakei 23K	5	4
Lactobacillus salivarius subsp. salivarius UCC118	7	5
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
Oenococcus oeni PSU-1
Pediococcus pentosaceus ATCC 25745	4	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
ahpC	Lactobacillus acidophilus NCFM	* Lactobacillus brevis ATCC 367 Site: position = -82 score = 4.91269 sequence = TTAGAATCATTCTTG Gene: LVIS_0086: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)	* Lactobacillus casei ATCC 334 Site: position = -31 score = 5.47394 sequence = TAATAATCATTCTAA Gene: LSEI_2506: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	* Lactobacillus fermentum IFO 3956 Site: position = -32 score = 4.99081 sequence = TGATAATCGTTCTAA Gene: LAF_0409: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	* Lactobacillus reuteri JCM 1112 Site: position = -94 score = 5.58996 sequence = TTAGAATTGTTCTAA Site: position = -33 score = 5.67877 sequence = TAAGAATGATTCTAA Gene: LAR_1019: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1450: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)
ahpF	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_0410: Alkyl hydroperoxide reductase protein F (EC 1.6.4.-)	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112 Gene: LAR_1018: Alkyl hydroperoxide reductase protein F (EC 1.6.4.-)	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1451: Alkyl hydroperoxide reductase protein F (EC 1.6.4.-)	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Alkyl hydroperoxide reductase protein F (EC 1.6.4.-)

CRON 2.
perR	Lactobacillus acidophilus NCFM	* Lactobacillus brevis ATCC 367 Site: position = -186 score = 5.45878 sequence = TTAGAATAATTCTTA Gene: LVIS_1882: Peroxide stress response transcriptional regulator PerR, Fur family	Lactobacillus casei ATCC 334 Gene: LSEI_0869: Peroxide stress response transcriptional regulator PerR, Fur family	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	* Lactobacillus fermentum IFO 3956 Site: position = -27 score = 5.57219 sequence = TTAAAATGATTATAA Gene: LAF_1362: Peroxide stress response transcriptional regulator PerR, Fur family	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -63 score = 4.80763 sequence = TTGGAATCCTTCTAA Site: position = -79 score = 4.96338 sequence = TAGTAATGTTTCTAA Gene: lp_3247: Peroxide stress response transcriptional regulator PerR, Fur family	* Lactobacillus reuteri JCM 1112 Site: position = -107 score = 5.32397 sequence = TTAGAATAATTATTA Site: position = -31 score = 5.45302 sequence = TTATAATTATTTTAA Gene: LAR_1232: Peroxide stress response transcriptional regulator PerR, Fur family	Lactobacillus rhamnosus GG Gene: LGG_00831: Peroxide stress response transcriptional regulator PerR, Fur family	* Lactobacillus sakei subsp. sakei 23K Site: position = -38 score = 4.66093 sequence = TGATAATGATTATCA Gene: LSA0466: Peroxide stress response transcriptional regulator PerR, Fur family	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -33 score = 4.76458 sequence = TTATAAAAGTTATAA Gene: LSL_1367: Peroxide stress response transcriptional regulator PerR, Fur family	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0338: Peroxide stress response transcriptional regulator PerR, Fur family	Peroxide stress response transcriptional regulator PerR, Fur family

CRON 3.
pcl2	Lactobacillus acidophilus NCFM	* Lactobacillus brevis ATCC 367 Site: position = -98 score = 5.57065 sequence = TAAGAATTATTCTAA Gene: LVIS_1881: Predicted membrane protein	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	* Lactobacillus fermentum IFO 3956 Site: position = -103 score = 5.3305 sequence = TTAGAATTCTTCTAA Site: position = -39 score = 5.72964 sequence = TTATAATGGTTCTAA Gene: LAF_1546: Predicted membrane protein	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -37 score = 5.57552 sequence = TAATAATGATTATAA Gene: lp_3360: Predicted membrane protein	* Lactobacillus reuteri JCM 1112 Site: position = -102 score = 5.42793 sequence = TTTTAATGATTCTAA Site: position = -38 score = 5.95331 sequence = TTATAATGATTCTAA Gene: LAR_1418: Predicted membrane protein	Lactobacillus rhamnosus GG	* Lactobacillus sakei subsp. sakei 23K Site: position = -43 score = 5.59483 sequence = TTATAATGGTTATAA Gene: LSA1194: Predicted membrane protein	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -38 score = 5.49284 sequence = TTATAATTTTTCTAA Gene: LSL_0409: Predicted membrane protein	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0493: Predicted membrane protein	2 Oenococcus oeni PSU-1 Gene: OEOE_1793: Predicted membrane protein Gene: OEOE_0482: Predicted membrane protein	* Pediococcus pentosaceus ATCC 25745 Site: position = -37 score = 5.707 sequence = TTAAAATGATTCTAA Gene: PEPE_0043: Predicted membrane protein	Predicted membrane protein
pcl1	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_1880: Predicted membrane protein	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1545: Predicted membrane protein	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_3359: Predicted membrane protein	Lactobacillus reuteri JCM 1112 Gene: LAR_1417: Predicted membrane protein	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA1195: Predicted membrane protein	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0410: Predicted membrane protein	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0494: Predicted membrane protein	2 Oenococcus oeni PSU-1 Gene: OEOE_1792: Predicted membrane protein Gene: OEOE_0481: Predicted membrane protein	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0044: Predicted membrane protein	Predicted membrane protein

CRON 4.
cueO	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_0394: Predicted copper oxidase	* Lactobacillus casei ATCC 334 Site: position = -192 score = 5.31346 sequence = TTAGATTAATTCTAA Gene: LSEI_2417: Predicted copper oxidase	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1452: Predicted copper oxidase	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -88 score = 5.55771 sequence = TTAAAATAATTCTAA Gene: lp_0355: Predicted copper oxidase	Lactobacillus reuteri JCM 1112	* Lactobacillus rhamnosus GG Site: position = -72 score = 4.7726 sequence = TTAGATTAATTCCAA Gene: LGG_02415: Predicted copper oxidase	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_A31: Predicted copper oxidase	Oenococcus oeni PSU-1 Gene: OEOE_0009: Predicted copper oxidase	* Pediococcus pentosaceus ATCC 25745 Site: position = -73 score = 5.31346 sequence = TTAGATTAATTCTAA Gene: PEPE_0502: Predicted copper oxidase	Predicted copper oxidase
ycnB	Lactobacillus acidophilus NCFM	* Lactobacillus brevis ATCC 367 Site: position = -39 score = 5.17713 sequence = TAAGAATATTTCTAA Gene: LVIS_1917: Predicted permease	Lactobacillus casei ATCC 334 Gene: LSEI_2416: Predicted permease	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	* Lactobacillus fermentum IFO 3956 Site: position = -109 score = 5.32475 sequence = TTATAATCATTTTAA Site: position = -30 score = 4.81188 sequence = TTATAAGTTTTCTAA Gene: LAF_1361: Predicted permease	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_3303: Predicted permease	* Lactobacillus reuteri JCM 1112 Site: position = -107 score = 5.4229 sequence = TTAAAATAATTATAA Site: position = -31 score = 5.60221 sequence = TAATAATTATTCTAA Gene: LAR_1231: Predicted permease	Lactobacillus rhamnosus GG Gene: LGG_02414: Predicted permease	Lactobacillus sakei subsp. sakei 23K	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -64 score = 4.56916 sequence = TTACAAAAATTCTAA Gene: LSL_1578: Predicted permease	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0546: Predicted permease	Oenococcus oeni PSU-1 Gene: OEOE_0192: Predicted permease	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0503: Predicted permease	Predicted permease

CRON 5.
cadA	Lactobacillus acidophilus NCFM Gene: LBA1929: Predicted cation-transporting ATP-ase	* Lactobacillus brevis ATCC 367 Site: position = -52 score = 4.56277 sequence = CAATAATTGTTATAA Gene: LVIS_0392: Predicted cation-transporting ATP-ase	* Lactobacillus casei ATCC 334 Site: position = -46 score = 5.20024 sequence = TTGTAATGGTTATAA Site: position = -80 score = 5.03426 sequence = TTATATTCGTTCTAA Gene: LSEI_2799: Predicted cation-transporting ATP-ase	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1992: Predicted cation-transporting ATP-ase	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571 Gene: lhv_2064: Predicted cation-transporting ATP-ase	Lactobacillus johnsonii NCC 533 Gene: LJ1792: Predicted cation-transporting ATP-ase	* Lactobacillus plantarum WCFS1 Site: position = -93 score = 5.37168 sequence = TTAGAATCATTCTTA Gene: lp_3327: Predicted cation-transporting ATP-ase	Lactobacillus reuteri JCM 1112 Gene: LAR_0171: Predicted cation-transporting ATP-ase	* Lactobacillus rhamnosus GG Site: position = -80 score = 5.03426 sequence = TTATATTCGTTCTAA Site: position = -46 score = 5.20024 sequence = TTGTAATGGTTATAA Gene: LGG_02803: Predicted cation-transporting ATP-ase	* Lactobacillus sakei subsp. sakei 23K Site: position = -65 score = 5.30157 sequence = TGATAATAATTCTAA Gene: LSA0969: Predicted cation-transporting ATP-ase	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -93 score = 5.49284 sequence = TTATAATTTTTCTAA Gene: LSL_0169: Predicted cation-transporting ATP-ase	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0090: Predicted cation-transporting ATP-ase	Predicted cation-transporting ATP-ase

CRON 6.
ybbL	Lactobacillus acidophilus NCFM Gene: LBA1499: Predicted ABC transporter, ATP-binding protein	Lactobacillus brevis ATCC 367 Gene: LVIS_2102: Predicted ABC transporter, ATP-binding protein	* Lactobacillus casei ATCC 334 Site: position = -40 score = 5.78694 sequence = TTAGAATGATTATAA Gene: LSEI_2588: Predicted ABC transporter, ATP-binding protein	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1021: Predicted ABC transporter, ATP-binding protein	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533 Gene: LJ0728: Predicted ABC transporter, ATP-binding protein	* Lactobacillus plantarum WCFS1 Site: position = -36 score = 5.95331 sequence = TTATAATGATTCTAA Gene: lp_3225: Predicted ABC transporter, ATP-binding protein	Lactobacillus reuteri JCM 1112	* Lactobacillus rhamnosus GG Site: position = -35 score = 5.02241 sequence = TTAGAATGGTTACAA Gene: LGG_02565: Predicted ABC transporter, ATP-binding protein	Lactobacillus sakei subsp. sakei 23K Gene: LSA0979: Predicted ABC transporter, ATP-binding protein	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -38 score = 5.49284 sequence = TTATAATTTTTCTAA Gene: LSL_1684: Predicted ABC transporter, ATP-binding protein	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_A10: Predicted ABC transporter, ATP-binding protein	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Predicted ABC transporter, ATP-binding protein
ybbM	Lactobacillus acidophilus NCFM Gene: LBA1500: Predicted ABC transporter, permease protein	Lactobacillus brevis ATCC 367 Gene: LVIS_2101: Predicted ABC transporter, permease protein	Lactobacillus casei ATCC 334 Gene: LSEI_2589: Predicted ABC transporter, permease protein	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0029: Predicted ABC transporter, permease protein	Lactobacillus fermentum IFO 3956 Gene: LAF_1020: Predicted ABC transporter, permease protein	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533 Gene: LJ0729: Predicted ABC transporter, permease protein	Lactobacillus plantarum WCFS1 Gene: lp_3224: Predicted ABC transporter, permease protein	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG Gene: LGG_02566: Predicted ABC transporter, permease protein	Lactobacillus sakei subsp. sakei 23K Gene: LSA0978: Predicted ABC transporter, permease protein	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1683: Predicted ABC transporter, permease protein	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_A09: Predicted ABC transporter, permease protein	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Predicted ABC transporter, permease protein

CRON 7.
npr	Lactobacillus acidophilus NCFM Gene: LBA1401: NADH peroxidase (EC 1.11.1.1)	* Lactobacillus brevis ATCC 367 Site: position = -90 score = 5.92175 sequence = TTAGAATGATTCTAA Gene: LVIS_B09: NADH peroxidase (EC 1.11.1.1)	* Lactobacillus casei ATCC 334 Site: position = -74 score = 4.73808 sequence = TTGGAACTATTCTAA Gene: LSEI_0397: NADH peroxidase (EC 1.11.1.1)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1460: NADH peroxidase (EC 1.11.1.1)	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	2 Lactobacillus plantarum WCFS1* Site: position = -95 score = 5.09679 sequence = TTAGAATAATTACAA Gene: lp_2544: NADH peroxidase (EC 1.11.1.1) Gene: lp_1445: NADH peroxidase (EC 1.11.1.1)	Lactobacillus reuteri JCM 1112	* Lactobacillus rhamnosus GG Site: position = -75 score = 5.4506 sequence = TTGTAATTATTCTAA Gene: LGG_00491: NADH peroxidase (EC 1.11.1.1)	* Lactobacillus sakei subsp. sakei 23K Site: position = -61 score = 4.96094 sequence = TTGTAATAATTATTA Gene: LSA0575: NADH peroxidase (EC 1.11.1.1)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0137: NADH peroxidase (EC 1.11.1.1)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0104: NADH peroxidase (EC 1.11.1.1)	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1619: NADH peroxidase (EC 1.11.1.1)	NADH peroxidase (EC 1.11.1.1)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog PerR - Lactobacillaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --