Statistics of regulated genes

Genome	Genes	Operons
Oenococcus oeni PSU-1
Lactobacillus reuteri JCM 1112	10	4
Lactobacillus helveticus DPC 4571	9	4
Lactobacillus fermentum IFO 3956	11	5
Lactobacillus salivarius subsp. salivarius UCC118	8	2
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	8	4
Lactobacillus acidophilus NCFM	9	4
Lactobacillus johnsonii NCC 533	9	4
Lactobacillus plantarum WCFS1	11	4
Lactobacillus casei ATCC 334	9	1
Lactobacillus brevis ATCC 367	6	4
Lactobacillus sakei subsp. sakei 23K	13	4
Pediococcus pentosaceus ATCC 25745	3	3
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	6	1
Lactobacillus rhamnosus GG	10	2

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes																Function
CRON 1.
codB	Oenococcus oeni PSU-1	* Lactobacillus reuteri JCM 1112 Site: position = -140 score = 47.77 sequence = GTTCTTTTAATGTAG... Gene: LAR_0247: Cytosine/purine/uracil/thiamine/allantoin permease family protein	Lactobacillus helveticus DPC 4571	* Lactobacillus fermentum IFO 3956 Site: position = -109 score = 49.7 sequence = AAGTCTTTAACGACG... Gene: LAF_0911: Cytosine/purine/uracil/thiamine/allantoin permease family protein	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_3374: Cytosine/purine/uracil/thiamine/allantoin permease family protein	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367 Gene: LVIS_0417: Cytosine/purine/uracil/thiamine/allantoin permease family protein	*2 Lactobacillus sakei subsp. sakei 23K Site: position = -122 score = 56.28 sequence = TAATTCCTTTTAAGT... Gene: LSA1211: Cytosine/purine/uracil/thiamine/allantoin permease family protein Gene: LSA1210: Cytosine/purine/uracil/thiamine/allantoin permease family protein	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0240: Cytosine/purine/uracil/thiamine/allantoin permease family protein	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG	Cytosine/purine/uracil/thiamine/allantoin permease family protein
codA	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112 Gene: LAR_0248: Cytosine deaminase (EC 3.5.4.1)	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956 Gene: LAF_0912: Cytosine deaminase (EC 3.5.4.1)	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367 Gene: LVIS_1932: Cytosine deaminase (EC 3.5.4.1)	2 Lactobacillus sakei subsp. sakei 23K Gene: LSA1212: Cytosine deaminase (EC 3.5.4.1) Gene: LSA1213: Cytosine deaminase (EC 3.5.4.1)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0241: Cytosine deaminase (EC 3.5.4.1)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG	Cytosine deaminase (EC 3.5.4.1)
ntd	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_1427: Purine trans deoxyribosylase (Nucleoside deoxyribosyltransferase-I) (EC 2.4.2.6)	Lactobacillus casei ATCC 334	* Lactobacillus brevis ATCC 367 Site: position = -146 score = 51.22 sequence = AGTCCTTTTAAATTA... Gene: LVIS_0416: Purine trans deoxyribosylase (Nucleoside deoxyribosyltransferase-I) (EC 2.4.2.6)	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0444: Purine trans deoxyribosylase (Nucleoside deoxyribosyltransferase-I) (EC 2.4.2.6)	Lactobacillus rhamnosus GG	Purine trans deoxyribosylase (Nucleoside deoxyribosyltransferase-I) (EC 2.4.2.6)
CRON 2.
pyrR	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112 Gene: LAR_0068: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	*2 Lactobacillus helveticus DPC 4571 Site: position = -142 score = 56.73 sequence = GATGCCCTTTAAAGT... Gene: lhv_0582: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR Site: position = -124 score = 56.45 sequence = AATGTCCTTTAAAAT... Gene: lhv_1447: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	* Lactobacillus fermentum IFO 3956 Site: position = -106 score = 30.79 sequence = ATGCCTTTAAGTGGA... Gene: LAF_0046: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -176 score = 39.38 sequence = AGTCCTTTAAACTAG... Gene: LSL_0827: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	*2 Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -116 score = 50.0 sequence = AATGTCCTTTAAAAT... Gene: LBUL_1954: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR Gene: LBUL_1518: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	*2 Lactobacillus acidophilus NCFM Site: position = -147 score = 63.05 sequence = GATGACCTTTAAAAT... Gene: LBA0563: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR Site: position = -133 score = 63.48 sequence = AATGTCCTTTAAAAT... Gene: LBA1383: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	*2 Lactobacillus johnsonii NCC 533 Gene: LJ1275: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR Site: position = -98 score = 61.09 sequence = AATGTCCTTTAAAAT... Gene: LJ1280: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	*2 Lactobacillus plantarum WCFS1 Site: position = -141 score = 59.0 sequence = AAGCACCTTTAACTT... Gene: lp_2704: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR Site: position = -143 score = 25.39 sequence = CGTCCTTTAATCCGG... Gene: lp_1782: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	* Lactobacillus casei ATCC 334 Site: position = -325 score = 56.83 sequence = AAGCACCTTTAACTA... Gene: LSEI_1457: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	Lactobacillus brevis ATCC 367 Gene: LVIS_0831: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	* Lactobacillus sakei subsp. sakei 23K Site: position = -141 score = 63.66 sequence = AAACCTTTAATTTCA... Gene: LSA0950: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0942: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1372: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	* Lactobacillus rhamnosus GG Site: position = -466 score = 60.16 sequence = AAGCACCTTTAACTA... Gene: LGG_01461: Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR	Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR
pyrP	Oenococcus oeni PSU-1 Gene: OEOE_0376: Xanthine/uracil permease	* Lactobacillus reuteri JCM 1112 Site: position = -94 score = 57.8 sequence = AGACCTTTAATCGGA... Gene: LAR_0450: Xanthine/uracil permease	Lactobacillus helveticus DPC 4571 Gene: lhv_0581: Xanthine/uracil permease	* Lactobacillus fermentum IFO 3956 Site: position = -115 score = 43.34 sequence = AGTCCTTTAATGGAA... Gene: LAF_0434: Xanthine/uracil permease	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0828: Xanthine/uracil permease	* Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -79 score = 41.01 sequence = GAACCTTTAAATTCA... Gene: LBUL_0487: Xanthine/uracil permease	Lactobacillus acidophilus NCFM Gene: LBA0562: Xanthine/uracil permease	* Lactobacillus johnsonii NCC 533 Site: position = -158 score = 55.64 sequence = GATGACCTTTAATAT... Gene: LJ0709: Xanthine/uracil permease	* Lactobacillus plantarum WCFS1 Site: position = -146 score = 59.79 sequence = CAGTTCCTTTAAATT... Gene: lp_2371: Xanthine/uracil permease	Lactobacillus casei ATCC 334 Gene: LSEI_1456: Xanthine/uracil permease	* Lactobacillus brevis ATCC 367 Site: position = -128 score = 47.31 sequence = ATAGTCCTTTAATAT... Gene: LVIS_1729: Xanthine/uracil permease	* Lactobacillus sakei subsp. sakei 23K Site: position = -169 score = 41.02 sequence = GAACCGTTTAATTGT... Gene: LSA0951: Xanthine/uracil permease	* Pediococcus pentosaceus ATCC 25745 Site: position = -145 score = 45.77 sequence = AGAAACCTTAATTTG... Gene: PEPE_1124: Xanthine/uracil permease	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1876: Xanthine/uracil permease	Lactobacillus rhamnosus GG Gene: LGG_01460: Xanthine/uracil permease	Xanthine/uracil permease
pyrB	Oenococcus oeni PSU-1 Gene: OEOE_0258: Aspartate carbamoyltransferase (EC 2.1.3.2)	* Lactobacillus reuteri JCM 1112 Site: position = -292 score = 59.56 sequence = ATACCTTTAACTTAG... Site: position = -148 score = 40.0 sequence = CGACCATTTAATTGT... Gene: LAR_0117: Aspartate carbamoyltransferase (EC 2.1.3.2)	* Lactobacillus helveticus DPC 4571 Site: position = -125 score = 46.77 sequence = ATCAACCATTTAATT... Gene: lhv_1446: Aspartate carbamoyltransferase (EC 2.1.3.2)	* Lactobacillus fermentum IFO 3956 Site: position = -269 score = 59.04 sequence = GATGTCCTTTAAGCT... Site: position = -146 score = 38.41 sequence = ATAAACCATCAAATT... Gene: LAF_1205: Aspartate carbamoyltransferase (EC 2.1.3.2)	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -303 score = 48.27 sequence = AAACCTTTAAGAATA... Site: position = -135 score = 37.74 sequence = AAACCATTTAATTGT... Gene: LSL_0190: Aspartate carbamoyltransferase (EC 2.1.3.2)	* Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -125 score = 46.77 sequence = ATCAACCATTTAATT... Gene: LBUL_1953: Aspartate carbamoyltransferase (EC 2.1.3.2)	* Lactobacillus acidophilus NCFM Site: position = -123 score = 40.14 sequence = CCCAACCATTTAATT... Gene: LBA1382: Aspartate carbamoyltransferase (EC 2.1.3.2)	* Lactobacillus johnsonii NCC 533 Site: position = -126 score = 46.52 sequence = GTCAACCATTTAATT... Gene: LJ1279: Aspartate carbamoyltransferase (EC 2.1.3.2)	* Lactobacillus plantarum WCFS1 Site: position = -136 score = 42.7 sequence = TAAAACCATTTAATT... Gene: lp_2703: Aspartate carbamoyltransferase (EC 2.1.3.2)	Lactobacillus casei ATCC 334 Gene: LSEI_1455: Aspartate carbamoyltransferase (EC 2.1.3.2)	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K Gene: LSA0952: Aspartate carbamoyltransferase (EC 2.1.3.2)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0313: Aspartate carbamoyltransferase (EC 2.1.3.2)	* Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Site: position = -133 score = 60.37 sequence = TAAAACCTTTAATCA... Gene: LEUM_1210: Aspartate carbamoyltransferase (EC 2.1.3.2)	Lactobacillus rhamnosus GG Gene: LGG_01459: Aspartate carbamoyltransferase (EC 2.1.3.2)	Aspartate carbamoyltransferase (EC 2.1.3.2)
pyrC	Oenococcus oeni PSU-1 Gene: OEOE_0259: Dihydroorotase (EC 3.5.2.3)	Lactobacillus reuteri JCM 1112 Gene: LAR_0118: Dihydroorotase (EC 3.5.2.3)	Lactobacillus helveticus DPC 4571 Gene: lhv_1445: Dihydroorotase (EC 3.5.2.3)	Lactobacillus fermentum IFO 3956 Gene: LAF_1204: Dihydroorotase (EC 3.5.2.3)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0191: Dihydroorotase (EC 3.5.2.3)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1952: Dihydroorotase (EC 3.5.2.3)	Lactobacillus acidophilus NCFM Gene: LBA1381: Dihydroorotase (EC 3.5.2.3)	Lactobacillus johnsonii NCC 533 Gene: LJ1278: Dihydroorotase (EC 3.5.2.3)	Lactobacillus plantarum WCFS1 Gene: lp_2702: Dihydroorotase (EC 3.5.2.3)	Lactobacillus casei ATCC 334 Gene: LSEI_1454: Dihydroorotase (EC 3.5.2.3)	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K Gene: LSA0953: Dihydroorotase (EC 3.5.2.3)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0314: Dihydroorotase (EC 3.5.2.3)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1209: Dihydroorotase (EC 3.5.2.3)	Lactobacillus rhamnosus GG Gene: LGG_01458: Dihydroorotase (EC 3.5.2.3)	Dihydroorotase (EC 3.5.2.3)
carA	Oenococcus oeni PSU-1 Gene: OEOE_0260: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	*2 Lactobacillus reuteri JCM 1112 Gene: LAR_0876: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Site: position = -198 score = 49.87 sequence = ATTATCCTTTAATTT... Gene: LAR_0081: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	2 Lactobacillus helveticus DPC 4571 Gene: lhv_1257: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Gene: lhv_1444: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	2 Lactobacillus fermentum IFO 3956 Gene: LAF_1203: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Gene: LAF_1162: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	2 Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0829: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Gene: LSL_0192: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	2 Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1951: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Gene: LBUL_0931: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	2 Lactobacillus acidophilus NCFM Gene: LBA1150: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Gene: LBA1380: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	2 Lactobacillus johnsonii NCC 533 Gene: LJ1185: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Gene: LJ1277: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	2 Lactobacillus plantarum WCFS1 Gene: lp_2701: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Gene: lp_1783: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	Lactobacillus casei ATCC 334 Gene: LSEI_1453: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	Lactobacillus brevis ATCC 367 Gene: LVIS_0830: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	Lactobacillus sakei subsp. sakei 23K Gene: LSA0954: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	2 Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0943: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Gene: PEPE_0315: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	2 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1371: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) Gene: LEUM_1208: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	Lactobacillus rhamnosus GG Gene: LGG_01457: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)
carB	Oenococcus oeni PSU-1 Gene: OEOE_0261: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	2 Lactobacillus reuteri JCM 1112 Gene: LAR_0877: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) Gene: LAR_0080: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	2 Lactobacillus helveticus DPC 4571 Gene: lhv_1443: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) Gene: lhv_1256: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	2 Lactobacillus fermentum IFO 3956 Gene: LAF_1202: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) Gene: LAF_1161: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0193: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	2 Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1950: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) Gene: LBUL_0932: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	2 Lactobacillus acidophilus NCFM Gene: LBA1149: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) Gene: LBA1379: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	2 Lactobacillus johnsonii NCC 533 Gene: LJ1184: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) Gene: LJ1276: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Lactobacillus plantarum WCFS1 Gene: lp_2700: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Lactobacillus casei ATCC 334 Gene: LSEI_1452: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Lactobacillus brevis ATCC 367 Gene: LVIS_0829: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Lactobacillus sakei subsp. sakei 23K Gene: LSA0955: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	2 Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0944: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) Gene: PEPE_0316: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	2 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1207: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) Gene: LEUM_1370: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Lactobacillus rhamnosus GG Gene: LGG_01456: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)
pyrD	Oenococcus oeni PSU-1 Gene: OEOE_0264: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Lactobacillus reuteri JCM 1112 Gene: LAR_0119: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Lactobacillus helveticus DPC 4571 Gene: lhv_2937: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Lactobacillus fermentum IFO 3956 Gene: LAF_1201: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0194: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	2 Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1955: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) Gene: LBUL_1421: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Lactobacillus acidophilus NCFM Gene: LBA1384: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Lactobacillus johnsonii NCC 533 Gene: LJ1281: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Lactobacillus plantarum WCFS1 Gene: lp_2699: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Lactobacillus casei ATCC 334 Gene: LSEI_1451: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K Gene: LSA0957: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0317: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG Gene: LGG_01455: Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)
pyrF	Oenococcus oeni PSU-1 Gene: OEOE_0262: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	Lactobacillus reuteri JCM 1112 Gene: LAR_0120: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	* Lactobacillus helveticus DPC 4571 Site: position = -118 score = 26.31 sequence = CAAACTTTAAACGGT... Gene: lhv_2938: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	* Lactobacillus fermentum IFO 3956 Site: position = -116 score = 45.39 sequence = TCACCATTTAAGTAA... Gene: LAF_0047: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0830: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	* Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -140 score = 19.19 sequence = TGAGCTTTAATTGGT... Gene: LBUL_1422: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	* Lactobacillus acidophilus NCFM Site: position = -118 score = 23.15 sequence = CAAACTTTAAACGGT... Gene: LBA1386: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	* Lactobacillus johnsonii NCC 533 Site: position = -115 score = 25.78 sequence = TAAACTTTAAACGGT... Gene: LJ1282: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	Lactobacillus plantarum WCFS1 Gene: lp_2698: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	Lactobacillus casei ATCC 334 Gene: LSEI_1450: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	* Lactobacillus brevis ATCC 367 Site: position = -129 score = 46.31 sequence = ATCAAACTTTAATTT... Gene: LVIS_2229: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	Lactobacillus sakei subsp. sakei 23K Gene: LSA0958: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	* Pediococcus pentosaceus ATCC 25745 Site: position = -96 score = 27.45 sequence = GAGTCGCTTTAAATC... Gene: PEPE_1675: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1206: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	Lactobacillus rhamnosus GG Gene: LGG_01454: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)
pyrE	Oenococcus oeni PSU-1 Gene: OEOE_0263: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus reuteri JCM 1112 Gene: LAR_0121: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus helveticus DPC 4571 Gene: lhv_1451: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus fermentum IFO 3956 Gene: LAF_0048: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0831: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1423: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus acidophilus NCFM Gene: LBA1387: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus johnsonii NCC 533 Gene: LJ1283: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus plantarum WCFS1 Gene: lp_2697: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus casei ATCC 334 Gene: LSEI_1449: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus brevis ATCC 367 Gene: LVIS_2228: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus sakei subsp. sakei 23K Gene: LSA0959: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1205: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Lactobacillus rhamnosus GG Gene: LGG_01453: Orotate phosphoribosyltransferase (EC 2.4.2.10)	Orotate phosphoribosyltransferase (EC 2.4.2.10)
pyrK	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K Gene: LSA0956: Dihydroorotate oxidase, electron transfer subunit	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG	Dihydroorotate oxidase, electron transfer subunit
CRON 3.
pyrG	Oenococcus oeni PSU-1 Gene: OEOE_1786: CTP synthase (EC 6.3.4.2)	Lactobacillus reuteri JCM 1112 Gene: LAR_0221: CTP synthase (EC 6.3.4.2)	Lactobacillus helveticus DPC 4571 Gene: lhv_0247: CTP synthase (EC 6.3.4.2)	Lactobacillus fermentum IFO 3956 Gene: LAF_0202: CTP synthase (EC 6.3.4.2)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0342: CTP synthase (EC 6.3.4.2)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0309: CTP synthase (EC 6.3.4.2)	Lactobacillus acidophilus NCFM Gene: LBA0233: CTP synthase (EC 6.3.4.2)	Lactobacillus johnsonii NCC 533 Gene: LJ0224: CTP synthase (EC 6.3.4.2)	Lactobacillus plantarum WCFS1 Gene: lp_0481: CTP synthase (EC 6.3.4.2)	Lactobacillus casei ATCC 334 Gene: LSEI_2571: CTP synthase (EC 6.3.4.2)	* Lactobacillus brevis ATCC 367 Site: position = -125 score = 17.84 sequence = GCTCCTTGCTACTTG... Gene: LVIS_0487: CTP synthase (EC 6.3.4.2)	* Lactobacillus sakei subsp. sakei 23K Site: position = -153 score = 19.88 sequence = TATATTCTATGGGCG... Gene: LSA1629: CTP synthase (EC 6.3.4.2)	* Pediococcus pentosaceus ATCC 25745 Site: position = -158 score = 26.26 sequence = GAGATCCTTTTGAGG... Gene: PEPE_1571: CTP synthase (EC 6.3.4.2)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0519: CTP synthase (EC 6.3.4.2)	* Lactobacillus rhamnosus GG Site: position = -118 score = 23.3 sequence = TAATATACATTTTGG... Gene: LGG_02546: CTP synthase (EC 6.3.4.2)	CTP synthase (EC 6.3.4.2)

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