Regulog TPP - Corynebacteriaceae

Properties
Regulator type:	RNA regulatory element
Name:	TPP
RFAM:	RF00059
Regulation mode:
Biological process:	Thiamine biosynthesis
Effector:	Thiamine pyrophosphate
Phylum:	Actinobacteria

Member of regulog collections

By taxonomy - Corynebacteriaceae
By RNA motif - TPP
By effector - Thiamine pyrophosphate
By pathway - Thiamine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Corynebacterium glutamicum ATCC 13032	13	5
Corynebacterium efficiens YS-314	12	4
Corynebacterium diphtheriae NCTC 13129	11	3
Corynebacterium aurimucosum ATCC 700975	10	2
Corynebacterium jeikeium K411	7	1
Corynebacterium urealyticum DSM 7109	12	3
Corynebacterium amycolatum SK46	5	2
Corynebacterium kroppenstedtii DSM 44385	10	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
oarX	* Corynebacterium glutamicum ATCC 13032 Site: position = -166 score = 63.54 sequence = TACTAGTGACACGGG... Gene: cg0825: 3-ketoacyl-(acyl-carrier-protein) reductase (EC 1.1.1.100)	Corynebacterium efficiens YS-314	Corynebacterium diphtheriae NCTC 13129	Corynebacterium aurimucosum ATCC 700975	Corynebacterium jeikeium K411	Corynebacterium urealyticum DSM 7109	Corynebacterium amycolatum SK46	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1720: 3-ketoacyl-(acyl-carrier-protein) reductase (EC 1.1.1.100)	3-ketoacyl-(acyl-carrier-protein) reductase (EC 1.1.1.100)

CRON 2.
thiC	* Corynebacterium glutamicum ATCC 13032 Site: position = -110 score = 55.87 sequence = AGGCAGTCCCCACGG... Gene: cg1476: Phosphomethylpyrimidine synthase	* Corynebacterium efficiens YS-314 Site: position = 100 score = 57.43 sequence = CGGCAGTCCCCACGG... Gene: CE1407: Phosphomethylpyrimidine synthase	* Corynebacterium diphtheriae NCTC 13129 Site: position = -110 score = 55.17 sequence = GTGTCCCCCGCGGGC... Gene: DIP0029: Phosphomethylpyrimidine synthase	* Corynebacterium aurimucosum ATCC 700975 Site: position = -109 score = 52.9 sequence = TGATACCCCACGGGT... Gene: cauri_1573: Phosphomethylpyrimidine synthase	* Corynebacterium jeikeium K411 Site: position = -114 score = 39.52 sequence = CACAACCGAACACGG... Gene: jk0855: Phosphomethylpyrimidine synthase	* Corynebacterium urealyticum DSM 7109 Site: position = -112 score = 58.04 sequence = TACCGAAATACGGGC... Gene: cur_1103: Phosphomethylpyrimidine synthase	* Corynebacterium amycolatum SK46 Site: position = -121 score = 50.96 sequence = ATTACAAAACCACGG... Gene: CORAM0001_0557: Phosphomethylpyrimidine synthase	* Corynebacterium kroppenstedtii DSM 44385 Site: position = -106 score = 52.77 sequence = CACGACCCCACGGGA... Gene: ckrop_1709: Phosphomethylpyrimidine synthase	Phosphomethylpyrimidine synthase
thiE	* Corynebacterium glutamicum ATCC 13032 Site: position = -113 score = 62.55 sequence = ACTTACCCCACGGGT... Gene: cg2236: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	* Corynebacterium efficiens YS-314 Site: position = -113 score = 51.52 sequence = CCAACCCCCACGGGC... Gene: CE1933: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0030: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1574: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Corynebacterium jeikeium K411 Gene: jk0854: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Corynebacterium urealyticum DSM 7109 Gene: cur_1104: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Corynebacterium amycolatum SK46	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1710: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
cg0121	Corynebacterium glutamicum ATCC 13032 Gene: cg0121: major facilitator superfamily permease	Corynebacterium efficiens YS-314 Gene: CE0097: major facilitator superfamily permease	Corynebacterium diphtheriae NCTC 13129	Corynebacterium aurimucosum ATCC 700975	Corynebacterium jeikeium K411 Gene: jk0853: major facilitator superfamily permease	Corynebacterium urealyticum DSM 7109 Gene: cur_1105: major facilitator superfamily permease	Corynebacterium amycolatum SK46	Corynebacterium kroppenstedtii DSM 44385	major facilitator superfamily permease
thiO	Corynebacterium glutamicum ATCC 13032 Gene: cg2237: Glycine oxidase ThiO (EC 1.4.3.19)	Corynebacterium efficiens YS-314 Gene: CE1934: Glycine oxidase ThiO (EC 1.4.3.19)	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0031: Glycine oxidase ThiO (EC 1.4.3.19)	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1575: Glycine oxidase ThiO (EC 1.4.3.19)	Corynebacterium jeikeium K411 Gene: jk0852: Glycine oxidase ThiO (EC 1.4.3.19)	Corynebacterium urealyticum DSM 7109 Gene: cur_1106: Glycine oxidase ThiO (EC 1.4.3.19)	* Corynebacterium amycolatum SK46 Site: position = -116 score = 57.59 sequence = TACCACGTTCCGCGG... Gene: CORAM0001_1432: Glycine oxidase ThiO (EC 1.4.3.19)	* Corynebacterium kroppenstedtii DSM 44385 Site: position = -26 score = 54.19 sequence = ATCGTCGACCTACGG... Gene: ckrop_1717: Glycine oxidase ThiO (EC 1.4.3.19)	Glycine oxidase ThiO (EC 1.4.3.19)
thiS	Corynebacterium glutamicum ATCC 13032 Gene: cg2238: Sulfur carrier protein ThiS	Corynebacterium efficiens YS-314 Gene: CE1935: Sulfur carrier protein ThiS	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0032: Sulfur carrier protein ThiS	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1576: Sulfur carrier protein ThiS	Corynebacterium jeikeium K411 Gene: jk0851: Sulfur carrier protein ThiS	Corynebacterium urealyticum DSM 7109 Gene: cur_1107: Sulfur carrier protein ThiS	Corynebacterium amycolatum SK46 Gene: CORAM0001_1431: Sulfur carrier protein ThiS	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1716: Sulfur carrier protein ThiS	Sulfur carrier protein ThiS
thiG	Corynebacterium glutamicum ATCC 13032 Gene: cg2239: Thiazole synthase	Corynebacterium efficiens YS-314 Gene: CE1936: Thiazole synthase	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0033: Thiazole synthase	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1577: Thiazole synthase	Corynebacterium jeikeium K411 Gene: jk0850: Thiazole synthase	Corynebacterium urealyticum DSM 7109 Gene: cur_1108: Thiazole synthase	Corynebacterium amycolatum SK46 Gene: CORAM0001_1430: Thiazole synthase	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1715: Thiazole synthase	Thiazole synthase
thiF	Corynebacterium glutamicum ATCC 13032 Gene: cg2240: Sulfur carrier protein adenylyltransferase ThiF	Corynebacterium efficiens YS-314 Gene: CE1937: Sulfur carrier protein adenylyltransferase ThiF	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0034: Sulfur carrier protein adenylyltransferase ThiF	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1578: Sulfur carrier protein adenylyltransferase ThiF	Corynebacterium jeikeium K411 Gene: jk0849: Sulfur carrier protein adenylyltransferase ThiF	Corynebacterium urealyticum DSM 7109 Gene: cur_1109: Sulfur carrier protein adenylyltransferase ThiF	Corynebacterium amycolatum SK46 Gene: CORAM0001_1429: Sulfur carrier protein adenylyltransferase ThiF	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1714: Sulfur carrier protein adenylyltransferase ThiF	Sulfur carrier protein adenylyltransferase ThiF
thiED-tenA	Corynebacterium glutamicum ATCC 13032 Gene: cg1654: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) / Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiaminase II (EC 3.5.99.2)	Corynebacterium efficiens YS-314 Gene: CE1591: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) / Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiaminase II (EC 3.5.99.2)	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0035: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1292: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Corynebacterium jeikeium K411 Gene: jk0297: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Corynebacterium urealyticum DSM 7109 Site: position = -143 score = 50.73 sequence = AATAACGCAAGGGGT... Gene: cur_0377: Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiaminase II (EC 3.5.99.2)	Corynebacterium amycolatum SK46 Gene: CORAM0001_1880: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) / Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Corynebacterium kroppenstedtii DSM 44385	Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) / Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiaminase II (EC 3.5.99.2)
thiM	* Corynebacterium glutamicum ATCC 13032 Site: position = -102 score = 52.11 sequence = AATACTAGGCACGGG... Gene: cg1655: Hydroxyethylthiazole kinase (EC 2.7.1.50)	* Corynebacterium efficiens YS-314 Site: position = -95 score = 55.5 sequence = AGAACCAGGCACGGG... Gene: CE1592: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Corynebacterium diphtheriae NCTC 13129	Corynebacterium aurimucosum ATCC 700975	Corynebacterium jeikeium K411	Corynebacterium urealyticum DSM 7109	Corynebacterium amycolatum SK46	Corynebacterium kroppenstedtii DSM 44385	Hydroxyethylthiazole kinase (EC 2.7.1.50)

CRON 3.
ykoE	* Corynebacterium glutamicum ATCC 13032 Site: position = -100 score = 51.03 sequence = TTCATAGACACGGGT... Gene: cg1227: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	* Corynebacterium efficiens YS-314 Site: position = -98 score = 60.62 sequence = CGATATTGCACGGGT... Gene: CE1134: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	* Corynebacterium diphtheriae NCTC 13129 Site: position = -119 score = 59.37 sequence = TTATAAATCACGGGT... Gene: DIP0951: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	* Corynebacterium aurimucosum ATCC 700975 Site: position = -166 score = 50.36 sequence = CACATCGTCACGGGT... Gene: cauri_0372: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium jeikeium K411	* Corynebacterium urealyticum DSM 7109 Site: position = -108 score = 37.2 sequence = CCGACCAACGCGGGA... Gene: cur_0414: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium amycolatum SK46 Gene: CORAM0001_0566: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	* Corynebacterium kroppenstedtii DSM 44385 Site: position = -163 score = 47.6 sequence = CAGTACTTCGCGGGA... Gene: ckrop_0610: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
ykoD	Corynebacterium glutamicum ATCC 13032 Gene: cg1228: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium efficiens YS-314 Gene: CE1135: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	* Corynebacterium diphtheriae NCTC 13129 Site: position = -106 score = 59.46 sequence = CGAGATGCCCGGGTG... Gene: DIP0953: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_0373: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium jeikeium K411	Corynebacterium urealyticum DSM 7109 Gene: cur_0415: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium amycolatum SK46 Gene: CORAM0001_0567: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_0611: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
ykoC	Corynebacterium glutamicum ATCC 13032 Gene: cg1229: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium efficiens YS-314 Gene: CE1136: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0954: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_0374: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium jeikeium K411	Corynebacterium urealyticum DSM 7109 Gene: cur_0416: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium amycolatum SK46 Gene: CORAM0001_0568: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_0612: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
hmpK	Corynebacterium glutamicum ATCC 13032 Gene: cg1230: predicted hydroxymethylpyrimidine kinase	Corynebacterium efficiens YS-314 Gene: CE1137: predicted hydroxymethylpyrimidine kinase	Corynebacterium diphtheriae NCTC 13129 Gene: DIP0955: predicted hydroxymethylpyrimidine kinase	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_0375: predicted hydroxymethylpyrimidine kinase	Corynebacterium jeikeium K411	Corynebacterium urealyticum DSM 7109 Gene: cur_0417: predicted hydroxymethylpyrimidine kinase	Corynebacterium amycolatum SK46 Gene: CORAM0001_0569: predicted hydroxymethylpyrimidine kinase	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_0613: predicted hydroxymethylpyrimidine kinase	predicted hydroxymethylpyrimidine kinase

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog TPP - Corynebacteriaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --