Regulog NagR - Bifidobacteriaceae

Properties
Regulator type:	Transcription factor
Regulator family:	ROK
Regulation mode:
Biological process:	Lacto-N-biose utilization; Galacto-N-biose utilization
Effector:	N-acetylglucosamine-6-phosphate
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 28 sites [see more]

Member of regulog collections

By taxonomy - Bifidobacteriaceae
By TF family - ROK
By effector - N-acetylglucosamine-6-phosphate
By pathway - Lacto-N-biose utilization
By pathway - Galacto-N-biose utilization

Statistics of regulated genes
Genome	Genes	Operons
Bifidobacterium longum subsp. infantis ATCC 15697	11	4
Bifidobacterium adolescentis ATCC 15703
Bifidobacterium angulatum DSM 20098
Bifidobacterium animalis subsp. lactis AD011
Bifidobacterium bifidum NCIMB 41171	10	5
Bifidobacterium breve DSM 20213	11	6
Bifidobacterium dentium Bd1
Bifidobacterium gallicum DSM 20093
Bifidobacterium longum NCC2705	11	4
Gardnerella vaginalis 409-05

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes											Function

CRON 1.
lnbA	* Bifidobacterium longum subsp. infantis ATCC 15697 Site: position = -95 score = 4.94539 sequence = AATTGTTAGTTGGGTTGACAATA Site: position = -175 score = 3.99586 sequence = GTGAGTTAATGAAATGAACAAAC Gene: Blon_2177: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, substrate-binding protein	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	* Bifidobacterium bifidum NCIMB 41171 Site: position = -101 score = 4.71854 sequence = AAATGTTAATGTAGTTGACATTT Gene: BbifN4_010100004949: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, substrate-binding protein	* Bifidobacterium breve DSM 20213 Site: position = -96 score = 5.201 sequence = AATTGTTAGTTAGGTTGACAATA Site: position = -184 score = 4.5779 sequence = CTTTGTAAGGAGTATTAATAAAA Gene: BIFBRE_00332: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, substrate-binding protein	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	* Bifidobacterium longum NCC2705 Site: position = -95 score = 5.175 sequence = AATTGTTAGCTAAGTTGACAATA Gene: BL1638: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, substrate-binding protein	Gardnerella vaginalis 409-05	Predicted galacto-N-biose-/lacto-N-biose ABC transporter, substrate-binding protein
lnbB	Bifidobacterium longum subsp. infantis ATCC 15697 Gene: Blon_2176: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 1	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171 Gene: BbifN4_010100004944: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 1	Bifidobacterium breve DSM 20213 Gene: BIFBRE_00333: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 1	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705 Gene: BL1639: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 1	Gardnerella vaginalis 409-05	Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 1
lnbC	Bifidobacterium longum subsp. infantis ATCC 15697 Gene: Blon_2175: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 2	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171 Gene: BbifN4_010100004939: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 2	Bifidobacterium breve DSM 20213 Gene: BIFBRE_00334: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 2	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705 Gene: BL1640: Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 2	Gardnerella vaginalis 409-05	Predicted galacto-N-biose-/lacto-N-biose ABC transporter, permease component 2
lnpA	* Bifidobacterium longum subsp. infantis ATCC 15697 Site: position = -31 score = 4.11728 sequence = TTTTGATGATCAACCTCACAAAG Gene: Blon_2174: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase (EC:2.4.1.211)	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	Bifidobacterium breve DSM 20213 Gene: BIFBRE_00335: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase (EC:2.4.1.211)	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705 Gene: BL1641: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase (EC:2.4.1.211)	Gardnerella vaginalis 409-05	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase (EC:2.4.1.211)
nahK	Bifidobacterium longum subsp. infantis ATCC 15697 Gene: Blon_2173: N-acetylhexosamine 1-kinase (EC:2.7.1.162)	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	* Bifidobacterium bifidum NCIMB 41171 Site: position = -144 score = 4.9176 sequence = TTATGTAACTATAATTAACAAAT Gene: BbifN4_010100004904: N-acetylhexosamine 1-kinase (EC:2.7.1.162)	* Bifidobacterium breve DSM 20213 Site: position = -69 score = 4.78152 sequence = TTATGTATATATACTTAACAAAT Gene: BIFBRE_00337: N-acetylhexosamine 1-kinase (EC:2.7.1.162)	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705 Gene: BL1642: N-acetylhexosamine 1-kinase (EC:2.7.1.162)	Gardnerella vaginalis 409-05	N-acetylhexosamine 1-kinase (EC:2.7.1.162)
galT2	Bifidobacterium longum subsp. infantis ATCC 15697 Gene: Blon_2172: UDP-glucose--hexose-1-phosphate uridylyltransferase (EC:2.7.7.12)	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171 Gene: BbifN4_010100004899: UDP-glucose--hexose-1-phosphate uridylyltransferase (EC:2.7.7.12)	* Bifidobacterium breve DSM 20213 Site: position = -40 score = 5.91668 sequence = AATTGTTAGGGTAATTAACAATA Gene: BIFBRE_00635: UDP-glucose--hexose-1-phosphate uridylyltransferase (EC:2.7.7.12)	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705 Gene: BL1643: UDP-glucose--hexose-1-phosphate uridylyltransferase (EC:2.7.7.12)	Gardnerella vaginalis 409-05	UDP-glucose--hexose-1-phosphate uridylyltransferase (EC:2.7.7.12)
galE2	Bifidobacterium longum subsp. infantis ATCC 15697 Gene: Blon_2171: UDP-glucose 4-epimerase (EC 5.1.3.2)	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171 Gene: BbifN4_010100004894: UDP-glucose 4-epimerase (EC 5.1.3.2)	Bifidobacterium breve DSM 20213 Gene: BIFBRE_00338: UDP-glucose 4-epimerase (EC 5.1.3.2)	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705 Gene: BL1644: UDP-glucose 4-epimerase (EC 5.1.3.2)	Gardnerella vaginalis 409-05	UDP-glucose 4-epimerase (EC 5.1.3.2)

CRON 2.
nagB	* Bifidobacterium longum subsp. infantis ATCC 15697 Site: position = -169 score = 6.51124 sequence = AATTGTTAGTATCATTAACAAAT Site: position = -251 score = 5.54749 sequence = AATTGTTATGAAACTTCACCAAT Gene: Blon_0881: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	* Bifidobacterium bifidum NCIMB 41171 Site: position = -135 score = 6.33079 sequence = ATTAGTTAGTATCATTAACAAAT Gene: BbifN4_010100002384: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	* Bifidobacterium breve DSM 20213 Site: position = -180 score = 5.46527 sequence = ATCTGTTAGGGAACTTCACTAAT Site: position = -100 score = 6.02054 sequence = AATTGTAAGTAGTATTAACAAAT Gene: BIFBRE_01706: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	* Bifidobacterium longum NCC2705 Site: position = -251 score = 5.25986 sequence = AACTGTTATGAAACTTCACTAAT Site: position = -169 score = 6.51124 sequence = AATTGTTAGTATCATTAACAAAT Gene: BL1343: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Gardnerella vaginalis 409-05	Glucosamine-6-phosphate deaminase (EC 3.5.99.6)
nagA	Bifidobacterium longum subsp. infantis ATCC 15697 Gene: Blon_0882: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171 Gene: BbifN4_010100002389: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Bifidobacterium breve DSM 20213 Gene: BIFBRE_01705: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	Bifidobacterium longum NCC2705 Gene: BL1344: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Gardnerella vaginalis 409-05	N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)

CRON 3.
nagR	* Bifidobacterium longum subsp. infantis ATCC 15697 Site: position = -191 score = 6.51124 sequence = ATTTGTTAATGATACTAACAATT Site: position = -109 score = 5.54749 sequence = ATTGGTGAAGTTTCATAACAATT Gene: Blon_0880: Transciptional regulator of lacto-N-biose and galacto-N-biose utilization, ROK family	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	2 Bifidobacterium bifidum NCIMB 41171* Site: position = -138 score = 6.33079 sequence = ATTTGTTAATGATACTAACTAAT Gene: BbifN4_010100002379: Transciptional regulator of lacto-N-biose and galacto-N-biose utilization, ROK family Site: position = -168 score = 4.9176 sequence = ATTTGTTAATTATAGTTACATAA Gene: BbifN4_010100004909: Transciptional regulator of lacto-N-biose and galacto-N-biose utilization, ROK family	* Bifidobacterium breve DSM 20213 Site: position = -116 score = 5.46527 sequence = ATTAGTGAAGTTCCCTAACAGAT Site: position = -196 score = 6.02054 sequence = ATTTGTTAATACTACTTACAATT Gene: BIFBRE_01707: Transciptional regulator of lacto-N-biose and galacto-N-biose utilization, ROK family	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	* Bifidobacterium longum NCC2705 Site: position = -109 score = 5.25986 sequence = ATTAGTGAAGTTTCATAACAGTT Site: position = -191 score = 6.51124 sequence = ATTTGTTAATGATACTAACAATT Gene: BL1342: Transciptional regulator of lacto-N-biose and galacto-N-biose utilization, ROK family	Gardnerella vaginalis 409-05	Transciptional regulator of lacto-N-biose and galacto-N-biose utilization, ROK family

CRON 4.
nagK	* Bifidobacterium longum subsp. infantis ATCC 15697 Site: position = -78 score = 5.34483 sequence = ATTTGTTAAGATAGTTGTCAATA Gene: Blon_0879: Predicted N-acetyl-glucosamine kinase, ROK family (EC 2.7.1.59)	Bifidobacterium adolescentis ATCC 15703	Bifidobacterium angulatum DSM 20098	Bifidobacterium animalis subsp. lactis AD011	Bifidobacterium bifidum NCIMB 41171	* Bifidobacterium breve DSM 20213 Site: position = -78 score = 5.34483 sequence = ATTTGTTAAGATAGTTGTCAATA Gene: BIFBRE_01708: Predicted N-acetyl-glucosamine kinase, ROK family (EC 2.7.1.59)	Bifidobacterium dentium Bd1	Bifidobacterium gallicum DSM 20093	* Bifidobacterium longum NCC2705 Site: position = -78 score = 5.13242 sequence = ATTTGTTAAGATGGTTGTCAATA Gene: BL1341: Predicted N-acetyl-glucosamine kinase, ROK family (EC 2.7.1.59)	Gardnerella vaginalis 409-05	Predicted N-acetyl-glucosamine kinase, ROK family (EC 2.7.1.59)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NagR - Bifidobacteriaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --