Regulog AgaR - Clostridia-1

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:
Biological process:	N-acetylgalactosamine utilization
Effector:
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 19 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-1
By TF family - GntR/Others
By pathway - N-acetylgalactosamine utilization

Statistics of regulated genes
Genome	Genes	Operons
Clostridium acetobutylicum ATCC 824
Clostridium beijerincki NCIMB 8052	8	3
Clostridium botulinum A str. ATCC 3502
Clostridium butyricum 5521	16	4
Clostridium kluyveri DSM 555
Clostridium novyi NT	12	5
Clostridium perfringens ATCC 13124	3	2
Clostridium tetani E88

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
agaA2	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -51 score = 5.95037 sequence = TAAGTGGTAATTACCAGTTG Site: position = -267 score = 5.76517 sequence = TAAGTGGTAATTACCAAATA Gene: CBY_3029: N-acetylgalactosamine-6-phosphate deacetylase (EC 3.5.1.25)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	N-acetylgalactosamine-6-phosphate deacetylase (EC 3.5.1.25)
Cbei_4539	Clostridium acetobutylicum ATCC 824	* Clostridium beijerincki NCIMB 8052 Site: position = -192 score = 4.81845 sequence = AAACTGGTAGTATCCAGTTA Gene: Cbei_4539: Putative transcriptional regulator with PTS regulatory domain	Clostridium botulinum A str. ATCC 3502 Gene: CBO3358: Putative transcriptional regulator with PTS regulatory domain	Clostridium butyricum 5521 Gene: CBY_3030: Putative transcriptional regulator with PTS regulatory domain	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Putative transcriptional regulator with PTS regulatory domain
Cbei_4538	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4538: PTS system, cellobiose-specific IIB component (EC 2.7.1.69)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3357: PTS system, cellobiose-specific IIB component (EC 2.7.1.69)	Clostridium butyricum 5521 Gene: CBY_3031: PTS system, cellobiose-specific IIB component (EC 2.7.1.69)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	PTS system, cellobiose-specific IIB component (EC 2.7.1.69)
Cbei_4537	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4537: PTS system, lichenan-, cellobiose-specific IIA component (EC 2.7.1.69); PTS system, cellobiose-specific IIC component (EC 2.7.1.69)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3356: PTS system, lichenan-, cellobiose-specific IIA component (EC 2.7.1.69); PTS system, cellobiose-specific IIC component (EC 2.7.1.69)	Clostridium butyricum 5521 Gene: CBY_3032: PTS system, lichenan-, cellobiose-specific IIA component (EC 2.7.1.69); PTS system, cellobiose-specific IIC component (EC 2.7.1.69)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	PTS system, lichenan-, cellobiose-specific IIA component (EC 2.7.1.69); PTS system, cellobiose-specific IIC component (EC 2.7.1.69)
agaK	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4536: Predicted N-acetylgalactosamine kinase (EC 2.7.1.157)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3355: Predicted N-acetylgalactosamine kinase (EC 2.7.1.157)	Clostridium butyricum 5521 Gene: CBY_3033: Predicted N-acetylgalactosamine kinase (EC 2.7.1.157)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Predicted N-acetylgalactosamine kinase (EC 2.7.1.157)
PF05913	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO3354: Bacterial protein of unknown function (DUF871)	Clostridium butyricum 5521 Gene: CBY_3034: Bacterial protein of unknown function (DUF871)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Bacterial protein of unknown function (DUF871)
Cbei_4535	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4535: PTS system, cellobiose-specific IIC component (EC 2.7.1.69)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3359: PTS system, cellobiose-specific IIC component (EC 2.7.1.69)	Clostridium butyricum 5521 Gene: CBY_3035: PTS system, cellobiose-specific IIC component (EC 2.7.1.69)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	PTS system, cellobiose-specific IIC component (EC 2.7.1.69)

CRON 2.
NT01CX_0299	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -235 score = 5.27539 sequence = GAACTGGTAATGACAACATT Site: position = -317 score = 5.78865 sequence = AATGTGGTAATAACAACATT Gene: NT01CX_0299: Predicted N-acetylgalactosamine permease	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Predicted N-acetylgalactosamine permease
NT01CX_0298	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0298: conserved hypothetical protein	Clostridium perfringens ATCC 13124	Clostridium tetani E88	conserved hypothetical protein
NT01CX_0297	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0297: N-acetylgalactosamine 6-sulfate sulfatase	Clostridium perfringens ATCC 13124	Clostridium tetani E88	N-acetylgalactosamine 6-sulfate sulfatase
agaK2	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3471: Predicted N-acetylgalactosamine kinase (EC 2.7.1.157)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0296: Predicted N-acetylgalactosamine kinase (EC 2.7.1.157)	* Clostridium perfringens ATCC 13124 Site: position = -40 score = 5.78808 sequence = CAAGTGGTAATTACAACTAT Gene: CPF_2149: Predicted N-acetylgalactosamine kinase (EC 2.7.1.157)	Clostridium tetani E88	Predicted N-acetylgalactosamine kinase (EC 2.7.1.157)

CRON 3.
Cbei_1383	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1383: Predicted N-acetylgalactosamine permease	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -76 score = 4.10729 sequence = CAACTTGTACGAACAAGTTG Gene: NT01CX_0301: Predicted N-acetylgalactosamine permease	Clostridium perfringens ATCC 13124 Gene: CPF_0087: Predicted N-acetylgalactosamine permease	Clostridium tetani E88 Gene: CTC00514: Predicted N-acetylgalactosamine permease	Predicted N-acetylgalactosamine permease
NT01CX_0300	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0300: N-acetylglucosamine-6-sulfatase	Clostridium perfringens ATCC 13124	Clostridium tetani E88	N-acetylglucosamine-6-sulfatase

CRON 4.
CBY_3473	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -19 score = 4.65378 sequence = AAATTGGTTAATACCAAAAA Gene: CBY_3473: PTS system, N-acetylgalactosamine- and galactosamine-specific IIB component (EC 2.7.1.69)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	PTS system, N-acetylgalactosamine- and galactosamine-specific IIB component (EC 2.7.1.69)
CBY_3474	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3474: PTS system, N-acetylgalactosamine- and galactosamine-specific IIC component (EC 2.7.1.69)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	PTS system, N-acetylgalactosamine- and galactosamine-specific IIC component (EC 2.7.1.69)
CBY_3475	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3475: PTS system, N-acetylgalactosamine- and galactosamine-specific IID component (EC 2.7.1.69)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	PTS system, N-acetylgalactosamine- and galactosamine-specific IID component (EC 2.7.1.69)
agaR	Clostridium acetobutylicum ATCC 824	* Clostridium beijerincki NCIMB 8052 Site: position = -171 score = 5.94456 sequence = TTAGTGGTAATTACCACTTG Site: position = -269 score = 5.14402 sequence = TAAGTGGACATTATCAGTTT Gene: Cbei_4563: Transcriptional regulator of N-Acetylgalactosamine utilization, GntR family	Clostridium botulinum A str. ATCC 3502	2 Clostridium butyricum 5521* Site: position = -201 score = 5.76517 sequence = TATTTGGTAATTACCACTTA Gene: CBY_3028: Transcriptional regulator of N-Acetylgalactosamine utilization, GntR family Gene: CBY_3476: Transcriptional regulator of N-Acetylgalactosamine utilization, GntR family	Clostridium kluyveri DSM 555	2 Clostridium novyi NT* Site: position = -41 score = 4.8302 sequence = TAAGTGGTATGTACAACATG Gene: NT01CX_0293: Transcriptional regulator of N-Acetylgalactosamine utilization, GntR family Site: position = -350 score = 4.10729 sequence = CAACTTGTTCGTACAAGTTG Gene: NT01CX_0302: Transcriptional regulator of N-Acetylgalactosamine utilization, GntR family	Clostridium perfringens ATCC 13124 Gene: CPF_2963: Transcriptional regulator of N-Acetylgalactosamine utilization, GntR family	Clostridium tetani E88	Transcriptional regulator of N-Acetylgalactosamine utilization, GntR family
agaS	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2904: Galactosamine-6-phosphate isomerase (EC 5.3.1.-)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3477: Galactosamine-6-phosphate isomerase (EC 5.3.1.-)	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -53 score = 5.07942 sequence = TAACTGGTAATGACAACACA Gene: NT01CX_0292: Galactosamine-6-phosphate isomerase (EC 5.3.1.-)	* Clostridium perfringens ATCC 13124 Site: position = -38 score = 5.46221 sequence = CAACTGGTAATGACAACATT Site: position = -83 score = 4.96257 sequence = TAACTTGTAATAACATCATT Gene: CPF_2961: Galactosamine-6-phosphate isomerase (EC 5.3.1.-)	Clostridium tetani E88	Galactosamine-6-phosphate isomerase (EC 5.3.1.-)
CBY_3478	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3478: PTS system, N-acetylgalactosamine- and galactosamine-specific IIA component (EC 2.7.1.69)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	PTS system, N-acetylgalactosamine- and galactosamine-specific IIA component (EC 2.7.1.69)
agaY	Clostridium acetobutylicum ATCC 824 Gene: CAC2952: Tagatose 1,6-diphosphate aldolase (EC 4.1.2.40)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO1993: Tagatose 1,6-diphosphate aldolase (EC 4.1.2.40)	2 Clostridium butyricum 5521 Gene: CBY_3479: Tagatose 1,6-diphosphate aldolase (EC 4.1.2.40) Gene: CBY_2990: Tagatose 1,6-diphosphate aldolase (EC 4.1.2.40)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0290: Tagatose 1,6-diphosphate aldolase (EC 4.1.2.40)	Clostridium perfringens ATCC 13124 Gene: CPF_2962: Tagatose 1,6-diphosphate aldolase (EC 4.1.2.40)	Clostridium tetani E88	Tagatose 1,6-diphosphate aldolase (EC 4.1.2.40)
agaA	Clostridium acetobutylicum ATCC 824	* Clostridium beijerincki NCIMB 8052 Site: position = -58 score = 5.14402 sequence = AAACTGATAATGTCCACTTA Site: position = -156 score = 5.94456 sequence = CAAGTGGTAATTACCACTAA Gene: Cbei_4564: N-acetylgalactosamine-6-phosphate deacetylase (EC 3.5.1.25)	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -285 score = 4.65378 sequence = TTTTTGGTATTAACCAATTT Gene: CBY_3472: N-acetylgalactosamine-6-phosphate deacetylase (EC 3.5.1.25)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0291: N-acetylgalactosamine-6-phosphate deacetylase (EC 3.5.1.25)	Clostridium perfringens ATCC 13124 Gene: CPF_2434: N-acetylgalactosamine-6-phosphate deacetylase (EC 3.5.1.25)	Clostridium tetani E88	N-acetylgalactosamine-6-phosphate deacetylase (EC 3.5.1.25)
agaZ	Clostridium acetobutylicum ATCC 824 Gene: CAC2951: Tagatose-6-phosphate kinase (EC 2.7.1.144) / 1-phosphofructokinase (EC 2.7.1.56)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO1992: Tagatose-6-phosphate kinase (EC 2.7.1.144) / 1-phosphofructokinase (EC 2.7.1.56)	Clostridium butyricum 5521 Gene: CBY_2991: Tagatose-6-phosphate kinase (EC 2.7.1.144) / 1-phosphofructokinase (EC 2.7.1.56)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0289: Tagatose-6-phosphate kinase (EC 2.7.1.144) / 1-phosphofructokinase (EC 2.7.1.56)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Tagatose-6-phosphate kinase (EC 2.7.1.144) / 1-phosphofructokinase (EC 2.7.1.56)
nagB	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4562: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_0397: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_2744: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Clostridium tetani E88 Gene: CTC02631: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Glucosamine-6-phosphate deaminase (EC 3.5.99.6)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog AgaR - Clostridia-1

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --