Regulog CueR - Comamonadaceae

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	activator (repressor)
Biological process:	Copper resistance
Effector:	Copper ion, (Cu+)
Phylum:	Proteobacteria/Beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 25 sites [see more]

Member of regulog collections

By taxonomy - Comamonadaceae
By trascription factor - CueR
By TF family - MerR
By effector - Copper ion, (Cu+)
By pathway - Copper resistance

Statistics of regulated genes
Genome	Genes	Operons
Acidovorax avenae subsp. citrulli AAC00-1	3	2
Acidovorax sp. JS42	6	4
Comamonas testosteroni KF-1	2	1
Delftia acidovorans SPH-1	3	2
Leptothrix cholodnii SP-6
Methylibium petroleiphilum PM1	8	5
Polaromonas naphthalenivorans CJ2	3	2
Polaromonas sp. JS666	6	4
Rhodoferax ferrireducens DSM 15236	2	2
Variovorax paradoxus S110	4	3
Verminephrobacter eiseniae EF01-2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
copA2	Acidovorax avenae subsp. citrulli AAC00-1	* Acidovorax sp. JS42 Site: position = -64 score = 5.33325 sequence = ACCTTCCCACGATGGTAAGCC Gene: Ajs_1372: Copper-translocating P-type ATPase (EC 3.6.3.4)	Comamonas testosteroni KF-1 Gene: CtesDRAFT_4495: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Delftia acidovorans SPH-1 Site: position = -58 score = 4.877 sequence = ACCTTGACATGGTGGCAATCT Gene: Daci_5724: Copper-translocating P-type ATPase (EC 3.6.3.4)	Leptothrix cholodnii SP-6	Methylibium petroleiphilum PM1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Copper-translocating P-type ATPase (EC 3.6.3.4)
cueR3	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42 Gene: Ajs_1373: Copper-responsive transcriptional regulator, MerR family	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Leptothrix cholodnii SP-6	Methylibium petroleiphilum PM1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Copper-responsive transcriptional regulator, MerR family

CRON 2.
Mpe_A1644	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Leptothrix cholodnii SP-6	* Methylibium petroleiphilum PM1 Site: position = -81 score = 5.25854 sequence = ACCTTCCCACGTTGTCAAGGT Gene: Mpe_A1644: hypothetical protein	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	hypothetical protein
copA3	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	Comamonas testosteroni KF-1 Gene: CtesDRAFT_1777: Copper-translocating P-type ATPase (EC 3.6.3.4)	Delftia acidovorans SPH-1	Leptothrix cholodnii SP-6	Methylibium petroleiphilum PM1 Gene: Mpe_A1645: Copper-translocating P-type ATPase (EC 3.6.3.4)	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Copper-translocating P-type ATPase (EC 3.6.3.4)

CRON 3.
copZ2	Acidovorax avenae subsp. citrulli AAC00-1	* Acidovorax sp. JS42 Site: position = -65 score = 5.12475 sequence = ACCTTCCCACCGTGACAAGGC Gene: Ajs_1368: Copper chaperone	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Leptothrix cholodnii SP-6 Gene: Lcho_1834: Copper chaperone	2 Methylibium petroleiphilum PM1* Site: position = -57 score = 5.24 sequence = ACCTTCCAACAGTAGGAGGGT Gene: Mpe_A1641: Copper chaperone Site: position = -61 score = 5.46484 sequence = ACCTTCCCACCGGGGCAACGT Gene: Mpe_A3536: Copper chaperone	* Polaromonas naphthalenivorans CJ2 Site: position = -67 score = 5.48205 sequence = ACTTTGCCACCGTGGGAAGGT Gene: Pnap_4089: Copper chaperone	2 Polaromonas sp. JS666* Site: position = -218 score = 5.61164 sequence = ACCCTGCCCCCGTGGGAAGGT Gene: Bpro_4871: Copper chaperone Site: position = -26 score = 5.01024 sequence = ACCTTCCCACAGTCGGAAGCA Gene: Bpro_3497: Copper chaperone	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Copper chaperone

CRON 4.
copZ	* Acidovorax avenae subsp. citrulli AAC00-1 Site: position = -110 score = 4.8873 sequence = CCCCTGACATCATGGCAAGGT Gene: Aave_0033: Copper chaperone	* Acidovorax sp. JS42 Site: position = -140 score = 5.03886 sequence = ACCCTGACATGCTGGCAAGGT Gene: Ajs_0018: Copper chaperone	* Comamonas testosteroni KF-1 Site: position = -80 score = 4.94241 sequence = ACCTTGTCATGATGTTAGGGT Gene: CtesDRAFT_3915: Copper chaperone	* Delftia acidovorans SPH-1 Site: position = -77 score = 5.3267 sequence = ACCTTGCCATGGTGTCAGGGT Gene: Daci_0035: Copper chaperone	Leptothrix cholodnii SP-6	Methylibium petroleiphilum PM1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	* Variovorax paradoxus S110 Site: position = -70 score = 4.94434 sequence = ACATTGACATCATGAGAAGGT Gene: Vapar_0030: Copper chaperone	Verminephrobacter eiseniae EF01-2 Gene: Veis_1021: Copper chaperone	Copper chaperone
cueR	Acidovorax avenae subsp. citrulli AAC00-1 Gene: Aave_0032: Copper resistance ranscriptional regulator, MerR family	Acidovorax sp. JS42 Gene: Ajs_0017: Copper resistance ranscriptional regulator, MerR family	Comamonas testosteroni KF-1 Gene: CtesDRAFT_3914: Copper resistance ranscriptional regulator, MerR family	Delftia acidovorans SPH-1 Gene: Daci_0034: Copper resistance ranscriptional regulator, MerR family	Leptothrix cholodnii SP-6	Methylibium petroleiphilum PM1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	* Rhodoferax ferrireducens DSM 15236 Site: position = 12 score = 6.01477 sequence = ACCTTCCCACGGTGGCAAGGT Gene: Rfer_0023: Copper resistance ranscriptional regulator, MerR family	Variovorax paradoxus S110 Gene: Vapar_0029: Copper resistance ranscriptional regulator, MerR family	Verminephrobacter eiseniae EF01-2	Copper resistance ranscriptional regulator, MerR family

CRON 5.
copA	* Acidovorax avenae subsp. citrulli AAC00-1 Site: position = -34 score = 4.8873 sequence = ACCTTGCCATGATGTCAGGGG Gene: Aave_0034: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Acidovorax sp. JS42 Site: position = -58 score = 5.03886 sequence = ACCTTGCCAGCATGTCAGGGT Gene: Ajs_0019: Copper-translocating P-type ATPase (EC 3.6.3.4)	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Leptothrix cholodnii SP-6 Gene: Lcho_1835: Copper-translocating P-type ATPase (EC 3.6.3.4)	2 Methylibium petroleiphilum PM1* Site: position = -34 score = 5.65196 sequence = ACTTTGCCATGATGGGAAGGT Gene: Mpe_A3535: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -59 score = 4.80881 sequence = ACCTTGCCATCGTTAGAACCT Gene: Mpe_A1640: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Polaromonas naphthalenivorans CJ2 Site: position = -82 score = 5.69883 sequence = ACCCTGCCATGATGGCAAGGT Gene: Pnap_4090: Copper-translocating P-type ATPase (EC 3.6.3.4)	2 Polaromonas sp. JS666* Site: position = -84 score = 5.65003 sequence = ACCCTGCCATGATGGTAAGGT Gene: Bpro_4872: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -72 score = 5.37456 sequence = ACTTTCCAACAGTGGCAAGGT Gene: Bpro_3496: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Rhodoferax ferrireducens DSM 15236 Site: position = -35 score = 5.81361 sequence = ACCTTGCCATGATGGGAAGGA Gene: Rfer_0024: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Variovorax paradoxus S110 Site: position = -34 score = 4.78556 sequence = ACCTTGCCATGATGTGAGACT Gene: Vapar_0031: Copper-translocating P-type ATPase (EC 3.6.3.4)	Verminephrobacter eiseniae EF01-2 Gene: Veis_1058: Copper-translocating P-type ATPase (EC 3.6.3.4)	Copper-translocating P-type ATPase (EC 3.6.3.4)
cueR2	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Leptothrix cholodnii SP-6	2 Methylibium petroleiphilum PM1 Gene: Mpe_A3534: Copper-responsive transcriptional regulator, MerR family Gene: Mpe_A1639: Copper-responsive transcriptional regulator, MerR family	Polaromonas naphthalenivorans CJ2 Gene: Pnap_4091: Copper-responsive transcriptional regulator, MerR family	2 Polaromonas sp. JS666 Gene: Bpro_4873: Copper-responsive transcriptional regulator, MerR family Gene: Bpro_3495: Copper-responsive transcriptional regulator, MerR family	Rhodoferax ferrireducens DSM 15236	* Variovorax paradoxus S110 Site: position = -60 score = 4.63388 sequence = ACTCTCCCATGGTGTGAAGGC Gene: Vapar_2999: Copper-responsive transcriptional regulator, MerR family	Verminephrobacter eiseniae EF01-2	Copper-responsive transcriptional regulator, MerR family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CueR - Comamonadaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --