Statistics of regulated genes

Genome	Genes	Operons
Rhodobacter sphaeroides 2.4.1	20	6
Paracoccus denitrificans PD1222	39	10
Jannaschia sp. CCS1	12	2
Rhodobacterales bacterium HTCC2654	2	1
Oceanicola granulosus HTCC2516	2	1
Loktanella vestfoldensis SKA53	2	1
Oceanicola batsensis HTCC2597	4	1
Roseovarius nubinhibens ISM	14	4
Roseovarius sp. 217	4	2
Sulfitobacter sp. EE-36	13	4
Silicibacter TM1040	19	6
Silicibacter pomeroyi DSS-3	11	3
Roseobacter sp. MED193	14	4
Hyphomonas neptunium ATCC 15444	10	2
Oceanicaulis alexandrii HTCC2633	4	1

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes																Function
CRON 1.
btuB	* Rhodobacter sphaeroides 2.4.1 Site: position = -326 score = 129.12 sequence = TATTGAGGAACGGCT... Gene: RSP_2402: Outer membrane vitamin B12 receptor BtuB	*2 Paracoccus denitrificans PD1222 Site: position = -347 score = 131.2 sequence = GCCATGAGGGCCGAG... Gene: Pden_1368: Outer membrane vitamin B12 receptor BtuB Site: position = -349 score = 101.88 sequence = CAATGCGGGGCCGCT... Gene: Pden_4382: Outer membrane vitamin B12 receptor BtuB	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	*2 Hyphomonas neptunium ATCC 15444 Site: position = -355 score = 140.25 sequence = CATCAACCCCATCAG... Gene: HNE_1514: Outer membrane vitamin B12 receptor BtuB Site: position = -248 score = 112.13 sequence = CGCCGCCTCACGCAA... Gene: HNE_1142: Outer membrane vitamin B12 receptor BtuB	* Oceanicaulis alexandrii HTCC2633 Site: position = -352 score = 110.46 sequence = ACACCGACATACGCG... Gene: OA2633_11725: Outer membrane vitamin B12 receptor BtuB	Outer membrane vitamin B12 receptor BtuB
btuF	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2403: Vitamin B12 ABC transporter, B12-binding component BtuF	2 Paracoccus denitrificans PD1222 Gene: Pden_1367: Vitamin B12 ABC transporter, B12-binding component BtuF Gene: Pden_4383: Vitamin B12 ABC transporter, B12-binding component BtuF	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_11354: Vitamin B12 ABC transporter, B12-binding component BtuF	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	2 Hyphomonas neptunium ATCC 15444 Gene: HNE_1515: Vitamin B12 ABC transporter, B12-binding component BtuF Gene: HNE_1143: Vitamin B12 ABC transporter, B12-binding component BtuF	Oceanicaulis alexandrii HTCC2633 Gene: OA2633_11730: Vitamin B12 ABC transporter, B12-binding component BtuF	Vitamin B12 ABC transporter, B12-binding component BtuF
btuC	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2404: Vitamin B12 ABC transporter, permease component BtuC	Paracoccus denitrificans PD1222 Gene: Pden_4384: Vitamin B12 ABC transporter, permease component BtuC	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_17252: Vitamin B12 ABC transporter, permease component BtuC	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	2 Hyphomonas neptunium ATCC 15444 Gene: HNE_1516: Vitamin B12 ABC transporter, permease component BtuC Gene: HNE_1144: Vitamin B12 ABC transporter, permease component BtuC	Oceanicaulis alexandrii HTCC2633 Gene: OA2633_11735: Vitamin B12 ABC transporter, permease component BtuC	Vitamin B12 ABC transporter, permease component BtuC
btuD	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2405: Vitamin B12 ABC transporter, ATPase component BtuD	Paracoccus denitrificans PD1222 Gene: Pden_4385: Vitamin B12 ABC transporter, ATPase component BtuD	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_17247: Vitamin B12 ABC transporter, ATPase component BtuD	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	2 Hyphomonas neptunium ATCC 15444 Gene: HNE_1517: Vitamin B12 ABC transporter, ATPase component BtuD Gene: HNE_1145: Vitamin B12 ABC transporter, ATPase component BtuD	Oceanicaulis alexandrii HTCC2633 Gene: OA2633_11740: Vitamin B12 ABC transporter, ATPase component BtuD	Vitamin B12 ABC transporter, ATPase component BtuD
cbiB	Rhodobacter sphaeroides 2.4.1 Gene: RSP_0430: Adenosylcobinamide-phosphate synthase	Paracoccus denitrificans PD1222 Gene: Pden_3631: Adenosylcobinamide-phosphate synthase	Jannaschia sp. CCS1 Gene: Jann_0370: Adenosylcobinamide-phosphate synthase	Rhodobacterales bacterium HTCC2654 Gene: RB2654_11358: Adenosylcobinamide-phosphate synthase	Oceanicola granulosus HTCC2516 Gene: OG2516_10811: Adenosylcobinamide-phosphate synthase	Loktanella vestfoldensis SKA53 Gene: SKA53_10054: Adenosylcobinamide-phosphate synthase	Oceanicola batsensis HTCC2597 Gene: OB2597_10279: Adenosylcobinamide-phosphate synthase	Roseovarius nubinhibens ISM Gene: ISM_13690: Adenosylcobinamide-phosphate synthase	Roseovarius sp. 217 Gene: ROS217_22072: Adenosylcobinamide-phosphate synthase	Sulfitobacter sp. EE-36 Gene: EE36_11344: Adenosylcobinamide-phosphate synthase	Silicibacter TM1040 Gene: TM1040_2585: Adenosylcobinamide-phosphate synthase	Silicibacter pomeroyi DSS-3 Gene: SPO3225: Adenosylcobinamide-phosphate synthase	Roseobacter sp. MED193 Gene: MED193_16272: Adenosylcobinamide-phosphate synthase	Hyphomonas neptunium ATCC 15444 Gene: HNE_1519: Adenosylcobinamide-phosphate synthase	Oceanicaulis alexandrii HTCC2633	Adenosylcobinamide-phosphate synthase
cobD	Rhodobacter sphaeroides 2.4.1 Gene: RSP_0789: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Paracoccus denitrificans PD1222 Gene: Pden_2200: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Jannaschia sp. CCS1 Gene: Jann_0369: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Rhodobacterales bacterium HTCC2654 Gene: RB2654_11353: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Oceanicola granulosus HTCC2516 Gene: OG2516_10806: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Loktanella vestfoldensis SKA53 Gene: SKA53_10049: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Oceanicola batsensis HTCC2597 Gene: OB2597_10274: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Roseovarius nubinhibens ISM Gene: ISM_13695: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Roseovarius sp. 217 Gene: ROS217_22067: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Sulfitobacter sp. EE-36 Gene: EE36_11349: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Silicibacter TM1040 Gene: TM1040_2584: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Silicibacter pomeroyi DSS-3 Gene: SPO3224: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Roseobacter sp. MED193 Gene: MED193_16277: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Hyphomonas neptunium ATCC 15444 Gene: HNE_1520: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)	Oceanicaulis alexandrii HTCC2633	L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
cbiZ	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2406: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Paracoccus denitrificans PD1222 Gene: Pden_4761: Adenosylcobinamide amidohydrolase (EC 3.5.1.90)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Adenosylcobinamide amidohydrolase (EC 3.5.1.90)
COG3313	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_1366: COG3313: Predicted Fe-S protein	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	COG3313: Predicted Fe-S protein
RSP_0787	* Rhodobacter sphaeroides 2.4.1 Site: position = -293 score = 107.7 sequence = CGGAAGGTGCGGGCG... Gene: RSP_0787: hypothetical protein	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	* Silicibacter TM1040 Site: position = -308 score = 125.5 sequence = GCGTAGCATCCAGAC... Gene: TM1040_0168: hypothetical protein	* Silicibacter pomeroyi DSS-3 Site: position = -251 score = 120.63 sequence = GCTACCGCTGGGTCG... Gene: SPO3547: hypothetical protein	* Roseobacter sp. MED193 Site: position = -441 score = 123.16 sequence = ATAGCCGTGTAACGG... Gene: MED193_11852: hypothetical protein	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	hypothetical protein
pduX	Rhodobacter sphaeroides 2.4.1 Gene: RSP_0788: hypothetical protein	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_11339: hypothetical protein	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	hypothetical protein
CRON 2.
cfrX	* Rhodobacter sphaeroides 2.4.1 Site: position = -292 score = 75.63 sequence = ACCACTTCCGGCGCG... Gene: RSP_2829: Predicted metal-binding protein	*2 Paracoccus denitrificans PD1222 Site: position = -277 score = 85.19 sequence = CACAGACATGGGGCG... Gene: Pden_2530: Predicted metal-binding protein Gene: Pden_2543: Predicted metal-binding protein	* Jannaschia sp. CCS1 Site: position = -221 score = 141.54 sequence = TGAACAGGGTCACGG... Gene: Jann_2934: Predicted metal-binding protein	Rhodobacterales bacterium HTCC2654 Gene: RB2654_11348: Predicted metal-binding protein	Oceanicola granulosus HTCC2516 Gene: OG2516_10801: Predicted metal-binding protein	Loktanella vestfoldensis SKA53 Gene: SKA53_10044: Predicted metal-binding protein	Oceanicola batsensis HTCC2597	* Roseovarius nubinhibens ISM Site: position = -321 score = 127.99 sequence = GCATTGTCGCCCCTG... Gene: ISM_12600: Predicted metal-binding protein	Roseovarius sp. 217 Gene: ROS217_22062: Predicted metal-binding protein	* Sulfitobacter sp. EE-36 Site: position = -311 score = 88.94 sequence = AATGCAGGGCGTATG... Gene: EE36_05358: Predicted metal-binding protein	*2 Silicibacter TM1040 Site: position = -336 score = 77.76 sequence = CGCAAGGAAATTTCG... Gene: TM1040_2208: Predicted metal-binding protein Gene: TM1040_2221: Predicted metal-binding protein	* Silicibacter pomeroyi DSS-3 Site: position = -292 score = 81.78 sequence = CGCATGTCCGCCCTG... Gene: SPO2861: Predicted metal-binding protein	* Roseobacter sp. MED193 Site: position = -216 score = 93.53 sequence = GCGCAAGGGGGTTTT... Gene: MED193_19614: Predicted metal-binding protein	Hyphomonas neptunium ATCC 15444 Gene: HNE_2170: Predicted metal-binding protein	Oceanicaulis alexandrii HTCC2633	Predicted metal-binding protein
cobW	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2828: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Paracoccus denitrificans PD1222 Gene: Pden_2531: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Jannaschia sp. CCS1 Gene: Jann_2933: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Rhodobacterales bacterium HTCC2654 Gene: RB2654_11398: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Oceanicola granulosus HTCC2516 Gene: OG2516_10831: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Loktanella vestfoldensis SKA53 Gene: SKA53_10074: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Oceanicola batsensis HTCC2597 Gene: OB2597_10309: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Roseovarius nubinhibens ISM Gene: ISM_12605: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Roseovarius sp. 217 Gene: ROS217_08014: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Sulfitobacter sp. EE-36 Gene: EE36_05363: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Silicibacter TM1040 Gene: TM1040_2209: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Silicibacter pomeroyi DSS-3 Gene: SPO2862: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Roseobacter sp. MED193 Gene: MED193_19609: CobW GTPase involved in cobalt insertion for B12 biosynthesis	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	CobW GTPase involved in cobalt insertion for B12 biosynthesis
engA	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1 Gene: Jann_2932: hypothetical protein	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	GTP-binding protein EngA
cobN	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2827: CobN component of cobalt chelatase involved in B12 biosynthesis	Paracoccus denitrificans PD1222 Gene: Pden_2532: CobN component of cobalt chelatase involved in B12 biosynthesis	Jannaschia sp. CCS1 Gene: Jann_2931: CobN component of cobalt chelatase involved in B12 biosynthesis	Rhodobacterales bacterium HTCC2654 Gene: RB2654_11408: CobN component of cobalt chelatase involved in B12 biosynthesis	Oceanicola granulosus HTCC2516 Gene: OG2516_10846: CobN component of cobalt chelatase involved in B12 biosynthesis	Loktanella vestfoldensis SKA53 Gene: SKA53_10089: CobN component of cobalt chelatase involved in B12 biosynthesis	Oceanicola batsensis HTCC2597 Gene: OB2597_10319: CobN component of cobalt chelatase involved in B12 biosynthesis	Roseovarius nubinhibens ISM Gene: ISM_12610: CobN component of cobalt chelatase involved in B12 biosynthesis	Roseovarius sp. 217 Gene: ROS217_08029: CobN component of cobalt chelatase involved in B12 biosynthesis	Sulfitobacter sp. EE-36 Gene: EE36_05368: CobN component of cobalt chelatase involved in B12 biosynthesis	Silicibacter TM1040 Gene: TM1040_2210: CobN component of cobalt chelatase involved in B12 biosynthesis	Silicibacter pomeroyi DSS-3 Gene: SPO2863: CobN component of cobalt chelatase involved in B12 biosynthesis	Roseobacter sp. MED193 Gene: MED193_19604: CobN component of cobalt chelatase involved in B12 biosynthesis	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	CobN component of cobalt chelatase involved in B12 biosynthesis
cobG	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_2533: Cobalamin biosynthesis protein CobG	Jannaschia sp. CCS1 Gene: Jann_2930: Cobalamin biosynthesis protein CobG	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM Gene: ISM_12615: Cobalamin biosynthesis protein CobG	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_05373: Cobalamin biosynthesis protein CobG	Silicibacter TM1040 Gene: TM1040_2211: Cobalamin biosynthesis protein CobG	Silicibacter pomeroyi DSS-3 Gene: SPO2864: Cobalamin biosynthesis protein CobG	Roseobacter sp. MED193 Gene: MED193_19599: Cobalamin biosynthesis protein CobG	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Cobalamin biosynthesis protein CobG
cbiC	Rhodobacter sphaeroides 2.4.1 Gene: RSP_6217: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Paracoccus denitrificans PD1222 Gene: Pden_2534: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Jannaschia sp. CCS1 Gene: Jann_2929: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Rhodobacterales bacterium HTCC2654 Gene: RB2654_16306: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Oceanicola granulosus HTCC2516 Gene: OG2516_09118: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Loktanella vestfoldensis SKA53 Gene: SKA53_10019: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Oceanicola batsensis HTCC2597 Gene: OB2597_10249: Cobalamin biosynthesis protein CobG / Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Roseovarius nubinhibens ISM Gene: ISM_12620: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Roseovarius sp. 217 Gene: ROS217_13496: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Sulfitobacter sp. EE-36 Gene: EE36_05378: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Silicibacter TM1040 Gene: TM1040_2212: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Silicibacter pomeroyi DSS-3 Gene: SPO2865: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Roseobacter sp. MED193 Gene: MED193_19594: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
cbiL	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2826: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Paracoccus denitrificans PD1222 Gene: Pden_2535: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Jannaschia sp. CCS1 Gene: Jann_2928: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Rhodobacterales bacterium HTCC2654 Gene: RB2654_16316: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Oceanicola granulosus HTCC2516 Gene: OG2516_09108: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Loktanella vestfoldensis SKA53 Gene: SKA53_10009: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Oceanicola batsensis HTCC2597 Gene: OB2597_10239: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Roseovarius nubinhibens ISM Gene: ISM_12625: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Roseovarius sp. 217 Gene: ROS217_13506: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Sulfitobacter sp. EE-36 Gene: EE36_05383: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Silicibacter TM1040 Gene: TM1040_2213: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Silicibacter pomeroyi DSS-3 Gene: SPO2866: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Roseobacter sp. MED193 Gene: MED193_19589: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
cbiH	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2824: Cobalt-precorrin-3b C17-methyltransferase	Paracoccus denitrificans PD1222 Gene: Pden_2536: Cobalt-precorrin-3b C17-methyltransferase	Jannaschia sp. CCS1 Gene: Jann_2927: Cobalt-precorrin-3b C17-methyltransferase	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM Gene: ISM_12630: Cobalt-precorrin-3b C17-methyltransferase	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_05388: Cobalt-precorrin-3b C17-methyltransferase	Silicibacter TM1040 Gene: TM1040_2214: Cobalt-precorrin-3b C17-methyltransferase	Silicibacter pomeroyi DSS-3 Gene: SPO2867: Cobalt-precorrin-3b C17-methyltransferase	Roseobacter sp. MED193 Gene: MED193_19584: Cobalt-precorrin-3b C17-methyltransferase	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Cobalt-precorrin-3b C17-methyltransferase
cbtC	* Rhodobacter sphaeroides 2.4.1 Site: position = -275 score = 109.1 sequence = TGTCACGCCGGGCTA... Gene: RSP_3186: Predicted cobalt transporter CbtC	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	* Oceanicola batsensis HTCC2597 Site: position = -244 score = 106.7 sequence = GCACAACCGAAAGGC... Gene: OB2597_10304: Predicted cobalt transporter CbtC	* Roseovarius nubinhibens ISM Site: position = -235 score = 117.47 sequence = ATCTCCTTCCATTCG... Gene: ISM_12665: Predicted cobalt transporter CbtC	Roseovarius sp. 217	* Sulfitobacter sp. EE-36 Site: position = -288 score = 110.69 sequence = GACCACCTATTCCGG... Gene: EE36_05423: Predicted cobalt transporter CbtC	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	* Roseobacter sp. MED193 Site: position = -280 score = 126.33 sequence = AGAGCAGTGACCTAT... Gene: MED193_19549: Predicted cobalt transporter CbtC	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Predicted cobalt transporter CbtC
RSP_2081	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654 Gene: RB2654_11403: Histone acetyltransferase HPA2 and related acetyltransferases	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597 Gene: OB2597_10314: Histone acetyltransferase HPA2 and related acetyltransferases	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Histone acetyltransferase HPA2 and related acetyltransferases
cobF	Rhodobacter sphaeroides 2.4.1 Gene: RSP_2819: Precorrin-6A synthase (EC 2.1.1.152)	Paracoccus denitrificans PD1222 Gene: Pden_2542: Precorrin-6A synthase (EC 2.1.1.152)	Jannaschia sp. CCS1 Gene: Jann_2920: Precorrin-6A synthase (EC 2.1.1.152)	Rhodobacterales bacterium HTCC2654 Gene: RB2654_13940: Precorrin-6A synthase (EC 2.1.1.152)	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM Gene: ISM_12670: Precorrin-6A synthase (EC 2.1.1.152)	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_05428: Precorrin-6A synthase (EC 2.1.1.152)	Silicibacter TM1040 Gene: TM1040_2224: Precorrin-6A synthase (EC 2.1.1.152)	Silicibacter pomeroyi DSS-3 Gene: SPO2874: Precorrin-6A synthase (EC 2.1.1.152)	Roseobacter sp. MED193 Gene: MED193_19544: Precorrin-6A synthase (EC 2.1.1.152)	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Precorrin-6A synthase (EC 2.1.1.152)
hupE	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	* Oceanicola granulosus HTCC2516 Site: position = -305 score = 108.97 sequence = CACAAAGATCCCCGC... Gene: OG2516_10826: HupE-UreJ family cobalt transporter	* Loktanella vestfoldensis SKA53 Site: position = -323 score = 105.97 sequence = GCACAACATGACGGC... Gene: SKA53_10069: HupE-UreJ family cobalt transporter	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	HupE-UreJ family cobalt transporter
cbiA	Rhodobacter sphaeroides 2.4.1 Gene: RSP_3185: Cobyrinic acid A,C-diamide synthase	Paracoccus denitrificans PD1222 Gene: Pden_2541: Cobyrinic acid A,C-diamide synthase	Jannaschia sp. CCS1 Gene: Jann_2922: Cobyrinic acid A,C-diamide synthase	Rhodobacterales bacterium HTCC2654 Gene: RB2654_01775: Cobyrinic acid A,C-diamide synthase	Oceanicola granulosus HTCC2516 Gene: OG2516_03595: Cobyrinic acid A,C-diamide synthase	Loktanella vestfoldensis SKA53 Gene: SKA53_03151: Cobyrinic acid A,C-diamide synthase	Oceanicola batsensis HTCC2597 Gene: OB2597_04415: Cobyrinic acid A,C-diamide synthase	Roseovarius nubinhibens ISM Gene: ISM_12655: Cobyrinic acid A,C-diamide synthase	Roseovarius sp. 217 Gene: ROS217_17927: Cobyrinic acid A,C-diamide synthase	Sulfitobacter sp. EE-36 Gene: EE36_05413: Cobyrinic acid A,C-diamide synthase	Silicibacter TM1040 Gene: TM1040_2219: Cobyrinic acid A,C-diamide synthase	Silicibacter pomeroyi DSS-3 Gene: SPO2872: Cobyrinic acid A,C-diamide synthase	Roseobacter sp. MED193 Gene: MED193_19559: Cobyrinic acid A,C-diamide synthase	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Cobyrinic acid A,C-diamide synthase
CRON 3.
btuF	* Rhodobacter sphaeroides 2.4.1 Site: position = -373 score = 100.61 sequence = CGGCTACTCAATCCT... Gene: RSP_3392: ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component	*2 Paracoccus denitrificans PD1222 Site: position = -322 score = 101.5 sequence = TACCAAGTCGCTGCA... Gene: Pden_2980: ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component Site: position = -293 score = 104.14 sequence = GCGCTATGGCGGAGT... Gene: Pden_1362: ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	* Roseovarius nubinhibens ISM Site: position = -322 score = 109.36 sequence = CGGGTGTCACTGCGG... Gene: ISM_07745: ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component	Roseovarius sp. 217	* Sulfitobacter sp. EE-36 Site: position = -344 score = 118.92 sequence = CTGTCATCGAAACCG... Gene: EE36_12323: ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	* Roseobacter sp. MED193 Site: position = -303 score = 111.96 sequence = TCTAAACGGCAAGAG... Gene: MED193_18509: ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component
btuC	Rhodobacter sphaeroides 2.4.1 Gene: RSP_3391: ABC transporter (iron.B12.siderophore.hemin) , permease component	2 Paracoccus denitrificans PD1222 Gene: Pden_2981: ABC transporter (iron.B12.siderophore.hemin) , permease component Gene: Pden_1361: ABC transporter (iron.B12.siderophore.hemin) , permease component	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM Gene: ISM_07740: ABC transporter (iron.B12.siderophore.hemin) , permease component	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_12318: ABC transporter (iron.B12.siderophore.hemin) , permease component	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193 Gene: MED193_18514: ABC transporter (iron.B12.siderophore.hemin) , permease component	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC transporter (iron.B12.siderophore.hemin) , permease component
btuD	Rhodobacter sphaeroides 2.4.1 Gene: RSP_3390: ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component	2 Paracoccus denitrificans PD1222 Gene: Pden_2982: ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component Gene: Pden_1360: ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM Gene: ISM_07735: ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_12313: ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193 Gene: MED193_18519: ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component
petE	Rhodobacter sphaeroides 2.4.1	2 Paracoccus denitrificans PD1222 Gene: Pden_2983: Pseudoazurin precursor Gene: Pden_1359: Pseudoazurin precursor	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM Gene: ISM_07730: Pseudoazurin precursor	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193 Gene: MED193_18524: Pseudoazurin precursor	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Pseudoazurin precursor
CRON 4.
cbtB	Rhodobacter sphaeroides 2.4.1	* Paracoccus denitrificans PD1222 Site: position = -241 score = 133.56 sequence = TAACATATGCGTGTA... Gene: Pden_2524: Putative cobalt transporter, subunit CbtB	Jannaschia sp. CCS1	* Rhodobacterales bacterium HTCC2654 Site: position = -238 score = 92.63 sequence = CCACAAGGATAAGGC... Gene: RB2654_11383: Putative cobalt transporter, subunit CbtB	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	* Roseovarius sp. 217 Site: position = -256 score = 111.32 sequence = GCATACGAGAGTGGC... Gene: ROS217_07994: Putative cobalt transporter, subunit CbtB	Sulfitobacter sp. EE-36	Silicibacter TM1040	* Silicibacter pomeroyi DSS-3 Site: position = -222 score = 119.05 sequence = GCTAAATGAAGGGGT... Gene: SPO2875: Putative cobalt transporter, subunit CbtB	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Putative cobalt transporter, subunit CbtB
cbtA	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_2525: Predicted cobalt transporter CbtA	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654 Gene: RB2654_11388: Predicted cobalt transporter CbtA	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217 Gene: ROS217_07999: Predicted cobalt transporter CbtA	Sulfitobacter sp. EE-36	* Silicibacter TM1040 Site: position = -352 score = 112.77 sequence = CATTGTCGACGGCAT... Gene: TM1040_2222: Predicted cobalt transporter CbtA	Silicibacter pomeroyi DSS-3 Gene: SPO2876: Predicted cobalt transporter CbtA	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Predicted cobalt transporter CbtA
Pden_2526	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_2526: hypothetical protein	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217 Gene: ROS217_08004: hypothetical protein	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_2223: hypothetical protein	Silicibacter pomeroyi DSS-3 Gene: SPO2877: hypothetical protein	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	hypothetical protein
bluB	* Rhodobacter sphaeroides 2.4.1 Site: position = -223 score = 92.21 sequence = CTTTGTGGCAGGGGT... Gene: RSP_3218: Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family	Paracoccus denitrificans PD1222 Gene: Pden_2527: Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM Gene: ISM_08825: Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family	Roseovarius sp. 217 Gene: ROS217_08499: Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family	* Sulfitobacter sp. EE-36 Site: position = -227 score = 104.56 sequence = GCCCAATGGCCGGGT... Gene: EE36_10479: Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family	Silicibacter TM1040 Gene: TM1040_2608: Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family	Silicibacter pomeroyi DSS-3 Gene: SPO3254: Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family	Roseobacter sp. MED193 Gene: MED193_16122: Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family
CRON 5.
cbiW	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	* Jannaschia sp. CCS1 Site: position = -273 score = 140.25 sequence = CTGAAATCAAACTGG... Gene: Jann_2250: hypothetical protein	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	* Silicibacter TM1040 Site: position = -302 score = 134.44 sequence = CGCATGAGAGGGGCG... Gene: TM1040_2933: hypothetical protein	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	hypothetical protein
btuF	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1 Gene: Jann_2249: ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_2934: ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component
btuC	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1 Gene: Jann_2248: ABC transporter (iron.B12.siderophore.hemin) , permease component	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_2935: ABC transporter (iron.B12.siderophore.hemin) , permease component	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC transporter (iron.B12.siderophore.hemin) , permease component
btuD	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1 Gene: Jann_2247: ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_2936: ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component
CRON 6.
nrdH	Rhodobacter sphaeroides 2.4.1	* Paracoccus denitrificans PD1222 Site: position = -284 score = 121.41 sequence = CTAACTGCAACGGTC... Gene: Pden_4375: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	* Silicibacter TM1040 Site: position = -295 score = 121.71 sequence = ATCAATATCGTGTTG... Gene: TM1040_0521: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib
nrdI	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_4376: Ribonucleotide reduction protein NrdI	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_0520: Ribonucleotide reduction protein NrdI	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Ribonucleotide reduction protein NrdI
nrdA	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_4377: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_0519: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)
nrdB	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_4378: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_0518: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)
CRON 7.
ISM_13370	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	* Roseovarius nubinhibens ISM Site: position = -341 score = 104.74 sequence = TAGGCTAAAGCTCTC... Gene: ISM_13370: hypothetical protein	* Roseovarius sp. 217 Site: position = -306 score = 107.21 sequence = TAGGCTGATCCTGTC... Gene: ROS217_16870: hypothetical protein	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	hypothetical protein
CRON 8.
Cseg_1811	Rhodobacter sphaeroides 2.4.1	* Paracoccus denitrificans PD1222 Site: position = -326 score = 132.3 sequence = TTTTACCGTCAGATC... Gene: Pden_1354: hypothetical protein	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	hypothetical protein
metE	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_1355: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
CRON 9.
btuB	Rhodobacter sphaeroides 2.4.1	* Paracoccus denitrificans PD1222 Site: position = -408 score = 127.92 sequence = CTACACGGTCGGGTG... Gene: Pden_4827: Outer membrane (iron.B12.siderophore.hemin) receptor	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Outer membrane (iron.B12.siderophore.hemin) receptor
btuD	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_4828: ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC transporter (iron.B12.siderophore.hemin) , ATP-binding component
btuF	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_4829: ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC transporter (iron.B12.siderophore.hemin) , periplasmic substrate-binding component
btuC	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_4830: ABC transporter (iron.B12.siderophore.hemin) , permease component	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	ABC transporter (iron.B12.siderophore.hemin) , permease component
CRON 10.
nrdD	Rhodobacter sphaeroides 2.4.1	* Paracoccus denitrificans PD1222 Site: position = -414 score = 119.0 sequence = CCCTATATGTAGGCA... Gene: Pden_2989: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
Pden_2988	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_2988: hypothetical protein	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	hypothetical protein
nrdG	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222 Gene: Pden_2987: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
CRON 11.
ardX	Rhodobacter sphaeroides 2.4.1 Gene: RSP_3978: Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	2 Paracoccus denitrificans PD1222 Gene: Pden_1189: Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Gene: Pden_2832: Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654 Gene: RB2654_10803: Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	Oceanicola granulosus HTCC2516 Gene: OG2516_15469: Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	Loktanella vestfoldensis SKA53 Gene: SKA53_15411: Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	* Silicibacter TM1040 Site: position = -338 score = 106.59 sequence = ATACAACTCTGCCCT... Gene: TM1040_3219: Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit
frdX	Rhodobacter sphaeroides 2.4.1 Gene: RSP_3979: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	2 Paracoccus denitrificans PD1222 Gene: Pden_1188: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Gene: Pden_2831: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654 Gene: RB2654_10798: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	Oceanicola granulosus HTCC2516 Gene: OG2516_15464: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	Loktanella vestfoldensis SKA53 Gene: SKA53_15406: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040 Gene: TM1040_3218: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

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