Regulog Cobalamin - Bacillales
| Regulator type: | RNA regulatory element |
| Name: | Cobalamin |
| RFAM: | RF00174 |
| Regulation mode: | |
| Biological process: | Cobalamin biosynthesis |
| Effector: | Adenosylcobalamin |
| Phylum: | Firmicutes |
Member of regulog collections
- By taxonomy - Bacillales
- By RNA motif - Cobalamin
- By effector - Adenosylcobalamin
- By pathway - Cobalamin biosynthesis
| Genome | Genes | Operons |
|---|---|---|
| Bacillus subtilis subsp. subtilis str. 168 | 4 | 1 |
| Bacillus amyloliquefaciens FZB42 | ||
| Bacillus pumilus SAFR-032 | 1 | 1 |
| Bacillus licheniformis DSM 13 | 1 | 1 |
| Anoxybacillus flavithermus WK1 | 35 | 3 |
| Geobacillus kaustophilus HTA426 | 34 | 3 |
| Bacillus cereus ATCC 14579 | 1 | 1 |
| Bacillus halodurans C-125 | 16 | 5 |
| Bacillus clausii KSM-K16 | 1 | 1 |
| Oceanobacillus iheyensis HTE831 | ||
| Paenibacillus sp. JDR-2 | 14 | 2 |
| Genes | Function | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CRON 1. | ||||||||||||
| metE |
Gene: BSU13180: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
Gene: RBAM_013040: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
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Bacillus pumilus SAFR-032 Site: position = -345 score = 113.89 sequence = AATTCATAGTTTGAG... Gene: BPUM_1215: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
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Bacillus licheniformis DSM 13 Site: position = -338 score = 113.96 sequence = ATTTCATCGCCGGGA... Gene: BLi01422: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
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Bacillus cereus ATCC 14579 Site: position = -315 score = 114.86 sequence = CTTTCAAAAGGAAAA... Gene: BC4003: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
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Bacillus halodurans C-125 Site: position = -340 score = 123.55 sequence = ATTTCATCGTTTGGG... Gene: BH0438: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
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Bacillus clausii KSM-K16 Site: position = -302 score = 60.74 sequence = TTTTATAGATGCAAC... Gene: ABC1449: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
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Gene: Pjdr2_2828: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
| CRON 2. | ||||||||||||
| nrdA |
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Anoxybacillus flavithermus WK1 Site: position = -316 score = 121.41 sequence = ATTGAAACCAACAAG... Gene: Aflv_0393: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) |
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Geobacillus kaustophilus HTA426 Site: position = -249 score = 123.93 sequence = TCGTTGCGCCAAGCA... Gene: GK0911: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) |
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Bacillus halodurans C-125 Site: position = -351 score = 119.7 sequence = GTGTTTGTGGACGGT... Gene: BH0501: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) |
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Gene: OB3089: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) |
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Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) |
| Aflv_2124 |
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Gene: Aflv_0392: transposase |
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transposase |
| Aflv_0391 |
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Gene: Aflv_0391: Flavodoxin |
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Gene: OB3088: Flavodoxin |
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Flavodoxin |
| nrdB |
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Gene: Aflv_0390: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) |
Gene: GK0912: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) |
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Gene: BH0502: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) |
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Gene: OB3087: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) |
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Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) |
| CRON 3. | ||||||||||||
| achX |
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Bacillus halodurans C-125 Site: position = -384 score = 114.33 sequence = AGCACGCTCAAGCAT... Gene: BH0798: Predicted thioesterase |
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Predicted thioesterase |
| CRON 4. | ||||||||||||
| Pjdr2_2684 |
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Paenibacillus sp. JDR-2 Site: position = -365 score = 102.52 sequence = ATACGAGATAAGTAT... Gene: Pjdr2_2684: S-layer domain protein |
S-layer domain protein |
| Pjdr2_2685 |
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Gene: Pjdr2_2685: Hypothetical protein |
Hypothetical protein |
| Pjdr2_2686 |
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Gene: Pjdr2_2686: Transmembrane component of B12-regulated ECF transporter |
Transmembrane component of B12-regulated ECF transporter |
| Pjdr2_2687 |
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Gene: Pjdr2_2687: Duplicated ATPase component B12-regulated ECF transporter |
Duplicated ATPase component B12-regulated ECF transporter |
| Pjdr2_2688 |
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Gene: Pjdr2_2688: Substrate-specific component of B12-regulated ECF transporter |
Substrate-specific component of B12-regulated ECF transporter |
| CRON 5. | ||||||||||||
| cbiW |
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Anoxybacillus flavithermus WK1 Site: position = -317 score = 111.83 sequence = ATATACGATCAGCAA... Gene: Aflv_2185: Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis |
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Geobacillus kaustophilus HTA426 Site: position = -378 score = 117.92 sequence = TAGGCGAGAAACAAA... Gene: GK1810: Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis |
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Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis |
| cbiM |
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Gene: Aflv_2184: Substrate-specific component CbiM of cobalt ECF transporter |
Gene: GK1809: Substrate-specific component CbiM of cobalt ECF transporter |
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Substrate-specific component CbiM of cobalt ECF transporter |
| cbiN |
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Gene: Aflv_2183: Additional substrate-specific component CbiN of cobalt ECF transporter |
Gene: GK1808: Additional substrate-specific component CbiN of cobalt ECF transporter |
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Additional substrate-specific component CbiN of cobalt ECF transporter |
| cbiQ |
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Gene: Aflv_2182: Transmembrane component CbiQ of energizing module of cobalt ECF transporter |
Gene: GK1807: Transmembrane component CbiQ of energizing module of cobalt ECF transporter |
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Transmembrane component CbiQ of energizing module of cobalt ECF transporter |
| cbiO |
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Gene: Aflv_2181: ATPase component CbiO of energizing module of cobalt ECF transporter |
Gene: GK1806: ATPase component CbiO of energizing module of cobalt ECF transporter |
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ATPase component CbiO of energizing module of cobalt ECF transporter |
| cbiH |
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Gene: Aflv_2180: Cobalt-precorrin-3b C17-methyltransferase |
Gene: GK1805: Cobalt-precorrin-3b C17-methyltransferase |
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Cobalt-precorrin-3b C17-methyltransferase |
| cbiX |
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Gene: Aflv_2179: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
Gene: GK1804: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
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Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
| cbiJ |
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Gene: Aflv_2178: Cobalt-precorrin-6x reductase (EC 1.3.1.54) |
Gene: GK1803: Cobalt-precorrin-6x reductase (EC 1.3.1.54) |
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Cobalt-precorrin-6x reductase (EC 1.3.1.54) |
| cbiC |
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Gene: Aflv_2177: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
Gene: GK1802: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
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Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
| cbiD |
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Gene: Aflv_2176: Cobalt-precorrin-6 synthase, anaerobic (EC 2.1.1.-) |
Gene: GK1801: Cobalt-precorrin-6 synthase, anaerobic (EC 2.1.1.-) |
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Cobalt-precorrin-6 synthase, anaerobic (EC 2.1.1.-) |
| cbiET |
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Gene: Aflv_2175: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
Gene: GK1800: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
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Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
| cbiL |
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Gene: Aflv_2174: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
Gene: GK1799: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
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Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
| cbiF |
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Gene: Aflv_2173: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
Gene: GK1798: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
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Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
| cbiG |
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Gene: Aflv_2172: Cobalamin biosynthesis protein CbiG |
Gene: GK1797: Cobalamin biosynthesis protein CbiG |
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Cobalamin biosynthesis protein CbiG |
| cbiA |
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Gene: Aflv_2171: Cobyrinic acid A,C-diamide synthase |
Gene: GK1796: Cobyrinic acid A,C-diamide synthase |
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Gene: BH1898: Cobyrinic acid A,C-diamide synthase |
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Cobyrinic acid A,C-diamide synthase |
| cbiP |
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Gene: Aflv_2170: Cobyric acid synthase |
Gene: GK1795: Cobyric acid synthase |
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Gene: BH1591: Cobyric acid synthase |
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Gene: Pjdr2_3625: Cobyric acid synthase |
Cobyric acid synthase |
| GK1794 |
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Gene: GK1794: Transposase |
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Transposase |
| cobT |
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Gene: Aflv_2169: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
Gene: GK1793: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
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Bacillus halodurans C-125 Site: position = -253 score = 89.81 sequence = CTTTAATAGGCTTCT... Gene: BH0284: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
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Gene: Pjdr2_3352: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
| cobA |
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Gene: Aflv_2168: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) |
Gene: GK1792: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) |
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Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) |
| btuR |
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Gene: Aflv_2167: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: GK1791: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
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Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
| btuF |
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Bacillus subtilis subsp. subtilis str. 168 Site: position = -245 score = 78.37 sequence = CGGATACGAATGTCA... Gene: BSU33180: Vitamin B12 ABC transporter, B12-binding component BtuF |
Gene: RBAM_030310: Vitamin B12 ABC transporter, B12-binding component BtuF |
Gene: BPUM_2981: Vitamin B12 ABC transporter, B12-binding component BtuF |
Gene: BLi03506: Vitamin B12 ABC transporter, B12-binding component BtuF |
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Anoxybacillus flavithermus WK1 Site: position = -396 score = 131.85 sequence = TATGTCCGTTGCAAA... Gene: Aflv_1041: Vitamin B12 ABC transporter, B12-binding component BtuF |
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Geobacillus kaustophilus HTA426 Site: position = -341 score = 122.23 sequence = CTAAATCAACTCGCA... Gene: GK2266: Vitamin B12 ABC transporter, B12-binding component BtuF |
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Bacillus halodurans C-125 Site: position = -407 score = 118.66 sequence = CGTATATCGCGCTGA... Gene: BH1585: Vitamin B12 ABC transporter, B12-binding component BtuF |
Gene: ABC2981: Vitamin B12 ABC transporter, B12-binding component BtuF |
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Paenibacillus sp. JDR-2 Site: position = -357 score = 95.13 sequence = ACGAATAAATCATGG... Gene: Pjdr2_3355: Vitamin B12 ABC transporter, B12-binding component BtuF |
Vitamin B12 ABC transporter, B12-binding component BtuF |
| btuC |
Gene: BSU33170: Vitamin B12 ABC transporter, permease component BtuC |
Gene: RBAM_030300: Vitamin B12 ABC transporter, permease component BtuC |
Gene: BPUM_2980: Vitamin B12 ABC transporter, permease component BtuC |
Gene: BLi03505: Vitamin B12 ABC transporter, permease component BtuC |
Gene: Aflv_1042: Vitamin B12 ABC transporter, permease component BtuC |
Gene: GK2265: Vitamin B12 ABC transporter, permease component BtuC |
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Gene: BH1586: Vitamin B12 ABC transporter, permease component BtuC |
Gene: ABC1837: Vitamin B12 ABC transporter, permease component BtuC |
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Gene: Pjdr2_3354: Vitamin B12 ABC transporter, permease component BtuC |
Vitamin B12 ABC transporter, permease component BtuC |
| btuD-cbiZ |
Gene: BSU33160: Vitamin B12 ABC transporter, ATPase component BtuD / Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
Gene: RBAM_030290: Vitamin B12 ABC transporter, ATPase component BtuD / Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
Gene: BPUM_2979: Vitamin B12 ABC transporter, ATPase component BtuD / Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
Gene: BLi03504: Vitamin B12 ABC transporter, ATPase component BtuD / Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
Gene: Aflv_1043: Vitamin B12 ABC transporter, ATPase component BtuD / Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
Gene: GK2264: Vitamin B12 ABC transporter, ATPase component BtuD / Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
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Gene: BH1587: Vitamin B12 ABC transporter, ATPase component BtuD / Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
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Vitamin B12 ABC transporter, ATPase component BtuD / Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
| cbiB |
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Gene: Aflv_1044: Adenosylcobinamide-phosphate synthase |
Gene: GK2263: Adenosylcobinamide-phosphate synthase |
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Gene: BH1588: Adenosylcobinamide-phosphate synthase |
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Gene: Pjdr2_3350: Adenosylcobinamide-phosphate synthase |
Adenosylcobinamide-phosphate synthase |
| cobD |
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Gene: Aflv_1045: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
Gene: GK2262: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
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Gene: BH1589: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
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Gene: Pjdr2_3348: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
| cobU |
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Gene: Aflv_1046: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: GK2261: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
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Gene: BH1590: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
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Gene: Pjdr2_3351: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
| cobS |
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Gene: Aflv_1047: Cobalamin synthase |
Gene: GK2260: Cobalamin synthase |
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Gene: BH1592: Cobalamin synthase |
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Gene: Pjdr2_3349: Cobalamin synthase |
Cobalamin synthase |
| cobC |
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Gene: Aflv_1048: Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) |
Gene: GK2259: Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) |
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Gene: BH1593: Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) |
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Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) |
| cobU2 |
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Gene: Aflv_1049: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: GK2258: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
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Gene: BH1594: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
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Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
| pduO |
Gene: BSU33150: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
Gene: RBAM_030280: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
Gene: BPUM_2969: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
Gene: BLi03499: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
Gene: Aflv_1050: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
Gene: GK2257: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
Gene: BC1479: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
Gene: BH1595: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
Gene: ABC1839: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
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Gene: Pjdr2_1405: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) |
| cblT |
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Gene: Aflv_1051: Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole |
Gene: GK2256: Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole |
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Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole |
| cblS |
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Gene: Aflv_1052: Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis |
Gene: GK2255: Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis |
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Gene: BH0853: Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis |
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Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis |
| btuD |
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Gene: ABC1838: Vitamin B12 ABC transporter, ATPase component BtuD |
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Gene: Pjdr2_3353: Vitamin B12 ABC transporter, ATPase component BtuD |
Vitamin B12 ABC transporter, ATPase component BtuD |
| cbiZ |
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Gene: Pjdr2_3347: Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
Adenosylcobinamide amidohydrolase (EC 3.5.1.90) |
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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Regulated Genes | [ Tab delimited format ] | DOWNLOAD |
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Regulatory Sites | [ FASTA format ] | DOWNLOAD |