Collection of regulogs for TyrR transcription factor

Transcription factor TyrR belongs to the Fis protein family and can act both as a repressor and as an activator of transcription at sigma-70-dependent promoters. The TyrR regulon controls genes that are essential for aromatic amino acid biosynthesis, transport, and catabolism. In E. coli, the tyrosine- and phenylalanine-responsive regulator TyrR represses most aromatic amino acid biosynthetic enzymes and transporters encoded by multiple aro and tyr genes scattered on the chromosome, and activates the tyrosine transporter encoded by the mtr gene. Its ortholog in Pseudomonas spp., known as PhhR, is a regulator responsible for activation of genes essential for phenylalanine degradation and homeostasis. more

In the Shewanella spp., we identified TyrR as a master regulator of the degradation pathways for various amino acids, including phenylalanine (phhAB operon), tyrosine (fahA-maiA operon), branched chain amino acids (ldh, brnQ, liu, ivd, and bkd operons), proline (putA gene), and oligopeptides (various peptidase genes), as well as some other pathways such as the glyoxylate shunt (aceBA operon), and the chorismate biosynthesis (aroA gene).