Regulog CopR - Lactobacillaceae

Properties
Regulator type:	Transcription factor
Regulator family:	CopY
Regulation mode:	repressor
Biological process:	Copper homeostasis
Effector:	Copper ion, (Cu2+)
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 34 sites [see more]

Member of regulog collections

By taxonomy - Lactobacillaceae
By TF family - CopY
By effector - Copper ion, (Cu2+)
By pathway - Copper homeostasis

Statistics of regulated genes
Genome	Genes	Operons
Lactobacillus acidophilus NCFM	4	1
Lactobacillus brevis ATCC 367	4	2
Lactobacillus casei ATCC 334	5	2
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	3	1
Lactobacillus fermentum IFO 3956	4	2
Lactobacillus helveticus DPC 4571	5	2
Lactobacillus johnsonii NCC 533	4	1
Lactobacillus plantarum WCFS1	2	2
Lactobacillus reuteri JCM 1112	4	2
Lactobacillus rhamnosus GG	2	1
Lactobacillus sakei subsp. sakei 23K	2	1
Lactobacillus salivarius subsp. salivarius UCC118	3	1
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	2	1
Oenococcus oeni PSU-1	2	1
Pediococcus pentosaceus ATCC 25745	2	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
copR	* Lactobacillus acidophilus NCFM Site: position = -32 score = 6.07433 sequence = ATAGTTACATTTGTAAACGA Gene: LBA1963: Copper transport transcriptional regulator CopR, CopY family	* Lactobacillus brevis ATCC 367 Site: position = -68 score = 5.40928 sequence = ATGACTACAGATGTAGACTC Site: position = -35 score = 6.0317 sequence = AAGATTACATTTGTAGTCTA Gene: LVIS_0270: Copper transport transcriptional regulator CopR, CopY family	2 Lactobacillus casei ATCC 334* Site: position = -29 score = 6.06101 sequence = TAGATTACAGATGTAAACGG Site: position = -59 score = 4.95698 sequence = TGGTTTACAGTTGTAAATTA Gene: LSEI_1745: Copper transport transcriptional regulator CopR, CopY family Site: position = -46 score = 4.57725 sequence = GAGACTACAAACGTAAACTT Site: position = -77 score = 5.38976 sequence = GTGACTACAGTTGTAAACTA Gene: LSEI_A02: Copper transport transcriptional regulator CopR, CopY family	* Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -31 score = 6.01919 sequence = AAGGTTATAGATGTAAACGA Site: position = -72 score = 4.7991 sequence = TTGTCGACAAATGTAAACCA Gene: LBUL_0587: Copper transport transcriptional regulator CopR, CopY family	* Lactobacillus fermentum IFO 3956 Site: position = -42 score = 4.56108 sequence = ACGGGTACACTTGTAAACTG Gene: LAF_1037: Copper transport transcriptional regulator CopR, CopY family	* Lactobacillus helveticus DPC 4571 Site: position = -32 score = 6.26191 sequence = ATATTTACAAATGTAAACTA Site: position = -59 score = 5.34835 sequence = AAGTTTACAAATGTAAAATT Gene: lhv_2094: Copper transport transcriptional regulator CopR, CopY family	* Lactobacillus johnsonii NCC 533 Site: position = -61 score = 5.37472 sequence = TTGTTGACAAGTGTAAACTA Site: position = -33 score = 6.33884 sequence = ATGATTACATTTGTAAACGA Gene: LJ1835: Copper transport transcriptional regulator CopR, CopY family	* Lactobacillus plantarum WCFS1 Site: position = -52 score = 5.19779 sequence = ACGTTTACGGTTGTAAACTA Gene: lp_3365: Copper transport transcriptional regulator CopR, CopY family	* Lactobacillus reuteri JCM 1112 Site: position = -32 score = 5.10309 sequence = GAATTTACATGTGTAAACGC Gene: LAR_0894: Copper transport transcriptional regulator CopR, CopY family	* Lactobacillus rhamnosus GG Site: position = -29 score = 6.21098 sequence = AAGATTACAAGTGTAAACGG Site: position = -59 score = 4.95698 sequence = TCGTTTACAGTTGTAAATTA Gene: LGG_01802: Copper transport transcriptional regulator CopR, CopY family	* Lactobacillus sakei subsp. sakei 23K Site: position = -35 score = 6.4399 sequence = ATAATTACAAATGTAAACGA Gene: LSA1461: Copper transport transcriptional regulator CopR, CopY family	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1318: Copper transport transcriptional regulator CopR, CopY family	* Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Site: position = -25 score = 5.92004 sequence = TAGTTTACAGTTGTAGACTA Gene: LEUM_0049: Copper transport transcriptional regulator CopR, CopY family	* Oenococcus oeni PSU-1 Site: position = -30 score = 5.8306 sequence = AAGTCTACAAGTGTAGACTA Gene: OEOE_1648: Copper transport transcriptional regulator CopR, CopY family	* Pediococcus pentosaceus ATCC 25745 Site: position = -35 score = 5.92558 sequence = AAGATTACATTTGTAAACAG Site: position = -61 score = 6.11324 sequence = AAGTTTACAAATGTAGTCTA Gene: PEPE_1646: Copper transport transcriptional regulator CopR, CopY family	Copper transport transcriptional regulator CopR, CopY family
copA2	Lactobacillus acidophilus NCFM Gene: LBA1964: Copper-exporting ATPase (EC 3.6.3.4)	* Lactobacillus brevis ATCC 367 Site: position = -139 score = 5.67733 sequence = AGGATTACATTTGTAAACAA Site: position = -184 score = 5.13496 sequence = TCGTTGACAGATGTAAACGA Gene: LVIS_0274: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0588: Copper-exporting ATPase (EC 3.6.3.4)	* Lactobacillus fermentum IFO 3956 Site: position = -80 score = 4.86402 sequence = TCGTTGACAATTGTAAACGG Site: position = -35 score = 5.73812 sequence = AGATTTACAGTTGTAAACGA Gene: LAF_0138: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus helveticus DPC 4571 Gene: lhv_2095: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus johnsonii NCC 533 Gene: LJ1836: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus plantarum WCFS1	* Lactobacillus reuteri JCM 1112 Site: position = -70 score = 4.55216 sequence = TTGTTGACAACTGTAAACTT Site: position = -27 score = 6.35405 sequence = ATGATTACAATTGTAAACTA Gene: LAR_0423: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -35 score = 5.36788 sequence = GTGATTACAAATGTAAATTA Gene: LSL_1706: Copper-exporting ATPase (EC 3.6.3.4)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Copper-exporting ATPase (EC 3.6.3.4)
copA3	Lactobacillus acidophilus NCFM Gene: LBA1965: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_0139: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus helveticus DPC 4571 Gene: lhv_2096: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus johnsonii NCC 533 Gene: LJ1837: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112 Gene: LAR_0424: Copper-exporting ATPase (EC 3.6.3.4)	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1705: Copper-exporting ATPase (EC 3.6.3.4)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Copper-exporting ATPase (EC 3.6.3.4)
copA	Lactobacillus acidophilus NCFM Gene: LBA1966: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus brevis ATCC 367 Gene: LVIS_0273: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0589: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus fermentum IFO 3956 Gene: LAF_0140: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus helveticus DPC 4571 Gene: lhv_2097: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus johnsonii NCC 533 Gene: LJ1838: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112 Gene: LAR_0425: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1704: Copper-translocating P-type ATPase (EC 3.6.3.4)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Copper-translocating P-type ATPase (EC 3.6.3.4)
LSEI_1744	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334 Gene: LSEI_1744: Hypothetical protein	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Hypothetical protein
copB	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_0269: Copper-translocating P-type ATPase (EC 3.6.3.4)	2 Lactobacillus casei ATCC 334 Gene: LSEI_1743: Copper-translocating P-type ATPase (EC 3.6.3.4) Gene: LSEI_A01: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1157: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus fermentum IFO 3956	* Lactobacillus helveticus DPC 4571 Site: position = -177 score = 5.38976 sequence = GTGACTACAGTTGTAAACTA Site: position = -146 score = 5.14339 sequence = GAGACTACAAATGTAAACTT Gene: lhv_1944: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -43 score = 5.85297 sequence = TAAATTACAGATGTAGACAA Site: position = -69 score = 4.72189 sequence = TCGTCTACAATTGTAAACTT Gene: lp_3363: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG Gene: LGG_01801: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus sakei subsp. sakei 23K Gene: LSA1460: Copper-translocating P-type ATPase (EC 3.6.3.4)	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0048: Copper-translocating P-type ATPase (EC 3.6.3.4)	Oenococcus oeni PSU-1 Gene: OEOE_1647: Copper-translocating P-type ATPase (EC 3.6.3.4)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1645: Copper-translocating P-type ATPase (EC 3.6.3.4)	Copper-translocating P-type ATPase (EC 3.6.3.4)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CopR - Lactobacillaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --