Regulog Cobalamin - Chloroflexia
| Regulator type: | RNA regulatory element |
| Name: | Cobalamin |
| RFAM: | RF00174 |
| Regulation mode: | |
| Biological process: | Cobalamin biosynthesis |
| Effector: | Adenosylcobalamin |
| Phylum: | Chloroflexi |
Member of regulog collections
- By taxonomy - Chloroflexi
- By RNA motif - Cobalamin
- By effector - Adenosylcobalamin
- By pathway - Cobalamin biosynthesis
| Genome | Genes | Operons |
|---|---|---|
| Chloroflexus aggregans DSM 9485 | 26 | 2 |
| Chloroflexus sp. Y-400-fl | 14 | 3 |
| Roseiflexus castenholzii DSM 13941 | 23 | 2 |
| Roseiflexus sp. RS-1 | 32 | 3 |
| Herpetosiphon aurantiacus ATCC 23779 | 16 | 3 |
| Genes | Function | |||||
|---|---|---|---|---|---|---|
| CRON 1. | ||||||
| btuR |
*
Chloroflexus aggregans DSM 9485 Site: position = -262 score = 62.66 sequence = GCAATTCCATACTCA... Gene: Cagg_1279: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
*
Chloroflexus sp. Y-400-fl Site: position = -272 score = 62.1 sequence = CAAGTTCGTAGATCG... Gene: Chy400_2789: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
*
Roseiflexus castenholzii DSM 13941 Site: position = -424 score = 61.32 sequence = TCAATCCAACGACCG... Gene: Rcas_0649: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
*
Roseiflexus sp. RS-1 Site: position = -361 score = 61.95 sequence = AATGCAACGACCGTC... Gene: RoseRS_0557: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
*
Herpetosiphon aurantiacus ATCC 23779 Site: position = -281 score = 59.13 sequence = AATTTACAAGTTTGT... Gene: Haur_1060: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
| cobN |
Gene: Cagg_1278: CobN component of cobalt chelatase involved in B12 biosynthesis |
Gene: Chy400_2788: CobN component of cobalt chelatase involved in B12 biosynthesis |
Gene: Rcas_0648: CobN component of cobalt chelatase involved in B12 biosynthesis |
Gene: RoseRS_0558: CobN component of cobalt chelatase involved in B12 biosynthesis |
Gene: Haur_1059: CobN component of cobalt chelatase involved in B12 biosynthesis |
CobN component of cobalt chelatase involved in B12 biosynthesis |
| cobT |
Gene: Cagg_1277: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
Gene: Chy400_2787: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
Gene: Rcas_0647: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
Gene: RoseRS_0559: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
|
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
| cbiM |
Gene: Cagg_1276: Substrate-specific component CbiM of cobalt ECF transporter |
Gene: Chy400_2786: Substrate-specific component CbiM of cobalt ECF transporter |
|
Gene: RoseRS_0560: Substrate-specific component CbiM of cobalt ECF transporter |
|
Substrate-specific component CbiM of cobalt ECF transporter |
| cbiN |
Gene: Cagg_1275: Additional substrate-specific component CbiN of cobalt ECF transporter |
Gene: Chy400_2785: Additional substrate-specific component CbiN of cobalt ECF transporter |
|
Gene: RoseRS_0561: Additional substrate-specific component CbiN of cobalt ECF transporter |
|
Additional substrate-specific component CbiN of cobalt ECF transporter |
| cbiQ |
Gene: Cagg_1274: Transmembrane component CbiQ of energizing module of cobalt ECF transporter |
|
|
Gene: RoseRS_0562: Transmembrane component CbiQ of energizing module of cobalt ECF transporter |
|
Transmembrane component CbiQ of energizing module of cobalt ECF transporter |
| cbiO |
Gene: Cagg_1273: ATPase component CbiO of energizing module of cobalt ECF transporter |
Gene: Chy400_2783: ATPase component CbiO of energizing module of cobalt ECF transporter |
Gene: Rcas_0646: ATPase component CbiO of energizing module of cobalt ECF transporter |
Gene: RoseRS_0563: ATPase component CbiO of energizing module of cobalt ECF transporter |
|
ATPase component CbiO of energizing module of cobalt ECF transporter |
| cbiB |
Gene: Cagg_1272: Adenosylcobinamide-phosphate synthase |
Gene: Chy400_2782: Adenosylcobinamide-phosphate synthase |
Gene: Rcas_0645: Adenosylcobinamide-phosphate synthase |
Gene: RoseRS_0564: Adenosylcobinamide-phosphate synthase |
Gene: Haur_1057: Adenosylcobinamide-phosphate synthase |
Adenosylcobinamide-phosphate synthase |
| cbiX |
Gene: Cagg_1271: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
Gene: Chy400_2779: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
Gene: Rcas_0644: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
Gene: RoseRS_0565: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
|
Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
| wrbA |
Gene: Cagg_1270: multimeric flavodoxin WrbA-like protein |
Gene: Chy400_2778: multimeric flavodoxin WrbA-like protein |
Gene: Rcas_0643: multimeric flavodoxin WrbA-like protein |
Gene: RoseRS_0566: multimeric flavodoxin WrbA-like protein |
|
multimeric flavodoxin WrbA-like protein |
| cbiC |
Gene: Cagg_1269: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
Gene: Chy400_2777: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
Gene: Rcas_0642: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
Gene: RoseRS_0567: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
|
Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
| cbiD |
Gene: Cagg_1268: Cobalt-precorrin-6 synthase, anaerobic |
Gene: Chy400_2776: Cobalt-precorrin-6 synthase, anaerobic |
Gene: Rcas_0641: Cobalt-precorrin-6 synthase, anaerobic |
Gene: RoseRS_0568: Cobalt-precorrin-6 synthase, anaerobic |
|
Cobalt-precorrin-6 synthase, anaerobic |
| cbiET |
Gene: Cagg_1267: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
Gene: Chy400_2775: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
Gene: Rcas_0640: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
Gene: RoseRS_0569: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
|
Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
| cbiL |
Gene: Cagg_1266: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
Gene: Chy400_2774: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
Gene: Rcas_0639: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
Gene: RoseRS_0570: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
|
Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
| cbiF |
Gene: Cagg_1265: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
Gene: Chy400_2773: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
Gene: Rcas_0638: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
Gene: RoseRS_0571: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
|
Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
| cbiGH |
Gene: Cagg_1264: Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase |
Gene: Chy400_2772: Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase |
Gene: Rcas_0637: Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase |
Gene: RoseRS_0572: Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase |
|
Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase |
| cobA |
Gene: Cagg_1263: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) |
Gene: Chy400_2771: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) |
Gene: Rcas_0636: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) |
Gene: RoseRS_0573: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) |
|
Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) |
| cbiA |
Gene: Cagg_1262: Cobyrinic acid A,C-diamide synthase |
Gene: Chy400_2770: Cobyrinic acid A,C-diamide synthase |
Gene: Rcas_0635: Cobyrinic acid A,C-diamide synthase |
Gene: RoseRS_0574: Cobyrinic acid A,C-diamide synthase |
Gene: Haur_2329: Cobyrinic acid A,C-diamide synthase |
Cobyrinic acid A,C-diamide synthase |
| cobU |
Gene: Cagg_1261: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: Chy400_2769: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: Rcas_0634: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: RoseRS_0575: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: Haur_1053: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
| cobD |
Gene: Cagg_1260: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
Gene: Chy400_2768: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
Gene: Rcas_0633: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
Gene: RoseRS_0576: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
Gene: Haur_1052: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
| cbiP |
Gene: Cagg_1259: Cobyric acid synthase |
Gene: Chy400_2767: Cobyric acid synthase |
Gene: Rcas_0632: Cobyric acid synthase |
Gene: RoseRS_0577: Cobyric acid synthase |
Gene: Haur_1051: Cobyric acid synthase |
Cobyric acid synthase |
| Haur_1058 |
|
|
|
|
Gene: Haur_1058: Methyltransferase type 11 |
Methyltransferase type 11 |
| btuF |
|
|
|
|
Gene: Haur_1056: Vitamin B12 ABC transporter, B12-binding component BtuF |
Vitamin B12 ABC transporter, B12-binding component BtuF |
| btuC |
|
|
|
|
Gene: Haur_1055: Vitamin B12 ABC transporter, permease component BtuC |
Vitamin B12 ABC transporter, permease component BtuC |
| btuD |
|
|
|
|
Gene: Haur_1054: Vitamin B12 ABC transporter, ATPase component BtuD |
Vitamin B12 ABC transporter, ATPase component BtuD |
| CRON 2. | ||||||
| cbrX |
*
Chloroflexus aggregans DSM 9485 Site: position = -313 score = 47.26 sequence = TGTATCACCCCACCG... Gene: Cagg_2179: LPXTG-motif cell wall anchor domain protein |
*
Chloroflexus sp. Y-400-fl Site: position = -267 score = 37.58 sequence = ATCAGACCTGTCCTG... Gene: Chy400_1314: LPXTG-motif cell wall anchor domain protein |
|
|
*
Herpetosiphon aurantiacus ATCC 23779 Site: position = -213 score = 47.67 sequence = ATCATAAATTGCTAT... Gene: Haur_3809: LPXTG-motif cell wall anchor domain protein |
LPXTG-motif cell wall anchor domain protein |
| cbrY |
Gene: Cagg_2178: hypothetical secreted protein, a putative component of B12 transporter, anchored in the membrane |
Gene: Chy400_1313: hypothetical secreted protein, a putative component of B12 transporter, anchored in the membrane |
|
|
Gene: Haur_3810: hypothetical secreted protein, a putative component of B12 transporter, anchored in the membrane |
hypothetical secreted protein, a putative component of B12 transporter, anchored in the membrane |
| cobC |
Gene: Cagg_2177: Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) |
Gene: Chy400_1312: Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) |
|
|
|
Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) |
| cobS |
Gene: Cagg_2176: Cobalamin 5'-phosphate synthase |
Gene: Chy400_1311: Cobalamin 5'-phosphate synthase |
Gene: Rcas_0173: Cobalamin 5'-phosphate synthase |
Gene: RoseRS_4584: Cobalamin 5'-phosphate synthase |
Gene: Haur_4390: Cobalamin 5'-phosphate synthase |
Cobalamin 5'-phosphate synthase |
| cbrV |
Gene: Cagg_2175: Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter |
Gene: Chy400_1310: Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter |
|
|
Gene: Haur_3811: Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter |
Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter |
| CRON 3. | ||||||
| nrdA |
|
|
|
|
*
Herpetosiphon aurantiacus ATCC 23779 Site: position = -279 score = 33.58 sequence = TACAAATTTTTTTGA... Gene: Haur_2575: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) |
Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) |
| nrdB |
|
|
|
|
Gene: Haur_2574: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) |
Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) |
| metE |
|
|
|
|
Gene: Haur_2573: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
| CRON 4. | ||||||
| RoseRS_3103 |
|
|
|
*
Roseiflexus sp. RS-1 Site: position = -344 score = 63.78 sequence = TAAACCTTTCAAACG... Gene: RoseRS_3103: hypothetical protein |
|
hypothetical protein |
| RoseRS_3102 |
|
|
|
Gene: RoseRS_3102: Core component MTH452 of predicted ECF transporter |
|
Core component MTH452 of predicted ECF transporter |
| RoseRS_3101 |
|
|
|
Gene: RoseRS_3101: Transmembrane component of energizing module of ECF transporters |
|
Transmembrane component of energizing module of ECF transporters |
| RoseRS_3100 |
|
|
|
Gene: RoseRS_3100: Duplicated ATPase component of energizing module of ECF transporters / ATPase component of general energizing module of ECF transporters |
|
Duplicated ATPase component of energizing module of ECF transporters / ATPase component of general energizing module of ECF transporters |
| cobN |
|
|
|
Gene: RoseRS_3099: Cobaltochelatase subunit CobN |
|
Cobaltochelatase subunit CobN |
| RoseRS_3098 |
|
|
|
Gene: RoseRS_3098: hypothetical protein |
|
hypothetical protein |
| CRON 5. | ||||||
| Rcas_2247 |
|
|
*
Roseiflexus castenholzii DSM 13941 Site: position = -325 score = 64.2 sequence = CAAGTGAATACCATC... Gene: Rcas_2247: hypothetical protein |
*
Roseiflexus sp. RS-1 Site: position = -197 score = 65.42 sequence = CAAGTGAATACCATC... Gene: RoseRS_3085: hypothetical protein |
|
hypothetical protein |
| btuF |
|
*
Chloroflexus sp. Y-400-fl Site: position = -421 score = 66.09 sequence = CAAGTTCATATCGTC... Gene: Chy400_0336: Vitamin B12 ABC transporter, B12-binding component BtuF |
Gene: Rcas_2248: Vitamin B12 ABC transporter, B12-binding component BtuF |
Gene: RoseRS_3086: Vitamin B12 ABC transporter, B12-binding component BtuF |
|
Vitamin B12 ABC transporter, B12-binding component BtuF |
| cbiW |
|
Gene: Chy400_0337: ferredoxin-like protein |
Gene: Rcas_2249: ferredoxin-like protein |
Gene: RoseRS_3087: ferredoxin-like protein |
|
ferredoxin-like protein |
| btuC |
|
Gene: Chy400_0338: Vitamin B12 ABC transporter, permease component BtuC |
Gene: Rcas_2250: Vitamin B12 ABC transporter, permease component BtuC |
Gene: RoseRS_3088: Vitamin B12 ABC transporter, permease component BtuC |
|
Vitamin B12 ABC transporter, permease component BtuC |
| btuD |
|
Gene: Chy400_0339: Vitamin B12 ABC transporter, ATP-binding component BtuD |
Gene: Rcas_2251: Vitamin B12 ABC transporter, ATP-binding component BtuD |
Gene: RoseRS_3089: Vitamin B12 ABC transporter, ATP-binding component BtuD |
|
Vitamin B12 ABC transporter, ATP-binding component BtuD |
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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Regulated Genes | [ Tab delimited format ] | DOWNLOAD |
|
Regulatory Sites | [ FASTA format ] | DOWNLOAD |